Running ‘spelling.R’ [0s/0s]
  Running ‘testthat.R’ [107s/91s]
Running the tests in ‘tests/testthat.R’ failed.
Complete output:
  > # This file is part of the standard setup for testthat.
  > # It is recommended that you do not modify it.
  > #
  > # Where should you do additional test configuration?
  > # Learn more about the roles of various files in:
  > # * https://r-pkgs.org/tests.html
  > # * https://testthat.r-lib.org/reference/test_package.html#special-files
  > 
  > library(testthat)
  > library(Colossus)
  > 
  > test_check("Colossus")
  Note: Starting Censoring weight Plot Function
  Note: 901 risk groups
  Saving 7 x 7 in image
  153.499294651964
  Note: Starting Plot Function
  Note: Getting Plot Info
  Note: 2 risk groups
  Note: 2 risk groups
  Note: Starting Plot Function
  Note: Getting Plot Info
  Error: no events
  Note: Starting Plot Function
  Note: Getting Plot Info
  Note: 2 risk groups
  Error: Plot type not given
  Note: Starting Plot Function
  Note: Getting Plot Info
  Note: 2 risk groups
  Error: Stratification Column not in dataframe
  Note: Starting Plot Function
  Note: Getting Plot Info
  Note: 2 risk groups
  Error: Stratification Column not given
  Note: Starting Plot Function
  Note: Getting Plot Info
  Note: 2 risk groups
  Error: dose column not given
  Note: Starting Plot Function
  Note: Getting Plot Info
  Note: 2 risk groups
  Error: dose column not given
  Note: Starting Plot Function
  Note: Getting Plot Info
  Note: 2 risk groups
  Error: ID column is not in the dataframe
  Note: Starting Plot Function
  Note: Getting Plot Info
  Note: 2 risk groups
  Error: ID column not given
  Note: Starting Plot Function
  Note: Getting Plot Info
  Note: 3 risk groups
  Note: 3 risk groups
  C++ Note: START_COX_GUESS
  C++ Note: Current Time, Fri Feb 23 05:58:17 2024
  
  C++ Note: Term checked 0  
  C++ Note: df99,163,Starting
  C++ Note: Current Time, Fri Feb 23 05:58:17 2024
  
  C++ Note: Grouping Start
  C++ Note: df100 566 0 0 -1,Prep_List
  C++ Note: Current Time, Fri Feb 23 05:58:17 2024
  
  C++ Note: starting subterms 1 in guess 0
  C++ Note: values checked -0.1  
  C++ Note: sums checked 3.91896  
  C++ Note: derivs checked 21.9591  
  C++ Note: second derivs checked 138.335  
  C++ Note: dose checked 7  
  C++ Note: non-dose checked 3.91896  
  C++ Note: LIN_non-dose checked 7  
  C++ Note: PLIN_non-dose checked 7  
  C++ Note: LOGLIN_non-dose checked 3.91896  
  C++ Note: risk checked 3.91896  
  C++ Note: risk1 checked 21.9591  
  C++ Note: risk2 checked 138.335  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 1.84393  
  C++ Note: risk1r checked 8.73121  
  C++ Note: risk2r checked 46.1633  
  C++ Note: riskl checked 1.84393  
  C++ Note: risk1l checked 8.73121  
  C++ Note: risk2l checked 46.1633  
  C++ Note: df101 0  
  C++ Note: df102 0  
  C++ Note: df103 0  
  C++ Note: df104 -0.1  
  C++ Note: df105 -nan  
  C++ Note: df106 -nan  
  C++ Note: riskr checked 1.84393  
  C++ Note: risk1r checked 8.73121  
  C++ Note: risk2r checked 46.1633  
  C++ Note: riskl checked 1.84393  
  C++ Note: risk1l checked 8.73121  
  C++ Note: risk2l checked 46.1633  
  C++ Note: df101 0  
  C++ Note: df102 0  
  C++ Note: df103 0  
  C++ Note: df104 -0.1  
  C++ Note: df105 -nan  
  C++ Note: df106 -nan  
  C++ Note: ending guess 0
  C++ Note: df501 0
  C++ Note: df504 -0.1  
  C++ Note: Refreshing matrices after all guesses
  C++ Note: Guess Results
  Guess number, parameter values, Log-Likelihood
  0, -0.1, 0<-- Best Guess
  C++ Note: starting subterms 1 in best guess 0
  C++ Note: values checked -0.1  
  C++ Note: sums checked 3.91896  
  C++ Note: derivs checked 21.9591  
  C++ Note: second derivs checked 138.335  
  C++ Note: dose checked 7  
  C++ Note: non-dose checked 3.91896  
  C++ Note: LIN_non-dose checked 7  
  C++ Note: PLIN_non-dose checked 7  
  C++ Note: LOGLIN_non-dose checked 3.91896  
  C++ Note: risk checked 3.91896  
  C++ Note: risk1 checked 21.9591  
  C++ Note: risk2 checked 138.335  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 1.84393  
  C++ Note: risk1r checked 8.73121  
  C++ Note: risk2r checked 46.1633  
  C++ Note: riskl checked 1.84393  
  C++ Note: risk1l checked 8.73121  
  C++ Note: risk2l checked 46.1633  
  C++ Note: df101 0  
  C++ Note: df102 0  
  C++ Note: df103 0  
  C++ Note: df104 -0.1  
  C++ Note: df105 -nan  
  C++ Note: df106 -nan  
  C++ Note: riskr checked 1.84393  
  C++ Note: risk1r checked 8.73121  
  C++ Note: risk2r checked 46.1633  
  C++ Note: riskl checked 1.84393  
  C++ Note: risk1l checked 8.73121  
  C++ Note: risk2l checked 46.1633  
  C++ Note: df101 0  
  C++ Note: df102 0  
  C++ Note: df103 0  
  C++ Note: df104 -0.1  
  C++ Note: df105 -nan  
  C++ Note: df106 -nan  
  C++ Note: Exiting Regression
  C++ Note: df501 0
  C++ Note: df504 -0.1  
  Note: starting ph_plot
  Note: nonStratified survival curve calculation
  C++ Note: START_PLOT
  C++ Note: Current Time, Fri Feb 23 05:58:17 2024
  
  C++ Note: Term checked 0  
  C++ Note: df99,57,Starting
  C++ Note: Current Time, Fri Feb 23 05:58:17 2024
  
  C++ Note: values checked -0.1  
  C++ Note: sums checked 3.91896  
  C++ Note: derivs checked 21.9591  
  C++ Note: second derivs checked 138.335  
  C++ Note: dose checked 7  
  C++ Note: non-dose checked 3.91896  
  C++ Note: LIN_non-dose checked 7  
  C++ Note: PLIN_non-dose checked 7  
  C++ Note: LOGLIN_non-dose checked 3.91896  
  C++ Note: risk checked 3.91896  
  C++ Note: risk1 checked 21.9591  
  C++ Note: risk2 checked 138.335  
  C++ Note: Grouping Start
  C++ Note: df100 660 0 0 -1,Prep_List
  C++ Note: Current Time, Fri Feb 23 05:58:17 2024
  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 1.84393  
  C++ Note: risk1r checked 8.73121  
  C++ Note: risk2r checked 46.1633  
  C++ Note: riskl checked 1.84393  
  C++ Note: risk1l checked 8.73121  
  C++ Note: risk2l checked 46.1633  
  C++ Note: df101 0  
  C++ Note: df102 0  
  C++ Note: df103 0  
  C++ Note: df104 -0.1  
  C++ Note: df105 -nan  
  C++ Note: df106 -nan  
  Note: writing survival data
  Note: Plotting Survival Curves
  Saving 7 x 7 in image
  Saving 7 x 7 in image
  Saving 7 x 7 in image
  Saving 7 x 7 in image
  Note: Starting Plot Function
  Note: Getting Plot Info
  Note: 3 risk groups
  Note: 3 risk groups
  C++ Note: START_COX_GUESS
  C++ Note: Current Time, Fri Feb 23 05:58:20 2024
  
  C++ Note: Term checked 0  
  C++ Note: df99,72,Starting
  C++ Note: Current Time, Fri Feb 23 05:58:20 2024
  
  C++ Note: Grouping Start
  C++ Note: df100 257 0 0 -1,Prep_List
  C++ Note: Current Time, Fri Feb 23 05:58:20 2024
  
  C++ Note: starting subterms 1 in guess 0
  C++ Note: values checked -0.1  
  C++ Note: sums checked 3.91896  
  C++ Note: derivs checked 21.9591  
  C++ Note: second derivs checked 138.335  
  C++ Note: dose checked 7  
  C++ Note: non-dose checked 3.91896  
  C++ Note: LIN_non-dose checked 7  
  C++ Note: PLIN_non-dose checked 7  
  C++ Note: LOGLIN_non-dose checked 3.91896  
  C++ Note: risk checked 3.91896  
  C++ Note: risk1 checked 21.9591  
  C++ Note: risk2 checked 138.335  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 7.11207  
  C++ Note: risk1r checked 41.5001  
  C++ Note: risk2r checked 269.583  
  C++ Note: riskl checked 2.29326  
  C++ Note: risk1l checked 12.3258  
  C++ Note: risk2l checked 74.9204  
  C++ Note: df101 -5.824  
  C++ Note: df102 -0.705933  
  C++ Note: df103 -15.0512  
  C++ Note: df104 -0.1  
  C++ Note: df105 0.046902  
  C++ Note: df106 8.25007  
  C++ Note: riskr checked 7.11207  
  C++ Note: risk1r checked 41.5001  
  C++ Note: risk2r checked 269.583  
  C++ Note: riskl checked 2.29326  
  C++ Note: risk1l checked 12.3258  
  C++ Note: risk2l checked 74.9204  
  C++ Note: df101 -5.824  
  C++ Note: df102 -0.705933  
  C++ Note: df103 -15.0512  
  C++ Note: df104 -0.1  
  C++ Note: df105 0.046902  
  C++ Note: df106 8.25007  
  C++ Note: ending guess 0
  C++ Note: df501 -5.823998
  C++ Note: df504 -0.1  
  C++ Note: Refreshing matrices after all guesses
  C++ Note: Guess Results
  Guess number, parameter values, Log-Likelihood
  0, -0.1, -5.823998<-- Best Guess
  C++ Note: starting subterms 1 in best guess 0
  C++ Note: values checked -0.1  
  C++ Note: sums checked 3.91896  
  C++ Note: derivs checked 21.9591  
  C++ Note: second derivs checked 138.335  
  C++ Note: dose checked 7  
  C++ Note: non-dose checked 3.91896  
  C++ Note: LIN_non-dose checked 7  
  C++ Note: PLIN_non-dose checked 7  
  C++ Note: LOGLIN_non-dose checked 3.91896  
  C++ Note: risk checked 3.91896  
  C++ Note: risk1 checked 21.9591  
  C++ Note: risk2 checked 138.335  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 7.11207  
  C++ Note: risk1r checked 41.5001  
  C++ Note: risk2r checked 269.583  
  C++ Note: riskl checked 2.29326  
  C++ Note: risk1l checked 12.3258  
  C++ Note: risk2l checked 74.9204  
  C++ Note: df101 -5.824  
  C++ Note: df102 -0.705933  
  C++ Note: df103 -15.0512  
  C++ Note: df104 -0.1  
  C++ Note: df105 0.046902  
  C++ Note: df106 8.25007  
  C++ Note: riskr checked 7.11207  
  C++ Note: risk1r checked 41.5001  
  C++ Note: risk2r checked 269.583  
  C++ Note: riskl checked 2.29326  
  C++ Note: risk1l checked 12.3258  
  C++ Note: risk2l checked 74.9204  
  C++ Note: df101 -5.824  
  C++ Note: df102 -0.705933  
  C++ Note: df103 -15.0512  
  C++ Note: df104 -0.1  
  C++ Note: df105 0.046902  
  C++ Note: df106 8.25007  
  C++ Note: Exiting Regression
  C++ Note: df501 -5.823998
  C++ Note: df504 -0.1  
  Note: starting ph_plot
  Note: Stratified survival curve calculation
  Note: 2  strata used
  Note: 2  strata used
  Note: 3 risk groups
  C++ Note: START_COX_GUESS
  C++ Note: Current Time, Fri Feb 23 05:58:20 2024
  
  C++ Note: Term checked 0  
  C++ Note: df99,67,Starting
  C++ Note: Current Time, Fri Feb 23 05:58:20 2024
  
  C++ Note: Grouping Start
  C++ Note: df100 15818 0 0 -1,Prep_List
  C++ Note: Current Time, Fri Feb 23 05:58:20 2024
  
  C++ Note: starting subterms 1 in guess 0
  C++ Note: values checked -0.1  
  C++ Note: sums checked 3.91896  
  C++ Note: derivs checked 21.9591  
  C++ Note: second derivs checked 138.335  
  C++ Note: dose checked 7  
  C++ Note: non-dose checked 3.91896  
  C++ Note: LIN_non-dose checked 7  
  C++ Note: PLIN_non-dose checked 7  
  C++ Note: LOGLIN_non-dose checked 3.91896  
  C++ Note: risk checked 3.91896  
  C++ Note: risk1 checked 21.9591  
  C++ Note: risk2 checked 138.335  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 2.2112 3.88777  
  C++ Note: riskl checked 1.05586 1.2374  
  C++ Note: df101 -3.56531  
  C++ Note: df102 0.377208  
  C++ Note: df103 -10.9514  
  C++ Note: df104 -0.1  
  C++ Note: df105 -0.0344437  
  C++ Note: df106 -9.45185  
  C++ Note: riskr checked 2.2112 3.88777  
  C++ Note: riskl checked 1.05586 1.2374  
  C++ Note: df101 -3.56531  
  C++ Note: df102 0.377208  
  C++ Note: df103 -10.9514  
  C++ Note: df104 -0.1  
  C++ Note: df105 -0.0344437  
  C++ Note: df106 -9.45185  
  C++ Note: ending guess 0
  C++ Note: df501 -3.56531
  C++ Note: df504 -0.1  
  C++ Note: Refreshing matrices after all guesses
  C++ Note: Guess Results
  Guess number, parameter values, Log-Likelihood
  0, -0.1, -3.56531<-- Best Guess
  C++ Note: starting subterms 1 in best guess 0
  C++ Note: values checked -0.1  
  C++ Note: sums checked 3.91896  
  C++ Note: derivs checked 21.9591  
  C++ Note: second derivs checked 138.335  
  C++ Note: dose checked 7  
  C++ Note: non-dose checked 3.91896  
  C++ Note: LIN_non-dose checked 7  
  C++ Note: PLIN_non-dose checked 7  
  C++ Note: LOGLIN_non-dose checked 3.91896  
  C++ Note: risk checked 3.91896  
  C++ Note: risk1 checked 21.9591  
  C++ Note: risk2 checked 138.335  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 2.2112 3.88777  
  C++ Note: riskl checked 1.05586 1.2374  
  C++ Note: df101 -3.56531  
  C++ Note: df102 0.377208  
  C++ Note: df103 -10.9514  
  C++ Note: df104 -0.1  
  C++ Note: df105 -0.0344437  
  C++ Note: df106 -9.45185  
  C++ Note: riskr checked 2.2112 3.88777  
  C++ Note: riskl checked 1.05586 1.2374  
  C++ Note: df101 -3.56531  
  C++ Note: df102 0.377208  
  C++ Note: df103 -10.9514  
  C++ Note: df104 -0.1  
  C++ Note: df105 -0.0344437  
  C++ Note: df106 -9.45185  
  C++ Note: Exiting Regression
  C++ Note: df501 -3.56531
  C++ Note: df504 -0.1  
  Note: Starting Stratification: Calculation
  C++ Note: START_PLOT
  C++ Note: Current Time, Fri Feb 23 05:58:20 2024
  
  C++ Note: Term checked 0  
  C++ Note: df99,93,Starting
  C++ Note: Current Time, Fri Feb 23 05:58:20 2024
  
  C++ Note: values checked -0.1  
  C++ Note: sums checked 3.91896  
  C++ Note: derivs checked 21.9591  
  C++ Note: second derivs checked 138.335  
  C++ Note: dose checked 7  
  C++ Note: non-dose checked 3.91896  
  C++ Note: LIN_non-dose checked 7  
  C++ Note: PLIN_non-dose checked 7  
  C++ Note: LOGLIN_non-dose checked 3.91896  
  C++ Note: risk checked 3.91896  
  C++ Note: risk1 checked 21.9591  
  C++ Note: risk2 checked 138.335  
  C++ Note: Grouping Start
  C++ Note: df100 551 0 0 -1,Prep_List
  C++ Note: Current Time, Fri Feb 23 05:58:20 2024
  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 2.2112 3.88777  
  C++ Note: riskl checked 1.05586 1.2374  
  C++ Note: df101 -3.56531  
  C++ Note: df102 0.377208  
  C++ Note: df103 -10.9514  
  C++ Note: df104 -0.1  
  C++ Note: df105 -0.0344437  
  C++ Note: df106 -9.45185  
  Note: Starting Stratification calculation  1
  Note: Starting Stratification calculation  2
  Saving 7 x 7 in image
  Note: Starting Plot Function
  Note: Getting Plot Info
  Note: 3 risk groups
  Note: 3 risk groups
  C++ Note: START_COX_GUESS
  C++ Note: Current Time, Fri Feb 23 05:58:21 2024
  
  C++ Note: Term checked 0  
  C++ Note: df99,78,Starting
  C++ Note: Current Time, Fri Feb 23 05:58:21 2024
  
  C++ Note: Grouping Start
  C++ Note: df100 1351 0 0 -1,Prep_List
  C++ Note: Current Time, Fri Feb 23 05:58:21 2024
  
  C++ Note: starting subterms 1 in guess 0
  C++ Note: values checked -0.1  
  C++ Note: sums checked 3.91896  
  C++ Note: derivs checked 21.9591  
  C++ Note: second derivs checked 138.335  
  C++ Note: dose checked 7  
  C++ Note: non-dose checked 3.91896  
  C++ Note: LIN_non-dose checked 7  
  C++ Note: PLIN_non-dose checked 7  
  C++ Note: LOGLIN_non-dose checked 3.91896  
  C++ Note: risk checked 3.91896  
  C++ Note: risk1 checked 21.9591  
  C++ Note: risk2 checked 138.335  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 1.84393  
  C++ Note: risk1r checked 8.73121  
  C++ Note: risk2r checked 46.1633  
  C++ Note: riskl checked 1.84393  
  C++ Note: risk1l checked 8.73121  
  C++ Note: risk2l checked 46.1633  
  C++ Note: df101 0  
  C++ Note: df102 0  
  C++ Note: df103 0  
  C++ Note: df104 -0.1  
  C++ Note: df105 -nan  
  C++ Note: df106 -nan  
  C++ Note: riskr checked 1.84393  
  C++ Note: risk1r checked 8.73121  
  C++ Note: risk2r checked 46.1633  
  C++ Note: riskl checked 1.84393  
  C++ Note: risk1l checked 8.73121  
  C++ Note: risk2l checked 46.1633  
  C++ Note: df101 0  
  C++ Note: df102 0  
  C++ Note: df103 0  
  C++ Note: df104 -0.1  
  C++ Note: df105 -nan  
  C++ Note: df106 -nan  
  C++ Note: ending guess 0
  C++ Note: df501 0
  C++ Note: df504 -0.1  
  C++ Note: Refreshing matrices after all guesses
  C++ Note: Guess Results
  Guess number, parameter values, Log-Likelihood
  0, -0.1, 0<-- Best Guess
  C++ Note: starting subterms 1 in best guess 0
  C++ Note: values checked -0.1  
  C++ Note: sums checked 3.91896  
  C++ Note: derivs checked 21.9591  
  C++ Note: second derivs checked 138.335  
  C++ Note: dose checked 7  
  C++ Note: non-dose checked 3.91896  
  C++ Note: LIN_non-dose checked 7  
  C++ Note: PLIN_non-dose checked 7  
  C++ Note: LOGLIN_non-dose checked 3.91896  
  C++ Note: risk checked 3.91896  
  C++ Note: risk1 checked 21.9591  
  C++ Note: risk2 checked 138.335  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 1.84393  
  C++ Note: risk1r checked 8.73121  
  C++ Note: risk2r checked 46.1633  
  C++ Note: riskl checked 1.84393  
  C++ Note: risk1l checked 8.73121  
  C++ Note: risk2l checked 46.1633  
  C++ Note: df101 0  
  C++ Note: df102 0  
  C++ Note: df103 0  
  C++ Note: df104 -0.1  
  C++ Note: df105 -nan  
  C++ Note: df106 -nan  
  C++ Note: riskr checked 1.84393  
  C++ Note: risk1r checked 8.73121  
  C++ Note: risk2r checked 46.1633  
  C++ Note: riskl checked 1.84393  
  C++ Note: risk1l checked 8.73121  
  C++ Note: risk2l checked 46.1633  
  C++ Note: df101 0  
  C++ Note: df102 0  
  C++ Note: df103 0  
  C++ Note: df104 -0.1  
  C++ Note: df105 -nan  
  C++ Note: df106 -nan  
  C++ Note: Exiting Regression
  C++ Note: df501 0
  C++ Note: df504 -0.1  
  C++ Note: START_PLOT
  C++ Note: Current Time, Fri Feb 23 05:58:21 2024
  
  C++ Note: Term checked 0  
  C++ Note: df99,147,Starting
  C++ Note: Current Time, Fri Feb 23 05:58:21 2024
  
  C++ Note: values checked -0.1  
  C++ Note: sums checked 5.29005  
  C++ Note: dose checked 7  
  C++ Note: non-dose checked 5.29005  
  C++ Note: LIN_non-dose checked 7  
  C++ Note: PLIN_non-dose checked 7  
  C++ Note: LOGLIN_non-dose checked 5.29005  
  C++ Note: risk checked 5.29005  
  Saving 7 x 7 in image
  Note: Starting Plot Function
  Note: Getting Plot Info
  Note: 86 risk groups
  Note: 86 risk groups
  C++ Note: START_COX_GUESS
  C++ Note: Current Time, Fri Feb 23 05:58:21 2024
  
  C++ Note: Term checked 0 1  
  C++ Note: df99,78,Starting
  C++ Note: Current Time, Fri Feb 23 05:58:21 2024
  
  C++ Note: Grouping Start
  C++ Note: df100 5209 0 0 -1,Prep_List
  C++ Note: Current Time, Fri Feb 23 05:58:22 2024
  
  C++ Note: starting subterms 2 in guess 0
  C++ Note: values checked 0.01 -15  
  C++ Note: sums checked 6437.95 3328  
  C++ Note: derivs checked 3813.95 0.000939732  
  C++ Note: second derivs checked 3813.95 0.000939732  
  C++ Note: dose checked 6400 6400  
  C++ Note: non-dose checked 6437.95 3328  
  C++ Note: LIN_non-dose checked 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400  
  C++ Note: LOGLIN_non-dose checked 6437.95 3328  
  C++ Note: risk checked 9787.82  
  C++ Note: risk1 checked 6011.82 0.000944651  
  C++ Note: risk2 checked 6011.82 0.000944651  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 6489.99  
  C++ Note: risk1r checked 4018.99 0.000575324  
  C++ Note: risk2r checked 4018.99 0.000575324  
  C++ Note: riskl checked 119.492  
  C++ Note: risk1l checked 49.4925 1.62651e-05  
  C++ Note: risk2l checked 49.4925 1.62651e-05  
  C++ Note: df101 -329.891 -329.891  
  C++ Note: df102 -21.7852 9.27193e-06  
  C++ Note: df103 -19.521 9.27193e-06  
  C++ Note: df104 0.01 -15  
  C++ Note: df105 1.11599 1  
  C++ Note: df106 15.1429 -3.55796e+07  
  C++ Note: riskr checked 6489.99  
  C++ Note: risk1r checked 4018.99 0.000575324  
  C++ Note: risk2r checked 4018.99 0.000575324  
  C++ Note: riskl checked 119.492  
  C++ Note: risk1l checked 49.4925 1.62651e-05  
  C++ Note: risk2l checked 49.4925 1.62651e-05  
  C++ Note: df101 -659.783 -659.783  
  C++ Note: df102 -43.5705 1.85439e-05  
  C++ Note: df103 -39.042 1.85439e-05  
  C++ Note: df104 0.01 -15  
  C++ Note: df105 1.11599 1  
  C++ Note: df106 15.1429 -3.55796e+07  
  C++ Note: ending guess 0
  C++ Note: df501 -659.7828
  C++ Note: df504 0.01 -15  
  C++ Note: Refreshing matrices after all guesses
  C++ Note: Guess Results
  Guess number, parameter values, Log-Likelihood
  0, 0.01 -15, -659.7828<-- Best Guess
  C++ Note: starting subterms 2 in best guess 0
  C++ Note: values checked 0.01 -15  
  C++ Note: sums checked 6437.95 3328  
  C++ Note: derivs checked 3813.95 0.000939732  
  C++ Note: second derivs checked 3813.95 0.000939732  
  C++ Note: dose checked 6400 6400  
  C++ Note: non-dose checked 6437.95 3328  
  C++ Note: LIN_non-dose checked 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400  
  C++ Note: LOGLIN_non-dose checked 6437.95 3328  
  C++ Note: risk checked 9787.82  
  C++ Note: risk1 checked 6011.82 0.000944651  
  C++ Note: risk2 checked 6011.82 0.000944651  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 6489.99  
  C++ Note: risk1r checked 4018.99 0.000575324  
  C++ Note: risk2r checked 4018.99 0.000575324  
  C++ Note: riskl checked 119.492  
  C++ Note: risk1l checked 49.4925 1.62651e-05  
  C++ Note: risk2l checked 49.4925 1.62651e-05  
  C++ Note: df101 -329.891 -329.891  
  C++ Note: df102 -21.7852 9.27193e-06  
  C++ Note: df103 -19.521 9.27193e-06  
  C++ Note: df104 0.01 -15  
  C++ Note: df105 1.11599 1  
  C++ Note: df106 15.1429 -3.55796e+07  
  C++ Note: riskr checked 6489.99  
  C++ Note: risk1r checked 4018.99 0.000575324  
  C++ Note: risk2r checked 4018.99 0.000575324  
  C++ Note: riskl checked 119.492  
  C++ Note: risk1l checked 49.4925 1.62651e-05  
  C++ Note: risk2l checked 49.4925 1.62651e-05  
  C++ Note: df101 -329.891 -329.891  
  C++ Note: df102 -21.7852 9.27193e-06  
  C++ Note: df103 -19.521 9.27193e-06  
  C++ Note: df104 0.01 -15  
  C++ Note: df105 1.11599 1  
  C++ Note: df106 15.1429 -3.55796e+07  
  C++ Note: Exiting Regression
  C++ Note: df501 -329.8914
  C++ Note: df504 0.01 -15  
  Note: 86 risk groups
  C++ Note: START_PLOT
  C++ Note: Current Time, Fri Feb 23 05:58:22 2024
  
  C++ Note: Term checked 0 1  
  C++ Note: df99,260,Starting
  C++ Note: Current Time, Fri Feb 23 05:58:22 2024
  
  C++ Note: values checked 0.01 -15  
  C++ Note: sums checked 6437.95 3328  
  C++ Note: derivs checked 3813.95 0.000939732  
  C++ Note: second derivs checked 3813.95 0.000939732  
  C++ Note: dose checked 6400 6400  
  C++ Note: non-dose checked 6437.95 3328  
  C++ Note: LIN_non-dose checked 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400  
  C++ Note: LOGLIN_non-dose checked 6437.95 3328  
  C++ Note: risk checked 9787.82  
  C++ Note: risk1 checked 6011.82 0.000944651  
  C++ Note: risk2 checked 6011.82 0.000944651  
  C++ Note: Grouping Start
  C++ Note: df100 4118 0 0 -1,Prep_List
  C++ Note: Current Time, Fri Feb 23 05:58:22 2024
  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 6489.99  
  C++ Note: risk1r checked 4018.99 0.000575324  
  C++ Note: risk2r checked 4018.99 0.000575324  
  C++ Note: riskl checked 119.492  
  C++ Note: risk1l checked 49.4925 1.62651e-05  
  C++ Note: risk2l checked 49.4925 1.62651e-05  
  C++ Note: df101 -329.891 -329.891  
  C++ Note: df102 -21.7852 9.27193e-06  
  C++ Note: df103 -19.521 9.27193e-06  
  C++ Note: df104 0.01 -15  
  C++ Note: df105 1.11599 1  
  C++ Note: df106 15.1429 -3.55796e+07  
  C++ Note: starting plot data 
  Saving 7 x 7 in image
  Saving 7 x 7 in image
  Saving 7 x 7 in image
  Saving 7 x 7 in image
  Note: Starting Plot Function
  Note: Getting Plot Info
  Note: 2 risk groups
  Note: 2 risk groups
  C++ Note: START_COX_GUESS
  C++ Note: Current Time, Fri Feb 23 05:58:24 2024
  
  C++ Note: Term checked 0  
  C++ Note: df99,81,Starting
  C++ Note: Current Time, Fri Feb 23 05:58:24 2024
  
  C++ Note: Grouping Start
  C++ Note: df100 279 0 0 -1,Prep_List
  C++ Note: Current Time, Fri Feb 23 05:58:24 2024
  
  C++ Note: starting subterms 1 in guess 0
  C++ Note: values checked -0.1  
  C++ Note: sums checked 3.91896  
  C++ Note: derivs checked 21.9591  
  C++ Note: second derivs checked 138.335  
  C++ Note: dose checked 7  
  C++ Note: non-dose checked 3.91896  
  C++ Note: LIN_non-dose checked 7  
  C++ Note: PLIN_non-dose checked 7  
  C++ Note: LOGLIN_non-dose checked 3.91896  
  C++ Note: risk checked 3.91896  
  C++ Note: risk1 checked 21.9591  
  C++ Note: risk2 checked 138.335  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 1.11965  
  C++ Note: risk1r checked 6.27591  
  C++ Note: risk2r checked 39.4822  
  C++ Note: riskl checked 1.11965  
  C++ Note: risk1l checked 6.27591  
  C++ Note: risk2l checked 39.4822  
  C++ Note: df101 0  
  C++ Note: df102 0  
  C++ Note: df103 0  
  C++ Note: df104 -0.1  
  C++ Note: df105 -nan  
  C++ Note: df106 -nan  
  C++ Note: riskr checked 1.11965  
  C++ Note: risk1r checked 6.27591  
  C++ Note: risk2r checked 39.4822  
  C++ Note: riskl checked 1.11965  
  C++ Note: risk1l checked 6.27591  
  C++ Note: risk2l checked 39.4822  
  C++ Note: df101 0  
  C++ Note: df102 0  
  C++ Note: df103 0  
  C++ Note: df104 -0.1  
  C++ Note: df105 -nan  
  C++ Note: df106 -nan  
  C++ Note: ending guess 0
  C++ Note: df501 0
  C++ Note: df504 -0.1  
  C++ Note: Refreshing matrices after all guesses
  C++ Note: Guess Results
  Guess number, parameter values, Log-Likelihood
  0, -0.1, 0<-- Best Guess
  C++ Note: starting subterms 1 in best guess 0
  C++ Note: values checked -0.1  
  C++ Note: sums checked 3.91896  
  C++ Note: derivs checked 21.9591  
  C++ Note: second derivs checked 138.335  
  C++ Note: dose checked 7  
  C++ Note: non-dose checked 3.91896  
  C++ Note: LIN_non-dose checked 7  
  C++ Note: PLIN_non-dose checked 7  
  C++ Note: LOGLIN_non-dose checked 3.91896  
  C++ Note: risk checked 3.91896  
  C++ Note: risk1 checked 21.9591  
  C++ Note: risk2 checked 138.335  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 1.11965  
  C++ Note: risk1r checked 6.27591  
  C++ Note: risk2r checked 39.4822  
  C++ Note: riskl checked 1.11965  
  C++ Note: risk1l checked 6.27591  
  C++ Note: risk2l checked 39.4822  
  C++ Note: df101 0  
  C++ Note: df102 0  
  C++ Note: df103 0  
  C++ Note: df104 -0.1  
  C++ Note: df105 -nan  
  C++ Note: df106 -nan  
  C++ Note: riskr checked 1.11965  
  C++ Note: risk1r checked 6.27591  
  C++ Note: risk2r checked 39.4822  
  C++ Note: riskl checked 1.11965  
  C++ Note: risk1l checked 6.27591  
  C++ Note: risk2l checked 39.4822  
  C++ Note: df101 0  
  C++ Note: df102 0  
  C++ Note: df103 0  
  C++ Note: df104 -0.1  
  C++ Note: df105 -nan  
  C++ Note: df106 -nan  
  C++ Note: Exiting Regression
  C++ Note: df501 0
  C++ Note: df504 -0.1  
  Note: starting ph_plot
  Note: nonStratified survival curve calculation
  C++ Note: START_PLOT
  C++ Note: Current Time, Fri Feb 23 05:58:24 2024
  
