checkRd: (-1) dec.sim.Rd:33: Lost braces; missing escapes or markup?
    33 | Assume there are $d$ dose levels to be studied. Denote the cumulative number of patients treated and cumulative number of DLTs at the current dose level are $n_i$ and $m_i$, respectively. $n_{max}$ is the maximum number of patients permitted to be treated at each dose level. The procedure is as follows
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checkRd: (-1) dec.sim.Rd:35: Lost braces in \itemize; meant \describe ?
checkRd: (-1) dec.sim.Rd:36: Lost braces in \itemize; meant \describe ?
checkRd: (-1) dec.sim.Rd:36: Lost braces; missing escapes or markup?
    36 | \item{Step 2 : }{If $n_i = n_{max}$, declare dose i as the MTD; otherwise, update $m_i$ and $n_i$ with additional cohort of patients and go to Step 1.}
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checkRd: (-1) dec.sim.Rd:37: Lost braces in \itemize; meant \describe ?
checkRd: (-1) dec.sim.Rd:37: Lost braces; missing escapes or markup?
    37 | \item{Step 3 : }{If the current dose level is the highest dose level, then: if n_i < n_max, update $m_i$ and $n_i$ with additional cohort of patients and go to Step 1; otherwise, stop the trial and declare that the MTD is higher than the highest dose level (inconclusive); If the current dose is not the lowest dose, then: if $n_{i-1} < n_{max}$, update $m_{i-1}$ and $n_{i-1}$ with additional cohort of patients and set the current dose level to be the next lower dose level, and go to Step 1; otherwise, stop the trial and declare the next lower dose level is the MTD; Additionally, if the decision is ``DU'', record this dose level as DU and never treat additional patients at the current dose level again.}
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checkRd: (-1) dec.sim.Rd:37: Lost braces; missing escapes or markup?
    37 | \item{Step 3 : }{If the current dose level is the highest dose level, then: if n_i < n_max, update $m_i$ and $n_i$ with additional cohort of patients and go to Step 1; otherwise, stop the trial and declare that the MTD is higher than the highest dose level (inconclusive); If the current dose is not the lowest dose, then: if $n_{i-1} < n_{max}$, update $m_{i-1}$ and $n_{i-1}$ with additional cohort of patients and set the current dose level to be the next lower dose level, and go to Step 1; otherwise, stop the trial and declare the next lower dose level is the MTD; Additionally, if the decision is ``DU'', record this dose level as DU and never treat additional patients at the current dose level again.}
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checkRd: (-1) dec.sim.Rd:37: Lost braces; missing escapes or markup?
    37 | \item{Step 3 : }{If the current dose level is the highest dose level, then: if n_i < n_max, update $m_i$ and $n_i$ with additional cohort of patients and go to Step 1; otherwise, stop the trial and declare that the MTD is higher than the highest dose level (inconclusive); If the current dose is not the lowest dose, then: if $n_{i-1} < n_{max}$, update $m_{i-1}$ and $n_{i-1}$ with additional cohort of patients and set the current dose level to be the next lower dose level, and go to Step 1; otherwise, stop the trial and declare the next lower dose level is the MTD; Additionally, if the decision is ``DU'', record this dose level as DU and never treat additional patients at the current dose level again.}
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checkRd: (-1) dec.sim.Rd:37: Lost braces; missing escapes or markup?
    37 | \item{Step 3 : }{If the current dose level is the highest dose level, then: if n_i < n_max, update $m_i$ and $n_i$ with additional cohort of patients and go to Step 1; otherwise, stop the trial and declare that the MTD is higher than the highest dose level (inconclusive); If the current dose is not the lowest dose, then: if $n_{i-1} < n_{max}$, update $m_{i-1}$ and $n_{i-1}$ with additional cohort of patients and set the current dose level to be the next lower dose level, and go to Step 1; otherwise, stop the trial and declare the next lower dose level is the MTD; Additionally, if the decision is ``DU'', record this dose level as DU and never treat additional patients at the current dose level again.}
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checkRd: (-1) dec.sim.Rd:38: Lost braces in \itemize; meant \describe ?
checkRd: (-1) dec.sim.Rd:38: Lost braces; missing escapes or markup?
