Running examples in ‘httk-Ex.R’ failed
The error most likely occurred in:

> base::assign(".ptime", proc.time(), pos = "CheckExEnv")
> ### Name: solve_dermal_pbtk
> ### Title: Solve_dermal_PBTK
> ### Aliases: solve_dermal_pbtk
> ### Keywords: Solve
> 
> ### ** Examples
> 
> 
> # Dermal exposure to default dose
> out <- solve_dermal_pbtk(chem.name="bisphenola")
Warning in solve_dermal_pbtk(chem.name = "bisphenola") :
  If route is not chosen, it is set to dermal by default.
Warning in solve_dermal_pbtk(chem.name = "bisphenola") :
  Vvehicle not specified, so set to 0.1 L.
Warning in solve_dermal_pbtk(chem.name = "bisphenola") :
  The initial.dose is automatically set to 1mg/kg.
Warning in get_clint(dtxsid = dtxsid, chem.name = chem.name, chem.cas = chem.cas,  :
  Clint is provided as a distribution.
Warning in apply_clint_adjustment(Clint.point, Fu_hep = Fu_hep, suppress.messages = suppress.messages) :
  Clint adjusted for in vitro partitioning (Kilford, 2008), see calc_hep_fu.
Warning in get_fup(dtxsid = dtxsid, chem.name = chem.name, chem.cas = chem.cas,  :
  Fraction unbound is provided as a distribution.
Warning in apply_fup_adjustment(fup.point, fup.correction = fup.adjustment,  :
  Fup adjusted for in vivo lipid partitioning (Pearce, 2017), see calc_fup_correction.
Warning in parameterize_dermal_pbtk(chem.name = "bisphenola", species = "Human",  :
  Funbound.plasma recalculated with adjustment.  Set adjusted.Funbound.plasma to FALSE to use original value.
Warning in available_rblood2plasma(chem.cas = chem.cas, species = species,  :
  Human in vivo measured Rblood2plasma used.
Warning in parameterize_dermal_pbtk(chem.name = "bisphenola", species = "Human",  :
  Since parameter Kvehicle2water is null, vehicle containing chemical is assumed to be water.
Warning in get_caco2(chem.cas = chem.cas, chem.name = chem.name, dtxsid = dtxsid,  :
  Default value of 1.6 used for Caco2 permeability.
DLSODA-  At T (=R1), too much accuracy requested  
      for precision of machine..  See TOLSF (=R2) 
In above message, R1 = 9.96383e-06, R2 = nan
 
Warning in lsoda(y, times, func, parms, ...) :
  Excessive precision requested.  scale up `rtol' and `atol' e.g by the factor 10
Warning in lsoda(y, times, func, parms, ...) :
  Returning early. Results are accurate, as far as they go
Error in (function (chem.name = NULL, chem.cas = NULL, dtxsid = NULL,  : 
  Some of the requested variables to monitor (monitor.vars) are not in
          the columns of the deSolve output object. These variables should
          belong to either the states or outputs of the model.
Calls: solve_dermal_pbtk -> do.call -> <Anonymous>
Execution halted
Examples with CPU (user + system) or elapsed time > 5s
                          user system elapsed
solve_1tri_pbtk          6.552  0.000  10.751
parameterize_steadystate 6.325  0.055   6.759
solve_1comp              5.467  0.000   7.581
parameterize_3comp2      4.527  0.027   5.916
calc_clearance_frac      4.271  0.079   5.197