  C++ Note: Term checked 0  
  C++ Note: df99,59,Starting
  C++ Note: Current Time, Fri Feb 23 05:58:24 2024
  
  C++ Note: values checked -0.1  
  C++ Note: sums checked 3.91896  
  C++ Note: derivs checked 21.9591  
  C++ Note: second derivs checked 138.335  
  C++ Note: dose checked 7  
  C++ Note: non-dose checked 3.91896  
  C++ Note: LIN_non-dose checked 7  
  C++ Note: PLIN_non-dose checked 7  
  C++ Note: LOGLIN_non-dose checked 3.91896  
  C++ Note: risk checked 3.91896  
  C++ Note: risk1 checked 21.9591  
  C++ Note: risk2 checked 138.335  
  C++ Note: Grouping Start
  C++ Note: df100 508 0 0 -1,Prep_List
  C++ Note: Current Time, Fri Feb 23 05:58:24 2024
  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 1.11965  
  C++ Note: risk1r checked 6.27591  
  C++ Note: risk2r checked 39.4822  
  C++ Note: riskl checked 1.11965  
  C++ Note: risk1l checked 6.27591  
  C++ Note: risk2l checked 39.4822  
  C++ Note: df101 0  
  C++ Note: df102 0  
  C++ Note: df103 0  
  C++ Note: df104 -0.1  
  C++ Note: df105 -nan  
  C++ Note: df106 -nan  
  Note: writing survival data
  Note: Plotting Martingale Residuals
  Note: Martingale Plot: d
  Saving 7 x 7 in image
  Saving 7 x 7 in image
  Note: Starting Plot Function
  Note: Getting Plot Info
  Note: 3 risk groups
  Note: 3 risk groups
  C++ Note: START_COX_GUESS
  C++ Note: Current Time, Fri Feb 23 05:58:26 2024
  
  C++ Note: Term checked 0  
  C++ Note: df99,76,Starting
  C++ Note: Current Time, Fri Feb 23 05:58:26 2024
  
  C++ Note: Grouping Start
  C++ Note: df100 207 0 0 -1,Prep_List
  C++ Note: Current Time, Fri Feb 23 05:58:26 2024
  
  C++ Note: starting subterms 1 in guess 0
  C++ Note: values checked -0.1  
  C++ Note: sums checked 3.91896  
  C++ Note: derivs checked 21.9591  
  C++ Note: second derivs checked 138.335  
  C++ Note: dose checked 7  
  C++ Note: non-dose checked 3.91896  
  C++ Note: LIN_non-dose checked 7  
  C++ Note: PLIN_non-dose checked 7  
  C++ Note: LOGLIN_non-dose checked 3.91896  
  C++ Note: risk checked 3.91896  
  C++ Note: risk1 checked 21.9591  
  C++ Note: risk2 checked 138.335  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 1.84393  
  C++ Note: risk1r checked 8.73121  
  C++ Note: risk2r checked 46.1633  
  C++ Note: riskl checked 1.84393  
  C++ Note: risk1l checked 8.73121  
  C++ Note: risk2l checked 46.1633  
  C++ Note: df101 0  
  C++ Note: df102 0  
  C++ Note: df103 0  
  C++ Note: df104 -0.1  
  C++ Note: df105 -nan  
  C++ Note: df106 -nan  
  C++ Note: riskr checked 1.84393  
  C++ Note: risk1r checked 8.73121  
  C++ Note: risk2r checked 46.1633  
  C++ Note: riskl checked 1.84393  
  C++ Note: risk1l checked 8.73121  
  C++ Note: risk2l checked 46.1633  
  C++ Note: df101 0  
  C++ Note: df102 0  
  C++ Note: df103 0  
  C++ Note: df104 -0.1  
  C++ Note: df105 -nan  
  C++ Note: df106 -nan  
  C++ Note: ending guess 0
  C++ Note: df501 0
  C++ Note: df504 -0.1  
  C++ Note: Refreshing matrices after all guesses
  C++ Note: Guess Results
  Guess number, parameter values, Log-Likelihood
  0, -0.1, 0<-- Best Guess
  C++ Note: starting subterms 1 in best guess 0
  C++ Note: values checked -0.1  
  C++ Note: sums checked 3.91896  
  C++ Note: derivs checked 21.9591  
  C++ Note: second derivs checked 138.335  
  C++ Note: dose checked 7  
  C++ Note: non-dose checked 3.91896  
  C++ Note: LIN_non-dose checked 7  
  C++ Note: PLIN_non-dose checked 7  
  C++ Note: LOGLIN_non-dose checked 3.91896  
  C++ Note: risk checked 3.91896  
  C++ Note: risk1 checked 21.9591  
  C++ Note: risk2 checked 138.335  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 1.84393  
  C++ Note: risk1r checked 8.73121  
  C++ Note: risk2r checked 46.1633  
  C++ Note: riskl checked 1.84393  
  C++ Note: risk1l checked 8.73121  
  C++ Note: risk2l checked 46.1633  
  C++ Note: df101 0  
  C++ Note: df102 0  
  C++ Note: df103 0  
  C++ Note: df104 -0.1  
  C++ Note: df105 -nan  
  C++ Note: df106 -nan  
  C++ Note: riskr checked 1.84393  
  C++ Note: risk1r checked 8.73121  
  C++ Note: risk2r checked 46.1633  
  C++ Note: riskl checked 1.84393  
  C++ Note: risk1l checked 8.73121  
  C++ Note: risk2l checked 46.1633  
  C++ Note: df101 0  
  C++ Note: df102 0  
  C++ Note: df103 0  
  C++ Note: df104 -0.1  
  C++ Note: df105 -nan  
  C++ Note: df106 -nan  
  C++ Note: Exiting Regression
  C++ Note: df501 0
  C++ Note: df504 -0.1  
  Note: starting ph_plot
  Note: nonStratified survival curve calculation
  C++ Note: START_PLOT
  C++ Note: Current Time, Fri Feb 23 05:58:26 2024
  
  C++ Note: Term checked 0  
  C++ Note: df99,105,Starting
  C++ Note: Current Time, Fri Feb 23 05:58:26 2024
  
  C++ Note: values checked -0.1  
  C++ Note: sums checked 3.91896  
  C++ Note: derivs checked 21.9591  
  C++ Note: second derivs checked 138.335  
  C++ Note: dose checked 7  
  C++ Note: non-dose checked 3.91896  
  C++ Note: LIN_non-dose checked 7  
  C++ Note: PLIN_non-dose checked 7  
  C++ Note: LOGLIN_non-dose checked 3.91896  
  C++ Note: risk checked 3.91896  
  C++ Note: risk1 checked 21.9591  
  C++ Note: risk2 checked 138.335  
  C++ Note: Grouping Start
  C++ Note: df100 10422 0 0 -1,Prep_List
  C++ Note: Current Time, Fri Feb 23 05:58:26 2024
  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 1.84393  
  C++ Note: risk1r checked 8.73121  
  C++ Note: risk2r checked 46.1633  
  C++ Note: riskl checked 1.84393  
  C++ Note: risk1l checked 8.73121  
  C++ Note: risk2l checked 46.1633  
  C++ Note: df101 0  
  C++ Note: df102 0  
  C++ Note: df103 0  
  C++ Note: df104 -0.1  
  C++ Note: df105 -nan  
  C++ Note: df106 -nan  
  Note: writing survival data
  Note: Plotting Survival Curves
  Saving 7 x 7 in image
  Saving 7 x 7 in image
  Saving 7 x 7 in image
  Saving 7 x 7 in image
  Note: Plotting Kaplan-Meier Curve
  Saving 7 x 7 in image
  Saving 7 x 7 in image
  Saving 7 x 7 in image
  Error: Cores Requested: 132 , Cores Available: 2
  Warning: a and e are equal
  Warning: a and e are equal
  Warning: b and f are equal
  Warning: a and d are equal
  Warning: a and f are equal
  Warning: a and b are equal
  Warning: a and c are equal
  Warning: a and b are equal
  Warning: a and c are equal
  Warning: a and b are equal
  Warning: a and c are equal
  Error: e not in data.table
  Error: e not in data.table
  Error: Iteration: a?+?b?+c has incorrect length of 4 but should be 3.
  Error: Incorrect operation of ++
  Error: Terms used: 2 , Terms with gmix types available: 1
  Error: Model formula FAILING_CHOICE not in acceptable list
  Error: Model formula MA not in acceptable list
  Error: Model formula EA not in acceptable list
  Note: Number of factors:1
  Note: Number of factors:7
  Error: a0 arguement was negative
  Error: a0 arguement was not a number
  Error: a0 arguement was not a number
  Error: a0 arguement was negative
  Error: a0 arguement was not a number
  Error: a0 arguement was not a number
  Error: a0 arguement was not a number
  Error: goal is too low
  Error: a0 arguement was negative
  Error: e missing from column names
  Error: The missing-value replacement is also NA
  Note: Column b had replaced values
  Note: Column b had replaced values
  Warning: Parameters used: 4, Covariates used: 5, Remaining filled with 0.01
  Error: Atleast one parameter must be free
  Error: Parameters used: 6, Covariates used: 5
  Error: Terms used: 4, Covariates used: 5
  Error: Terms used: 6, Covariates used: 5
  Error: Term types used: 4, Covariates used: 5
  Error: Term types used: 6, Covariates used: 5
  Error: lin_int missing
  Error: step_int missing
  Error: loglin_top missing
  Error: lin_quad_int missing
  Error: lin_exp_int missing
  Error: lin_exp_exp_slope missing
  Error: step_slope missing
  Error: lin_slope missing
  Error: lin_quad_slope missing
  Error: lin_exp_slope missing
  Error: lin_exp_int missing
  Error: Parameters used in first option: 5, Parameters used in different option: 4, please fix parameter length
  Warning: Parameters used: 4, Covariates used: 5, Remaining filled with 0.01
  Error: Parameters used: 6, Covariates used: 5
  Error: Terms used: 4, Covariates used: 5
  Error: Terms used: 6, Covariates used: 5
  Error: Term types used: 4, Covariates used: 5
  Error: Term types used: 6, Covariates used: 5
  Error: verbosity arguement not valid
  Error: verbosity arguement not valid
  Error: verbosity arguement not valid
  C++ Error: A non-positive risk was detected: -0.3510469
  C++ Warning: final failing values -0.1 -0.1 6 0.1  
  C++ Warning: final failing terms loglin lin_exp_slope lin_exp_int lin_exp_exp_slope  
  C++ Error: A non-positive risk was detected: -22.07898
  C++ Warning: final failing values 0.3114733 6.621023 -0.6804936 2.090425  
  C++ Warning: final failing terms loglin lin_exp_slope lin_exp_int lin_exp_exp_slope  
  C++ Error: A non-positive risk was detected: -0.3510469
  C++ Warning: final failing values -0.1 -0.1 6 0.1  
  C++ Warning: final failing terms loglin lin_exp_slope lin_exp_int lin_exp_exp_slope  
  Error: Default Parameters used: 7, Covariates used: 4
  Error: Terms used: 1, Covariates used: 4
  Error: Terms used: 8, Covariates used: 4
  Error: Term types used: 1, Covariates used: 4
  Error: Term types used: 5, Covariates used: 4
  C++ Note: START_RISK_CHECK
  C++ Note: Current Time, Fri Feb 23 05:58:47 2024
  
  C++ Note: Term checked 0 1 1 2  
  C++ Note: df99,94,Starting
  C++ Note: Current Time, Fri Feb 23 05:58:47 2024
  
  C++ Note: starting subterms 3
  C++ Note: values checked -0.75 0.1 -0.05 -1.5  
  C++ Note: sums checked 4.889466 -2.95 -2.95 1  
  C++ Note: dose checked 7 7 7  
  C++ Note: non-dose checked 4.889466 -2.95 1  
  C++ Note: LIN_non-dose checked 7 -2.95 7  
  C++ Note: PLIN_non-dose checked 7 7 1  
  C++ Note: LOGLIN_non-dose checked 4.889466 7 7  
  C++ Note: df99,1878,Prep_Terms
  C++ Note: Current Time, Fri Feb 23 05:58:47 2024
  
  Note: 2 risk groups
  C++ Note: START_RISK_CHECK
  C++ Note: Current Time, Fri Feb 23 05:58:47 2024
  
  C++ Note: Term checked 0 1 1 2  
  C++ Note: df99,99,Starting
  C++ Note: Current Time, Fri Feb 23 05:58:47 2024
  
  C++ Note: starting subterms 3
  C++ Note: values checked 0.1 0.1 0.1 0.1  
  C++ Note: sums checked 7.420684 8.15 8.15 7.4  
  C++ Note: dose checked 7 7 7  
  C++ Note: non-dose checked 7.420684 8.15 7.4  
  C++ Note: LIN_non-dose checked 7 8.15 7  
  C++ Note: PLIN_non-dose checked 7 7 7.4  
  C++ Note: LOGLIN_non-dose checked 7.420684 7 7  
  C++ Note: df99,555,Prep_Terms
  C++ Note: Current Time, Fri Feb 23 05:58:47 2024
  
  Warning: rmin and rmax lists not equal size, defaulting to lin and loglin min/max values
  C++ Note: START_RISK_CHECK
  C++ Note: Current Time, Fri Feb 23 05:58:48 2024
  
  C++ Note: Term checked 0 0 0 0  
  C++ Note: df99,85,Starting
  C++ Note: Current Time, Fri Feb 23 05:58:48 2024
  
  C++ Note: starting subterms 1
  C++ Note: values checked -0.1 6 0.1 0.1  
  C++ Note: sums checked 6.978181e+23 6.978181e+23 6.978181e+23 6.978181e+23  
  C++ Note: dose checked 7  
  C++ Note: non-dose checked 6.978181e+23  
  C++ Note: LIN_non-dose checked 7  
  C++ Note: PLIN_non-dose checked 7  
  C++ Note: LOGLIN_non-dose checked 6.978181e+23  
  C++ Note: df99,455,Prep_Terms
  C++ Note: Current Time, Fri Feb 23 05:58:48 2024
  
  Note: 1 valid guesses
  C++ Note: START_RISK_CHECK
  C++ Note: Current Time, Fri Feb 23 05:58:48 2024
  
  C++ Note: Term checked 0 0 0 0  
  C++ Note: df99,72,Starting
  C++ Note: Current Time, Fri Feb 23 05:58:48 2024
  
  C++ Note: starting subterms 1
  C++ Note: values checked -0.4274357 5.493962 -0.05393039 0.4584183  
  C++ Note: sums checked 2.432842e+21 2.432842e+21 2.432842e+21 2.432842e+21  
  C++ Note: dose checked 7  
  C++ Note: non-dose checked 2.432842e+21  
  C++ Note: LIN_non-dose checked 7  
  C++ Note: PLIN_non-dose checked 7  
  C++ Note: LOGLIN_non-dose checked 2.432842e+21  
  C++ Note: df99,395,Prep_Terms
  C++ Note: Current Time, Fri Feb 23 05:58:48 2024
  
  Note: 2 valid guesses
  C++ Note: START_RISK_CHECK
  C++ Note: Current Time, Fri Feb 23 05:58:48 2024
  
  C++ Note: Term checked 0 0 0 0  
  C++ Note: df99,71,Starting
  C++ Note: Current Time, Fri Feb 23 05:58:48 2024
  
  C++ Note: starting subterms 1
  C++ Note: values checked 0.3791375 6.582781 -0.6402704 -0.6977468  
  C++ Note: sums checked 9.625741e+21 9.625741e+21 9.625741e+21 9.625741e+21  
  C++ Note: dose checked 7  
  C++ Note: non-dose checked 9.625741e+21  
  C++ Note: LIN_non-dose checked 7  
  C++ Note: PLIN_non-dose checked 7  
  C++ Note: LOGLIN_non-dose checked 9.625741e+21  
  C++ Note: df99,709,Prep_Terms
  C++ Note: Current Time, Fri Feb 23 05:58:48 2024
  
  Note: 3 valid guesses
  C++ Note: START_RISK_CHECK
  C++ Note: Current Time, Fri Feb 23 05:58:48 2024
  
  C++ Note: Term checked 0 0 0 0  
  C++ Note: df99,72,Starting
  C++ Note: Current Time, Fri Feb 23 05:58:48 2024
  
  C++ Note: starting subterms 1
  C++ Note: values checked -0.05541605 6.772286 0.5354521 -0.2480899  
  C++ Note: sums checked 2.385009e+27 2.385009e+27 2.385009e+27 2.385009e+27  
  C++ Note: dose checked 7  
  C++ Note: non-dose checked 2.385009e+27  
  C++ Note: LIN_non-dose checked 7  
  C++ Note: PLIN_non-dose checked 7  
  C++ Note: LOGLIN_non-dose checked 2.385009e+27  
  C++ Note: df99,385,Prep_Terms
  C++ Note: Current Time, Fri Feb 23 05:58:48 2024
  
  Note: 4 valid guesses
  C++ Note: START_RISK_CHECK
  C++ Note: Current Time, Fri Feb 23 05:58:48 2024
  
  C++ Note: Term checked 0 0 0 0  
  C++ Note: df99,69,Starting
  C++ Note: Current Time, Fri Feb 23 05:58:48 2024
  
  C++ Note: starting subterms 1
  C++ Note: values checked -0.9593677 6.066911 0.9913972 0.9076145  
  C++ Note: sums checked 2.435372e+27 2.435372e+27 2.435372e+27 2.435372e+27  
  C++ Note: dose checked 7  
  C++ Note: non-dose checked 2.435372e+27  
  C++ Note: LIN_non-dose checked 7  
  C++ Note: PLIN_non-dose checked 7  
  C++ Note: LOGLIN_non-dose checked 2.435372e+27  
  C++ Note: df99,430,Prep_Terms
  C++ Note: Current Time, Fri Feb 23 05:58:48 2024
  
  Note: 5 valid guesses
  C++ Note: START_RISK_CHECK
  C++ Note: Current Time, Fri Feb 23 05:58:48 2024
  
  C++ Note: Term checked 0 0 0 0  
  C++ Note: df99,82,Starting
  C++ Note: Current Time, Fri Feb 23 05:58:48 2024
  
  C++ Note: starting subterms 1
  C++ Note: values checked 0.3426743 5.591611 0.9322217 0.6147173  
  C++ Note: sums checked 1.74475e+29 1.74475e+29 1.74475e+29 1.74475e+29  
  C++ Note: dose checked 7  
  C++ Note: non-dose checked 1.74475e+29  
  C++ Note: LIN_non-dose checked 7  
  C++ Note: PLIN_non-dose checked 7  
  C++ Note: LOGLIN_non-dose checked 1.74475e+29  
  C++ Note: df99,402,Prep_Terms
  C++ Note: Current Time, Fri Feb 23 05:58:48 2024
  
  Note: 6 valid guesses
  C++ Note: START_RISK_CHECK
  C++ Note: Current Time, Fri Feb 23 05:58:48 2024
  
  C++ Note: Term checked 0 0 0 0  
  C++ Note: df99,71,Starting
  C++ Note: Current Time, Fri Feb 23 05:58:48 2024
  
  C++ Note: starting subterms 1
  C++ Note: values checked 0.4342272 6.914775 0.2073906 -0.06254969  
  C++ Note: sums checked 1.954588e+29 1.954588e+29 1.954588e+29 1.954588e+29  
  C++ Note: dose checked 7  
  C++ Note: non-dose checked 1.954588e+29  
  C++ Note: LIN_non-dose checked 7  
  C++ Note: PLIN_non-dose checked 7  
  C++ Note: LOGLIN_non-dose checked 1.954588e+29  
  C++ Note: df99,381,Prep_Terms
  C++ Note: Current Time, Fri Feb 23 05:58:48 2024
  
  Note: 7 valid guesses
  C++ Note: START_RISK_CHECK
  C++ Note: Current Time, Fri Feb 23 05:58:48 2024
  
  C++ Note: Term checked 0 0 0 0  
  C++ Note: df99,68,Starting
  C++ Note: Current Time, Fri Feb 23 05:58:48 2024
  
  C++ Note: starting subterms 1
  C++ Note: values checked -0.7824165 6.930744 -0.5768546 0.3504801  
  C++ Note: sums checked 1.406083e+23 1.406083e+23 1.406083e+23 1.406083e+23  
  C++ Note: dose checked 7  
  C++ Note: non-dose checked 1.406083e+23  
  C++ Note: LIN_non-dose checked 7  
  C++ Note: PLIN_non-dose checked 7  
  C++ Note: LOGLIN_non-dose checked 1.406083e+23  
  C++ Note: df99,379,Prep_Terms
  C++ Note: Current Time, Fri Feb 23 05:58:48 2024
  
  Note: 8 valid guesses
  C++ Note: START_RISK_CHECK
  C++ Note: Current Time, Fri Feb 23 05:58:48 2024
  
  C++ Note: Term checked 0 0 0 0  
  C++ Note: df99,69,Starting
  C++ Note: Current Time, Fri Feb 23 05:58:48 2024
  
  C++ Note: starting subterms 1
  C++ Note: values checked -0.1164239 5.125287 -0.2510802 0.1073408  
  C++ Note: sums checked 1.04575e+19 1.04575e+19 1.04575e+19 1.04575e+19  
  C++ Note: dose checked 7  
  C++ Note: non-dose checked 1.04575e+19  
  C++ Note: LIN_non-dose checked 7  
  C++ Note: PLIN_non-dose checked 7  
  C++ Note: LOGLIN_non-dose checked 1.04575e+19  
  C++ Note: df99,388,Prep_Terms
  C++ Note: Current Time, Fri Feb 23 05:58:48 2024
  
  Note: 9 valid guesses
  C++ Note: START_RISK_CHECK
  C++ Note: Current Time, Fri Feb 23 05:58:48 2024
  
  C++ Note: Term checked 0 0 0 0  
  C++ Note: df99,16135,Starting
  C++ Note: Current Time, Fri Feb 23 05:58:48 2024
  
  C++ Note: starting subterms 1
  C++ Note: values checked -0.1700342 5.931429 0.5614845 -0.8685551  
  C++ Note: sums checked 2.093664e+21 2.093664e+21 2.093664e+21 2.093664e+21  
  C++ Note: dose checked 7  
  C++ Note: non-dose checked 2.093664e+21  
  C++ Note: LIN_non-dose checked 7  
  C++ Note: PLIN_non-dose checked 7  
  C++ Note: LOGLIN_non-dose checked 2.093664e+21  
  C++ Note: df99,16502,Prep_Terms
  C++ Note: Current Time, Fri Feb 23 05:58:48 2024
  
  C++ Note: START_RISK_CHECK
  C++ Note: Current Time, Fri Feb 23 05:58:48 2024
  
  C++ Note: Term checked 0 0 0 0  
  C++ Note: df99,84,Starting
  C++ Note: Current Time, Fri Feb 23 05:58:48 2024
  
  C++ Note: starting subterms 1
  C++ Note: values checked -0.1 6 0.1 0.1  
  C++ Note: sums checked 6.978181e+23 6.978181e+23 6.978181e+23 6.978181e+23  
  C++ Note: dose checked 7  
  C++ Note: non-dose checked 6.978181e+23  
  C++ Note: LIN_non-dose checked 7  
  C++ Note: PLIN_non-dose checked 7  
  C++ Note: LOGLIN_non-dose checked 6.978181e+23  
  C++ Note: df99,426,Prep_Terms
  C++ Note: Current Time, Fri Feb 23 05:58:48 2024
  
  Note: 1 valid guesses
  C++ Note: START_RISK_CHECK
  C++ Note: Current Time, Fri Feb 23 05:58:48 2024
  
  C++ Note: Term checked 0 0 0 0  
  C++ Note: df99,70,Starting
  C++ Note: Current Time, Fri Feb 23 05:58:48 2024
  
  C++ Note: starting subterms 1
  C++ Note: values checked -0.1754804 6.635718 0.1097716 0.1876334  
  C++ Note: sums checked 2.592778e+26 2.592778e+26 2.592778e+26 2.592778e+26  
  C++ Note: dose checked 7  
  C++ Note: non-dose checked 2.592778e+26  
  C++ Note: LIN_non-dose checked 7  
  C++ Note: PLIN_non-dose checked 7  
  C++ Note: LOGLIN_non-dose checked 2.592778e+26  
  C++ Note: df99,363,Prep_Terms
  C++ Note: Current Time, Fri Feb 23 05:58:48 2024
  
  Note: 2 valid guesses
  C++ Note: START_RISK_CHECK
  C++ Note: Current Time, Fri Feb 23 05:58:48 2024
  
  C++ Note: Term checked 0 0 0 0  
  C++ Note: df99,64,Starting
  C++ Note: Current Time, Fri Feb 23 05:58:48 2024
  
  C++ Note: starting subterms 1
  C++ Note: values checked -0.06703916 6.701765 0.1577501 0.1654986  
  C++ Note: sums checked 1.572908e+27 1.572908e+27 1.572908e+27 1.572908e+27  
  C++ Note: dose checked 7  
  C++ Note: non-dose checked 1.572908e+27  
  C++ Note: LIN_non-dose checked 7  
  C++ Note: PLIN_non-dose checked 7  
  C++ Note: LOGLIN_non-dose checked 1.572908e+27  
  C++ Note: df99,367,Prep_Terms
  C++ Note: Current Time, Fri Feb 23 05:58:48 2024
  
  Note: 3 valid guesses
  C++ Note: START_RISK_CHECK
  C++ Note: Current Time, Fri Feb 23 05:58:48 2024
  
  C++ Note: Term checked 0 0 0 0  
  C++ Note: df99,67,Starting
  C++ Note: Current Time, Fri Feb 23 05:58:48 2024
  
  C++ Note: starting subterms 1
  C++ Note: values checked -0.0277784 6.667652 0.1838576 0.1485466  
  C++ Note: sums checked 1.78897e+27 1.78897e+27 1.78897e+27 1.78897e+27  
  C++ Note: dose checked 7  
  C++ Note: non-dose checked 1.78897e+27  
  C++ Note: LIN_non-dose checked 7  
  C++ Note: PLIN_non-dose checked 7  
  C++ Note: LOGLIN_non-dose checked 1.78897e+27  
  C++ Note: df99,385,Prep_Terms
  C++ Note: Current Time, Fri Feb 23 05:58:48 2024
  
  Note: 4 valid guesses
  C++ Note: START_RISK_CHECK
  C++ Note: Current Time, Fri Feb 23 05:58:48 2024
  
  C++ Note: Term checked 0 0 0 0  
  C++ Note: df99,66,Starting
  C++ Note: Current Time, Fri Feb 23 05:58:48 2024
  
  C++ Note: starting subterms 1
  C++ Note: values checked -0.1164405 5.248971 0.1879392 0.1997472  
  C++ Note: sums checked 3.787405e+21 3.787405e+21 3.787405e+21 3.787405e+21  
  C++ Note: dose checked 7  
  C++ Note: non-dose checked 3.787405e+21  
  C++ Note: LIN_non-dose checked 7  
  C++ Note: PLIN_non-dose checked 7  
  C++ Note: LOGLIN_non-dose checked 3.787405e+21  
  C++ Note: df99,378,Prep_Terms
  C++ Note: Current Time, Fri Feb 23 05:58:48 2024
  
  Note: 5 valid guesses
  C++ Note: START_RISK_CHECK
  C++ Note: Current Time, Fri Feb 23 05:58:48 2024
  
  C++ Note: Term checked 0 0 0 0  
  C++ Note: df99,56,Starting
  C++ Note: Current Time, Fri Feb 23 05:58:48 2024
  
  C++ Note: starting subterms 1
  C++ Note: values checked -0.04070713 5.615794 0.04674884 0.1155706  
  C++ Note: sums checked 2.672491e+22 2.672491e+22 2.672491e+22 2.672491e+22  
  C++ Note: dose checked 7  
  C++ Note: non-dose checked 2.672491e+22  
  C++ Note: LIN_non-dose checked 7  
  C++ Note: PLIN_non-dose checked 7  
  C++ Note: LOGLIN_non-dose checked 2.672491e+22  
  C++ Note: df99,376,Prep_Terms
  C++ Note: Current Time, Fri Feb 23 05:58:48 2024
  
  Note: 6 valid guesses
  C++ Note: START_RISK_CHECK
  C++ Note: Current Time, Fri Feb 23 05:58:48 2024
  
  C++ Note: Term checked 0 0 0 0  
  C++ Note: df99,60,Starting
  C++ Note: Current Time, Fri Feb 23 05:58:48 2024
  
  C++ Note: starting subterms 1
  C++ Note: values checked -0.19115 6.664808 0.1305788 0.1158852  
  C++ Note: sums checked 1.849835e+26 1.849835e+26 1.849835e+26 1.849835e+26  
  C++ Note: dose checked 7  
  C++ Note: non-dose checked 1.849835e+26  
  C++ Note: LIN_non-dose checked 7  
  C++ Note: PLIN_non-dose checked 7  
  C++ Note: LOGLIN_non-dose checked 1.849835e+26  
  C++ Note: df99,342,Prep_Terms
  C++ Note: Current Time, Fri Feb 23 05:58:48 2024
  
  Note: 7 valid guesses
  C++ Note: START_RISK_CHECK
  C++ Note: Current Time, Fri Feb 23 05:58:48 2024
  
  C++ Note: Term checked 0 0 0 0  
  C++ Note: df99,68,Starting
  C++ Note: Current Time, Fri Feb 23 05:58:48 2024
  
  C++ Note: starting subterms 1
  C++ Note: values checked -0.1135234 5.774454 0.002896217 0.1172774  
  C++ Note: sums checked 3.95964e+22 3.95964e+22 3.95964e+22 3.95964e+22  
  C++ Note: dose checked 7  
  C++ Note: non-dose checked 3.95964e+22  
  C++ Note: LIN_non-dose checked 7  
  C++ Note: PLIN_non-dose checked 7  
  C++ Note: LOGLIN_non-dose checked 3.95964e+22  
  C++ Note: df99,375,Prep_Terms
  C++ Note: Current Time, Fri Feb 23 05:58:48 2024
  
  Note: 8 valid guesses
  C++ Note: START_RISK_CHECK
  C++ Note: Current Time, Fri Feb 23 05:58:48 2024
  
  C++ Note: Term checked 0 0 0 0  
  C++ Note: df99,68,Starting
  C++ Note: Current Time, Fri Feb 23 05:58:48 2024
  
  C++ Note: starting subterms 1
  C++ Note: values checked -0.004260891 6.507799 0.1525121 0.1020665  
  C++ Note: sums checked 2.60387e+26 2.60387e+26 2.60387e+26 2.60387e+26  
  C++ Note: dose checked 7  
  C++ Note: non-dose checked 2.60387e+26  
  C++ Note: LIN_non-dose checked 7  
  C++ Note: PLIN_non-dose checked 7  
  C++ Note: LOGLIN_non-dose checked 2.60387e+26  
  C++ Note: df99,375,Prep_Terms
  C++ Note: Current Time, Fri Feb 23 05:58:48 2024
  
  Note: 9 valid guesses
  C++ Note: START_RISK_CHECK
  C++ Note: Current Time, Fri Feb 23 05:58:48 2024
  
  C++ Note: Term checked 0 0 0 0  
  C++ Note: df99,63,Starting
  C++ Note: Current Time, Fri Feb 23 05:58:48 2024
  
  C++ Note: starting subterms 1
  C++ Note: values checked -0.1331517 5.671983 0.04164038 0.1362467  
  C++ Note: sums checked 2.21862e+22 2.21862e+22 2.21862e+22 2.21862e+22  
  C++ Note: dose checked 7  
  C++ Note: non-dose checked 2.21862e+22  
  C++ Note: LIN_non-dose checked 7  
  C++ Note: PLIN_non-dose checked 7  
  C++ Note: LOGLIN_non-dose checked 2.21862e+22  
  C++ Note: df99,332,Prep_Terms
  C++ Note: Current Time, Fri Feb 23 05:58:48 2024
  