    38 | \item{Step 4 : }{If the current dose level is the highest dose level, then: if $n_i < n_{max}$, update $m_i$ and $n_i$ with additional cohort of patients and go to Step 1; otherwise, stop the trial and declare that the MTD is higher than the highest dose level (inconclusive); If the next higher dose level is of status DU, then: if $n_i < n_{max}$, update $m_i$ and $n_i$ with additional cohort of patients and go to step 1; otherwise stop, the current dose level is MTD; Otherwise: if $n_{i+1} < n_{max}$, update $m_{i+1}$ and  $n_{i+1}$ with additional cohort of patients, set the current dose level to be next higher dose level, and go to step 1; else, the current dose level is the MTD. }
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checkRd: (-1) dec.sim.Rd:38: Lost braces; missing escapes or markup?
    38 | \item{Step 4 : }{If the current dose level is the highest dose level, then: if $n_i < n_{max}$, update $m_i$ and $n_i$ with additional cohort of patients and go to Step 1; otherwise, stop the trial and declare that the MTD is higher than the highest dose level (inconclusive); If the next higher dose level is of status DU, then: if $n_i < n_{max}$, update $m_i$ and $n_i$ with additional cohort of patients and go to step 1; otherwise stop, the current dose level is MTD; Otherwise: if $n_{i+1} < n_{max}$, update $m_{i+1}$ and  $n_{i+1}$ with additional cohort of patients, set the current dose level to be next higher dose level, and go to step 1; else, the current dose level is the MTD. }
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checkRd: (-1) dec.sim.Rd:38: Lost braces; missing escapes or markup?
    38 | \item{Step 4 : }{If the current dose level is the highest dose level, then: if $n_i < n_{max}$, update $m_i$ and $n_i$ with additional cohort of patients and go to Step 1; otherwise, stop the trial and declare that the MTD is higher than the highest dose level (inconclusive); If the next higher dose level is of status DU, then: if $n_i < n_{max}$, update $m_i$ and $n_i$ with additional cohort of patients and go to step 1; otherwise stop, the current dose level is MTD; Otherwise: if $n_{i+1} < n_{max}$, update $m_{i+1}$ and  $n_{i+1}$ with additional cohort of patients, set the current dose level to be next higher dose level, and go to step 1; else, the current dose level is the MTD. }
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checkRd: (-1) dec.sim.Rd:38: Lost braces; missing escapes or markup?
    38 | \item{Step 4 : }{If the current dose level is the highest dose level, then: if $n_i < n_{max}$, update $m_i$ and $n_i$ with additional cohort of patients and go to Step 1; otherwise, stop the trial and declare that the MTD is higher than the highest dose level (inconclusive); If the next higher dose level is of status DU, then: if $n_i < n_{max}$, update $m_i$ and $n_i$ with additional cohort of patients and go to step 1; otherwise stop, the current dose level is MTD; Otherwise: if $n_{i+1} < n_{max}$, update $m_{i+1}$ and  $n_{i+1}$ with additional cohort of patients, set the current dose level to be next higher dose level, and go to step 1; else, the current dose level is the MTD. }
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checkRd: (-1) dec.sim.Rd:38: Lost braces; missing escapes or markup?
    38 | \item{Step 4 : }{If the current dose level is the highest dose level, then: if $n_i < n_{max}$, update $m_i$ and $n_i$ with additional cohort of patients and go to Step 1; otherwise, stop the trial and declare that the MTD is higher than the highest dose level (inconclusive); If the next higher dose level is of status DU, then: if $n_i < n_{max}$, update $m_i$ and $n_i$ with additional cohort of patients and go to step 1; otherwise stop, the current dose level is MTD; Otherwise: if $n_{i+1} < n_{max}$, update $m_{i+1}$ and  $n_{i+1}$ with additional cohort of patients, set the current dose level to be next higher dose level, and go to step 1; else, the current dose level is the MTD. }
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checkRd: (-1) dec.sim.Rd:38: Lost braces; missing escapes or markup?
    38 | \item{Step 4 : }{If the current dose level is the highest dose level, then: if $n_i < n_{max}$, update $m_i$ and $n_i$ with additional cohort of patients and go to Step 1; otherwise, stop the trial and declare that the MTD is higher than the highest dose level (inconclusive); If the next higher dose level is of status DU, then: if $n_i < n_{max}$, update $m_i$ and $n_i$ with additional cohort of patients and go to step 1; otherwise stop, the current dose level is MTD; Otherwise: if $n_{i+1} < n_{max}$, update $m_{i+1}$ and  $n_{i+1}$ with additional cohort of patients, set the current dose level to be next higher dose level, and go to step 1; else, the current dose level is the MTD. }
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