  Error: tform not implemented bad_bad
  Error: der_iden should be within 0:(length(Term_n)-1)
  Error: der_iden should be within 0:(length(Term_n)-1)
  Error: Constraint matrix has incorrect number of columns
  Error: Constraint rows and constant lengths do not match
  Error: verbosity arguement not valid
  Warning: model covariate order changed
  C++ Note: START_POIS_GUESS
  C++ Note: Current Time, Fri Feb 23 05:58:48 2024
  
  C++ Note: Term checked 0 1 2  
  C++ Note: df99,81,Starting
  C++ Note: Current Time, Fri Feb 23 05:58:48 2024
  
  C++ Note: starting subterms 3 in guess 0
  C++ Note: values checked 0.1 0.1 0.01  
  C++ Note: sums checked 1227.86 1227.86 1016.5  
  C++ Note: derivs checked 2642.9 2642.9 1673.67  
  C++ Note: second derivs checked 8128.8 8128.8 4753.83  
  C++ Note: dose checked 1000 1000 1000  
  C++ Note: non-dose checked 1227.86 1227.86 1016.5  
  C++ Note: LIN_non-dose checked 1000 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000 1000  
  C++ Note: LOGLIN_non-dose checked 1227.86 1227.86 1016.5  
  C++ Note: risk checked 4013.81  
  C++ Note: risk1 checked 8941.13 3612.05 2052.13  
  C++ Note: risk2 checked 27844.6 11453.9 5824.6  
  C++ Note: df101 -4468.35 -4468.35 -4468.35  
  C++ Note: df102 -9879.25 -3993.2 -2231.83  
  C++ Note: df103 -31510.7 -12805.3 -6405.1  
  C++ Note: df104 0.1 0.1 0.01  
  C++ Note: Checking Deviance 8708.7
  C++ Note: df105 0.313521 0.311839 0.348445  
  C++ Note: df106 0.452296 1.11899 2.0021  
  C++ Note: Starting Halves
  C++ Note: df501 -4468.349
  C++ Note: df504 0.1 0.1 0.01  
  C++ Note: values checked -0.135141 -0.133879 -0.251334  
  C++ Note: sums checked 782.011 783.679 702.913  
  C++ Note: derivs checked 1319.73 1324.44 842.615  
  C++ Note: second derivs checked 3728.78 3743.98 2036.92  
  C++ Note: dose checked 1000 1000 1000  
  C++ Note: non-dose checked 782.011 783.679 702.913  
  C++ Note: LIN_non-dose checked 1000 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000 1000  
  C++ Note: LOGLIN_non-dose checked 782.011 783.679 702.913  
  C++ Note: risk checked 1965.72  
  C++ Note: risk1 checked 3163.46 913.434 659.857  
  C++ Note: risk2 checked 8795.01 2439.43 1596.9  
  C++ Note: df101 -2242.84 -2242.84 -2242.84  
  C++ Note: df102 -3351.74 -965.337 -691.473  
  C++ Note: df103 -9953.48 -2620.71 -1705.66  
  C++ Note: df104 -0.135141 -0.133879 -0.251334  
  C++ Note: Checking Deviance 4257.68
  C++ Note: df105 0.336741 0.368349 0.4054  
  C++ Note: df106 0.669156 2.32337 3.24356  
  C++ Note: df100 12585 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:48 2024
  
  C++ Note: df100 12697 0 0 0,Update_Calc
  C++ Note: Current Time, Fri Feb 23 05:58:48 2024
  
  C++ Note: df101 -2242.839 -2242.839 -2242.839  
  C++ Note: df102 -3351.744 -965.3375 -691.4734  
  C++ Note: df103 -9953.479 -2620.711 -1705.659  
  C++ Note: df104 -0.1351407 -0.1338794 -0.2513338  
  C++ Note: Checking Deviance 4257.677
  C++ Note: df105 0.336741 0.3683494 0.4053995  
  C++ Note: df106 0.6691556 2.323373 3.243564  
  C++ Note: df101 -2242.84 -2242.84 -2242.84  
  C++ Note: df102 -3351.74 -965.337 -691.473  
  C++ Note: df103 -9953.48 -2620.71 -1705.66  
  C++ Note: df104 -0.135141 -0.133879 -0.251334  
  C++ Note: Checking Deviance 4257.68
  C++ Note: df105 0.336741 0.368349 0.4054  
  C++ Note: df106 0.669156 2.32337 3.24356  
  C++ Note: ending guess 0
  C++ Note: df501 -2242.839
  C++ Note: df504 -0.1351407 -0.1338794 -0.2513338  
  C++ Note: Refreshing matrices after all guesses
  C++ Note: Guess Results
  Guess number, parameter values, Log-Likelihood
  0, -0.1351407 -0.1338794 -0.2513338, -2242.839<-- Best Guess
  C++ Note: starting subterms 3 in best guess 0
  C++ Note: values checked -0.135141 -0.133879 -0.251334  
  C++ Note: sums checked 782.011 783.679 702.913  
  C++ Note: derivs checked 1319.73 1324.44 842.615  
  C++ Note: second derivs checked 3728.78 3743.98 2036.92  
  C++ Note: dose checked 1000 1000 1000  
  C++ Note: non-dose checked 782.011 783.679 702.913  
  C++ Note: LIN_non-dose checked 1000 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000 1000  
  C++ Note: LOGLIN_non-dose checked 782.011 783.679 702.913  
  C++ Note: risk checked 1965.72  
  C++ Note: risk1 checked 3163.46 913.434 659.857  
  C++ Note: risk2 checked 8795.01 2439.43 1596.9  
  C++ Note: Made Risk Side Lists
  C++ Note: df101 -2242.84 -2242.84 -2242.84  
  C++ Note: df102 -3351.74 -965.337 -691.473  
  C++ Note: df103 -9953.48 -2620.71 -1705.66  
  C++ Note: df104 -0.135141 -0.133879 -0.251334  
  C++ Note: Checking Deviance 4257.68
  C++ Note: df105 0.336741 0.368349 0.4054  
  C++ Note: df106 0.669156 2.32337 3.24356  
  C++ Note: Starting Halves
  C++ Note: df501 -2242.839
  C++ Note: df504 -0.1351407 -0.1338794 -0.2513338  
  C++ Note: values checked -0.387696 -0.410141 -0.555383  
  C++ Note: sums checked 541.3 526.659 518.003  
  C++ Note: derivs checked 670.898 634.058 432.303  
  C++ Note: second derivs checked 1697.13 1586.95 858.5  
  C++ Note: dose checked 1000 1000 1000  
  C++ Note: non-dose checked 541.3 526.659 518.003  
  C++ Note: LIN_non-dose checked 1000 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000 1000  
  C++ Note: LOGLIN_non-dose checked 541.3 526.659 518.003  
  C++ Note: risk checked 1186.02  
  C++ Note: risk1 checked 1283.24 262.365 234.766  
  C++ Note: risk2 checked 3119.87 539.909 466.794  
  C++ Note: df101 -1445.9 -1445.9 -1445.9  
  C++ Note: df102 -1227.8 -255.227 -230.91  
  C++ Note: df103 -3532.08 -521.089 -470.654  
  C++ Note: df104 -0.387696 -0.410141 -0.555383  
  C++ Note: Checking Deviance 2663.81
  C++ Note: df105 0.347615 0.489796 0.490615  
  C++ Note: df106 1.17763 5.66516 6.26175  
  C++ Note: df100 16156 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:48 2024
  
  C++ Note: df100 16257 0 0 0,Update_Calc
  C++ Note: Current Time, Fri Feb 23 05:58:48 2024
  
  C++ Note: df101 -1445.903 -1445.903 -1445.903  
  C++ Note: df102 -1227.804 -255.2273 -230.9102  
  C++ Note: df103 -3532.081 -521.0891 -470.6545  
  C++ Note: df104 -0.3876964 -0.4101414 -0.5553835  
  C++ Note: Checking Deviance 2663.805
  C++ Note: df105 0.3476148 0.4897959 0.4906152  
  C++ Note: df106 1.177633 5.665156 6.261752  
  C++ Note: df101 -1445.9 -1445.9 -1445.9  
  C++ Note: df102 -1227.8 -255.227 -230.91  
  C++ Note: df103 -3532.08 -521.089 -470.654  
  C++ Note: df104 -0.387696 -0.410141 -0.555383  
  C++ Note: Checking Deviance 2663.81
  C++ Note: df105 0.347615 0.489796 0.490615  
  C++ Note: df106 1.17763 5.66516 6.26175  
  C++ Note: df501 -1445.903
  C++ Note: df504 -0.3876964 -0.4101414 -0.5553835  
  Error: Atleast one parameter must be free
  Warning: model covariate order changed
  Error: no events
  Warning: model covariate order changed
  C++ Note: START_POIS_GUESS
  C++ Note: Current Time, Fri Feb 23 05:58:48 2024
  
  C++ Note: Term checked 0 1 2  
  C++ Note: df99,77,Starting
  C++ Note: Current Time, Fri Feb 23 05:58:48 2024
  
  C++ Note: starting subterms 3 in guess 0
  C++ Note: values checked 0.1 0.1 0.01  
  C++ Note: sums checked 1105.17 1227.86 1016.5  
  C++ Note: derivs checked 1105.17 2642.9 1673.67  
  C++ Note: second derivs checked 1105.17 8128.8 4753.83  
  C++ Note: dose checked 1000 1000 1000  
  C++ Note: non-dose checked 1105.17 1227.86 1016.5  
  C++ Note: LIN_non-dose checked 1000 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000 1000  
  C++ Note: LOGLIN_non-dose checked 1105.17 1227.86 1016.5  
  C++ Note: risk checked 3585.58  
  C++ Note: risk1 checked 3585.58 2920.86 1849.69  
  C++ Note: risk2 checked 3585.58 8983.72 5253.79  
  C++ Note: df101 -3995.85 -3995.85 -3995.85  
  C++ Note: df102 -3939.7 -3210.37 -2007.32  
  C++ Note: df103 -4053.7 -10003.9 -5776.08  
  C++ Note: df104 0.1 0.1 0.01  
  C++ Note: Checking Deviance 7763.69
  C++ Note: df105 0.971878 0.320911 0.347522  
  C++ Note: df106 1.01425 1.24467 1.99064  
  C++ Note: Starting Halves
  C++ Note: df501 -3995.846
  C++ Note: df504 0.1 0.1 0.01  
  C++ Note: values checked -0.628908 -0.140684 -0.250642  
  C++ Note: sums checked 533.174 774.753 703.497  
  C++ Note: derivs checked 533.174 1299.25 844.026  
  C++ Note: second derivs checked 533.174 3662.75 2041.23  
  C++ Note: dose checked 1000 1000 1000  
  C++ Note: non-dose checked 533.174 774.753 703.497  
  C++ Note: LIN_non-dose checked 1000 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000 1000  
  C++ Note: LOGLIN_non-dose checked 533.174 774.753 703.497  
  C++ Note: risk checked 1321.34  
  C++ Note: risk1 checked 1321.34 692.724 450.012  
  C++ Note: risk2 checked 1321.34 1952.88 1088.33  
  C++ Note: df101 -1554.54 -1554.54 -1554.54  
  C++ Note: df102 -1381.74 -717.543 -455.39  
  C++ Note: df103 -1495.74 -2074.01 -1130.47  
  C++ Note: df104 -0.628908 -0.140684 -0.250642  
  C++ Note: Checking Deviance 2881.09
  C++ Note: df105 0.923784 0.345968 0.402831  
  C++ Note: df106 1.12506 2.16648 3.41366  
  C++ Note: df100 14274 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:48 2024
  
  C++ Note: df100 14413 0 0 0,Update_Calc
  C++ Note: Current Time, Fri Feb 23 05:58:48 2024
  
  C++ Note: df101 -1554.544 -1554.544 -1554.544  
  C++ Note: df102 -1381.744 -717.5426 -455.3897  
  C++ Note: df103 -1495.744 -2074.015 -1130.474  
  C++ Note: df104 -0.6289081 -0.1406835 -0.2506418  
  C++ Note: Checking Deviance 2881.088
  C++ Note: df105 0.9237837 0.3459679 0.4028308  
  C++ Note: df106 1.125059 2.166483 3.413657  
  C++ Note: df101 -1554.54 -1554.54 -1554.54  
  C++ Note: df102 -1381.74 -717.543 -455.39  
  C++ Note: df103 -1495.74 -2074.01 -1130.47  
  C++ Note: df104 -0.628908 -0.140684 -0.250642  
  C++ Note: Checking Deviance 2881.09
  C++ Note: df105 0.923784 0.345968 0.402831  
  C++ Note: df106 1.12506 2.16648 3.41366  
  C++ Note: ending guess 0
  C++ Note: df501 -1554.544
  C++ Note: df504 -0.6289081 -0.1406835 -0.2506418  
  C++ Note: Refreshing matrices after all guesses
  C++ Note: Guess Results
  Guess number, parameter values, Log-Likelihood
  0, -0.6289081 -0.1406835 -0.2506418, -1554.544<-- Best Guess
  C++ Note: starting subterms 3 in best guess 0
  C++ Note: values checked -0.628908 -0.140684 -0.250642  
  C++ Note: sums checked 533.174 774.753 703.497  
  C++ Note: derivs checked 533.174 1299.25 844.026  
  C++ Note: second derivs checked 533.174 3662.75 2041.23  
  C++ Note: dose checked 1000 1000 1000  
  C++ Note: non-dose checked 533.174 774.753 703.497  
  C++ Note: LIN_non-dose checked 1000 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000 1000  
  C++ Note: LOGLIN_non-dose checked 533.174 774.753 703.497  
  C++ Note: risk checked 1321.34  
  C++ Note: risk1 checked 1321.34 692.724 450.012  
  C++ Note: risk2 checked 1321.34 1952.88 1088.33  
  C++ Note: Made Risk Side Lists
  C++ Note: df101 -1554.54 -1554.54 -1554.54  
  C++ Note: df102 -1381.74 -717.543 -455.39  
  C++ Note: df103 -1495.74 -2074.01 -1130.47  
  C++ Note: df104 -0.628908 -0.140684 -0.250642  
  C++ Note: Checking Deviance 2881.09
  C++ Note: df105 0.923784 0.345968 0.402831  
  C++ Note: df106 1.12506 2.16648 3.41366  
  C++ Note: Starting Halves
  C++ Note: df501 -1554.544
  C++ Note: df504 -0.6289081 -0.1406835 -0.2506418  
  C++ Note: values checked -1.32175 -0.400159 -0.552765  
  C++ Note: sums checked 266.669 533.068 519.138  
  C++ Note: derivs checked 266.669 650.137 434.559  
  C++ Note: second derivs checked 266.669 1634.94 864.441  
  C++ Note: dose checked 1000 1000 1000  
  C++ Note: non-dose checked 266.669 533.068 519.138  
  C++ Note: LIN_non-dose checked 1000 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000 1000  
  C++ Note: LOGLIN_non-dose checked 266.669 533.068 519.138  
  C++ Note: risk checked 547.26  
  C++ Note: risk1 checked 547.26 173.372 115.884  
  C++ Note: risk2 checked 547.26 435.989 230.52  
  C++ Note: df101 -783.766 -783.766 -783.766  
  C++ Note: df102 -506.374 -153.977 -97.5406  
  C++ Note: df103 -620.374 -402.806 -203.526  
  C++ Note: df104 -1.32175 -0.400159 -0.552765  
  C++ Note: Checking Deviance 1339.53
  C++ Note: df105 0.81624 0.382261 0.479254  
  C++ Note: df106 1.5478 5.09014 8.03527  
  C++ Note: df100 17736 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:48 2024
  
  C++ Note: df100 17830 0 0 0,Update_Calc
  C++ Note: Current Time, Fri Feb 23 05:58:48 2024
  
  C++ Note: df101 -783.7655 -783.7655 -783.7655  
  C++ Note: df102 -506.3739 -153.9773 -97.54064  
  C++ Note: df103 -620.3739 -402.8065 -203.5259  
  C++ Note: df104 -1.321746 -0.4001595 -0.5527648  
  C++ Note: Checking Deviance 1339.531
  C++ Note: df105 0.8162399 0.3822611 0.4792542  
  C++ Note: df106 1.5478 5.090138 8.035272  
  C++ Note: df101 -783.766 -783.766 -783.766  
  C++ Note: df102 -506.374 -153.977 -97.5406  
  C++ Note: df103 -620.374 -402.806 -203.526  
  C++ Note: df104 -1.32175 -0.400159 -0.552765  
  C++ Note: Checking Deviance 1339.53
  C++ Note: df105 0.81624 0.382261 0.479254  
  C++ Note: df106 1.5478 5.09014 8.03527  
  C++ Note: df501 -783.7655
  C++ Note: df504 -1.321746 -0.4001595 -0.5527648  
  Warning: model covariate order changed
  Error: guesses: 100 , iterations per guess: c(1, 1)
  Warning: rmin and rmax lists not equal size, defaulting to lin and loglin min/max values
  Warning: rmin and rmax lists not equal size, defaulting to lin and loglin min/max values
  C++ Note: START_RISK_CHECK
  C++ Note: Current Time, Fri Feb 23 05:58:48 2024
  
  C++ Note: Term checked 1  
  C++ Note: df99,63,Starting
  C++ Note: Current Time, Fri Feb 23 05:58:48 2024
  
  C++ Note: starting subterms 2
  C++ Note: values checked 0.01  
  C++ Note: sums checked 10679.25  
  C++ Note: dose checked 6400 6400  
  C++ Note: non-dose checked 6400 10679.25  
  C++ Note: LIN_non-dose checked 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400  
  C++ Note: LOGLIN_non-dose checked 6400 10679.25  
  C++ Note: df99,1613,Prep_Terms
  C++ Note: Current Time, Fri Feb 23 05:58:48 2024
  
  Note: 1 valid guesses
  C++ Note: START_RISK_CHECK
  C++ Note: Current Time, Fri Feb 23 05:58:48 2024
  
  C++ Note: Term checked 1  
  C++ Note: df99,46,Starting
  C++ Note: Current Time, Fri Feb 23 05:58:48 2024
  
  C++ Note: starting subterms 2
  C++ Note: values checked -0.2932833  
  C++ Note: sums checked 2.005206  
  C++ Note: dose checked 6400 6400  
  C++ Note: non-dose checked 6400 2.005206  
  C++ Note: LIN_non-dose checked 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400  
  C++ Note: LOGLIN_non-dose checked 6400 2.005206  
  C++ Note: df99,778,Prep_Terms
  C++ Note: Current Time, Fri Feb 23 05:58:48 2024
  
  C++ Note: START_POIS_GUESS
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: Term checked 1  
  C++ Note: df99,72,Starting
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: starting subterms 2 in guess 0
  C++ Note: values checked 0.01  
  C++ Note: sums checked 10679.3  
  C++ Note: derivs checked 564819  
  C++ Note: second derivs checked 3.34438e+07  
  C++ Note: dose checked 6400 6400  
  C++ Note: non-dose checked 6400 10679.3  
  C++ Note: LIN_non-dose checked 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400  
  C++ Note: LOGLIN_non-dose checked 6400 10679.3  
  C++ Note: risk checked 121.53  
  C++ Note: risk1 checked 4019.07  
  C++ Note: risk2 checked 237975  
  C++ Note: df101 -455.955  
  C++ Note: df102 -880.754  
  C++ Note: df103 -164749  
  C++ Note: df104 0.01  
  C++ Note: Checking Deviance 739.91
  C++ Note: df105 0.00534604  
  C++ Note: df106 0.517687  
  C++ Note: Starting Halves
  C++ Note: df501 -455.9548
  C++ Note: df504 0.01  
  C++ Note: values checked 0.00599047  
  C++ Note: sums checked 8661.97  
  C++ Note: derivs checked 446431  
  C++ Note: second derivs checked 2.5943e+07  
  C++ Note: dose checked 6400 6400  
  C++ Note: non-dose checked 6400 8661.97  
  C++ Note: LIN_non-dose checked 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400  
  C++ Note: LOGLIN_non-dose checked 6400 8661.97  
  C++ Note: risk checked 107.176  
  C++ Note: risk1 checked 3176.66  
  C++ Note: risk2 checked 184602  
  C++ Note: df101 -453.592  
  C++ Note: df102 -334.069  
  C++ Note: df103 -110449  
  C++ Note: df104 0.00599047  
  C++ Note: Checking Deviance 735.184
  C++ Note: df105 0.00302466  
  C++ Note: df106 1.35778  
  C++ Note: df100 5051 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: df100 5142 0 0 0,Update_Calc
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: df101 -453.5921  
  C++ Note: df102 -334.0694  
  C++ Note: df103 -110448.7  
  C++ Note: df104 0.005990473  
  C++ Note: Checking Deviance 735.1842
  C++ Note: df105 0.003024657  
  C++ Note: df106 1.357778  
  C++ Note: Starting Halves
  C++ Note: df501 -453.5921
  C++ Note: df504 0.005990473  
  C++ Note: values checked 0.00372198  
  C++ Note: sums checked 7712.93  
  C++ Note: derivs checked 391577  
  C++ Note: second derivs checked 2.25045e+07  
  C++ Note: dose checked 6400 6400  
  C++ Note: non-dose checked 6400 7712.93  
  C++ Note: LIN_non-dose checked 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400  
  C++ Note: LOGLIN_non-dose checked 6400 7712.93  
  C++ Note: risk checked 100.423  
  C++ Note: risk1 checked 2786.34  
  C++ Note: risk2 checked 160135  
  C++ Note: df101 -453.097  
  C++ Note: df102 -112.117  
  C++ Note: df103 -85914.4  
  C++ Note: df104 0.00372198  
  C++ Note: Checking Deviance 734.193
  C++ Note: df105 0.00130499  
  C++ Note: df106 4.04127  
  C++ Note: df100 16703 1 2 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: df100 16787 0 0 0,Update_Calc
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: df101 -453.0965  
  C++ Note: df102 -112.1175  
  C++ Note: df103 -85914.38  
  C++ Note: df104 0.00372198  
  C++ Note: Checking Deviance 734.193
  C++ Note: df105 0.001304991  
  C++ Note: df106 4.041266  
  C++ Note: Starting Halves
  C++ Note: df501 -453.0965
  C++ Note: df504 0.00372198  
  C++ Note: values checked 0.00274324  
  C++ Note: sums checked 7340.24  
  C++ Note: derivs checked 370210  
  C++ Note: second derivs checked 2.11728e+07  
  C++ Note: dose checked 6400 6400  
  C++ Note: non-dose checked 6400 7340.24  
  C++ Note: LIN_non-dose checked 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400  
  C++ Note: LOGLIN_non-dose checked 6400 7340.24  
  C++ Note: risk checked 97.771  
  C++ Note: risk1 checked 2634.29  
  C++ Note: risk2 checked 150659  
  C++ Note: df101 -453.026  
  C++ Note: df102 -32.671  
  C++ Note: df103 -76546.2  
  C++ Note: df104 0.00274324  
  C++ Note: Checking Deviance 734.053
  C++ Note: df105 0.000426814  
  C++ Note: df106 13.8663  
  C++ Note: df100 18759 1 3 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: df100 18825 0 0 0,Update_Calc
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: df101 -453.0264  
  C++ Note: df102 -32.67097  
  C++ Note: df103 -76546.19  
  C++ Note: df104 0.002743237  
  C++ Note: Checking Deviance 734.0528
  C++ Note: df105 0.0004268137  
  C++ Note: df106 13.86633  
  C++ Note: Starting Halves
  C++ Note: df501 -453.0264
  C++ Note: df504 0.002743237  
  C++ Note: values checked 0.00242313  
  C++ Note: sums checked 7222.81  
  C++ Note: derivs checked 363499  
  C++ Note: second derivs checked 2.07555e+07  
  C++ Note: dose checked 6400 6400  
  C++ Note: non-dose checked 6400 7222.81  
  C++ Note: LIN_non-dose checked 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400  
  C++ Note: LOGLIN_non-dose checked 6400 7222.81  
  C++ Note: risk checked 96.9354  
  C++ Note: risk1 checked 2586.54  
  C++ Note: risk2 checked 147689  
  C++ Note: df101 -453.02  
  C++ Note: df102 -8.6361  
  C++ Note: df103 -73632  
  C++ Note: df104 0.00242313  
  C++ Note: Checking Deviance 734.04
  C++ Note: df105 0.000117287  
  C++ Note: df106 52.4565  
  C++ Note: df100 20675 1 4 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: df100 20764 0 0 0,Update_Calc
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: df101 -453.0198  
  C++ Note: df102 -8.636103  
  C++ Note: df103 -73632.01  
  C++ Note: df104 0.002423127  
  C++ Note: Checking Deviance 734.0397
  C++ Note: df105 0.0001172873  
  C++ Note: df106 52.45651  
  C++ Note: Starting Halves
  C++ Note: df501 -453.0198
  C++ Note: df504 0.002423127  
  C++ Note: values checked 0.00233516  
  C++ Note: sums checked 7190.92  
  C++ Note: derivs checked 361679  
  C++ Note: second derivs checked 2.06424e+07  
  C++ Note: dose checked 6400 6400  
  C++ Note: non-dose checked 6400 7190.92  
  C++ Note: LIN_non-dose checked 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400  
  C++ Note: LOGLIN_non-dose checked 6400 7190.92  
  C++ Note: risk checked 96.7085  
  C++ Note: risk1 checked 2573.58  
  C++ Note: risk2 checked 146884  
  C++ Note: df101 -453.019  
  C++ Note: df102 -2.19373  
  C++ Note: df103 -72843.8  
  C++ Note: df104 0.00233516  
  C++ Note: Checking Deviance 734.039
  C++ Note: df105 3.01155e-05  
  C++ Note: df106 206.506  
  C++ Note: df100 22704 1 5 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: df100 22784 0 0 0,Update_Calc
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: df101 -453.0194  
  C++ Note: df102 -2.193732  
  C++ Note: df103 -72843.83  
  C++ Note: df104 0.002335161  
  C++ Note: Checking Deviance 734.0387
  C++ Note: df105 3.011555e-05  
  C++ Note: df106 206.5063  
  C++ Note: df101 -453.019  
  C++ Note: df102 -2.19373  
  C++ Note: df103 -72843.8  
  C++ Note: df104 0.00233516  
  C++ Note: Checking Deviance 734.039
  C++ Note: df105 3.01155e-05  
  C++ Note: df106 206.506  
  C++ Note: ending guess 0
  C++ Note: df501 -453.0194
  C++ Note: df504 0.002335161  
  C++ Note: starting subterms 2 in guess 1
  C++ Note: values checked -0.293283  
  C++ Note: sums checked 2.00521  
  C++ Note: derivs checked 41.9771  
  C++ Note: second derivs checked 901.899  
  C++ Note: dose checked 6400 6400  
  C++ Note: non-dose checked 6400 2.00521  
  C++ Note: LIN_non-dose checked 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400  
  C++ Note: LOGLIN_non-dose checked 6400 2.00521  
  C++ Note: risk checked 45.5546  
  C++ Note: risk1 checked 0.298696  
  C++ Note: risk2 checked 6.41761  
  C++ Note: df101 -469.809  
  C++ Note: df102 -0.0645319  
  C++ Note: df103 -0.835232  
  C++ Note: df104 -0.293283  
  C++ Note: Checking Deviance 767.619
  C++ Note: df105 0.0772622  
  C++ Note: df106 7280.27  
  C++ Note: Starting Halves
  C++ Note: df501 -453.0194
  C++ Note: df504 0.002335161  
  C++ Note: values checked -0.35123  
  C++ Note: sums checked 0.606424  
  C++ Note: derivs checked 12.3567  
  C++ Note: second derivs checked 256.65  
  C++ Note: dose checked 6400 6400  
  C++ Note: non-dose checked 6400 0.606424  
  C++ Note: LIN_non-dose checked 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400  
  C++ Note: LOGLIN_non-dose checked 6400 0.606424  
  C++ Note: risk checked 45.5446  
  C++ Note: risk1 checked 0.0879263  
  C++ Note: risk2 checked 1.82624  
  C++ Note: df101 -469.807  
  C++ Note: df102 -0.0270017  
  C++ Note: df103 -0.444374  
  C++ Note: df104 -0.35123  
  C++ Note: Checking Deviance 767.614
  C++ Note: df105 0.0607633  
  C++ Note: df106 17399.2  
  C++ Note: df100 38149 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: values checked -0.322257  
  C++ Note: sums checked 1.0983  
  C++ Note: derivs checked 22.6578  
  C++ Note: second derivs checked 477.914  
  C++ Note: dose checked 6400 6400  
  C++ Note: non-dose checked 6400 1.0983  
  C++ Note: LIN_non-dose checked 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400  
  C++ Note: LOGLIN_non-dose checked 6400 1.0983  
  C++ Note: risk checked 45.5481  
  C++ Note: risk1 checked 0.161226  
  C++ Note: risk2 checked 3.40068  
  C++ Note: df101 -469.808  
  C++ Note: df102 -0.0427797  
  C++ Note: df103 -0.650122  
  C++ Note: df104 -0.322257  
  C++ Note: Checking Deviance 767.616
  C++ Note: df105 0.0658025  
  C++ Note: df106 10982  
  C++ Note: df100 39973 2 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: values checked -0.30777  
  C++ Note: sums checked 1.48239  
  C++ Note: derivs checked 30.7963  
  C++ Note: second derivs checked 655.313  
  C++ Note: dose checked 6400 6400  
  C++ Note: non-dose checked 6400 1.48239  
  C++ Note: LIN_non-dose checked 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400  
  C++ Note: LOGLIN_non-dose checked 6400 1.48239  
  C++ Note: risk checked 45.5508  
  C++ Note: risk1 checked 0.219136  
  C++ Note: risk2 checked 4.66299  
  C++ Note: df101 -469.809  
  C++ Note: df102 -0.0529677  
  C++ Note: df103 -0.754657  
  C++ Note: df104 -0.30777  
  C++ Note: Checking Deviance 767.617
  C++ Note: df105 0.0701878  
  C++ Note: df106 8869.72  
  C++ Note: df100 41813 3 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: values checked -0.300527  
  C++ Note: sums checked 1.7236  
  C++ Note: derivs checked 35.9413  
  C++ Note: second derivs checked 768.406  
  C++ Note: dose checked 6400 6400  
  C++ Note: non-dose checked 6400 1.7236  
  C++ Note: LIN_non-dose checked 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400  
  C++ Note: LOGLIN_non-dose checked 6400 1.7236  
  C++ Note: risk checked 45.5526  
  C++ Note: risk1 checked 0.255746  
  C++ Note: risk2 checked 5.46772  
  C++ Note: df101 -469.809  
  C++ Note: df102 -0.0586024  
  C++ Note: df103 -0.799909  
  C++ Note: df104 -0.300527  
  C++ Note: Checking Deviance 767.618
  C++ Note: df105 0.0732613  
  C++ Note: df106 8016.89  
  C++ Note: df100 43659 4 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: values checked -0.296905  
  C++ Note: sums checked 1.85894  
  C++ Note: derivs checked 38.8384  
  C++ Note: second derivs checked 832.376  
  C++ Note: dose checked 6400 6400  
  C++ Note: non-dose checked 6400 1.85894  
  C++ Note: LIN_non-dose checked 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400  
  C++ Note: LOGLIN_non-dose checked 6400 1.85894  
  C++ Note: risk checked 45.5535  
  C++ Note: risk1 checked 0.276361  
  C++ Note: risk2 checked 5.92291  
  C++ Note: df101 -469.809  
  C++ Note: df102 -0.0615351  
  C++ Note: df103 -0.81913  
  C++ Note: df104 -0.296905  
  C++ Note: Checking Deviance 767.618
  C++ Note: df105 0.0751224  
  C++ Note: df106 7634.82  
  C++ Note: df100 45430 5 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: Changing back to best
  C++ Note: values checked -0.293283  
  C++ Note: sums checked 2.00521  
  C++ Note: derivs checked 41.9771  
  C++ Note: second derivs checked 901.899  
  C++ Note: dose checked 6400 6400  
  C++ Note: non-dose checked 6400 2.00521  
  C++ Note: LIN_non-dose checked 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400  
  C++ Note: LOGLIN_non-dose checked 6400 2.00521  
  C++ Note: risk checked 45.5546  
  C++ Note: risk1 checked 0.298696  
  C++ Note: risk2 checked 6.41761  
  C++ Note: df101 -469.809  
  C++ Note: df102 -0.0645319  
  C++ Note: df103 -0.835232  
  C++ Note: df104 -0.293283  
  C++ Note: Checking Deviance 767.619
  C++ Note: df105 0.0772622  
  C++ Note: df106 7280.27  
  C++ Note: df100 47231 0 0 0,Update_Calc
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: df101 -469.8095  
  C++ Note: df102 -0.06453188  
  C++ Note: df103 -0.8352318  
  C++ Note: df104 -0.2932833  
  C++ Note: Checking Deviance 767.6189
  C++ Note: df105 0.07726224  
  C++ Note: df106 7280.27  
  C++ Note: Starting Halves
  C++ Note: df501 -453.0194
  C++ Note: df504 0.002335161  
  C++ Note: values checked -0.324533  
  C++ Note: sums checked 1.04793  
  C++ Note: derivs checked 21.5962  
  C++ Note: second derivs checked 454.924  
  C++ Note: dose checked 6400 6400  
  C++ Note: non-dose checked 6400 1.04793  
  C++ Note: LIN_non-dose checked 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400  
  C++ Note: LOGLIN_non-dose checked 6400 1.04793  
  C++ Note: risk checked 45.5477  
  C++ Note: risk1 checked 0.153671  
  C++ Note: risk2 checked 3.23709  
  C++ Note: df101 -469.808  
  C++ Note: df102 -0.0413189  
  C++ Note: df103 -0.633107  
  C++ Note: df104 -0.324533  
  C++ Note: Checking Deviance 767.616
  C++ Note: df105 0.0652638  
  C++ Note: df106 11370.3  
  C++ Note: df100 49427 1 2 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: values checked -0.308908  
  C++ Note: sums checked 1.44775  
  C++ Note: derivs checked 30.0596  
  C++ Note: second derivs checked 639.175  
  C++ Note: dose checked 6400 6400  
  C++ Note: non-dose checked 6400 1.44775  
  C++ Note: LIN_non-dose checked 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400  
  C++ Note: LOGLIN_non-dose checked 6400 1.44775  
  C++ Note: risk checked 45.5506  
  C++ Note: risk1 checked 0.213894  
  C++ Note: risk2 checked 4.54816  
  C++ Note: df101 -469.809  
  C++ Note: df102 -0.052113  
  C++ Note: df103 -0.746937  
  C++ Note: df104 -0.308908  
  C++ Note: Checking Deviance 767.617
  C++ Note: df105 0.069769  
  C++ Note: df106 9015.18  
  C++ Note: df100 51221 2 2 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: values checked -0.301096  
  C++ Note: sums checked 1.70326  
  C++ Note: derivs checked 35.5066  
  C++ Note: second derivs checked 758.827  
  C++ Note: dose checked 6400 6400  
  C++ Note: non-dose checked 6400 1.70326  
  C++ Note: LIN_non-dose checked 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400  
  C++ Note: LOGLIN_non-dose checked 6400 1.70326  
  C++ Note: risk checked 45.5524  
  C++ Note: risk1 checked 0.252654  
  C++ Note: risk2 checked 5.39956  
  C++ Note: df101 -469.809  
  C++ Note: df102 -0.058148  
  C++ Note: df103 -0.796649  
  C++ Note: df104 -0.301096  
  C++ Note: Checking Deviance 767.618
  C++ Note: df105 0.0729908  
  C++ Note: df106 8079.53  
  C++ Note: df100 52977 3 2 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: values checked -0.29719  
  C++ Note: sums checked 1.84792  
  C++ Note: derivs checked 38.6023  
  C++ Note: second derivs checked 827.155  
  C++ Note: dose checked 6400 6400  
  C++ Note: non-dose checked 6400 1.84792  
  C++ Note: LIN_non-dose checked 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400  
  C++ Note: LOGLIN_non-dose checked 6400 1.84792  
  C++ Note: risk checked 45.5534  
  C++ Note: risk1 checked 0.274681  
  C++ Note: risk2 checked 5.88576  
  C++ Note: df101 -469.809  
  C++ Note: df102 -0.0613021  
  C++ Note: df103 -0.817724  
  C++ Note: df104 -0.29719  
  C++ Note: Checking Deviance 767.618
  C++ Note: df105 0.0749668  
  C++ Note: df106 7663.83  
  C++ Note: df100 54742 4 2 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: values checked -0.295236  
  C++ Note: sums checked 1.92492  
  C++ Note: derivs checked 40.2532  
  C++ Note: second derivs checked 863.686  
  C++ Note: dose checked 6400 6400  
  C++ Note: non-dose checked 6400 1.92492  
  C++ Note: LIN_non-dose checked 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400  
  C++ Note: LOGLIN_non-dose checked 6400 1.92492  
  C++ Note: risk checked 45.554  
  C++ Note: risk1 checked 0.286429  
  C++ Note: risk2 checked 6.14571  
  C++ Note: df101 -469.809  
  C++ Note: df102 -0.0629084  
  C++ Note: df103 -0.82698  
  C++ Note: df104 -0.295236  
  C++ Note: Checking Deviance 767.619
  C++ Note: df105 0.0760701  
  C++ Note: df106 7468.14  
  C++ Note: df100 56532 5 2 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: Changing back to best
  C++ Note: values checked -0.293283  
  C++ Note: sums checked 2.00521  
  C++ Note: derivs checked 41.9771  
  C++ Note: second derivs checked 901.899  
  C++ Note: dose checked 6400 6400  
  C++ Note: non-dose checked 6400 2.00521  
  C++ Note: LIN_non-dose checked 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400  
  C++ Note: LOGLIN_non-dose checked 6400 2.00521  
  C++ Note: risk checked 45.5546  
  C++ Note: risk1 checked 0.298696  
  C++ Note: risk2 checked 6.41761  
  C++ Note: df101 -469.809  
  C++ Note: df102 -0.0645319  
  C++ Note: df103 -0.835232  
  C++ Note: df104 -0.293283  
  C++ Note: Checking Deviance 767.619
  C++ Note: df105 0.0772622  
  C++ Note: df106 7280.27  
  C++ Note: df100 58199 0 0 0,Update_Calc
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: df101 -469.8095  
  C++ Note: df102 -0.06453188  
  C++ Note: df103 -0.8352318  
  C++ Note: df104 -0.2932833  
  C++ Note: Checking Deviance 767.6189
  C++ Note: df105 0.07726224  
  C++ Note: df106 7280.27  
  C++ Note: Starting Halves
  C++ Note: df501 -453.0194
  C++ Note: df504 0.002335161  
  C++ Note: values checked -0.29426  
  C++ Note: sums checked 1.96464  
  C++ Note: derivs checked 41.1059  
  C++ Note: second derivs checked 882.578  
  C++ Note: dose checked 6400 6400  
  C++ Note: non-dose checked 6400 1.96464  
  C++ Note: LIN_non-dose checked 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400  
  C++ Note: LOGLIN_non-dose checked 6400 1.96464  
  C++ Note: risk checked 45.5543  
  C++ Note: risk1 checked 0.292496  
  C++ Note: risk2 checked 6.28013  
  C++ Note: df101 -469.809  
  C++ Note: df102 -0.0637181  
  C++ Note: df103 -0.831239  
  C++ Note: df104 -0.29426  
  C++ Note: Checking Deviance 767.619
  C++ Note: df105 0.0766544  
  C++ Note: df106 7373.24  
  C++ Note: df100 60148 1 3 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: values checked -0.293772  
  C++ Note: sums checked 1.98482  
  C++ Note: derivs checked 41.5391  
  C++ Note: second derivs checked 892.184  
  C++ Note: dose checked 6400 6400  
  C++ Note: non-dose checked 6400 1.98482  
  C++ Note: LIN_non-dose checked 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400  
  C++ Note: LOGLIN_non-dose checked 6400 1.98482  
  C++ Note: risk checked 45.5544  
  C++ Note: risk1 checked 0.295579  
  C++ Note: risk2 checked 6.34848  
  C++ Note: df101 -469.809  
  C++ Note: df102 -0.0641245  
  C++ Note: df103 -0.83327  
  C++ Note: df104 -0.293772  
  C++ Note: Checking Deviance 767.619
  C++ Note: df105 0.0769553  
  C++ Note: df106 7326.52  
  C++ Note: df100 61872 2 3 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: values checked -0.293527  
  C++ Note: sums checked 1.99498  
  C++ Note: derivs checked 41.7575  
  C++ Note: second derivs checked 897.027  
  C++ Note: dose checked 6400 6400  
  C++ Note: non-dose checked 6400 1.99498  
  C++ Note: LIN_non-dose checked 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400  
  C++ Note: LOGLIN_non-dose checked 6400 1.99498  
  C++ Note: risk checked 45.5545  
  C++ Note: risk1 checked 0.297133  
  C++ Note: risk2 checked 6.38295  
  C++ Note: df101 -469.809  
  C++ Note: df102 -0.0643281  
  C++ Note: df103 -0.834259  
  C++ Note: df104 -0.293527  
  C++ Note: Checking Deviance 767.619
  C++ Note: df105 0.077108  
  C++ Note: df106 7303.33  
  C++ Note: df100 63642 3 3 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: values checked -0.293405  
  C++ Note: sums checked 2.00009  
  C++ Note: derivs checked 41.8672  
  C++ Note: second derivs checked 899.46  
  C++ Note: dose checked 6400 6400  
  C++ Note: non-dose checked 6400 2.00009  
  C++ Note: LIN_non-dose checked 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400  
  C++ Note: LOGLIN_non-dose checked 6400 2.00009  
  C++ Note: risk checked 45.5545  
  C++ Note: risk1 checked 0.297913  
  C++ Note: risk2 checked 6.40026  
  C++ Note: df101 -469.809  
  C++ Note: df102 -0.0644299  
  C++ Note: df103 -0.834748  
  C++ Note: df104 -0.293405  
  C++ Note: Checking Deviance 767.619
  C++ Note: df105 0.0771849  
  C++ Note: df106 7291.79  
  C++ Note: df100 65583 4 3 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: values checked -0.293344  
  C++ Note: sums checked 2.00265  
  C++ Note: derivs checked 41.9221  
  C++ Note: second derivs checked 900.678  
  C++ Note: dose checked 6400 6400  
  C++ Note: non-dose checked 6400 2.00265  
  C++ Note: LIN_non-dose checked 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400  
  C++ Note: LOGLIN_non-dose checked 6400 2.00265  
  C++ Note: risk checked 45.5545  
  C++ Note: risk1 checked 0.298304  
  C++ Note: risk2 checked 6.40893  
  C++ Note: df101 -469.809  
  C++ Note: df102 -0.0644809  
  C++ Note: df103 -0.83499  
  C++ Note: df104 -0.293344  
  C++ Note: Checking Deviance 767.619
  C++ Note: df105 0.0772235  
  C++ Note: df106 7286.02  
  C++ Note: df100 67394 5 3 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: Changing back to best
  C++ Note: values checked -0.293283  
  C++ Note: sums checked 2.00521  
  C++ Note: derivs checked 41.9771  
  C++ Note: second derivs checked 901.899  
  C++ Note: dose checked 6400 6400  
  C++ Note: non-dose checked 6400 2.00521  
  C++ Note: LIN_non-dose checked 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400  
  C++ Note: LOGLIN_non-dose checked 6400 2.00521  
  C++ Note: risk checked 45.5546  
  C++ Note: risk1 checked 0.298696  
  C++ Note: risk2 checked 6.41761  
  C++ Note: df101 -469.809  
  C++ Note: df102 -0.0645319  
  C++ Note: df103 -0.835232  
  C++ Note: df104 -0.293283  
  C++ Note: Checking Deviance 767.619
  C++ Note: df105 0.0772622  
  C++ Note: df106 7280.27  
  C++ Note: df100 69338 0 0 0,Update_Calc
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: df101 -469.8095  
  C++ Note: df102 -0.06453188  
  C++ Note: df103 -0.8352318  
  C++ Note: df104 -0.2932833  
  C++ Note: Checking Deviance 767.6189
  C++ Note: df105 0.07726224  
  C++ Note: df106 7280.27  
  C++ Note: Starting Halves
  C++ Note: df501 -453.0194
  C++ Note: df504 0.002335161  
  C++ Note: values checked -0.293314  
  C++ Note: sums checked 2.00393  
  C++ Note: derivs checked 41.9496  
  C++ Note: second derivs checked 901.288  
  C++ Note: dose checked 6400 6400  
  C++ Note: non-dose checked 6400 2.00393  
  C++ Note: LIN_non-dose checked 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400  
  C++ Note: LOGLIN_non-dose checked 6400 2.00393  
  C++ Note: risk checked 45.5545  
  C++ Note: risk1 checked 0.2985  
  C++ Note: risk2 checked 6.41327  
  C++ Note: df101 -469.809  
  C++ Note: df102 -0.0645064  
  C++ Note: df103 -0.835111  
  C++ Note: df104 -0.293314  
  C++ Note: Checking Deviance 767.619
  C++ Note: df105 0.0772429  
  C++ Note: df106 7283.15  
  C++ Note: df100 71504 1 4 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: values checked -0.293299  
  C++ Note: sums checked 2.00457  
  C++ Note: derivs checked 41.9634  
  C++ Note: second derivs checked 901.593  
  C++ Note: dose checked 6400 6400  
  C++ Note: non-dose checked 6400 2.00457  
  C++ Note: LIN_non-dose checked 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400  
  C++ Note: LOGLIN_non-dose checked 6400 2.00457  
  C++ Note: risk checked 45.5546  
  C++ Note: risk1 checked 0.298598  
  C++ Note: risk2 checked 6.41544  
  C++ Note: df101 -469.809  
  C++ Note: df102 -0.0645191  
  C++ Note: df103 -0.835172  
  C++ Note: df104 -0.293299  
  C++ Note: Checking Deviance 767.619
  C++ Note: df105 0.0772526  
  C++ Note: df106 7281.71  
  C++ Note: df100 73535 2 4 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: values checked -0.293291  
  C++ Note: sums checked 2.00489  
  C++ Note: derivs checked 41.9703  
  C++ Note: second derivs checked 901.746  
  C++ Note: dose checked 6400 6400  
  C++ Note: non-dose checked 6400 2.00489  
  C++ Note: LIN_non-dose checked 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400  
  C++ Note: LOGLIN_non-dose checked 6400 2.00489  
  C++ Note: risk checked 45.5546  
  C++ Note: risk1 checked 0.298647  
  C++ Note: risk2 checked 6.41653  
  C++ Note: df101 -469.809  
  C++ Note: df102 -0.0645255  
  C++ Note: df103 -0.835202  
  C++ Note: df104 -0.293291  
  C++ Note: Checking Deviance 767.619
  C++ Note: df105 0.0772574  
  C++ Note: df106 7280.99  
  C++ Note: df100 75643 3 4 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: values checked -0.293287  
  C++ Note: sums checked 2.00505  
  C++ Note: derivs checked 41.9737  
  C++ Note: second derivs checked 901.822  
  C++ Note: dose checked 6400 6400  
  C++ Note: non-dose checked 6400 2.00505  
  C++ Note: LIN_non-dose checked 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400  
  C++ Note: LOGLIN_non-dose checked 6400 2.00505  
  C++ Note: risk checked 45.5546  
  C++ Note: risk1 checked 0.298671  
  C++ Note: risk2 checked 6.41707  
  C++ Note: df101 -469.809  
  C++ Note: df102 -0.0645287  
  C++ Note: df103 -0.835217  
  C++ Note: df104 -0.293287  
  C++ Note: Checking Deviance 767.619
  C++ Note: df105 0.0772598  
  C++ Note: df106 7280.63  
  C++ Note: df100 77618 4 4 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: values checked -0.293285  
  C++ Note: sums checked 2.00513  
  C++ Note: derivs checked 41.9754  
  C++ Note: second derivs checked 901.86  
  C++ Note: dose checked 6400 6400  
  C++ Note: non-dose checked 6400 2.00513  
  C++ Note: LIN_non-dose checked 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400  
  C++ Note: LOGLIN_non-dose checked 6400 2.00513  
  C++ Note: risk checked 45.5546  
  C++ Note: risk1 checked 0.298683  
  C++ Note: risk2 checked 6.41734  
  C++ Note: df101 -469.809  
  C++ Note: df102 -0.0645303  
  C++ Note: df103 -0.835224  
  C++ Note: df104 -0.293285  
  C++ Note: Checking Deviance 767.619
  C++ Note: df105 0.077261  
  C++ Note: df106 7280.45  
  C++ Note: df100 79577 5 4 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: Changing back to best
  C++ Note: values checked -0.293283  
  C++ Note: sums checked 2.00521  
  C++ Note: derivs checked 41.9771  
  C++ Note: second derivs checked 901.899  
  C++ Note: dose checked 6400 6400  
  C++ Note: non-dose checked 6400 2.00521  
  C++ Note: LIN_non-dose checked 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400  
  C++ Note: LOGLIN_non-dose checked 6400 2.00521  
  C++ Note: risk checked 45.5546  
  C++ Note: risk1 checked 0.298696  
  C++ Note: risk2 checked 6.41761  
  C++ Note: df101 -469.809  
  C++ Note: df102 -0.0645319  
  C++ Note: df103 -0.835232  
  C++ Note: df104 -0.293283  
  C++ Note: Checking Deviance 767.619
  C++ Note: df105 0.0772622  
  C++ Note: df106 7280.27  
  C++ Note: df100 81377 0 0 0,Update_Calc
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: df101 -469.8095  
  C++ Note: df102 -0.06453188  
  C++ Note: df103 -0.8352318  
  C++ Note: df104 -0.2932833  
  C++ Note: Checking Deviance 767.6189
  C++ Note: df105 0.07726224  
  C++ Note: df106 7280.27  
  C++ Note: Starting Halves
  C++ Note: df501 -453.0194
  C++ Note: df504 0.002335161  
  C++ Note: values checked -0.293284  
  C++ Note: sums checked 2.00517  
  C++ Note: derivs checked 41.9763  
  C++ Note: second derivs checked 901.88  
  C++ Note: dose checked 6400 6400  
  C++ Note: non-dose checked 6400 2.00517  
  C++ Note: LIN_non-dose checked 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400  
  C++ Note: LOGLIN_non-dose checked 6400 2.00517  
  C++ Note: risk checked 45.5546  
  C++ Note: risk1 checked 0.298689  
  C++ Note: risk2 checked 6.41748  
  C++ Note: df101 -469.809  
  C++ Note: df102 -0.0645311  
  C++ Note: df103 -0.835228  
  C++ Note: df104 -0.293284  
  C++ Note: Checking Deviance 767.619
  C++ Note: df105 0.0772616  
  C++ Note: df106 7280.36  
  C++ Note: df100 83299 1 5 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: values checked -0.293284  
  C++ Note: sums checked 2.00519  
  C++ Note: derivs checked 41.9767  
  C++ Note: second derivs checked 901.889  
  C++ Note: dose checked 6400 6400  
  C++ Note: non-dose checked 6400 2.00519  
  C++ Note: LIN_non-dose checked 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400  
  C++ Note: LOGLIN_non-dose checked 6400 2.00519  
  C++ Note: risk checked 45.5546  
  C++ Note: risk1 checked 0.298692  
  C++ Note: risk2 checked 6.41754  
  C++ Note: df101 -469.809  
  C++ Note: df102 -0.0645315  
  C++ Note: df103 -0.83523  
  C++ Note: df104 -0.293284  
  C++ Note: Checking Deviance 767.619
  C++ Note: df105 0.0772619  
  C++ Note: df106 7280.31  
  C++ Note: df100 96226 2 5 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: values checked -0.293284  
  C++ Note: sums checked 2.0052  
  C++ Note: derivs checked 41.9769  
  C++ Note: second derivs checked 901.894  
  C++ Note: dose checked 6400 6400  
  C++ Note: non-dose checked 6400 2.0052  
  C++ Note: LIN_non-dose checked 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400  
  C++ Note: LOGLIN_non-dose checked 6400 2.0052  
  C++ Note: risk checked 45.5546  
  C++ Note: risk1 checked 0.298694  
  C++ Note: risk2 checked 6.41758  
  C++ Note: df101 -469.809  
  C++ Note: df102 -0.0645317  
  C++ Note: df103 -0.835231  
  C++ Note: df104 -0.293284  
  C++ Note: Checking Deviance 767.619
  C++ Note: df105 0.0772621  
  C++ Note: df106 7280.29  
  C++ Note: df100 98306 3 5 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: values checked -0.293283  
  C++ Note: sums checked 2.0052  
  C++ Note: derivs checked 41.977  
  C++ Note: second derivs checked 901.896  
  C++ Note: dose checked 6400 6400  
  C++ Note: non-dose checked 6400 2.0052  
  C++ Note: LIN_non-dose checked 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400  
  C++ Note: LOGLIN_non-dose checked 6400 2.0052  
  C++ Note: risk checked 45.5546  
  C++ Note: risk1 checked 0.298695  
  C++ Note: risk2 checked 6.4176  
  C++ Note: df101 -469.809  
  C++ Note: df102 -0.0645318  
  C++ Note: df103 -0.835231  
  C++ Note: df104 -0.293283  
  C++ Note: Checking Deviance 767.619
  C++ Note: df105 0.0772622  
  C++ Note: df106 7280.28  
  C++ Note: df100 100175 4 5 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: values checked -0.293283  
  C++ Note: sums checked 2.0052  
  C++ Note: derivs checked 41.9771  
  C++ Note: second derivs checked 901.897  
  C++ Note: dose checked 6400 6400  
  C++ Note: non-dose checked 6400 2.0052  
  C++ Note: LIN_non-dose checked 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400  
  C++ Note: LOGLIN_non-dose checked 6400 2.0052  
  C++ Note: risk checked 45.5546  
  C++ Note: risk1 checked 0.298695  
  C++ Note: risk2 checked 6.4176  
  C++ Note: df101 -469.809  
  C++ Note: df102 -0.0645318  
  C++ Note: df103 -0.835232  
  C++ Note: df104 -0.293283  
  C++ Note: Checking Deviance 767.619
  C++ Note: df105 0.0772622  
  C++ Note: df106 7280.28  
  C++ Note: df100 102016 5 5 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: Changing back to best
  C++ Note: values checked -0.293283  
  C++ Note: sums checked 2.00521  
  C++ Note: derivs checked 41.9771  
  C++ Note: second derivs checked 901.899  
  C++ Note: dose checked 6400 6400  
  C++ Note: non-dose checked 6400 2.00521  
  C++ Note: LIN_non-dose checked 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400  
  C++ Note: LOGLIN_non-dose checked 6400 2.00521  
  C++ Note: risk checked 45.5546  
  C++ Note: risk1 checked 0.298696  
  C++ Note: risk2 checked 6.41761  
  C++ Note: df101 -469.809  
  C++ Note: df102 -0.0645319  
  C++ Note: df103 -0.835232  
  C++ Note: df104 -0.293283  
  C++ Note: Checking Deviance 767.619
  C++ Note: df105 0.0772622  
  C++ Note: df106 7280.27  
  C++ Note: df100 103794 0 0 0,Update_Calc
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: df101 -469.8095  
  C++ Note: df102 -0.06453188  
  C++ Note: df103 -0.8352318  
  C++ Note: df104 -0.2932833  
  C++ Note: Checking Deviance 767.6189
  C++ Note: df105 0.07726224  
  C++ Note: df106 7280.27  
  C++ Note: df101 -469.809  
  C++ Note: df102 -0.0645319  
  C++ Note: df103 -0.835232  
  C++ Note: df104 -0.293283  
  C++ Note: Checking Deviance 767.619
  C++ Note: df105 0.0772622  
  C++ Note: df106 7280.27  
  C++ Note: ending guess 1
  C++ Note: df501 -453.0194
  C++ Note: df504 0.002335161  
  C++ Note: Refreshing matrices after all guesses
  C++ Note: Guess Results
  Guess number, parameter values, Log-Likelihood
  0, 0.002335161, -453.0194<-- Best Guess
  1, -0.2932833, -469.8095
  C++ Note: starting subterms 2 in best guess 0
  C++ Note: values checked 0.00233516  
  C++ Note: sums checked 7190.92  
  C++ Note: derivs checked 361679  
  C++ Note: second derivs checked 2.06424e+07  
  C++ Note: dose checked 6400 6400  
  C++ Note: non-dose checked 6400 7190.92  
  C++ Note: LIN_non-dose checked 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400  
  C++ Note: LOGLIN_non-dose checked 6400 7190.92  
  C++ Note: risk checked 96.7085  
  C++ Note: risk1 checked 2573.58  
  C++ Note: risk2 checked 146884  
  C++ Note: Made Risk Side Lists
  C++ Note: df101 -453.019  
  C++ Note: df102 -2.19373  
  C++ Note: df103 -72843.8  
  C++ Note: df104 0.00233516  
  C++ Note: Checking Deviance 734.039
  C++ Note: df105 3.01155e-05  
  C++ Note: df106 206.506  
  C++ Note: Starting Halves
  C++ Note: df501 -453.0194
  C++ Note: df504 0.002335161  
  C++ Note: values checked 0.00231257  
  C++ Note: sums checked 7182.75  
  C++ Note: derivs checked 361213  
  C++ Note: second derivs checked 2.06134e+07  
  C++ Note: dose checked 6400 6400  
  C++ Note: non-dose checked 6400 7182.75  
  C++ Note: LIN_non-dose checked 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400  
  C++ Note: LOGLIN_non-dose checked 6400 7182.75  
  C++ Note: risk checked 96.6504  
  C++ Note: risk1 checked 2570.27  
  C++ Note: risk2 checked 146678  
  C++ Note: df101 -453.019  
  C++ Note: df102 -0.550709  
  C++ Note: df103 -72642.3  
  C++ Note: df104 0.00231257  
  C++ Note: Checking Deviance 734.039
  C++ Note: df105 7.58111e-06  
  C++ Note: df106 822.611  
  C++ Note: df100 120695 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: df100 120776 0 0 0,Update_Calc
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: df101 -453.0193  
  C++ Note: df102 -0.5507093  
  C++ Note: df103 -72642.32  
  C++ Note: df104 0.002312575  
  C++ Note: Checking Deviance 734.0386
  C++ Note: df105 7.581108e-06  
  C++ Note: df106 822.6106  
  C++ Note: df101 -453.019  
  C++ Note: df102 -0.550709  
  C++ Note: df103 -72642.3  
  C++ Note: df104 0.00231257  
  C++ Note: Checking Deviance 734.039
  C++ Note: df105 7.58111e-06  
  C++ Note: df106 822.611  
  C++ Note: df501 -453.0193
  C++ Note: df504 0.002312575  
  Note: INITIAL TERM COMPLETE
  -453.019321355954-0.550709301883533-72642.32341779490.002312574716865620.00371026677080554736.038642711906914.802695981256734.038642711906list(Term_n = 1, tforms = "loglin", names = "t0")list(Iteration = 1, `Maximum Step` = 1, `Derivative Limiting` = 0.550709301883533)FALSE
  Warning: rmin and rmax lists not equal size, defaulting to lin and loglin min/max values
  C++ Note: START_RISK_CHECK
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: Term checked 1 2  
  C++ Note: df99,77,Starting
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: starting subterms 3
  C++ Note: values checked 0.002312575 -15  
  C++ Note: sums checked 7182.753 2624.001  
  C++ Note: dose checked 6400 6400 6400  
  C++ Note: non-dose checked 6400 7182.753 2624.001  
  C++ Note: LIN_non-dose checked 6400 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400 6400  
  C++ Note: LOGLIN_non-dose checked 6400 7182.753 2624.001  
  C++ Note: df99,1312,Prep_Terms
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  Note: 1 valid guesses
  C++ Note: START_RISK_CHECK
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: Term checked 1 2  
  C++ Note: df99,55,Starting
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: starting subterms 3
  C++ Note: values checked 0.002312575 -15.86416  
  C++ Note: sums checked 7182.753 2624  
  C++ Note: dose checked 6400 6400 6400  
  C++ Note: non-dose checked 6400 7182.753 2624  
  C++ Note: LIN_non-dose checked 6400 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400 6400  
  C++ Note: LOGLIN_non-dose checked 6400 7182.753 2624  
  C++ Note: df99,1223,Prep_Terms
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: START_POIS_GUESS
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: Term checked 1 2  
  C++ Note: df99,72,Starting
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: starting subterms 3 in guess 0
  C++ Note: values checked 0.00231257 -15  
  C++ Note: sums checked 7182.75 2624  
  C++ Note: derivs checked 361213 0.00115509  
  C++ Note: second derivs checked 2.06134e+07 0.00115509  
  C++ Note: dose checked 6400 6400 6400  
  C++ Note: non-dose checked 6400 7182.75 2624  
  C++ Note: LIN_non-dose checked 6400 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400 6400  
  C++ Note: LOGLIN_non-dose checked 6400 7182.75 2624  
  C++ Note: risk checked 69.0234  
  C++ Note: risk1 checked 1835.57 8.45116e-06  
  C++ Note: risk2 checked 104751 8.45116e-06  
  C++ Note: df101 -449.751 -449.751  
  C++ Note: df102 694.655 2.09788e-06  
  C++ Note: df103 -32968.8 2.09788e-06  
  C++ Note: df104 0.00231257 -15  
  C++ Note: Checking Deviance 727.502
  C++ Note: df105 -0.02107 1  
  C++ Note: df106 -0.647445 -2.14383e+08  
  C++ Note: Starting Halves
  C++ Note: df501 -449.7512
  C++ Note: df504 0.002312575 -15  
  C++ Note: values checked 0.0181151 -14.1481  
  C++ Note: sums checked 16582.9 2624  
  C++ Note: derivs checked 921141 0.0027077  
  C++ Note: second derivs checked 5.6465e+07 0.0027077  
  C++ Note: dose checked 6400 6400 6400  
  C++ Note: non-dose checked 6400 16582.9 2624  
  C++ Note: LIN_non-dose checked 6400 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400 6400  
  C++ Note: LOGLIN_non-dose checked 6400 16582.9 2624  
  C++ Note: risk checked 116.792  
  C++ Note: risk1 checked 4680.95 3.35213e-05  
  C++ Note: risk2 checked 286938 3.35213e-05  
  C++ Note: df101 -448.753 -448.753  
  C++ Note: df102 -1059.27 -8.05569e-06  
  C++ Note: df103 -222055 -8.05571e-06  
  C++ Note: df104 0.0181151 -14.1481  
  C++ Note: Checking Deviance 725.506
  C++ Note: df105 0.00477029 0.999998  
  C++ Note: df106 0.423645 5.57063e+07  
  C++ Note: df100 7401 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: df100 7498 0 0 0,Update_Calc
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: df101 -448.753 -448.753  
  C++ Note: df102 -1059.267 -8.055693e-06  
  C++ Note: df103 -222055 -8.05571e-06  
  C++ Note: df104 0.0181151 -14.14807  
  C++ Note: Checking Deviance 725.506
  C++ Note: df105 0.004770292 0.9999979  
  C++ Note: df106 0.4236448 5.570632e+07  
  C++ Note: Starting Halves
  C++ Note: df501 -448.753
  C++ Note: df504 0.0181151 -14.14807  
  C++ Note: values checked 0.0145374 -14.3335  
  C++ Note: sums checked 13622.2 2624  
  C++ Note: derivs checked 740922 0.00224951  
  C++ Note: second derivs checked 4.47533e+07 0.00224951  
  C++ Note: dose checked 6400 6400 6400  
  C++ Note: non-dose checked 6400 13622.2 2624  
  C++ Note: LIN_non-dose checked 6400 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400 6400  
  C++ Note: LOGLIN_non-dose checked 6400 13622.2 2624  
  C++ Note: risk checked 101.747  
  C++ Note: risk1 checked 3765.14 2.42613e-05  
  C++ Note: risk2 checked 227423 2.42613e-05  
  C++ Note: df101 -446.246 -446.246  
  C++ Note: df102 -378.967 -3.2978e-06  
  C++ Note: df103 -160567 -3.29781e-06  
  C++ Note: df104 0.0145374 -14.3335  
  C++ Note: Checking Deviance 720.492
  C++ Note: df105 0.00236018 0.999996  
  C++ Note: df106 1.17753 1.35316e+08  
  C++ Note: df100 22086 1 2 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: df100 22177 0 0 0,Update_Calc
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: df101 -446.2458 -446.2458  
  C++ Note: df102 -378.9665 -3.297802e-06  
  C++ Note: df103 -160566.9 -3.297813e-06  
  C++ Note: df104 0.01453739 -14.33346  
  C++ Note: Checking Deviance 720.4915
  C++ Note: df105 0.002360179 0.9999964  
  C++ Note: df106 1.177533 1.353161e+08  
  C++ Note: Starting Halves
  C++ Note: df501 -446.2458
  C++ Note: df504 0.01453739 -14.33346  
  C++ Note: values checked 0.0127673 -14.6275  
  C++ Note: sums checked 12378.2 2624  
  C++ Note: derivs checked 666059 0.0016765  
  C++ Note: second derivs checked 3.99267e+07 0.0016765  
  C++ Note: dose checked 6400 6400 6400  
  C++ Note: non-dose checked 6400 12378.2 2624  
  C++ Note: LIN_non-dose checked 6400 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400 6400  
  C++ Note: LOGLIN_non-dose checked 6400 12378.2 2624  
  C++ Note: risk checked 95.425  
  C++ Note: risk1 checked 3384.71 1.69579e-05  
  C++ Note: risk2 checked 202895 1.69579e-05  
  C++ Note: df101 -445.813 -445.813  
  C++ Note: df102 -117.841 -1.39473e-06  
  C++ Note: df103 -134954 -1.39474e-06  
  C++ Note: df104 0.0127673 -14.6275  
  C++ Note: Checking Deviance 719.625
  C++ Note: df105 0.000873194 0.999995  
  C++ Note: df106 3.78318 3.19641e+08  
  C++ Note: df100 25189 1 3 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: df100 25273 0 0 0,Update_Calc
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: df101 -445.8127 -445.8127  
  C++ Note: df102 -117.8408 -1.39473e-06  
  C++ Note: df103 -134953.8 -1.394736e-06  
  C++ Note: df104 0.01276725 -14.62747  
  C++ Note: Checking Deviance 719.6255
  C++ Note: df105 0.0008731937 0.9999953  
  C++ Note: df106 3.783177 3.19641e+08  
  C++ Note: Starting Halves
  C++ Note: df501 -445.8127
  C++ Note: df504 0.01276725 -14.62747  
  C++ Note: values checked 0.0121124 -15.1102  
  C++ Note: sums checked 11950.4 2624  
  C++ Note: derivs checked 640454 0.00103454  
  C++ Note: second derivs checked 3.82819e+07 0.00103454  
  C++ Note: dose checked 6400 6400 6400  
  C++ Note: non-dose checked 6400 11950.4 2624  
  C++ Note: LIN_non-dose checked 6400 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400 6400  
  C++ Note: LOGLIN_non-dose checked 6400 11950.4 2624  
  C++ Note: risk checked 93.2513  
  C++ Note: risk1 checked 3254.59 1.02261e-05  
  C++ Note: risk2 checked 194537 1.02261e-05  
  C++ Note: df101 -445.764 -445.764  
  C++ Note: df102 -32.3484 -6.35105e-07  
  C++ Note: df103 -126196 -6.35107e-07  
  C++ Note: df104 0.0121124 -15.1102  
  C++ Note: Checking Deviance 719.528
  C++ Note: df105 0.000256336 0.999996  
  C++ Note: df106 13.7801 7.01874e+08  
  C++ Note: df100 28228 1 4 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: df100 28316 0 0 0,Update_Calc
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: df101 -445.7639 -445.7639  
  C++ Note: df102 -32.34844 -6.35105e-07  
  C++ Note: df103 -126195.7 -6.351075e-07  
  C++ Note: df104 0.01211236 -15.11022  
  C++ Note: Checking Deviance 719.5277
  C++ Note: df105 0.0002563356 0.9999961  
  C++ Note: df106 13.78007 7.018743e+08  
  C++ Note: Starting Halves
  C++ Note: df501 -445.7639
  C++ Note: df504 0.01211236 -15.11022  
  C++ Note: values checked 0.0119201 -15.758  
  C++ Note: sums checked 11828 2624  
  C++ Note: derivs checked 633140 0.000541285  
  C++ Note: second derivs checked 3.78127e+07 0.000541285  
  C++ Note: dose checked 6400 6400 6400  
  C++ Note: non-dose checked 6400 11828 2624  
  C++ Note: LIN_non-dose checked 6400 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400 6400  
  C++ Note: LOGLIN_non-dose checked 6400 11828 2624  
  C++ Note: risk checked 92.6292  
  C++ Note: risk1 checked 3217.42 5.3147e-06  
  C++ Note: risk2 checked 192153 5.3147e-06  
  C++ Note: df101 -445.76 -445.76  
  C++ Note: df102 -8.32807 -2.98518e-07  
  C++ Note: df103 -123695 -2.98519e-07  
  C++ Note: df104 0.0119201 -15.758  
  C++ Note: Checking Deviance 719.52
  C++ Note: df105 6.73276e-05 0.999998  
  C++ Note: df106 53.525 1.49324e+09  
  C++ Note: df100 41923 1 5 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: df100 42011 0 0 0,Update_Calc
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: df101 -445.76 -445.76  
  C++ Note: df102 -8.328071 -2.985182e-07  
  C++ Note: df103 -123694.8 -2.985189e-07  
  C++ Note: df104 0.01192011 -15.75799  
  C++ Note: Checking Deviance 719.5199
  C++ Note: df105 6.732758e-05 0.9999977  
  C++ Note: df106 53.525 1.493242e+09  
  C++ Note: df101 -445.76 -445.76  
  C++ Note: df102 -8.32807 -2.98518e-07  
  C++ Note: df103 -123695 -2.98519e-07  
  C++ Note: df104 0.0119201 -15.758  
  C++ Note: Checking Deviance 719.52
  C++ Note: df105 6.73276e-05 0.999998  
  C++ Note: df106 53.525 1.49324e+09  
  C++ Note: ending guess 0
  C++ Note: df501 -445.76
  C++ Note: df504 0.01192011 -15.75799  
  C++ Note: starting subterms 3 in guess 1
  C++ Note: values checked 0.00231257 -15.8642  
  C++ Note: sums checked 7182.75 2624  
  C++ Note: derivs checked 361213 0.000486761  
  C++ Note: second derivs checked 2.06134e+07 0.000486761  
  C++ Note: dose checked 6400 6400 6400  
  C++ Note: non-dose checked 6400 7182.75 2624  
  C++ Note: LIN_non-dose checked 6400 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400 6400  
  C++ Note: LOGLIN_non-dose checked 6400 7182.75 2624  
  C++ Note: risk checked 69.0234  
  C++ Note: risk1 checked 1835.57 3.56138e-06  
  C++ Note: risk2 checked 104751 3.56138e-06  
  C++ Note: df101 -449.751 -449.751  
  C++ Note: df102 694.655 8.84062e-07  
  C++ Note: df103 -32968.8 8.84061e-07  
  C++ Note: df104 0.00231257 -15.8642  
  C++ Note: Checking Deviance 727.502
  C++ Note: df105 -0.0210701 1  
  C++ Note: df106 -0.647445 -5.08733e+08  
  C++ Note: Starting Halves
  C++ Note: df501 -445.76
  C++ Note: df504 0.01192011 -15.75799  
  C++ Note: values checked 0.0181151 -15.0122  
  C++ Note: sums checked 16582.9 2624  
  C++ Note: derivs checked 921141 0.00114104  
  C++ Note: second derivs checked 5.6465e+07 0.00114104  
  C++ Note: dose checked 6400 6400 6400  
  C++ Note: non-dose checked 6400 16582.9 2624  
  C++ Note: LIN_non-dose checked 6400 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400 6400  
  C++ Note: LOGLIN_non-dose checked 6400 16582.9 2624  
  C++ Note: risk checked 116.792  
  C++ Note: risk1 checked 4680.96 1.41261e-05  
  C++ Note: risk2 checked 286938 1.41261e-05  
  C++ Note: df101 -448.753 -448.753  
  C++ Note: df102 -1059.27 -3.39472e-06  
  C++ Note: df103 -222055 -3.39472e-06  
  C++ Note: df104 0.0181151 -15.0122  
  C++ Note: Checking Deviance 725.506
  C++ Note: df105 0.0047703 0.999999  
  C++ Note: df106 0.423644 1.32192e+08  
  C++ Note: df100 49373 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: values checked 0.0102138 -15.4382  
  C++ Note: sums checked 10800.8 2624  
  C++ Note: derivs checked 572020 0.000745262  
  C++ Note: second derivs checked 3.3903e+07 0.000745262  
  C++ Note: dose checked 6400 6400 6400  
  C++ Note: non-dose checked 6400 10800.8 2624  
  C++ Note: LIN_non-dose checked 6400 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400 6400  
  C++ Note: LOGLIN_non-dose checked 6400 10800.8 2624  
  C++ Note: risk checked 87.4092  
  C++ Note: risk1 checked 2906.83 6.90513e-06  
  C++ Note: risk2 checked 172285 6.90513e-06  
  C++ Note: df101 -445.915 -445.915  
  C++ Note: df102 184.595 -2.0811e-08  
  C++ Note: df103 -102833 -2.08123e-08  
  C++ Note: df104 0.0102138 -15.4382  
  C++ Note: Checking Deviance 719.831
  C++ Note: df105 -0.0017951 0.999938  
  C++ Note: df106 -2.41564 2.14269e+10  
  C++ Note: df100 61771 2 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: values checked 0.00626321 -15.6512  
  C++ Note: sums checked 8784.7 2624  
  C++ Note: derivs checked 453568 0.0006023  
  C++ Note: second derivs checked 2.63923e+07 0.0006023  
  C++ Note: dose checked 6400 6400 6400  
  C++ Note: non-dose checked 6400 8784.7 2624  
  C++ Note: LIN_non-dose checked 6400 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400 6400  
  C++ Note: LOGLIN_non-dose checked 6400 8784.7 2624  
  C++ Note: risk checked 77.164  
  C++ Note: risk1 checked 2304.89 4.92643e-06  
  C++ Note: risk2 checked 134118 4.92643e-06  
  C++ Note: df101 -447.336 -447.336  
  C++ Note: df102 508.325 6.02115e-07  
  C++ Note: df103 -62884.4 6.02115e-07  
  C++ Note: df104 0.00626321 -15.6512  
  C++ Note: Checking Deviance 722.672
  C++ Note: df105 -0.00808349 1  
  C++ Note: df106 -0.880019 -7.42941e+08  
  C++ Note: df100 64304 3 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: values checked 0.00428789 -15.7577  
  C++ Note: sums checked 7938.18 2624  
  C++ Note: derivs checked 404541 0.000541457  
  C++ Note: second derivs checked 2.33147e+07 0.000541457  
  C++ Note: dose checked 6400 6400 6400  
  C++ Note: non-dose checked 6400 7938.18 2624  
  C++ Note: LIN_non-dose checked 6400 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400 6400  
  C++ Note: LOGLIN_non-dose checked 6400 7938.18 2624  
  C++ Note: risk checked 72.8622  
  C++ Note: risk1 checked 2055.75 4.18189e-06  
  C++ Note: risk2 checked 118478 4.18189e-06  
  C++ Note: df101 -448.452 -448.452  
  C++ Note: df102 616.247 7.74917e-07  
  C++ Note: df103 -46783.7 7.74916e-07  
  C++ Note: df104 0.00428789 -15.7577  
  C++ Note: Checking Deviance 724.904
  C++ Note: df105 -0.0131723 1  
  C++ Note: df106 -0.727715 -5.7871e+08  
  C++ Note: df100 77924 4 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: values checked 0.00330023 -15.8109  
  C++ Note: sums checked 7549.77 2624  
  C++ Note: derivs checked 382210 0.000513381  
  C++ Note: second derivs checked 2.19201e+07 0.000513381  
  C++ Note: dose checked 6400 6400 6400  
  C++ Note: non-dose checked 6400 7549.77 2624  
  C++ Note: LIN_non-dose checked 6400 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400 6400  
  C++ Note: LOGLIN_non-dose checked 6400 7549.77 2624  
  C++ Note: risk checked 70.8885  
  C++ Note: risk1 checked 1942.27 3.85764e-06  
  C++ Note: risk2 checked 111391 3.85764e-06  
  C++ Note: df101 -449.082 -449.082  
  C++ Note: df102 658.861 8.36371e-07  
  C++ Note: df103 -39603.2 8.36371e-07  
  C++ Note: df104 0.00330023 -15.8109  
  C++ Note: Checking Deviance 726.165
  C++ Note: df105 -0.0166366 1  
  C++ Note: df106 -0.681604 -5.36941e+08  
  C++ Note: df100 80558 5 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: Changing back to best
  C++ Note: values checked 0.00231257 -15.8642  
  C++ Note: sums checked 7182.75 2624  
  C++ Note: derivs checked 361213 0.000486761  
  C++ Note: second derivs checked 2.06134e+07 0.000486761  
  C++ Note: dose checked 6400 6400 6400  
  C++ Note: non-dose checked 6400 7182.75 2624  
  C++ Note: LIN_non-dose checked 6400 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400 6400  
  C++ Note: LOGLIN_non-dose checked 6400 7182.75 2624  
  C++ Note: risk checked 69.0234  
  C++ Note: risk1 checked 1835.57 3.56138e-06  
  C++ Note: risk2 checked 104751 3.56138e-06  
  C++ Note: df101 -449.751 -449.751  
  C++ Note: df102 694.655 8.84062e-07  
  C++ Note: df103 -32968.8 8.84061e-07  
  C++ Note: df104 0.00231257 -15.8642  
  C++ Note: Checking Deviance 727.502
  C++ Note: df105 -0.0210701 1  
  C++ Note: df106 -0.647445 -5.08733e+08  
  C++ Note: df100 83195 0 0 0,Update_Calc
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: df101 -449.7512 -449.7512  
  C++ Note: df102 694.6552 8.84062e-07  
  C++ Note: df103 -32968.84 8.840614e-07  
  C++ Note: df104 0.002312575 -15.86416  
  C++ Note: Checking Deviance 727.5024
  C++ Note: df105 -0.02107006 1.000001  
  C++ Note: df106 -0.6474452 -5.087327e+08  
  C++ Note: Starting Halves
  C++ Note: df501 -445.76
  C++ Note: df504 0.01192011 -15.75799  
  C++ Note: values checked 0.0181151 -15.8329  
  C++ Note: sums checked 16582.9 2624  
  C++ Note: derivs checked 921141 0.000502213  
  C++ Note: second derivs checked 5.6465e+07 0.000502213  
  C++ Note: dose checked 6400 6400 6400  
  C++ Note: non-dose checked 6400 16582.9 2624  
  C++ Note: LIN_non-dose checked 6400 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400 6400  
  C++ Note: LOGLIN_non-dose checked 6400 16582.9 2624  
  C++ Note: risk checked 116.792  
  C++ Note: risk1 checked 4680.96 6.21738e-06  
  C++ Note: risk2 checked 286938 6.21738e-06  
  C++ Note: df101 -448.753 -448.753  
  C++ Note: df102 -1059.27 -1.49413e-06  
  C++ Note: df103 -222055 -1.49413e-06  
  C++ Note: df104 0.0181151 -15.8329  
  C++ Note: Checking Deviance 725.506
  C++ Note: df105 0.00477029 1  
  C++ Note: df106 0.423644 3.00343e+08  
  C++ Note: df100 85945 1 2 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: values checked 0.0102138 -15.8485  
  C++ Note: sums checked 10800.8 2624  
  C++ Note: derivs checked 572020 0.000494427  
  C++ Note: second derivs checked 3.3903e+07 0.000494427  
  C++ Note: dose checked 6400 6400 6400  
  C++ Note: non-dose checked 6400 10800.8 2624  
  C++ Note: LIN_non-dose checked 6400 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400 6400  
  C++ Note: LOGLIN_non-dose checked 6400 10800.8 2624  
  C++ Note: risk checked 87.4092  
  C++ Note: risk1 checked 2906.83 4.58105e-06  
  C++ Note: risk2 checked 172285 4.58105e-06  
  C++ Note: df101 -445.915 -445.915  
  C++ Note: df102 184.595 -1.38063e-08  
  C++ Note: df103 -102833 -1.38069e-08  
  C++ Note: df104 0.0102138 -15.8485  
  C++ Note: Checking Deviance 719.831
  C++ Note: df105 -0.0017951 0.999959  
  C++ Note: df106 -2.41564 3.2298e+10  
  C++ Note: df100 105864 2 2 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: values checked 0.00626321 -15.8563  
  C++ Note: sums checked 8784.7 2624  
  C++ Note: derivs checked 453568 0.000490579  
  C++ Note: second derivs checked 2.63923e+07 0.000490579  
  C++ Note: dose checked 6400 6400 6400  
  C++ Note: non-dose checked 6400 8784.7 2624  
  C++ Note: LIN_non-dose checked 6400 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400 6400  
  C++ Note: LOGLIN_non-dose checked 6400 8784.7 2624  
  C++ Note: risk checked 77.164  
  C++ Note: risk1 checked 2304.89 4.01263e-06  
  C++ Note: risk2 checked 134118 4.01263e-06  
  C++ Note: df101 -447.336 -447.336  
  C++ Note: df102 508.325 4.90429e-07  
  C++ Note: df103 -62884.4 4.90429e-07  
  C++ Note: df104 0.00626321 -15.8563  
  C++ Note: Checking Deviance 722.672
  C++ Note: df105 -0.00808349 1  
  C++ Note: df106 -0.880019 -9.12132e+08  
  C++ Note: df100 108682 3 2 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: values checked 0.00428789 -15.8603  
  C++ Note: sums checked 7938.18 2624  
  C++ Note: derivs checked 404541 0.000488666  
  C++ Note: second derivs checked 2.33147e+07 0.000488666  
  C++ Note: dose checked 6400 6400 6400  
  C++ Note: non-dose checked 6400 7938.18 2624  
  C++ Note: LIN_non-dose checked 6400 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400 6400  
  C++ Note: LOGLIN_non-dose checked 6400 7938.18 2624  
  C++ Note: risk checked 72.8622  
  C++ Note: risk1 checked 2055.75 3.77416e-06  
  C++ Note: risk2 checked 118478 3.77416e-06  
  C++ Note: df101 -448.452 -448.452  
  C++ Note: df102 616.247 6.99364e-07  
  C++ Note: df103 -46783.7 6.99364e-07  
  C++ Note: df104 0.00428789 -15.8603  
  C++ Note: Checking Deviance 724.904
  C++ Note: df105 -0.0131723 1  
  C++ Note: df106 -0.727715 -6.41228e+08  
  C++ Note: df100 111511 4 2 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: values checked 0.00330023 -15.8622  
  C++ Note: sums checked 7549.77 2624  
  C++ Note: derivs checked 382210 0.000487713  
  C++ Note: second derivs checked 2.19201e+07 0.000487713  
  C++ Note: dose checked 6400 6400 6400  
  C++ Note: non-dose checked 6400 7549.77 2624  
  C++ Note: LIN_non-dose checked 6400 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400 6400  
  C++ Note: LOGLIN_non-dose checked 6400 7549.77 2624  
  C++ Note: risk checked 70.8885  
  C++ Note: risk1 checked 1942.27 3.66476e-06  
  C++ Note: risk2 checked 111391 3.66476e-06  
  C++ Note: df101 -449.082 -449.082  
  C++ Note: df102 658.861 7.94554e-07  
  C++ Note: df103 -39603.2 7.94553e-07  
  C++ Note: df104 0.00330023 -15.8622  
  C++ Note: Checking Deviance 726.165
  C++ Note: df105 -0.0166366 1  
  C++ Note: df106 -0.681604 -5.65201e+08  
  C++ Note: df100 114244 5 2 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: Changing back to best
  C++ Note: values checked 0.00231257 -15.8642  
  C++ Note: sums checked 7182.75 2624  
  C++ Note: derivs checked 361213 0.000486761  
  C++ Note: second derivs checked 2.06134e+07 0.000486761  
  C++ Note: dose checked 6400 6400 6400  
  C++ Note: non-dose checked 6400 7182.75 2624  
  C++ Note: LIN_non-dose checked 6400 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400 6400  
  C++ Note: LOGLIN_non-dose checked 6400 7182.75 2624  
  C++ Note: risk checked 69.0234  
  C++ Note: risk1 checked 1835.57 3.56138e-06  
  C++ Note: risk2 checked 104751 3.56138e-06  
  C++ Note: df101 -449.751 -449.751  
  C++ Note: df102 694.655 8.84062e-07  
  C++ Note: df103 -32968.8 8.84061e-07  
  C++ Note: df104 0.00231257 -15.8642  
  C++ Note: Checking Deviance 727.502
  C++ Note: df105 -0.0210701 1  
  C++ Note: df106 -0.647445 -5.08733e+08  
  C++ Note: df100 144064 0 0 0,Update_Calc
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: df101 -449.7512 -449.7512  
  C++ Note: df102 694.6552 8.84062e-07  
  C++ Note: df103 -32968.84 8.840614e-07  
  C++ Note: df104 0.002312575 -15.86416  
  C++ Note: Checking Deviance 727.5024
  C++ Note: df105 -0.02107006 1.000001  
  C++ Note: df106 -0.6474452 -5.087327e+08  
  C++ Note: Starting Halves
  C++ Note: df501 -445.76
  C++ Note: df504 0.01192011 -15.75799  
  C++ Note: values checked 0.00328914 -15.8632  
  C++ Note: sums checked 7545.53 2624  
  C++ Note: derivs checked 381967 0.000487237  
  C++ Note: second derivs checked 2.1905e+07 0.000487237  
  C++ Note: dose checked 6400 6400 6400  
  C++ Note: non-dose checked 6400 7545.53 2624  
  C++ Note: LIN_non-dose checked 6400 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400 6400  
  C++ Note: LOGLIN_non-dose checked 6400 7545.53 2624  
  C++ Note: risk checked 70.8669  
  C++ Note: risk1 checked 1941.04 3.66007e-06  
  C++ Note: risk2 checked 111314 3.66007e-06  
  C++ Note: df101 -449.09 -449.09  
  C++ Note: df102 659.3 7.94831e-07  
  C++ Note: df103 -39525.7 7.9483e-07  
  C++ Note: df104 0.00328914 -15.8632  
  C++ Note: Checking Deviance 726.179
  C++ Note: df105 -0.0166803 1  
  C++ Note: df106 -0.681161 -5.65013e+08  
  C++ Note: df100 147301 1 3 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: values checked 0.00280086 -15.8637  
  C++ Note: sums checked 7361.61 2624  
  C++ Note: derivs checked 371432 0.000486999  
  C++ Note: second derivs checked 2.12488e+07 0.000486999  
  C++ Note: dose checked 6400 6400 6400  
  C++ Note: non-dose checked 6400 7361.61 2624  
  C++ Note: LIN_non-dose checked 6400 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400 6400  
  C++ Note: LOGLIN_non-dose checked 6400 7361.61 2624  
  C++ Note: risk checked 69.9323  
  C++ Note: risk1 checked 1887.5 3.61003e-06  
  C++ Note: risk2 checked 107980 3.61003e-06  
  C++ Note: df101 -449.416 -449.416  
  C++ Note: df102 677.778 8.40097e-07  
  C++ Note: df103 -36182 8.40097e-07  
  C++ Note: df104 0.00280086 -15.8637  
  C++ Note: Checking Deviance 726.832
  C++ Note: df105 -0.0187325 1  
  C++ Note: df106 -0.663073 -5.34957e+08  
  C++ Note: df100 151414 2 3 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: values checked 0.00255672 -15.8639  
  C++ Note: sums checked 7271.56 2624  
  C++ Note: derivs checked 366284 0.00048688  
  C++ Note: second derivs checked 2.09286e+07 0.00048688  
  C++ Note: dose checked 6400 6400 6400  
  C++ Note: non-dose checked 6400 7271.56 2624  
  C++ Note: LIN_non-dose checked 6400 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400 6400  
  C++ Note: LOGLIN_non-dose checked 6400 7271.56 2624  
  C++ Note: risk checked 69.4747  
  C++ Note: risk1 checked 1861.34 3.58554e-06  
  C++ Note: risk2 checked 106353 3.58554e-06  
  C++ Note: df101 -449.583 -449.583  
  C++ Note: df102 686.413 8.6224e-07  
  C++ Note: df103 -34559.3 8.62239e-07  
  C++ Note: df104 0.00255672 -15.8639  
  C++ Note: Checking Deviance 727.165
  C++ Note: df105 -0.0198619 1  
  C++ Note: df106 -0.654974 -5.21413e+08  
  C++ Note: df100 154213 3 3 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: values checked 0.00243465 -15.864  
  C++ Note: sums checked 7227 2624  
  C++ Note: derivs checked 363738 0.000486821  
  C++ Note: second derivs checked 2.07704e+07 0.000486821  
  C++ Note: dose checked 6400 6400 6400  
  C++ Note: non-dose checked 6400 7227 2624  
  C++ Note: LIN_non-dose checked 6400 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400 6400  
  C++ Note: LOGLIN_non-dose checked 6400 7227 2624  
  C++ Note: risk checked 69.2482  
  C++ Note: risk1 checked 1848.41 3.57341e-06  
  C++ Note: risk2 checked 105549 3.57341e-06  
  C++ Note: df101 -449.667 -449.667  
  C++ Note: df102 690.582 8.73191e-07  
  C++ Note: df103 -33760.1 8.7319e-07  
  C++ Note: df104 0.00243465 -15.864  
  C++ Note: Checking Deviance 727.333
  C++ Note: df105 -0.0204556 1  
  C++ Note: df106 -0.651141 -5.1497e+08  
  C++ Note: df100 165827 4 3 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: values checked 0.00237361 -15.8641  
  C++ Note: sums checked 7204.84 2624  
  C++ Note: derivs checked 362473 0.000486791  
  C++ Note: second derivs checked 2.06917e+07 0.000486791  
  C++ Note: dose checked 6400 6400 6400  
  C++ Note: non-dose checked 6400 7204.84 2624  
  C++ Note: LIN_non-dose checked 6400 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400 6400  
  C++ Note: LOGLIN_non-dose checked 6400 7204.84 2624  
  C++ Note: risk checked 69.1356  
  C++ Note: risk1 checked 1841.98 3.56738e-06  
  C++ Note: risk2 checked 105149 3.56738e-06  
  C++ Note: df101 -449.709 -449.709  
  C++ Note: df102 692.631 8.78636e-07  
  C++ Note: df103 -33363.4 8.78636e-07  
  C++ Note: df104 0.00237361 -15.8641  
  C++ Note: Checking Deviance 727.418
  C++ Note: df105 -0.0207602 1  
  C++ Note: df106 -0.649276 -5.11826e+08  
  C++ Note: df100 168435 5 3 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: Changing back to best
  C++ Note: values checked 0.00231257 -15.8642  
  C++ Note: sums checked 7182.75 2624  
  C++ Note: derivs checked 361213 0.000486761  
  C++ Note: second derivs checked 2.06134e+07 0.000486761  
  C++ Note: dose checked 6400 6400 6400  
  C++ Note: non-dose checked 6400 7182.75 2624  
  C++ Note: LIN_non-dose checked 6400 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400 6400  
  C++ Note: LOGLIN_non-dose checked 6400 7182.75 2624  
  C++ Note: risk checked 69.0234  
  C++ Note: risk1 checked 1835.57 3.56138e-06  
  C++ Note: risk2 checked 104751 3.56138e-06  
  C++ Note: df101 -449.751 -449.751  
  C++ Note: df102 694.655 8.84062e-07  
  C++ Note: df103 -32968.8 8.84061e-07  
  C++ Note: df104 0.00231257 -15.8642  
  C++ Note: Checking Deviance 727.502
  C++ Note: df105 -0.0210701 1  
  C++ Note: df106 -0.647445 -5.08733e+08  
  C++ Note: df100 170907 0 0 0,Update_Calc
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: df101 -449.7512 -449.7512  
  C++ Note: df102 694.6552 8.84062e-07  
  C++ Note: df103 -32968.84 8.840614e-07  
  C++ Note: df104 0.002312575 -15.86416  
  C++ Note: Checking Deviance 727.5024
  C++ Note: df105 -0.02107006 1.000001  
  C++ Note: df106 -0.6474452 -5.087327e+08  
  C++ Note: Starting Halves
  C++ Note: df501 -445.76
  C++ Note: df504 0.01192011 -15.75799  
  C++ Note: values checked 0.00234309 -15.8641  
  C++ Note: sums checked 7193.79 2624  
  C++ Note: derivs checked 361842 0.000486776  
  C++ Note: second derivs checked 2.06525e+07 0.000486776  
  C++ Note: dose checked 6400 6400 6400  
  C++ Note: non-dose checked 6400 7193.79 2624  
  C++ Note: LIN_non-dose checked 6400 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400 6400  
  C++ Note: LOGLIN_non-dose checked 6400 7193.79 2624  
  C++ Note: risk checked 69.0795  
  C++ Note: risk1 checked 1838.77 3.56438e-06  
  C++ Note: risk2 checked 104950 3.56438e-06  
  C++ Note: df101 -449.73 -449.73  
  C++ Note: df102 693.646 8.81352e-07  
  C++ Note: df103 -33165.9 8.81351e-07  
  C++ Note: df104 0.00234309 -15.8641  
  C++ Note: Checking Deviance 727.46
  C++ Note: df105 -0.0209144 1  
  C++ Note: df106 -0.648357 -5.10273e+08  
  C++ Note: df100 184880 1 4 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: values checked 0.00232783 -15.8641  
  C++ Note: sums checked 7188.27 2624  
  C++ Note: derivs checked 361527 0.000486769  
  C++ Note: second derivs checked 2.0633e+07 0.000486769  
  C++ Note: dose checked 6400 6400 6400  
  C++ Note: non-dose checked 6400 7188.27 2624  
  C++ Note: LIN_non-dose checked 6400 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400 6400  
  C++ Note: LOGLIN_non-dose checked 6400 7188.27 2624  
  C++ Note: risk checked 69.0514  
  C++ Note: risk1 checked 1837.17 3.56288e-06  
  C++ Note: risk2 checked 104850 3.56288e-06  
  C++ Note: df101 -449.741 -449.741  
  C++ Note: df102 694.151 8.82707e-07  
  C++ Note: df103 -33067.3 8.82707e-07  
  C++ Note: df104 0.00232783 -15.8641  
  C++ Note: Checking Deviance 727.481
  C++ Note: df105 -0.0209921 1  
  C++ Note: df106 -0.6479 -5.09501e+08  
  C++ Note: df100 199583 2 4 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: values checked 0.0023202 -15.8641  
  C++ Note: sums checked 7185.51 2624  
  C++ Note: derivs checked 361370 0.000486765  
  C++ Note: second derivs checked 2.06232e+07 0.000486765  
  C++ Note: dose checked 6400 6400 6400  
  C++ Note: non-dose checked 6400 7185.51 2624  
  C++ Note: LIN_non-dose checked 6400 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400 6400  
  C++ Note: LOGLIN_non-dose checked 6400 7185.51 2624  
  C++ Note: risk checked 69.0374  
  C++ Note: risk1 checked 1836.37 3.56213e-06  
  C++ Note: risk2 checked 104801 3.56213e-06  
  C++ Note: df101 -449.746 -449.746  
  C++ Note: df102 694.403 8.83385e-07  
  C++ Note: df103 -33018.1 8.83384e-07  
  C++ Note: df104 0.0023202 -15.8641  
  C++ Note: Checking Deviance 727.492
  C++ Note: df105 -0.021031 1  
  C++ Note: df106 -0.647672 -5.09117e+08  
  C++ Note: df100 202461 3 4 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: values checked 0.00231639 -15.8642  
  C++ Note: sums checked 7184.13 2624  
  C++ Note: derivs checked 361291 0.000486763  
  C++ Note: second derivs checked 2.06183e+07 0.000486763  
  C++ Note: dose checked 6400 6400 6400  
  C++ Note: non-dose checked 6400 7184.13 2624  
  C++ Note: LIN_non-dose checked 6400 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400 6400  
  C++ Note: LOGLIN_non-dose checked 6400 7184.13 2624  
  C++ Note: risk checked 69.0304  
  C++ Note: risk1 checked 1835.97 3.56175e-06  
  C++ Note: risk2 checked 104776 3.56175e-06  
  C++ Note: df101 -449.749 -449.749  
  C++ Note: df102 694.529 8.83723e-07  
  C++ Note: df103 -32993.4 8.83723e-07  
  C++ Note: df104 0.00231639 -15.8642  
  C++ Note: Checking Deviance 727.497
  C++ Note: df105 -0.0210505 1  
  C++ Note: df106 -0.647559 -5.08925e+08  
  C++ Note: df100 205080 4 4 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: values checked 0.00231448 -15.8642  
  C++ Note: sums checked 7183.44 2624  
  C++ Note: derivs checked 361252 0.000486762  
  C++ Note: second derivs checked 2.06159e+07 0.000486762  
  C++ Note: dose checked 6400 6400 6400  
  C++ Note: non-dose checked 6400 7183.44 2624  
  C++ Note: LIN_non-dose checked 6400 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400 6400  
  C++ Note: LOGLIN_non-dose checked 6400 7183.44 2624  
  C++ Note: risk checked 69.0269  
  C++ Note: risk1 checked 1835.77 3.56156e-06  
  C++ Note: risk2 checked 104763 3.56156e-06  
  C++ Note: df101 -449.75 -449.75  
  C++ Note: df102 694.592 8.83893e-07  
  C++ Note: df103 -32981.1 8.83892e-07  
  C++ Note: df104 0.00231448 -15.8642  
  C++ Note: Checking Deviance 727.5
  C++ Note: df105 -0.0210603 1  
  C++ Note: df106 -0.647502 -5.08829e+08  
  C++ Note: df100 207966 5 4 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: Changing back to best
  C++ Note: values checked 0.00231257 -15.8642  
  C++ Note: sums checked 7182.75 2624  
  C++ Note: derivs checked 361213 0.000486761  
  C++ Note: second derivs checked 2.06134e+07 0.000486761  
  C++ Note: dose checked 6400 6400 6400  
  C++ Note: non-dose checked 6400 7182.75 2624  
  C++ Note: LIN_non-dose checked 6400 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400 6400  
  C++ Note: LOGLIN_non-dose checked 6400 7182.75 2624  
  C++ Note: risk checked 69.0234  
  C++ Note: risk1 checked 1835.57 3.56138e-06  
  C++ Note: risk2 checked 104751 3.56138e-06  
  C++ Note: df101 -449.751 -449.751  
  C++ Note: df102 694.655 8.84062e-07  
  C++ Note: df103 -32968.8 8.84061e-07  
  C++ Note: df104 0.00231257 -15.8642  
  C++ Note: Checking Deviance 727.502
  C++ Note: df105 -0.0210701 1  
  C++ Note: df106 -0.647445 -5.08733e+08  
  C++ Note: df100 210540 0 0 0,Update_Calc
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: df101 -449.7512 -449.7512  
  C++ Note: df102 694.6552 8.84062e-07  
  C++ Note: df103 -32968.84 8.840614e-07  
  C++ Note: df104 0.002312575 -15.86416  
  C++ Note: Checking Deviance 727.5024
  C++ Note: df105 -0.02107006 1.000001  
  C++ Note: df106 -0.6474452 -5.087327e+08  
  C++ Note: Starting Halves
  C++ Note: df501 -445.76
  C++ Note: df504 0.01192011 -15.75799  
  C++ Note: values checked 0.00231353 -15.8642  
  C++ Note: sums checked 7183.1 2624  
  C++ Note: derivs checked 361232 0.000486762  
  C++ Note: second derivs checked 2.06146e+07 0.000486762  
  C++ Note: dose checked 6400 6400 6400  
  C++ Note: non-dose checked 6400 7183.1 2624  
  C++ Note: LIN_non-dose checked 6400 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400 6400  
  C++ Note: LOGLIN_non-dose checked 6400 7183.1 2624  
  C++ Note: risk checked 69.0251  
  C++ Note: risk1 checked 1835.67 3.56147e-06  
  C++ Note: risk2 checked 104757 3.56147e-06  
  C++ Note: df101 -449.751 -449.751  
  C++ Note: df102 694.624 8.83977e-07  
  C++ Note: df103 -32975 8.83977e-07  
  C++ Note: df104 0.00231353 -15.8642  
  C++ Note: Checking Deviance 727.501
  C++ Note: df105 -0.0210652 1  
  C++ Note: df106 -0.647474 -5.08781e+08  
  C++ Note: df100 221858 1 5 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: values checked 0.00231305 -15.8642  
  C++ Note: sums checked 7182.93 2624  
  C++ Note: derivs checked 361222 0.000486762  
  C++ Note: second derivs checked 2.0614e+07 0.000486762  
  C++ Note: dose checked 6400 6400 6400  
  C++ Note: non-dose checked 6400 7182.93 2624  
  C++ Note: LIN_non-dose checked 6400 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400 6400  
  C++ Note: LOGLIN_non-dose checked 6400 7182.93 2624  
  C++ Note: risk checked 69.0243  
  C++ Note: risk1 checked 1835.62 3.56142e-06  
  C++ Note: risk2 checked 104754 3.56142e-06  
  C++ Note: df101 -449.751 -449.751  
  C++ Note: df102 694.639 8.8402e-07  
  C++ Note: df103 -32971.9 8.84019e-07  
  C++ Note: df104 0.00231305 -15.8642  
  C++ Note: Checking Deviance 727.502
  C++ Note: df105 -0.0210676 1  
  C++ Note: df106 -0.647459 -5.08757e+08  
  C++ Note: df100 224529 2 5 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: values checked 0.00231281 -15.8642  
  C++ Note: sums checked 7182.84 2624  
  C++ Note: derivs checked 361218 0.000486761  
  C++ Note: second derivs checked 2.06137e+07 0.000486761  
  C++ Note: dose checked 6400 6400 6400  
  C++ Note: non-dose checked 6400 7182.84 2624  
  C++ Note: LIN_non-dose checked 6400 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400 6400  
  C++ Note: LOGLIN_non-dose checked 6400 7182.84 2624  
  C++ Note: risk checked 69.0238  
  C++ Note: risk1 checked 1835.6 3.5614e-06  
  C++ Note: risk2 checked 104753 3.5614e-06  
  C++ Note: df101 -449.751 -449.751  
  C++ Note: df102 694.647 8.84041e-07  
  C++ Note: df103 -32970.4 8.8404e-07  
  C++ Note: df104 0.00231281 -15.8642  
  C++ Note: Checking Deviance 727.502
  C++ Note: df105 -0.0210688 1  
  C++ Note: df106 -0.647452 -5.08745e+08  
  C++ Note: df100 227123 3 5 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: values checked 0.00231269 -15.8642  
  C++ Note: sums checked 7182.8 2624  
  C++ Note: derivs checked 361215 0.000486761  
  C++ Note: second derivs checked 2.06136e+07 0.000486761  
  C++ Note: dose checked 6400 6400 6400  
  C++ Note: non-dose checked 6400 7182.8 2624  
  C++ Note: LIN_non-dose checked 6400 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400 6400  
  C++ Note: LOGLIN_non-dose checked 6400 7182.8 2624  
  C++ Note: risk checked 69.0236  
  C++ Note: risk1 checked 1835.58 3.56139e-06  
  C++ Note: risk2 checked 104752 3.56139e-06  
  C++ Note: df101 -449.751 -449.751  
  C++ Note: df102 694.651 8.84051e-07  
  C++ Note: df103 -32969.6 8.84051e-07  
  C++ Note: df104 0.00231269 -15.8642  
  C++ Note: Checking Deviance 727.502
  C++ Note: df105 -0.0210694 1  
  C++ Note: df106 -0.647449 -5.08739e+08  
  C++ Note: df100 241708 4 5 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: values checked 0.00231263 -15.8642  
  C++ Note: sums checked 7182.77 2624  
  C++ Note: derivs checked 361214 0.000486761  
  C++ Note: second derivs checked 2.06135e+07 0.000486761  
  C++ Note: dose checked 6400 6400 6400  
  C++ Note: non-dose checked 6400 7182.77 2624  
  C++ Note: LIN_non-dose checked 6400 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400 6400  
  C++ Note: LOGLIN_non-dose checked 6400 7182.77 2624  
  C++ Note: risk checked 69.0235  
  C++ Note: risk1 checked 1835.58 3.56138e-06  
  C++ Note: risk2 checked 104751 3.56138e-06  
  C++ Note: df101 -449.751 -449.751  
  C++ Note: df102 694.653 8.84057e-07  
  C++ Note: df103 -32969.2 8.84056e-07  
  C++ Note: df104 0.00231263 -15.8642  
  C++ Note: Checking Deviance 727.502
  C++ Note: df105 -0.0210698 1  
  C++ Note: df106 -0.647447 -5.08736e+08  
  C++ Note: df100 244280 5 5 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: Changing back to best
  C++ Note: values checked 0.00231257 -15.8642  
  C++ Note: sums checked 7182.75 2624  
  C++ Note: derivs checked 361213 0.000486761  
  C++ Note: second derivs checked 2.06134e+07 0.000486761  
  C++ Note: dose checked 6400 6400 6400  
  C++ Note: non-dose checked 6400 7182.75 2624  
  C++ Note: LIN_non-dose checked 6400 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400 6400  
  C++ Note: LOGLIN_non-dose checked 6400 7182.75 2624  
  C++ Note: risk checked 69.0234  
  C++ Note: risk1 checked 1835.57 3.56138e-06  
  C++ Note: risk2 checked 104751 3.56138e-06  
  C++ Note: df101 -449.751 -449.751  
  C++ Note: df102 694.655 8.84062e-07  
  C++ Note: df103 -32968.8 8.84061e-07  
  C++ Note: df104 0.00231257 -15.8642  
  C++ Note: Checking Deviance 727.502
  C++ Note: df105 -0.0210701 1  
  C++ Note: df106 -0.647445 -5.08733e+08  
  C++ Note: df100 246873 0 0 0,Update_Calc
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: df101 -449.7512 -449.7512  
  C++ Note: df102 694.6552 8.84062e-07  
  C++ Note: df103 -32968.84 8.840614e-07  
  C++ Note: df104 0.002312575 -15.86416  
  C++ Note: Checking Deviance 727.5024
  C++ Note: df105 -0.02107006 1.000001  
  C++ Note: df106 -0.6474452 -5.087327e+08  
  C++ Note: df101 -449.751 -449.751  
  C++ Note: df102 694.655 8.84062e-07  
  C++ Note: df103 -32968.8 8.84061e-07  
  C++ Note: df104 0.00231257 -15.8642  
  C++ Note: Checking Deviance 727.502
  C++ Note: df105 -0.0210701 1  
  C++ Note: df106 -0.647445 -5.08733e+08  
  C++ Note: ending guess 1
  C++ Note: df501 -445.76
  C++ Note: df504 0.01192011 -15.75799  
  C++ Note: Refreshing matrices after all guesses
  C++ Note: Guess Results
  Guess number, parameter values, Log-Likelihood
  0, 0.01192011 -15.75799, -445.76<-- Best Guess
  1, 0.002312575 -15.86416, -449.7512
  C++ Note: starting subterms 3 in best guess 0
  C++ Note: values checked 0.0119201 -15.758  
  C++ Note: sums checked 11828 2624  
  C++ Note: derivs checked 633140 0.000541285  
  C++ Note: second derivs checked 3.78127e+07 0.000541285  
  C++ Note: dose checked 6400 6400 6400  
  C++ Note: non-dose checked 6400 11828 2624  
  C++ Note: LIN_non-dose checked 6400 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400 6400  
  C++ Note: LOGLIN_non-dose checked 6400 11828 2624  
  C++ Note: risk checked 92.6292  
  C++ Note: risk1 checked 3217.42 5.3147e-06  
  C++ Note: risk2 checked 192153 5.3147e-06  
  C++ Note: Made Risk Side Lists
  C++ Note: df101 -445.76 -445.76  
  C++ Note: df102 -8.32807 -2.98518e-07  
  C++ Note: df103 -123695 -2.98519e-07  
  C++ Note: df104 0.0119201 -15.758  
  C++ Note: Checking Deviance 719.52
  C++ Note: df105 6.73276e-05 0.999998  
  C++ Note: df106 53.525 1.49324e+09  
  C++ Note: Starting Halves
  C++ Note: df501 -445.76
  C++ Note: df504 0.01192011 -15.75799  
  C++ Note: values checked 0.0118696 -16.4784  
  C++ Note: sums checked 11796.1 2624  
  C++ Note: derivs checked 631233 0.000263353  
  C++ Note: second derivs checked 3.76904e+07 0.000263353  
  C++ Note: dose checked 6400 6400 6400  
  C++ Note: non-dose checked 6400 11796.1 2624  
  C++ Note: LIN_non-dose checked 6400 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400 6400  
  C++ Note: LOGLIN_non-dose checked 6400 11796.1 2624  
  C++ Note: risk checked 92.467  
  C++ Note: risk1 checked 3207.73 2.58125e-06  
  C++ Note: risk2 checked 191531 2.58125e-06  
  C++ Note: df101 -445.76 -445.76  
  C++ Note: df102 -2.09852 -1.40954e-07  
  C++ Note: df103 -123043 -1.40954e-07  
  C++ Note: df104 0.0118696 -16.4784  
  C++ Note: Checking Deviance 719.519
  C++ Note: df105 1.70551e-05 0.999999  
  C++ Note: df106 212.417 3.16245e+09  
  C++ Note: df100 260862 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: df100 260951 0 0 0,Update_Calc
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: df101 -445.7597 -445.7597  
  C++ Note: df102 -2.098516 -1.409538e-07  
  C++ Note: df103 -123043.1 -1.409539e-07  
  C++ Note: df104 0.01186962 -16.47844  
  C++ Note: Checking Deviance 719.5194
  C++ Note: df105 1.705513e-05 0.9999989  
  C++ Note: df106 212.4166 3.162453e+09  
  C++ Note: df101 -445.76 -445.76  
  C++ Note: df102 -2.09852 -1.40954e-07  
  C++ Note: df103 -123043 -1.40954e-07  
  C++ Note: df104 0.0118696 -16.4784  
  C++ Note: Checking Deviance 719.519
  C++ Note: df105 1.70551e-05 0.999999  
  C++ Note: df106 212.417 3.16245e+09  
  C++ Note: df501 -445.7597
  C++ Note: df504 0.01186962 -16.47844  
  Error: Atleast one parameter must be free
  Warning: rmin and rmax lists not equal size, defaulting to lin and loglin min/max values
  C++ Note: START_RISK_CHECK
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: Term checked 0 1  
  C++ Note: df99,79,Starting
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: starting subterms 2
  C++ Note: values checked 0.01 -15  
  C++ Note: sums checked 6437.949 3328.001  
  C++ Note: dose checked 6400 6400  
  C++ Note: non-dose checked 6437.949 3328.001  
  C++ Note: LIN_non-dose checked 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400  
  C++ Note: LOGLIN_non-dose checked 6437.949 3328.001  
  C++ Note: df99,977,Prep_Terms
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: START_POIS_GUESS
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: Term checked 0 1  
  C++ Note: df99,72,Starting
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: starting subterms 2 in guess 0
  C++ Note: values checked 0.01 -15  
  C++ Note: sums checked 6437.95 3328  
  C++ Note: derivs checked 3813.95 0.000939732  
  C++ Note: second derivs checked 3813.95 0.000939732  
  C++ Note: dose checked 6400 6400  
  C++ Note: non-dose checked 6437.95 3328  
  C++ Note: LIN_non-dose checked 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400  
  C++ Note: LOGLIN_non-dose checked 6437.95 3328  
  C++ Note: risk checked 9787.82  
  C++ Note: risk1 checked 6011.82 0.000944651  
  C++ Note: risk2 checked 6011.82 0.000944651  
  C++ Note: df101 -493394 -493394  
  C++ Note: df102 -303241 -0.047634  
  C++ Note: df103 -303274 -0.047634  
  C++ Note: df104 0.01 -15  
  C++ Note: Checking Deviance 986616
  C++ Note: df105 0.999891 1  
  C++ Note: df106 1.62707 1.0358e+07  
  C++ Note: Starting Halves
  C++ Note: df501 -493394.2
  C++ Note: df504 0.01 -15  
  C++ Note: values checked -0.739918 -15.3574  
  C++ Note: sums checked 4425.73 3328  
  C++ Note: derivs checked 1801.73 0.000657348  
  C++ Note: second derivs checked 1801.73 0.000657348  
  C++ Note: dose checked 6400 6400  
  C++ Note: non-dose checked 4425.73 3328  
  C++ Note: LIN_non-dose checked 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400  
  C++ Note: LOGLIN_non-dose checked 4425.73 3328  
  C++ Note: risk checked 6616.01  
  C++ Note: risk1 checked 2840.01 0.000478342  
  C++ Note: risk2 checked 2840.01 0.000478342  
  C++ Note: df101 -333413 -333413  
  C++ Note: df102 -143235 -0.0241165  
  C++ Note: df103 -143268 -0.0241165  
  C++ Note: df104 -0.739918 -15.3574  
  C++ Note: Checking Deviance 666655
  C++ Note: df105 0.99977 1  
  C++ Note: df106 2.32774 1.38251e+07  
  C++ Note: df100 5961 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: df100 6036 0 0 0,Update_Calc
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: df101 -333413.3 -333413.3  
  C++ Note: df102 -143235 -0.02411648  
  C++ Note: df103 -143268 -0.02411648  
  C++ Note: df104 -0.7399184 -15.35738  
  C++ Note: Checking Deviance 666654.6
  C++ Note: df105 0.9997697 1  
  C++ Note: df106 2.327736 1.382512e+07  
  C++ Note: Starting Halves
  C++ Note: df501 -333413.3
  C++ Note: df504 -0.7399184 -15.35738  
  C++ Note: values checked -1.48975 -15.8512  
  C++ Note: sums checked 3475.22 3328  
  C++ Note: derivs checked 851.224 0.000401193  
  C++ Note: second derivs checked 851.224 0.000401193  
  C++ Note: dose checked 6400 6400  
  C++ Note: non-dose checked 3475.22 3328  
  C++ Note: LIN_non-dose checked 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400  
  C++ Note: LOGLIN_non-dose checked 3475.22 3328  
  C++ Note: risk checked 5117.76  
  C++ Note: risk1 checked 1341.76 0.000239343  
  C++ Note: risk2 checked 1341.76 0.000239343  
  C++ Note: df101 -257857 -257857  
  C++ Note: df102 -67653.7 -0.0120654  
  C++ Note: df103 -67686.7 -0.0120654  
  C++ Note: df104 -1.48975 -15.8512  
  C++ Note: Checking Deviance 515541
  C++ Note: df105 0.999512 1  
  C++ Note: df106 3.81142 2.13716e+07  
  C++ Note: df100 9074 1 2 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: df100 9163 0 0 0,Update_Calc
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: df101 -257856.7 -257856.7  
  C++ Note: df102 -67653.71 -0.01206537  
  C++ Note: df103 -67686.71 -0.01206537  
  C++ Note: df104 -1.489746 -15.85115  
  C++ Note: Checking Deviance 515541.4
  C++ Note: df105 0.9995125 1  
  C++ Note: df106 3.81142 2.137163e+07  
  C++ Note: Starting Halves
  C++ Note: df501 -257856.7
  C++ Note: df504 -1.489746 -15.85115  
  C++ Note: values checked -2.23938 -16.4535  
  C++ Note: sums checked 3026.24 3328  
  C++ Note: derivs checked 402.237 0.00021966  
  C++ Note: second derivs checked 402.237 0.00021966  
  C++ Note: dose checked 6400 6400  
  C++ Note: non-dose checked 3026.24 3328  
  C++ Note: LIN_non-dose checked 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400  
  C++ Note: LOGLIN_non-dose checked 3026.24 3328  
  C++ Note: risk checked 4410.03  
  C++ Note: risk1 checked 634.034 0.000117441  
  C++ Note: risk2 checked 634.034 0.000117441  
  C++ Note: df101 -222179 -222179  
  C++ Note: df102 -31951.6 -0.00591976  
  C++ Note: df103 -31984.6 -0.00591976  
  C++ Note: df104 -2.23938 -16.4535  
  C++ Note: Checking Deviance 444187
  C++ Note: df105 0.998968 1  
  C++ Note: df106 6.95362 3.75318e+07  
  C++ Note: df100 12214 1 3 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: df100 12452 0 0 0,Update_Calc
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: df101 -222179.4 -222179.4  
  C++ Note: df102 -31951.63 -0.005919756  
  C++ Note: df103 -31984.63 -0.005919756  
  C++ Note: df104 -2.23938 -16.45351  
  C++ Note: Checking Deviance 444186.7
  C++ Note: df105 0.9989683 1  
  C++ Note: df106 6.953616 3.753185e+07  
  C++ Note: Starting Halves
  C++ Note: df501 -222179.4
  C++ Note: df504 -2.23938 -16.45351  
  C++ Note: values checked -2.98861 -17.1257  
  C++ Note: sums checked 2814.15 3328  
  C++ Note: derivs checked 190.15 0.000112156  
  C++ Note: second derivs checked 190.15 0.000112156  
  C++ Note: dose checked 6400 6400  
  C++ Note: non-dose checked 2814.15 3328  
  C++ Note: LIN_non-dose checked 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400  
  C++ Note: LOGLIN_non-dose checked 2814.15 3328  
  C++ Note: risk checked 4075.73  
  C++ Note: risk1 checked 299.728 5.66831e-05  
  C++ Note: risk2 checked 299.728 5.66831e-05  
  C++ Note: df101 -205340 -205340  
  C++ Note: df102 -15087.2 -0.00285705  
  C++ Note: df103 -15120.2 -0.00285705  
  C++ Note: df104 -2.98861 -17.1257  
  C++ Note: Checking Deviance 410507
  C++ Note: df105 0.997817 1  
  C++ Note: df106 13.6102 7.18712e+07  
  C++ Note: df100 14931 1 4 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: df100 15073 0 0 0,Update_Calc
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: df101 -205339.6 -205339.6  
  C++ Note: df102 -15087.16 -0.002857052  
  C++ Note: df103 -15120.16 -0.002857052  
  C++ Note: df104 -2.988606 -17.1257  
  C++ Note: Checking Deviance 410507.3
  C++ Note: df105 0.9978175 1  
  C++ Note: df106 13.61022 7.187117e+07  
  C++ Note: Starting Halves
  C++ Note: df501 -205339.6
  C++ Note: df504 -2.988606 -17.1257  
  C++ Note: values checked -3.73697 -17.8368  
  C++ Note: sums checked 2713.97 3328  
  C++ Note: derivs checked 89.9678 5.50787e-05  
  C++ Note: second derivs checked 89.9678 5.50787e-05  
  C++ Note: dose checked 6400 6400  
  C++ Note: non-dose checked 2713.97 3328  
  C++ Note: LIN_non-dose checked 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400  
  C++ Note: LOGLIN_non-dose checked 2713.97 3328  
  C++ Note: risk checked 3917.81  
  C++ Note: risk1 checked 141.814 2.70754e-05  
  C++ Note: risk2 checked 141.814 2.70754e-05  
  C++ Note: df101 -197398 -197398  
  C++ Note: df102 -7120.96 -0.00136467  
  C++ Note: df103 -7153.96 -0.00136467  
  C++ Note: df104 -3.73697 -17.8368  
  C++ Note: Checking Deviance 394624
  C++ Note: df105 0.995387 1  
  C++ Note: df106 27.7207 1.44649e+08  
  C++ Note: df100 18002 1 5 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: df100 18130 0 0 0,Update_Calc
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: df101 -197398.1 -197398.1  
  C++ Note: df102 -7120.961 -0.001364671  
  C++ Note: df103 -7153.961 -0.001364671  
  C++ Note: df104 -3.736969 -17.83683  
  C++ Note: Checking Deviance 394624.2
  C++ Note: df105 0.9953872 1  
  C++ Note: df106 27.72071 1.446488e+08  
  C++ Note: df101 -197398 -197398  
  C++ Note: df102 -7120.96 -0.00136467  
  C++ Note: df103 -7153.96 -0.00136467  
  C++ Note: df104 -3.73697 -17.8368  
  C++ Note: Checking Deviance 394624
  C++ Note: df105 0.995387 1  
  C++ Note: df106 27.7207 1.44649e+08  
  C++ Note: ending guess 0
  C++ Note: df501 -197398.1
  C++ Note: df504 -3.736969 -17.83683  
  C++ Note: Refreshing matrices after all guesses
  C++ Note: Guess Results
  Guess number, parameter values, Log-Likelihood
  0, -3.736969 -17.83683, -197398.1<-- Best Guess
  C++ Note: starting subterms 2 in best guess 0
  C++ Note: values checked -3.73697 -17.8368  
  C++ Note: sums checked 2713.97 3328  
  C++ Note: derivs checked 89.9678 5.50787e-05  
  C++ Note: second derivs checked 89.9678 5.50787e-05  
  C++ Note: dose checked 6400 6400  
  C++ Note: non-dose checked 2713.97 3328  
  C++ Note: LIN_non-dose checked 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400  
  C++ Note: LOGLIN_non-dose checked 2713.97 3328  
  C++ Note: risk checked 3917.81  
  C++ Note: risk1 checked 141.814 2.70754e-05  
  C++ Note: risk2 checked 141.814 2.70754e-05  
  C++ Note: Made Risk Side Lists
  C++ Note: df101 -197398 -197398  
  C++ Note: df102 -7120.96 -0.00136467  
  C++ Note: df103 -7153.96 -0.00136467  
  C++ Note: df104 -3.73697 -17.8368  
  C++ Note: Checking Deviance 394624
  C++ Note: df105 0.995387 1  
  C++ Note: df106 27.7207 1.44649e+08  
  C++ Note: Starting Halves
  C++ Note: df501 -197398.1
  C++ Note: df504 -3.736969 -17.83683  
  C++ Note: values checked -4.48351 -18.568  
  C++ Note: sums checked 2666.65 3328  
  C++ Note: derivs checked 42.645 2.65127e-05  
  C++ Note: second derivs checked 42.645 2.65127e-05  
  C++ Note: dose checked 6400 6400  
  C++ Note: non-dose checked 2666.65 3328  
  C++ Note: LIN_non-dose checked 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400  
  C++ Note: LOGLIN_non-dose checked 2666.65 3328  
  C++ Note: risk checked 3843.22  
  C++ Note: risk1 checked 67.2201 1.286e-05  
  C++ Note: risk2 checked 67.2201 1.286e-05  
  C++ Note: df101 -193660 -193660  
  C++ Note: df102 -3358 -0.000648169  
  C++ Note: df103 -3391 -0.000648169  
  C++ Note: df104 -4.48351 -18.568  
  C++ Note: Checking Deviance 387148
  C++ Note: df105 0.990268 1  
  C++ Note: df106 57.6711 2.9878e+08  
  C++ Note: df100 24629 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: df100 24706 0 0 0,Update_Calc
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: df101 -193659.8 -193659.8  
  C++ Note: df102 -3358.003 -0.0006481694  
  C++ Note: df103 -3391.003 -0.0006481694  
  C++ Note: df104 -4.48351 -18.56797  
  C++ Note: Checking Deviance 387147.6
  C++ Note: df105 0.9902684 1  
  C++ Note: df106 57.67112 2.987796e+08  
  C++ Note: df101 -193660 -193660  
  C++ Note: df102 -3358 -0.000648169  
  C++ Note: df103 -3391 -0.000648169  
  C++ Note: df104 -4.48351 -18.568  
  C++ Note: Checking Deviance 387148
  C++ Note: df105 0.990268 1  
  C++ Note: df106 57.6711 2.9878e+08  
  C++ Note: df501 -193659.8
  C++ Note: df504 -4.48351 -18.56797  
  Error: guesses_control and model_control have different strata options
  Warning: rmin and rmax lists not equal size, defaulting to lin and loglin min/max values
  C++ Note: START_RISK_CHECK
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: Term checked 0 1  
  C++ Note: df99,64,Starting
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: starting subterms 2
  C++ Note: values checked 0.01 -15  
  C++ Note: sums checked 6437.949 3328.001  
  C++ Note: dose checked 6400 6400  
  C++ Note: non-dose checked 6437.949 3328.001  
  C++ Note: LIN_non-dose checked 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400  
  C++ Note: LOGLIN_non-dose checked 6437.949 3328.001  
  C++ Note: df99,1074,Prep_Terms
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: START_POIS_GUESS
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: Term checked 0 1  
  C++ Note: df99,68,Starting
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: starting subterms 2 in guess 0
  C++ Note: values checked 0.01 -15  
  C++ Note: sums checked 6437.95 3328  
  C++ Note: derivs checked 3813.95 0.000939732  
  C++ Note: second derivs checked 3813.95 0.000939732  
  C++ Note: dose checked 6400 6400  
  C++ Note: non-dose checked 6437.95 3328  
  C++ Note: LIN_non-dose checked 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400  
  C++ Note: LOGLIN_non-dose checked 6437.95 3328  
  C++ Note: risk checked 9787.82  
  C++ Note: risk1 checked 6011.82 0.000944651  
  C++ Note: risk2 checked 6011.82 0.000944651  
  C++ Note: df101 -493394 -493394  
  C++ Note: df102 -303241 -0.047634  
  C++ Note: df103 -303274 -0.047634  
  C++ Note: df104 0.01 -15  
  C++ Note: Checking Deviance 986616
  C++ Note: df105 0.999891 1  
  C++ Note: df106 1.62707 1.0358e+07  
  C++ Note: Starting Halves
  C++ Note: df501 -493394.2
  C++ Note: df504 0.01 -15  
  C++ Note: values checked -0.739918 -15.3574  
  C++ Note: sums checked 4425.73 3328  
  C++ Note: derivs checked 1801.73 0.000657348  
  C++ Note: second derivs checked 1801.73 0.000657348  
  C++ Note: dose checked 6400 6400  
  C++ Note: non-dose checked 4425.73 3328  
  C++ Note: LIN_non-dose checked 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400  
  C++ Note: LOGLIN_non-dose checked 4425.73 3328  
  C++ Note: risk checked 6616.01  
  C++ Note: risk1 checked 2840.01 0.000478342  
  C++ Note: risk2 checked 2840.01 0.000478342  
  C++ Note: df101 -333413 -333413  
  C++ Note: df102 -143235 -0.0241165  
  C++ Note: df103 -143268 -0.0241165  
  C++ Note: df104 -0.739918 -15.3574  
  C++ Note: Checking Deviance 666655
  C++ Note: df105 0.99977 1  
  C++ Note: df106 2.32774 1.38251e+07  
  C++ Note: df100 12952 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: df100 13046 0 0 0,Update_Calc
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: df101 -333413.3 -333413.3  
  C++ Note: df102 -143235 -0.02411648  
  C++ Note: df103 -143268 -0.02411648  
  C++ Note: df104 -0.7399184 -15.35738  
  C++ Note: Checking Deviance 666654.6
  C++ Note: df105 0.9997697 1  
  C++ Note: df106 2.327736 1.382512e+07  
  C++ Note: Starting Halves
  C++ Note: df501 -333413.3
  C++ Note: df504 -0.7399184 -15.35738  
  C++ Note: values checked -1.48975 -15.8512  
  C++ Note: sums checked 3475.22 3328  
  C++ Note: derivs checked 851.224 0.000401193  
  C++ Note: second derivs checked 851.224 0.000401193  
  C++ Note: dose checked 6400 6400  
  C++ Note: non-dose checked 3475.22 3328  
  C++ Note: LIN_non-dose checked 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400  
  C++ Note: LOGLIN_non-dose checked 3475.22 3328  
  C++ Note: risk checked 5117.76  
  C++ Note: risk1 checked 1341.76 0.000239343  
  C++ Note: risk2 checked 1341.76 0.000239343  
  C++ Note: df101 -257857 -257857  
  C++ Note: df102 -67653.7 -0.0120654  
  C++ Note: df103 -67686.7 -0.0120654  
  C++ Note: df104 -1.48975 -15.8512  
  C++ Note: Checking Deviance 515541
  C++ Note: df105 0.999512 1  
  C++ Note: df106 3.81142 2.13716e+07  
  C++ Note: df100 15648 1 2 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: df100 15735 0 0 0,Update_Calc
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: df101 -257856.7 -257856.7  
  C++ Note: df102 -67653.71 -0.01206537  
  C++ Note: df103 -67686.71 -0.01206537  
  C++ Note: df104 -1.489746 -15.85115  
  C++ Note: Checking Deviance 515541.4
  C++ Note: df105 0.9995125 1  
  C++ Note: df106 3.81142 2.137163e+07  
  C++ Note: Starting Halves
  C++ Note: df501 -257856.7
  C++ Note: df504 -1.489746 -15.85115  
  C++ Note: values checked -2.23938 -16.4535  
  C++ Note: sums checked 3026.24 3328  
  C++ Note: derivs checked 402.237 0.00021966  
  C++ Note: second derivs checked 402.237 0.00021966  
  C++ Note: dose checked 6400 6400  
  C++ Note: non-dose checked 3026.24 3328  
  C++ Note: LIN_non-dose checked 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400  
  C++ Note: LOGLIN_non-dose checked 3026.24 3328  
  C++ Note: risk checked 4410.03  
  C++ Note: risk1 checked 634.034 0.000117441  
  C++ Note: risk2 checked 634.034 0.000117441  
  C++ Note: df101 -222179 -222179  
  C++ Note: df102 -31951.6 -0.00591976  
  C++ Note: df103 -31984.6 -0.00591976  
  C++ Note: df104 -2.23938 -16.4535  
  C++ Note: Checking Deviance 444187
  C++ Note: df105 0.998968 1  
  C++ Note: df106 6.95362 3.75318e+07  
  C++ Note: df100 18118 1 3 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: df100 18204 0 0 0,Update_Calc
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: df101 -222179.4 -222179.4  
  C++ Note: df102 -31951.63 -0.005919756  
  C++ Note: df103 -31984.63 -0.005919756  
  C++ Note: df104 -2.23938 -16.45351  
  C++ Note: Checking Deviance 444186.7
  C++ Note: df105 0.9989683 1  
  C++ Note: df106 6.953616 3.753185e+07  
  C++ Note: Starting Halves
  C++ Note: df501 -222179.4
  C++ Note: df504 -2.23938 -16.45351  
  C++ Note: values checked -2.98861 -17.1257  
  C++ Note: sums checked 2814.15 3328  
  C++ Note: derivs checked 190.15 0.000112156  
  C++ Note: second derivs checked 190.15 0.000112156  
  C++ Note: dose checked 6400 6400  
  C++ Note: non-dose checked 2814.15 3328  
  C++ Note: LIN_non-dose checked 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400  
  C++ Note: LOGLIN_non-dose checked 2814.15 3328  
  C++ Note: risk checked 4075.73  
  C++ Note: risk1 checked 299.728 5.66831e-05  
  C++ Note: risk2 checked 299.728 5.66831e-05  
  C++ Note: df101 -205340 -205340  
  C++ Note: df102 -15087.2 -0.00285705  
  C++ Note: df103 -15120.2 -0.00285705  
  C++ Note: df104 -2.98861 -17.1257  
  C++ Note: Checking Deviance 410507
  C++ Note: df105 0.997817 1  
  C++ Note: df106 13.6102 7.18712e+07  
  C++ Note: df100 33008 1 4 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: df100 33102 0 0 0,Update_Calc
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: df101 -205339.6 -205339.6  
  C++ Note: df102 -15087.16 -0.002857052  
  C++ Note: df103 -15120.16 -0.002857052  
  C++ Note: df104 -2.988606 -17.1257  
  C++ Note: Checking Deviance 410507.3
  C++ Note: df105 0.9978175 1  
  C++ Note: df106 13.61022 7.187117e+07  
  C++ Note: Starting Halves
  C++ Note: df501 -205339.6
  C++ Note: df504 -2.988606 -17.1257  
  C++ Note: values checked -3.73697 -17.8368  
  C++ Note: sums checked 2713.97 3328  
  C++ Note: derivs checked 89.9678 5.50787e-05  
  C++ Note: second derivs checked 89.9678 5.50787e-05  
  C++ Note: dose checked 6400 6400  
  C++ Note: non-dose checked 2713.97 3328  
  C++ Note: LIN_non-dose checked 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400  
  C++ Note: LOGLIN_non-dose checked 2713.97 3328  
  C++ Note: risk checked 3917.81  
  C++ Note: risk1 checked 141.814 2.70754e-05  
  C++ Note: risk2 checked 141.814 2.70754e-05  
  C++ Note: df101 -197398 -197398  
  C++ Note: df102 -7120.96 -0.00136467  
  C++ Note: df103 -7153.96 -0.00136467  
  C++ Note: df104 -3.73697 -17.8368  
  C++ Note: Checking Deviance 394624
  C++ Note: df105 0.995387 1  
  C++ Note: df106 27.7207 1.44649e+08  
  C++ Note: df100 35658 1 5 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: df100 35742 0 0 0,Update_Calc
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: df101 -197398.1 -197398.1  
  C++ Note: df102 -7120.961 -0.001364671  
  C++ Note: df103 -7153.961 -0.001364671  
  C++ Note: df104 -3.736969 -17.83683  
  C++ Note: Checking Deviance 394624.2
  C++ Note: df105 0.9953872 1  
  C++ Note: df106 27.72071 1.446488e+08  
  C++ Note: df101 -197398 -197398  
  C++ Note: df102 -7120.96 -0.00136467  
  C++ Note: df103 -7153.96 -0.00136467  
  C++ Note: df104 -3.73697 -17.8368  
  C++ Note: Checking Deviance 394624
  C++ Note: df105 0.995387 1  
  C++ Note: df106 27.7207 1.44649e+08  
  C++ Note: ending guess 0
  C++ Note: df501 -197398.1
  C++ Note: df504 -3.736969 -17.83683  
  C++ Note: Refreshing matrices after all guesses
  C++ Note: Guess Results
  Guess number, parameter values, Log-Likelihood
  0, -3.736969 -17.83683, -197398.1<-- Best Guess
  C++ Note: starting subterms 2 in best guess 0
  C++ Note: values checked -3.73697 -17.8368  
  C++ Note: sums checked 2713.97 3328  
  C++ Note: derivs checked 89.9678 5.50787e-05  
  C++ Note: second derivs checked 89.9678 5.50787e-05  
  C++ Note: dose checked 6400 6400  
  C++ Note: non-dose checked 2713.97 3328  
  C++ Note: LIN_non-dose checked 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400  
  C++ Note: LOGLIN_non-dose checked 2713.97 3328  
  C++ Note: risk checked 3917.81  
  C++ Note: risk1 checked 141.814 2.70754e-05  
  C++ Note: risk2 checked 141.814 2.70754e-05  
  C++ Note: Made Risk Side Lists
  C++ Note: df101 -197398 -197398  
  C++ Note: df102 -7120.96 -0.00136467  
  C++ Note: df103 -7153.96 -0.00136467  
  C++ Note: df104 -3.73697 -17.8368  
  C++ Note: Checking Deviance 394624
  C++ Note: df105 0.995387 1  
  C++ Note: df106 27.7207 1.44649e+08  
  C++ Note: Starting Halves
  C++ Note: df501 -197398.1
  C++ Note: df504 -3.736969 -17.83683  
  C++ Note: values checked -4.48351 -18.568  
  C++ Note: sums checked 2666.65 3328  
  C++ Note: derivs checked 42.645 2.65127e-05  
  C++ Note: second derivs checked 42.645 2.65127e-05  
  C++ Note: dose checked 6400 6400  
  C++ Note: non-dose checked 2666.65 3328  
  C++ Note: LIN_non-dose checked 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400  
  C++ Note: LOGLIN_non-dose checked 2666.65 3328  
  C++ Note: risk checked 3843.22  
  C++ Note: risk1 checked 67.2201 1.286e-05  
  C++ Note: risk2 checked 67.2201 1.286e-05  
  C++ Note: df101 -193660 -193660  
  C++ Note: df102 -3358 -0.000648169  
  C++ Note: df103 -3391 -0.000648169  
  C++ Note: df104 -4.48351 -18.568  
  C++ Note: Checking Deviance 387148
  C++ Note: df105 0.990268 1  
  C++ Note: df106 57.6711 2.9878e+08  
  C++ Note: df100 41252 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: df100 41342 0 0 0,Update_Calc
  C++ Note: Current Time, Fri Feb 23 05:58:49 2024
  
  C++ Note: df101 -193659.8 -193659.8  
  C++ Note: df102 -3358.003 -0.0006481694  
  C++ Note: df103 -3391.003 -0.0006481694  
  C++ Note: df104 -4.48351 -18.56797  
  C++ Note: Checking Deviance 387147.6
  C++ Note: df105 0.9902684 1  
  C++ Note: df106 57.67112 2.987796e+08  
  C++ Note: df101 -193660 -193660  
  C++ Note: df102 -3358 -0.000648169  
  C++ Note: df103 -3391 -0.000648169  
  C++ Note: df104 -4.48351 -18.568  
  C++ Note: Checking Deviance 387148
  C++ Note: df105 0.990268 1  
  C++ Note: df106 57.6711 2.9878e+08  
  C++ Note: df501 -193659.8
  C++ Note: df504 -4.48351 -18.56797  
  Error: Atleast one parameter must be free
  Warning: rmin and rmax lists not equal size, defaulting to lin and loglin min/max values
  C++ Note: START_RISK_CHECK
  C++ Note: Current Time, Fri Feb 23 05:58:50 2024
  
  C++ Note: Term checked 0 1  
  C++ Note: df99,70,Starting
  C++ Note: Current Time, Fri Feb 23 05:58:50 2024
  
  C++ Note: starting subterms 2
  C++ Note: values checked 0.01 -15  
  C++ Note: sums checked 6437.949 0.001957775  
  C++ Note: dose checked 6400 6400  
  C++ Note: non-dose checked 6437.949 0.001957775  
  C++ Note: LIN_non-dose checked 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400  
  C++ Note: LOGLIN_non-dose checked 6437.949 0.001957775  
  C++ Note: df99,16403,Prep_Terms
  C++ Note: Current Time, Fri Feb 23 05:58:50 2024
  
  C++ Note: START_POIS_GUESS
  C++ Note: Current Time, Fri Feb 23 05:58:50 2024
  
  C++ Note: Term checked 0 1  
  C++ Note: df99,102,Starting
  C++ Note: Current Time, Fri Feb 23 05:58:50 2024
  
  C++ Note: starting subterms 2 in guess 0
  C++ Note: values checked 0.01 -15  
  C++ Note: sums checked 6437.95 0.00195777  
  C++ Note: derivs checked 3813.95 0.00195777  
  C++ Note: second derivs checked 3813.95 0.00195777  
  C++ Note: dose checked 6400 6400  
  C++ Note: non-dose checked 6437.95 0.00195777  
  C++ Note: LIN_non-dose checked 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400  
  C++ Note: LOGLIN_non-dose checked 6437.95 0.00195777  
  C++ Note: risk checked 6437.95  
  C++ Note: risk1 checked 3813.95 0.00196938  
  C++ Note: risk2 checked 3813.95 0.00196938  
  C++ Note: df101 -324424 -324424  
  C++ Note: df102 -192366 -0.0993192  
  C++ Note: df103 -192399 -0.0993192  
  C++ Note: df104 0.01 -15  
  C++ Note: Checking Deviance 648676
  C++ Note: df105 0.999828 1  
  C++ Note: df106 1.68649 3.26648e+06  
  C++ Note: Starting Halves
  C++ Note: df501 -324424.1
  C++ Note: df504 0.01 -15  
  C++ Note: values checked -0.739871 -15.3056  
  C++ Note: sums checked 4425.81 0.00144221  
  C++ Note: derivs checked 1801.81 0.00144221  
  C++ Note: second derivs checked 1801.81 0.00144221  
  C++ Note: dose checked 6400 6400  
  C++ Note: non-dose checked 4425.81 0.00144221  
  C++ Note: LIN_non-dose checked 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400  
  C++ Note: LOGLIN_non-dose checked 4425.81 0.00144221  
  C++ Note: risk checked 4425.82  
  C++ Note: risk1 checked 1801.81 0.000997333  
  C++ Note: risk2 checked 1801.81 0.000997333  
  C++ Note: df101 -222944 -222944  
  C++ Note: df102 -90861.8 -0.0502905  
  C++ Note: df103 -90894.8 -0.0502905  
  C++ Note: df104 -0.739871 -15.3056  
  C++ Note: Checking Deviance 445716
  C++ Note: df105 0.999637 1  
  C++ Note: df106 2.45366 4.43313e+06  
  C++ Note: df100 13128 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:50 2024
  
  C++ Note: df100 20817 0 0 0,Update_Calc
  C++ Note: Current Time, Fri Feb 23 05:58:50 2024
  
  C++ Note: df101 -222944.2 -222944.2  
  C++ Note: df102 -90861.77 -0.05029052  
  C++ Note: df103 -90894.77 -0.05029052  
  C++ Note: df104 -0.7398713 -15.30563  
  C++ Note: Checking Deviance 445716.4
  C++ Note: df105 0.9996369 1  
  C++ Note: df106 2.453663 4433125  
  C++ Note: Starting Halves
  C++ Note: df501 -222944.2
  C++ Note: df504 -0.7398713 -15.30563  
  C++ Note: values checked -1.4896 -15.7503  
  C++ Note: sums checked 3475.35 0.000924527  
  C++ Note: derivs checked 851.349 0.000924527  
  C++ Note: second derivs checked 851.349 0.000924527  
  C++ Note: dose checked 6400 6400  
  C++ Note: non-dose checked 3475.35 0.000924527  
  C++ Note: LIN_non-dose checked 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400  
  C++ Note: LOGLIN_non-dose checked 3475.35 0.000924527  
  C++ Note: risk checked 3475.35  
  C++ Note: risk1 checked 851.349 0.00050204  
  C++ Note: risk2 checked 851.349 0.00050204  
  C++ Note: df101 -175021 -175021  
  C++ Note: df102 -42914.3 -0.0253124  
  C++ Note: df103 -42947.3 -0.0253124  
  C++ Note: df104 -1.4896 -15.7503  
  C++ Note: Checking Deviance 349871
  C++ Note: df105 0.999232 1  
  C++ Note: df106 4.07839 6.91445e+06  
  C++ Note: df100 26506 1 2 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:50 2024
  
  C++ Note: df100 26742 0 0 0,Update_Calc
  C++ Note: Current Time, Fri Feb 23 05:58:50 2024
  
  C++ Note: df101 -175021.5 -175021.5  
  C++ Note: df102 -42914.34 -0.02531243  
  C++ Note: df103 -42947.34 -0.02531243  
  C++ Note: df104 -1.489599 -15.75028  
  C++ Note: Checking Deviance 349871
  C++ Note: df105 0.9992316 1  
  C++ Note: df106 4.078392 6914448  
  C++ Note: Starting Halves
  C++ Note: df501 -175021.5
  C++ Note: df504 -1.489599 -15.75028  
  C++ Note: values checked -2.23902 -16.3166  
  C++ Note: sums checked 3026.38 0.000524773  
  C++ Note: derivs checked 402.38 0.000524773  
  C++ Note: second derivs checked 402.38 0.000524773  
  C++ Note: dose checked 6400 6400  
  C++ Note: non-dose checked 3026.38 0.000524773  
  C++ Note: LIN_non-dose checked 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400  
  C++ Note: LOGLIN_non-dose checked 3026.38 0.000524773  
  C++ Note: risk checked 3026.38  
  C++ Note: risk1 checked 402.38 0.00024815  
  C++ Note: risk2 checked 402.38 0.00024815  
  C++ Note: df101 -152397 -152397  
  C++ Note: df102 -20265.6 -0.0125105  
  C++ Note: df103 -20298.6 -0.0125105  
  C++ Note: df104 -2.23902 -16.3166  
  C++ Note: Checking Deviance 304623
  C++ Note: df105 0.998374 1  
  C++ Note: df106 7.52001 1.21815e+07  
  C++ Note: df100 31992 1 3 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:50 2024
  
  C++ Note: df100 32267 0 0 0,Update_Calc
  C++ Note: Current Time, Fri Feb 23 05:58:50 2024
  
  C++ Note: df101 -152397.5 -152397.5  
  C++ Note: df102 -20265.58 -0.01251054  
  C++ Note: df103 -20298.58 -0.01251054  
  C++ Note: df104 -2.239023 -16.3166  
  C++ Note: Checking Deviance 304622.9
  C++ Note: df105 0.9983743 1  
  C++ Note: df106 7.520014 1.218152e+07  
  C++ Note: Starting Halves
  C++ Note: df501 -152397.5
  C++ Note: df504 -2.239023 -16.3166  
  C++ Note: values checked -2.9878 -16.967  
  C++ Note: sums checked 2814.3 0.000273851  
  C++ Note: derivs checked 190.303 0.000273851  
  C++ Note: second derivs checked 190.303 0.000273851  
  C++ Note: dose checked 6400 6400  
  C++ Note: non-dose checked 2814.3 0.000273851  
  C++ Note: LIN_non-dose checked 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400  
  C++ Note: LOGLIN_non-dose checked 2814.3 0.000273851  
  C++ Note: risk checked 2814.3  
  C++ Note: risk1 checked 190.303 0.000120422  
  C++ Note: risk2 checked 190.303 0.000120422  
  C++ Note: df101 -141724 -141724  
  C++ Note: df102 -9567.07 -0.0060708  
  C++ Note: df103 -9600.07 -0.0060708  
  C++ Note: df104 -2.9878 -16.967  
  C++ Note: Checking Deviance 283275
  C++ Note: df105 0.996563 1  
  C++ Note: df106 14.8137 2.33451e+07  
  C++ Note: df100 44162 1 4 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:50 2024
  
  C++ Note: df100 44263 0 0 0,Update_Calc
  C++ Note: Current Time, Fri Feb 23 05:58:50 2024
  
  C++ Note: df101 -141723.6 -141723.6  
  C++ Note: df102 -9567.07 -0.006070799  
  C++ Note: df103 -9600.07 -0.006070799  
  C++ Note: df104 -2.987803 -16.96698  
  C++ Note: Checking Deviance 283275.3
  C++ Note: df105 0.9965625 1  
  C++ Note: df106 14.81369 2.334514e+07  
  C++ Note: Starting Halves
  C++ Note: df501 -141723.6
  C++ Note: df504 -2.987803 -16.96698  
  C++ Note: values checked -3.73523 -17.6664  
  C++ Note: sums checked 2714.12 0.000136068  
  C++ Note: derivs checked 90.1248 0.000136068  
  C++ Note: second derivs checked 90.1248 0.000136068  
  C++ Note: dose checked 6400 6400  
  C++ Note: non-dose checked 2714.12 0.000136068  
  C++ Note: LIN_non-dose checked 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400  
  C++ Note: LOGLIN_non-dose checked 2714.12 0.000136068  
  C++ Note: risk checked 2714.12  
  C++ Note: risk1 checked 90.1248 5.77042e-05  
  C++ Note: risk2 checked 90.1248 5.77042e-05  
  C++ Note: df101 -136695 -136695  
  C++ Note: df102 -4513.46 -0.00290896  
  C++ Note: df103 -4546.46 -0.00290896  
  C++ Note: df104 -3.73523 -17.6664  
  C++ Note: Checking Deviance 273217
  C++ Note: df105 0.992742 1  
  C++ Note: df106 30.286 4.6991e+07  
  C++ Note: df100 49620 1 5 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:50 2024
  
  C++ Note: df100 49717 0 0 0,Update_Calc
  C++ Note: Current Time, Fri Feb 23 05:58:50 2024
  
  C++ Note: df101 -136694.7 -136694.7  
  C++ Note: df102 -4513.458 -0.002908957  
  C++ Note: df103 -4546.458 -0.002908957  
  C++ Note: df104 -3.735225 -17.66641  
  C++ Note: Checking Deviance 273217.4
  C++ Note: df105 0.9927416 1  
  C++ Note: df106 30.28602 4.699096e+07  
  C++ Note: df101 -136695 -136695  
  C++ Note: df102 -4513.46 -0.00290896  
  C++ Note: df103 -4546.46 -0.00290896  
  C++ Note: df104 -3.73523 -17.6664  
  C++ Note: Checking Deviance 273217
  C++ Note: df105 0.992742 1  
  C++ Note: df106 30.286 4.6991e+07  
  C++ Note: ending guess 0
  C++ Note: df501 -136694.7
  C++ Note: df504 -3.735225 -17.66641  
  C++ Note: Refreshing matrices after all guesses
  C++ Note: Guess Results
  Guess number, parameter values, Log-Likelihood
  0, -3.735225 -17.66641, -136694.7<-- Best Guess
  C++ Note: starting subterms 2 in best guess 0
  C++ Note: values checked -3.73523 -17.6664  
  C++ Note: sums checked 2714.12 0.000136068  
  C++ Note: derivs checked 90.1248 0.000136068  
  C++ Note: second derivs checked 90.1248 0.000136068  
  C++ Note: dose checked 6400 6400  
  C++ Note: non-dose checked 2714.12 0.000136068  
  C++ Note: LIN_non-dose checked 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400  
  C++ Note: LOGLIN_non-dose checked 2714.12 0.000136068  
  C++ Note: risk checked 2714.12  
  C++ Note: risk1 checked 90.1248 5.77042e-05  
  C++ Note: risk2 checked 90.1248 5.77042e-05  
  C++ Note: Made Risk Side Lists
  C++ Note: df101 -136695 -136695  
  C++ Note: df102 -4513.46 -0.00290896  
  C++ Note: df103 -4546.46 -0.00290896  
  C++ Note: df104 -3.73523 -17.6664  
  C++ Note: Checking Deviance 273217
  C++ Note: df105 0.992742 1  
  C++ Note: df106 30.286 4.6991e+07  
  C++ Note: Starting Halves
  C++ Note: df501 -136694.7
  C++ Note: df504 -3.735225 -17.66641  
  C++ Note: values checked -4.47978 -18.3917  
  C++ Note: sums checked 2666.8 6.58842e-05  
  C++ Note: derivs checked 42.8043 6.58842e-05  
  C++ Note: second derivs checked 42.8043 6.58842e-05  
  C++ Note: dose checked 6400 6400  
  C++ Note: non-dose checked 2666.8 6.58842e-05  
  C++ Note: LIN_non-dose checked 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400  
  C++ Note: LOGLIN_non-dose checked 2666.8 6.58842e-05  
  C++ Note: risk checked 2666.8  
  C++ Note: risk1 checked 42.8043 2.74532e-05  
  C++ Note: risk2 checked 42.8043 2.74532e-05  
  C++ Note: df101 -134332 -134332  
  C++ Note: df102 -2126.32 -0.00138394  
  C++ Note: df103 -2159.32 -0.00138394  
  C++ Note: df104 -4.47978 -18.3917  
  C++ Note: Checking Deviance 268492
  C++ Note: df105 0.984717 1  
  C++ Note: df106 63.1759 9.7065e+07  
  C++ Note: df100 60447 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:50 2024
  
  C++ Note: df100 60547 0 0 0,Update_Calc
  C++ Note: Current Time, Fri Feb 23 05:58:50 2024
  
  C++ Note: df101 -134332.1 -134332.1  
  C++ Note: df102 -2126.318 -0.00138394  
  C++ Note: df103 -2159.318 -0.00138394  
  C++ Note: df104 -4.479781 -18.39167  
  C++ Note: Checking Deviance 268492.2
  C++ Note: df105 0.9847174 1  
  C++ Note: df106 63.17594 9.706499e+07  
  C++ Note: df101 -134332 -134332  
  C++ Note: df102 -2126.32 -0.00138394  
  C++ Note: df103 -2159.32 -0.00138394  
  C++ Note: df104 -4.47978 -18.3917  
  C++ Note: Checking Deviance 268492
  C++ Note: df105 0.984717 1  
  C++ Note: df106 63.1759 9.7065e+07  
  C++ Note: df501 -134332.1
  C++ Note: df504 -4.479781 -18.39167  
  Note: Starting Plot Function
  Note: Getting Plot Info
  Note: 2 risk groups
  Note: 2 risk groups
  C++ Note: START_COX_GUESS
  C++ Note: Current Time, Fri Feb 23 05:58:50 2024
  
  C++ Note: Term checked 0  
  C++ Note: df99,66,Starting
  C++ Note: Current Time, Fri Feb 23 05:58:50 2024
  
  C++ Note: Grouping Start
  C++ Note: df100 180 0 0 -1,Prep_List
  C++ Note: Current Time, Fri Feb 23 05:58:50 2024
  
  C++ Note: starting subterms 1 in guess 0
  C++ Note: values checked -0.1  
  C++ Note: sums checked 3.91896  
  C++ Note: derivs checked 21.9591  
  C++ Note: second derivs checked 138.335  
  C++ Note: dose checked 7  
  C++ Note: non-dose checked 3.91896  
  C++ Note: LIN_non-dose checked 7  
  C++ Note: PLIN_non-dose checked 7  
  C++ Note: LOGLIN_non-dose checked 3.91896  
  C++ Note: risk checked 3.91896  
  C++ Note: risk1 checked 21.9591  
  C++ Note: risk2 checked 138.335  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 1.11965  
  C++ Note: risk1r checked 6.27591  
  C++ Note: risk2r checked 39.4822  
  C++ Note: riskl checked 1.11965  
  C++ Note: risk1l checked 6.27591  
  C++ Note: risk2l checked 39.4822  
  C++ Note: df101 0  
  C++ Note: df102 0  
  C++ Note: df103 0  
  C++ Note: df104 -0.1  
  C++ Note: df105 -nan  
  C++ Note: df106 -nan  
  C++ Note: riskr checked 1.11965  
  C++ Note: risk1r checked 6.27591  
  C++ Note: risk2r checked 39.4822  
  C++ Note: riskl checked 1.11965  
  C++ Note: risk1l checked 6.27591  
  C++ Note: risk2l checked 39.4822  
  C++ Note: df101 0  
  C++ Note: df102 0  
  C++ Note: df103 0  
  C++ Note: df104 -0.1  
  C++ Note: df105 -nan  
  C++ Note: df106 -nan  
  C++ Note: ending guess 0
  C++ Note: df501 0
  C++ Note: df504 -0.1  
  C++ Note: Refreshing matrices after all guesses
  C++ Note: Guess Results
  Guess number, parameter values, Log-Likelihood
  0, -0.1, 0<-- Best Guess
  C++ Note: starting subterms 1 in best guess 0
  C++ Note: values checked -0.1  
  C++ Note: sums checked 3.91896  
  C++ Note: derivs checked 21.9591  
  C++ Note: second derivs checked 138.335  
  C++ Note: dose checked 7  
  C++ Note: non-dose checked 3.91896  
  C++ Note: LIN_non-dose checked 7  
  C++ Note: PLIN_non-dose checked 7  
  C++ Note: LOGLIN_non-dose checked 3.91896  
  C++ Note: risk checked 3.91896  
  C++ Note: risk1 checked 21.9591  
  C++ Note: risk2 checked 138.335  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 1.11965  
  C++ Note: risk1r checked 6.27591  
  C++ Note: risk2r checked 39.4822  
  C++ Note: riskl checked 1.11965  
  C++ Note: risk1l checked 6.27591  
  C++ Note: risk2l checked 39.4822  
  C++ Note: df101 0  
  C++ Note: df102 0  
  C++ Note: df103 0  
  C++ Note: df104 -0.1  
  C++ Note: df105 -nan  
  C++ Note: df106 -nan  
  C++ Note: riskr checked 1.11965  
  C++ Note: risk1r checked 6.27591  
  C++ Note: risk2r checked 39.4822  
  C++ Note: riskl checked 1.11965  
  C++ Note: risk1l checked 6.27591  
  C++ Note: risk2l checked 39.4822  
  C++ Note: df101 0  
  C++ Note: df102 0  
  C++ Note: df103 0  
  C++ Note: df104 -0.1  
  C++ Note: df105 -nan  
  C++ Note: df106 -nan  
  C++ Note: Exiting Regression
  C++ Note: df501 0
  C++ Note: df504 -0.1  
  Note: starting ph_plot
  Note: nonStratified survival curve calculation
  C++ Note: START_PLOT
  C++ Note: Current Time, Fri Feb 23 05:58:50 2024
  
  C++ Note: Term checked 0  
  C++ Note: df99,66,Starting
  C++ Note: Current Time, Fri Feb 23 05:58:50 2024
  
  C++ Note: values checked -0.1  
  C++ Note: sums checked 3.91896  
  C++ Note: derivs checked 21.9591  
  C++ Note: second derivs checked 138.335  
  C++ Note: dose checked 7  
  C++ Note: non-dose checked 3.91896  
  C++ Note: LIN_non-dose checked 7  
  C++ Note: PLIN_non-dose checked 7  
  C++ Note: LOGLIN_non-dose checked 3.91896  
  C++ Note: risk checked 3.91896  
  C++ Note: risk1 checked 21.9591  
  C++ Note: risk2 checked 138.335  
  C++ Note: Grouping Start
  C++ Note: df100 531 0 0 -1,Prep_List
  C++ Note: Current Time, Fri Feb 23 05:58:50 2024
  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 1.11965  
  C++ Note: risk1r checked 6.27591  
  C++ Note: risk2r checked 39.4822  
  C++ Note: riskl checked 1.11965  
  C++ Note: risk1l checked 6.27591  
  C++ Note: risk2l checked 39.4822  
  C++ Note: df101 0  
  C++ Note: df102 0  
  C++ Note: df103 0  
  C++ Note: df104 -0.1  
  C++ Note: df105 -nan  
  C++ Note: df106 -nan  
  Note: writing survival data
  Note: Plotting Martingale Residuals
  Note: Martingale Plot: d
  Saving 7 x 7 in image
  Saving 7 x 7 in image
  Note: Starting Censoring weight Plot Function
  Note: 908 risk groups
  Note: 908 risk groups
  C++ Note: START_COX_GUESS
  C++ Note: Current Time, Fri Feb 23 05:58:51 2024
  
  C++ Note: Term checked 0 0  
  C++ Note: df99,82,Starting
  C++ Note: Current Time, Fri Feb 23 05:58:51 2024
  
  C++ Note: Grouping Start
  C++ Note: df100 4486 0 0 -1,Prep_List
  C++ Note: Current Time, Fri Feb 23 05:58:51 2024
  
  C++ Note: starting subterms 1 in guess 0
  C++ Note: values checked 0 0  
  C++ Note: sums checked 1000 1000  
  C++ Note: derivs checked 3524.8 501  
  C++ Note: second derivs checked 19954.8 501  
  C++ Note: dose checked 1000  
  C++ Note: non-dose checked 1000  
  C++ Note: LIN_non-dose checked 1000  
  C++ Note: PLIN_non-dose checked 1000  
  C++ Note: LOGLIN_non-dose checked 1000  
  C++ Note: risk checked 1000  
  C++ Note: risk1 checked 3524.8 501  
  C++ Note: risk2 checked 19954.8 501  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 494240  
  C++ Note: risk1r checked 2.44264e+06 246462  
  C++ Note: risk2r checked 1.56997e+07 246462  
  C++ Note: riskl checked 908  
  C++ Note: risk1l checked 2745.2 459  
  C++ Note: risk2l checked 13223.2 459  
  C++ Note: df101 -11072.7 -11072.7  
  C++ Note: df102 -4819.96 25.3826  
  C++ Note: df103 -8962.58 -452.53  
  C++ Note: df104 0 0  
  C++ Note: df105 0.537787 -0.0560903  
  C++ Note: df106 2.29725 -436.231  
  C++ Note: Starting Halves
  C++ Note: df501 -11072.66
  C++ Note: df504 0 0  
  C++ Note: riskr checked 494240  
  C++ Note: risk1r checked 2.44264e+06 246462  
  C++ Note: risk2r checked 1.56997e+07 246462  
  C++ Note: riskl checked 908  
  C++ Note: risk1l checked 2745.2 459  
  C++ Note: risk2l checked 13223.2 459  
  C++ Note: df101 -5536.33 -5536.33  
  C++ Note: df102 -2409.98 12.6913  
  C++ Note: df103 -4481.29 -226.265  
  C++ Note: df104 0 0  
  C++ Note: df105 0.537787 -0.0560903  
  C++ Note: df106 2.29725 -436.231  
  C++ Note: ending guess 0
  C++ Note: df501 -5536.328
  C++ Note: df504 0 0  
  C++ Note: Refreshing matrices after all guesses
  C++ Note: Guess Results
  Guess number, parameter values, Log-Likelihood
  0, 0 0, -5536.328<-- Best Guess
  C++ Note: starting subterms 1 in best guess 0
  C++ Note: values checked 0 0  
  C++ Note: sums checked 1000 1000  
  C++ Note: derivs checked 3524.8 501  
  C++ Note: second derivs checked 19954.8 501  
  C++ Note: dose checked 1000  
  C++ Note: non-dose checked 1000  
  C++ Note: LIN_non-dose checked 1000  
  C++ Note: PLIN_non-dose checked 1000  
  C++ Note: LOGLIN_non-dose checked 1000  
  C++ Note: risk checked 1000  
  C++ Note: risk1 checked 3524.8 501  
  C++ Note: risk2 checked 19954.8 501  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 494240  
  C++ Note: risk1r checked 2.44264e+06 246462  
  C++ Note: risk2r checked 1.56997e+07 246462  
  C++ Note: riskl checked 908  
  C++ Note: risk1l checked 2745.2 459  
  C++ Note: risk2l checked 13223.2 459  
  C++ Note: df101 -11072.7 -11072.7  
  C++ Note: df102 -4819.96 25.3826  
  C++ Note: df103 -8962.58 -452.53  
  C++ Note: df104 0 0  
  C++ Note: df105 0.537787 -0.0560903  
  C++ Note: df106 2.29725 -436.231  
  C++ Note: riskr checked 494240  
  C++ Note: risk1r checked 2.44264e+06 246462  
  C++ Note: risk2r checked 1.56997e+07 246462  
  C++ Note: riskl checked 908  
  C++ Note: risk1l checked 2745.2 459  
  C++ Note: risk2l checked 13223.2 459  
  C++ Note: df101 -5536.33 -5536.33  
  C++ Note: df102 -2409.98 12.6913  
  C++ Note: df103 -4481.29 -226.265  
  C++ Note: df104 0 0  
  C++ Note: df105 0.537787 -0.0560903  
  C++ Note: df106 2.29725 -436.231  
  C++ Note: Exiting Regression
  C++ Note: df501 -5536.328
  C++ Note: df504 0 0  
  C++ Note: START_PLOT
  C++ Note: Current Time, Fri Feb 23 05:58:51 2024
  
  C++ Note: Term checked 0 0  
  C++ Note: df99,71,Starting
  C++ Note: Current Time, Fri Feb 23 05:58:51 2024
  
  C++ Note: values checked 0 0  
  C++ Note: sums checked 1000 1000  
  C++ Note: derivs checked 3524.8 501  
  C++ Note: second derivs checked 19954.8 501  
  C++ Note: dose checked 1000  
  C++ Note: non-dose checked 1000  
  C++ Note: LIN_non-dose checked 1000  
  C++ Note: PLIN_non-dose checked 1000  
  C++ Note: LOGLIN_non-dose checked 1000  
  C++ Note: risk checked 1000  
  C++ Note: risk1 checked 3524.8 501  
  C++ Note: risk2 checked 19954.8 501  
  C++ Note: Grouping Start
  C++ Note: df100 5145 0 0 -1,Prep_List
  C++ Note: Current Time, Fri Feb 23 05:58:51 2024
  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 494240  
  C++ Note: risk1r checked 2.44264e+06 246462  
  C++ Note: risk2r checked 1.56997e+07 246462  
  C++ Note: riskl checked 908  
  C++ Note: risk1l checked 2745.2 459  
  C++ Note: risk2l checked 13223.2 459  
  C++ Note: df101 -5536.33 -5536.33  
  C++ Note: df102 -2409.98 12.6913  
  C++ Note: df103 -4481.29 -226.265  
  C++ Note: df104 0 0  
  C++ Note: df105 0.537787 -0.0560903  
  C++ Note: df106 2.29725 -436.231  
  Saving 7 x 7 in image
  Note: Starting Censoring weight Plot Function
  Error: Atleast one parameter must be free
  Note: Starting Censoring weight Plot Function
  Error: no events
  Note: Starting Plot Function
  Note: Getting Plot Info
  Note: 3 risk groups
  Note: 3 risk groups
  C++ Note: START_COX_GUESS
  C++ Note: Current Time, Fri Feb 23 05:58:52 2024
  
  C++ Note: Term checked 0  
  C++ Note: df99,61,Starting
  C++ Note: Current Time, Fri Feb 23 05:58:52 2024
  
  C++ Note: Grouping Start
  C++ Note: df100 197 0 0 -1,Prep_List
  C++ Note: Current Time, Fri Feb 23 05:58:52 2024
  
  C++ Note: starting subterms 1 in guess 0
  C++ Note: values checked -0.1  
  C++ Note: sums checked 133.292  
  C++ Note: derivs checked 64.8996  
  C++ Note: second derivs checked 42.5489  
  C++ Note: dose checked 140  
  C++ Note: non-dose checked 133.292  
  C++ Note: LIN_non-dose checked 140  
  C++ Note: PLIN_non-dose checked 140  
  C++ Note: LOGLIN_non-dose checked 133.292  
  C++ Note: risk checked 133.292  
  C++ Note: risk1 checked 64.8996  
  C++ Note: risk2 checked 42.5489  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 57.1409  
  C++ Note: risk1r checked 27.6759  
  C++ Note: risk2r checked 17.8657  
  C++ Note: riskl checked 57.1409  
  C++ Note: risk1l checked 27.6759  
  C++ Note: risk2l checked 17.8657  
  C++ Note: df101 -179.767  
  C++ Note: df102 0.466579  
  C++ Note: df103 -4.66473  
  C++ Note: df104 -0.1  
  C++ Note: df105 -0.100023  
  C++ Note: df106 -385.288  
  C++ Note: riskr checked 57.1409  
  C++ Note: risk1r checked 27.6759  
  C++ Note: risk2r checked 17.8657  
  C++ Note: riskl checked 57.1409  
  C++ Note: risk1l checked 27.6759  
  C++ Note: risk2l checked 17.8657  
  C++ Note: df101 -179.767  
  C++ Note: df102 0.466579  
  C++ Note: df103 -4.66473  
  C++ Note: df104 -0.1  
  C++ Note: df105 -0.100023  
  C++ Note: df106 -385.288  
  C++ Note: ending guess 0
  C++ Note: df501 -179.7673
  C++ Note: df504 -0.1  
  C++ Note: Refreshing matrices after all guesses
  C++ Note: Guess Results
  Guess number, parameter values, Log-Likelihood
  0, -0.1, -179.7673<-- Best Guess
  C++ Note: starting subterms 1 in best guess 0
  C++ Note: values checked -0.1  
  C++ Note: sums checked 133.292  
  C++ Note: derivs checked 64.8996  
  C++ Note: second derivs checked 42.5489  
  C++ Note: dose checked 140  
  C++ Note: non-dose checked 133.292  
  C++ Note: LIN_non-dose checked 140  
  C++ Note: PLIN_non-dose checked 140  
  C++ Note: LOGLIN_non-dose checked 133.292  
  C++ Note: risk checked 133.292  
  C++ Note: risk1 checked 64.8996  
  C++ Note: risk2 checked 42.5489  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 57.1409  
  C++ Note: risk1r checked 27.6759  
  C++ Note: risk2r checked 17.8657  
  C++ Note: riskl checked 57.1409  
  C++ Note: risk1l checked 27.6759  
  C++ Note: risk2l checked 17.8657  
  C++ Note: df101 -179.767  
  C++ Note: df102 0.466579  
  C++ Note: df103 -4.66473  
  C++ Note: df104 -0.1  
  C++ Note: df105 -0.100023  
  C++ Note: df106 -385.288  
  C++ Note: riskr checked 57.1409  
  C++ Note: risk1r checked 27.6759  
  C++ Note: risk2r checked 17.8657  
  C++ Note: riskl checked 57.1409  
  C++ Note: risk1l checked 27.6759  
  C++ Note: risk2l checked 17.8657  
  C++ Note: df101 -179.767  
  C++ Note: df102 0.466579  
  C++ Note: df103 -4.66473  
  C++ Note: df104 -0.1  
  C++ Note: df105 -0.100023  
  C++ Note: df106 -385.288  
  C++ Note: Exiting Regression
  C++ Note: df501 -179.7673
  C++ Note: df504 -0.1  
  C++ Note: START_PLOT
  C++ Note: Current Time, Fri Feb 23 05:58:52 2024
  
  C++ Note: Term checked 0  
  C++ Note: df99,144,Starting
  C++ Note: Current Time, Fri Feb 23 05:58:52 2024
  
  C++ Note: values checked -0.1  
  C++ Note: sums checked 95.199  
  C++ Note: dose checked 100  
  C++ Note: non-dose checked 95.199  
  C++ Note: LIN_non-dose checked 100  
  C++ Note: PLIN_non-dose checked 100  
  C++ Note: LOGLIN_non-dose checked 95.199  
  C++ Note: risk checked 95.199  
  Saving 7 x 7 in image
  Warning: model covariate order changed
  Note: 26 risk groups
  C++ Note: START_COX_GUESS
  C++ Note: Current Time, Fri Feb 23 05:58:53 2024
  
  C++ Note: Term checked 0 0 1  
  C++ Note: df99,83,Starting
  C++ Note: Current Time, Fri Feb 23 05:58:53 2024
  
  C++ Note: Grouping Start
  C++ Note: df100 440 0 0 -1,Prep_List
  C++ Note: Current Time, Fri Feb 23 05:58:53 2024
  
  C++ Note: starting subterms 2 in guess 0
  C++ Note: values checked 0.426096 0.646539 0.157278  
  C++ Note: sums checked 7274.1 7274.1 1341.83  
  C++ Note: derivs checked 4601.97 23182.6 2733.27  
  C++ Note: second derivs checked 4601.97 82544.2 8524.37  
  C++ Note: dose checked 1000 1000  
  C++ Note: non-dose checked 7274.1 1341.83  
  C++ Note: LIN_non-dose checked 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000  
  C++ Note: LOGLIN_non-dose checked 7274.1 1341.83  
  C++ Note: risk checked 17001  
  C++ Note: risk1 checked 10706.4 54122.7 19625.6  
  C++ Note: risk2 checked 10706.4 192502 61415.9  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 45411.7  
  C++ Note: risk1r checked 28767.4 144720 52387.3  
  C++ Note: risk2r checked 28767.4 514964 151495  
  C++ Note: riskl checked 498.666  
  C++ Note: risk1l checked 304.226 1582.04 793.308  
  C++ Note: risk2l checked 304.226 5554.38 2609.55  
  C++ Note: df101 -124.812 -124.812 -124.812  
  C++ Note: df102 -0.467622 -22.6674 2.97163  
  C++ Note: df103 -6.02126 -30.6469 -1.27345  
  C++ Note: df104 0.426096 0.646539 0.157278  
  C++ Note: df105 0.0776618 0.739632 -2.33354  
  C++ Note: df106 266.907 5.50621 -42.001  
  C++ Note: Starting Halves
  C++ Note: df501 -124.8115
  C++ Note: df504 0.4260961 0.646539 0.1572781  
  C++ Note: values checked 0.600743 0.0965281 1.15728  
  C++ Note: sums checked 1773.98 1773.98 32135.8  
  C++ Note: derivs checked 1194.6 4043.19 134742  
  C++ Note: second derivs checked 1194.6 12805.3 616015  
  C++ Note: dose checked 1000 1000  
  C++ Note: non-dose checked 1773.98 32135.8  
  C++ Note: LIN_non-dose checked 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000  
  C++ Note: LOGLIN_non-dose checked 1773.98 32135.8  
  C++ Note: risk checked 58026.5  
  C++ Note: risk1 checked 37651.2 135360 236019  
  C++ Note: risk2 checked 37651.2 427814 1.08252e+06  
  C++ Note: riskr checked 119495  
  C++ Note: risk1r checked 76635.5 283568 429089  
  C++ Note: risk2r checked 76635.5 896488 1.77407e+06  
  C++ Note: riskl checked 1711.94  
  C++ Note: risk1l checked 1027.65 4618.5 6140.17  
  C++ Note: risk2l checked 1027.65 15652.6 24115.3  
  C++ Note: df101 -118.395 -118.395 -118.395  
  C++ Note: df102 -0.782638 -0.410558 -4.43759  
  C++ Note: df103 -5.94091 -49.8573 -9.26764  
  C++ Note: df104 0.600743 0.0965281 1.15728  
  C++ Note: df105 0.131737 0.00823466 0.478826  
  C++ Note: df106 151.277 288.376 26.68  
  C++ Note: df100 4699 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:53 2024
  
  C++ Note: riskr checked 119495  
  C++ Note: risk1r checked 76635.5 283568 429089  
  C++ Note: risk2r checked 76635.5 896488 1.77407e+06  
  C++ Note: riskl checked 1711.94  
  C++ Note: risk1l checked 1027.65 4618.5 6140.17  
  C++ Note: risk2l checked 1027.65 15652.6 24115.3  
  C++ Note: df101 -118.395 -118.395 -118.395  
  C++ Note: df102 -0.782638 -0.410558 -4.43759  
  C++ Note: df103 -5.94091 -49.8573 -9.26764  
  C++ Note: df104 0.600743 0.0965281 1.15728  
  C++ Note: df105 0.131737 0.00823466 0.478826  
  C++ Note: df106 151.277 288.376 26.68  
  C++ Note: ending guess 0
  C++ Note: df501 -118.395
  C++ Note: df504 0.6007434 0.09652814 1.157278  
  C++ Note: Refreshing matrices after all guesses
  C++ Note: Guess Results
  Guess number, parameter values, Log-Likelihood
  0, 0.6007434 0.09652814 1.157278, -118.395<-- Best Guess
  C++ Note: starting subterms 2 in best guess 0
  C++ Note: values checked 0.600743 0.0965281 1.15728  
  C++ Note: sums checked 1773.98 1773.98 32135.8  
  C++ Note: derivs checked 1194.6 4043.19 134742  
  C++ Note: second derivs checked 1194.6 12805.3 616015  
  C++ Note: dose checked 1000 1000  
  C++ Note: non-dose checked 1773.98 32135.8  
  C++ Note: LIN_non-dose checked 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000  
  C++ Note: LOGLIN_non-dose checked 1773.98 32135.8  
  C++ Note: risk checked 58026.5  
  C++ Note: risk1 checked 37651.2 135360 236019  
  C++ Note: risk2 checked 37651.2 427814 1.08252e+06  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 119495  
  C++ Note: risk1r checked 76635.5 283568 429089  
  C++ Note: risk2r checked 76635.5 896488 1.77407e+06  
  C++ Note: riskl checked 1711.94  
  C++ Note: risk1l checked 1027.65 4618.5 6140.17  
  C++ Note: risk2l checked 1027.65 15652.6 24115.3  
  C++ Note: df101 -236.79 -236.79 -236.79  
  C++ Note: df102 -1.56528 -0.821116 -8.87517  
  C++ Note: df103 -11.8818 -99.7146 -18.5353  
  C++ Note: df104 0.600743 0.0965281 1.15728  
  C++ Note: df105 0.131737 0.00823466 0.478826  
  C++ Note: df106 151.277 288.376 26.68  
  C++ Note: Starting Halves
  C++ Note: df501 -118.395
  C++ Note: df504 0.6007434 0.09652814 1.157278  
  C++ Note: values checked 0.469257 0.102151 0.78977  
  C++ Note: sums checked 1647.84 1647.84 7760.94  
  C++ Note: derivs checked 1060.93 3775.1 27203.7  
  C++ Note: second derivs checked 1060.93 11977.1 111988  
  C++ Note: dose checked 1000 1000  
  C++ Note: non-dose checked 1647.84 7760.94  
  C++ Note: LIN_non-dose checked 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000  
  C++ Note: LOGLIN_non-dose checked 1647.84 7760.94  
  C++ Note: risk checked 14328.5  
  C++ Note: risk1 checked 8953.84 33119.7 44341.6  
  C++ Note: risk2 checked 8953.84 104570 182492  
  C++ Note: riskr checked 34488.8  
  C++ Note: risk1r checked 21529.9 80578.6 94839.5  
  C++ Note: risk2r checked 21529.9 254610 351090  
  C++ Note: riskl checked 470.725  
  C++ Note: risk1l checked 299.436 1220.36 1425.98  
  C++ Note: risk2l checked 299.436 4016.13 5259.82  
  C++ Note: df101 -117.31 -117.31 -117.31  
  C++ Note: df102 -0.252504 -0.212118 -1.1189  
  C++ Note: df103 -6.08937 -50.5934 -9.22555  
  C++ Note: df104 0.469257 0.102151 0.78977  
  C++ Note: df105 0.0414663 0.00419259 0.121283  
  C++ Note: df106 464.589 553.044 104.844  
  C++ Note: df100 22006 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:53 2024
  
  C++ Note: riskr checked 34488.8  
  C++ Note: risk1r checked 21529.9 80578.6 94839.5  
  C++ Note: risk2r checked 21529.9 254610 351090  
  C++ Note: riskl checked 470.725  
  C++ Note: risk1l checked 299.436 1220.36 1425.98  
  C++ Note: risk2l checked 299.436 4016.13 5259.82  
  C++ Note: df101 -117.31 -117.31 -117.31  
  C++ Note: df102 -0.252504 -0.212118 -1.1189  
  C++ Note: df103 -6.08937 -50.5934 -9.22555  
  C++ Note: df104 0.469257 0.102151 0.78977  
  C++ Note: df105 0.0414663 0.00419259 0.121283  
  C++ Note: df106 464.589 553.044 104.844  
  C++ Note: riskr checked 34488.8  
  C++ Note: risk1r checked 21529.9 80578.6 94839.5  
  C++ Note: risk2r checked 21529.9 254610 351090  
  C++ Note: riskl checked 470.725  
  C++ Note: risk1l checked 299.436 1220.36 1425.98  
  C++ Note: risk2l checked 299.436 4016.13 5259.82  
  C++ Note: df101 -117.31 -117.31 -117.31  
  C++ Note: df102 -0.252504 -0.212118 -1.1189  
  C++ Note: df103 -6.08937 -50.5934 -9.22555  
  C++ Note: df104 0.469257 0.102151 0.78977  
  C++ Note: df105 0.0414663 0.00419259 0.121283  
  C++ Note: df106 464.589 553.044 104.844  
  C++ Note: Exiting Regression
  C++ Note: df501 -117.3104
  C++ Note: df504 0.4692569 0.1021509 0.7897698  
  Error: Atleast one parameter must be free
  Warning: model covariate order changed
  Error: no events
  Warning: model covariate order changed
  Note: 26 risk groups
  Note: Initial starts: 1 , Number of iterations provided: 4 . Colossus requires one more iteration counts than number of guesses (for best guess)
  C++ Note: START_COX_GUESS
  C++ Note: Current Time, Fri Feb 23 05:58:53 2024
  
  C++ Note: Term checked 0 0 1  
  C++ Note: df99,71,Starting
  C++ Note: Current Time, Fri Feb 23 05:58:53 2024
  
  C++ Note: Grouping Start
  C++ Note: df100 408 0 0 -1,Prep_List
  C++ Note: Current Time, Fri Feb 23 05:58:53 2024
  
  C++ Note: starting subterms 2 in guess 0
  C++ Note: values checked 0.426096 0.646539 0.157278  
  C++ Note: sums checked 7274.1 7274.1 1341.83  
  C++ Note: derivs checked 4601.97 23182.6 2733.27  
  C++ Note: second derivs checked 4601.97 82544.2 8524.37  
  C++ Note: dose checked 1000 1000  
  C++ Note: non-dose checked 7274.1 1341.83  
  C++ Note: LIN_non-dose checked 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000  
  C++ Note: LOGLIN_non-dose checked 7274.1 1341.83  
  C++ Note: risk checked 17001  
  C++ Note: risk1 checked 10706.4 54122.7 19625.6  
  C++ Note: risk2 checked 10706.4 192502 61415.9  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 45411.7  
  C++ Note: risk1r checked 28767.4 144720 52387.3  
  C++ Note: risk2r checked 28767.4 514964 151495  
  C++ Note: riskl checked 498.666  
  C++ Note: risk1l checked 304.226 1582.04 793.308  
  C++ Note: risk2l checked 304.226 5554.38 2609.55  
  C++ Note: df101 -124.812 -124.812 -124.812  
  C++ Note: df102 -0.467622 -22.6674 2.97163  
  C++ Note: df103 -6.02126 -30.6469 -1.27345  
  C++ Note: df104 0.426096 0.646539 0.157278  
  C++ Note: df105 0.0776618 0.739632 -2.33354  
  C++ Note: df106 266.907 5.50621 -42.001  
  C++ Note: Starting Halves
  C++ Note: df501 -124.8115
  C++ Note: df504 0.4260961 0.646539 0.1572781  
  C++ Note: values checked 0.600743 0.0965281 1.15728  
  C++ Note: sums checked 1773.98 1773.98 32135.8  
  C++ Note: derivs checked 1194.6 4043.19 134742  
  C++ Note: second derivs checked 1194.6 12805.3 616015  
  C++ Note: dose checked 1000 1000  
  C++ Note: non-dose checked 1773.98 32135.8  
  C++ Note: LIN_non-dose checked 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000  
  C++ Note: LOGLIN_non-dose checked 1773.98 32135.8  
  C++ Note: risk checked 58026.5  
  C++ Note: risk1 checked 37651.2 135360 236019  
  C++ Note: risk2 checked 37651.2 427814 1.08252e+06  
  C++ Note: riskr checked 119495  
  C++ Note: risk1r checked 76635.5 283568 429089  
  C++ Note: risk2r checked 76635.5 896488 1.77407e+06  
  C++ Note: riskl checked 1711.94  
  C++ Note: risk1l checked 1027.65 4618.5 6140.17  
  C++ Note: risk2l checked 1027.65 15652.6 24115.3  
  C++ Note: df101 -118.395 -118.395 -118.395  
  C++ Note: df102 -0.782638 -0.410558 -4.43759  
  C++ Note: df103 -5.94091 -49.8573 -9.26764  
  C++ Note: df104 0.600743 0.0965281 1.15728  
  C++ Note: df105 0.131737 0.00823466 0.478826  
  C++ Note: df106 151.277 288.376 26.68  
  C++ Note: df100 4185 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:53 2024
  
  C++ Note: riskr checked 119495  
  C++ Note: risk1r checked 76635.5 283568 429089  
  C++ Note: risk2r checked 76635.5 896488 1.77407e+06  
  C++ Note: riskl checked 1711.94  
  C++ Note: risk1l checked 1027.65 4618.5 6140.17  
  C++ Note: risk2l checked 1027.65 15652.6 24115.3  
  C++ Note: df101 -118.395 -118.395 -118.395  
  C++ Note: df102 -0.782638 -0.410558 -4.43759  
  C++ Note: df103 -5.94091 -49.8573 -9.26764  
  C++ Note: df104 0.600743 0.0965281 1.15728  
  C++ Note: df105 0.131737 0.00823466 0.478826  
  C++ Note: df106 151.277 288.376 26.68  
  C++ Note: ending guess 0
  C++ Note: df501 -118.395
  C++ Note: df504 0.6007434 0.09652814 1.157278  
  C++ Note: Refreshing matrices after all guesses
  C++ Note: Guess Results
  Guess number, parameter values, Log-Likelihood
  0, 0.6007434 0.09652814 1.157278, -118.395<-- Best Guess
  C++ Note: starting subterms 2 in best guess 0
  C++ Note: values checked 0.600743 0.0965281 1.15728  
  C++ Note: sums checked 1773.98 1773.98 32135.8  
  C++ Note: derivs checked 1194.6 4043.19 134742  
  C++ Note: second derivs checked 1194.6 12805.3 616015  
  C++ Note: dose checked 1000 1000  
  C++ Note: non-dose checked 1773.98 32135.8  
  C++ Note: LIN_non-dose checked 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000  
  C++ Note: LOGLIN_non-dose checked 1773.98 32135.8  
  C++ Note: risk checked 58026.5  
  C++ Note: risk1 checked 37651.2 135360 236019  
  C++ Note: risk2 checked 37651.2 427814 1.08252e+06  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 119495  
  C++ Note: risk1r checked 76635.5 283568 429089  
  C++ Note: risk2r checked 76635.5 896488 1.77407e+06  
  C++ Note: riskl checked 1711.94  
  C++ Note: risk1l checked 1027.65 4618.5 6140.17  
  C++ Note: risk2l checked 1027.65 15652.6 24115.3  
  C++ Note: df101 -118.395 -118.395 -118.395  
  C++ Note: df102 -0.782638 -0.410558 -4.43759  
  C++ Note: df103 -5.94091 -49.8573 -9.26764  
  C++ Note: df104 0.600743 0.0965281 1.15728  
  C++ Note: df105 0.131737 0.00823466 0.478826  
  C++ Note: df106 151.277 288.376 26.68  
  C++ Note: Starting Halves
  C++ Note: df501 -118.395
  C++ Note: df504 0.6007434 0.09652814 1.157278  
  C++ Note: values checked 0.469257 0.102151 0.78977  
  C++ Note: sums checked 1647.84 1647.84 7760.94  
  C++ Note: derivs checked 1060.93 3775.1 27203.7  
  C++ Note: second derivs checked 1060.93 11977.1 111988  
  C++ Note: dose checked 1000 1000  
  C++ Note: non-dose checked 1647.84 7760.94  
  C++ Note: LIN_non-dose checked 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000  
  C++ Note: LOGLIN_non-dose checked 1647.84 7760.94  
  C++ Note: risk checked 14328.5  
  C++ Note: risk1 checked 8953.84 33119.7 44341.6  
  C++ Note: risk2 checked 8953.84 104570 182492  
  C++ Note: riskr checked 34488.8  
  C++ Note: risk1r checked 21529.9 80578.6 94839.5  
  C++ Note: risk2r checked 21529.9 254610 351090  
  C++ Note: riskl checked 470.725  
  C++ Note: risk1l checked 299.436 1220.36 1425.98  
  C++ Note: risk2l checked 299.436 4016.13 5259.82  
  C++ Note: df101 -117.31 -117.31 -117.31  
  C++ Note: df102 -0.252504 -0.212118 -1.1189  
  C++ Note: df103 -6.08937 -50.5934 -9.22555  
  C++ Note: df104 0.469257 0.102151 0.78977  
  C++ Note: df105 0.0414663 0.00419259 0.121283  
  C++ Note: df106 464.589 553.044 104.844  
  C++ Note: df100 22791 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:53 2024
  
  C++ Note: riskr checked 34488.8  
  C++ Note: risk1r checked 21529.9 80578.6 94839.5  
  C++ Note: risk2r checked 21529.9 254610 351090  
  C++ Note: riskl checked 470.725  
  C++ Note: risk1l checked 299.436 1220.36 1425.98  
  C++ Note: risk2l checked 299.436 4016.13 5259.82  
  C++ Note: df101 -117.31 -117.31 -117.31  
  C++ Note: df102 -0.252504 -0.212118 -1.1189  
  C++ Note: df103 -6.08937 -50.5934 -9.22555  
  C++ Note: df104 0.469257 0.102151 0.78977  
  C++ Note: df105 0.0414663 0.00419259 0.121283  
  C++ Note: df106 464.589 553.044 104.844  
  C++ Note: riskr checked 34488.8  
  C++ Note: risk1r checked 21529.9 80578.6 94839.5  
  C++ Note: risk2r checked 21529.9 254610 351090  
  C++ Note: riskl checked 470.725  
  C++ Note: risk1l checked 299.436 1220.36 1425.98  
  C++ Note: risk2l checked 299.436 4016.13 5259.82  
  C++ Note: df101 -117.31 -117.31 -117.31  
  C++ Note: df102 -0.252504 -0.212118 -1.1189  
  C++ Note: df103 -6.08937 -50.5934 -9.22555  
  C++ Note: df104 0.469257 0.102151 0.78977  
  C++ Note: df105 0.0414663 0.00419259 0.121283  
  C++ Note: df106 464.589 553.044 104.844  
  C++ Note: Exiting Regression
  C++ Note: df501 -117.3104
  C++ Note: df504 0.4692569 0.1021509 0.7897698  
  Warning: model covariate order changed
  Note: 26 risk groups
  Note: Initial starts: 3 , Number of iterations provided: 2 . Colossus requires one more iteration counts than number of guesses (for best guess)
  C++ Note: START_COX_GUESS
  C++ Note: Current Time, Fri Feb 23 05:58:53 2024
  
  C++ Note: Term checked 0 0 1  
  C++ Note: df99,84,Starting
  C++ Note: Current Time, Fri Feb 23 05:58:53 2024
  
  C++ Note: Grouping Start
  C++ Note: df100 442 0 0 -1,Prep_List
  C++ Note: Current Time, Fri Feb 23 05:58:53 2024
  
  C++ Note: starting subterms 2 in guess 0
  C++ Note: values checked 0.426096 0.646539 0.157278  
  C++ Note: sums checked 7274.1 7274.1 1341.83  
  C++ Note: derivs checked 4601.97 23182.6 2733.27  
  C++ Note: second derivs checked 4601.97 82544.2 8524.37  
  C++ Note: dose checked 1000 1000  
  C++ Note: non-dose checked 7274.1 1341.83  
  C++ Note: LIN_non-dose checked 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000  
  C++ Note: LOGLIN_non-dose checked 7274.1 1341.83  
  C++ Note: risk checked 17001  
  C++ Note: risk1 checked 10706.4 54122.7 19625.6  
  C++ Note: risk2 checked 10706.4 192502 61415.9  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 45411.7  
  C++ Note: risk1r checked 28767.4 144720 52387.3  
  C++ Note: risk2r checked 28767.4 514964 151495  
  C++ Note: riskl checked 498.666  
  C++ Note: risk1l checked 304.226 1582.04 793.308  
  C++ Note: risk2l checked 304.226 5554.38 2609.55  
  C++ Note: df101 -249.623 -249.623 -249.623  
  C++ Note: df102 -0.935244 -45.3348 5.94327  
  C++ Note: df103 -12.0425 -61.2938 -2.54689  
  C++ Note: df104 0.426096 0.646539 0.157278  
  C++ Note: df105 0.0776618 0.739632 -2.33354  
  C++ Note: df106 266.907 5.50621 -42.001  
  C++ Note: Starting Halves
  C++ Note: df501 -249.6231
  C++ Note: df504 0.4260961 0.646539 0.1572781  
  C++ Note: values checked 0.600743 0.0965281 1.15728  
  C++ Note: sums checked 1773.98 1773.98 32135.8  
  C++ Note: derivs checked 1194.6 4043.19 134742  
  C++ Note: second derivs checked 1194.6 12805.3 616015  
  C++ Note: dose checked 1000 1000  
  C++ Note: non-dose checked 1773.98 32135.8  
  C++ Note: LIN_non-dose checked 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000  
  C++ Note: LOGLIN_non-dose checked 1773.98 32135.8  
  C++ Note: risk checked 58026.5  
  C++ Note: risk1 checked 37651.2 135360 236019  
  C++ Note: risk2 checked 37651.2 427814 1.08252e+06  
  C++ Note: riskr checked 119495  
  C++ Note: risk1r checked 76635.5 283568 429089  
  C++ Note: risk2r checked 76635.5 896488 1.77407e+06  
  C++ Note: riskl checked 1711.94  
  C++ Note: risk1l checked 1027.65 4618.5 6140.17  
  C++ Note: risk2l checked 1027.65 15652.6 24115.3  
  C++ Note: df101 -118.395 -118.395 -118.395  
  C++ Note: df102 -0.782638 -0.410558 -4.43759  
  C++ Note: df103 -5.94091 -49.8573 -9.26764  
  C++ Note: df104 0.600743 0.0965281 1.15728  
  C++ Note: df105 0.131737 0.00823466 0.478826  
  C++ Note: df106 151.277 288.376 26.68  
  C++ Note: df100 15810 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:53 2024
  
  C++ Note: riskr checked 119495  
  C++ Note: risk1r checked 76635.5 283568 429089  
  C++ Note: risk2r checked 76635.5 896488 1.77407e+06  
  C++ Note: riskl checked 1711.94  
  C++ Note: risk1l checked 1027.65 4618.5 6140.17  
  C++ Note: risk2l checked 1027.65 15652.6 24115.3  
  C++ Note: df101 -118.395 -118.395 -118.395  
  C++ Note: df102 -0.782638 -0.410558 -4.43759  
  C++ Note: df103 -5.94091 -49.8573 -9.26764  
  C++ Note: df104 0.600743 0.0965281 1.15728  
  C++ Note: df105 0.131737 0.00823466 0.478826  
  C++ Note: df106 151.277 288.376 26.68  
  C++ Note: ending guess 0
  C++ Note: df501 -118.395
  C++ Note: df504 0.6007434 0.09652814 1.157278  
  C++ Note: starting subterms 2 in guess 1
  C++ Note: values checked 0.426096 0.646539 0.157278  
  C++ Note: sums checked 7274.1 7274.1 1341.83  
  C++ Note: derivs checked 4601.97 23182.6 2733.27  
  C++ Note: second derivs checked 4601.97 82544.2 8524.37  
  C++ Note: dose checked 1000 1000  
  C++ Note: non-dose checked 7274.1 1341.83  
  C++ Note: LIN_non-dose checked 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000  
  C++ Note: LOGLIN_non-dose checked 7274.1 1341.83  
  C++ Note: risk checked 17001  
  C++ Note: risk1 checked 10706.4 54122.7 19625.6  
  C++ Note: risk2 checked 10706.4 192502 61415.9  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 45411.7  
  C++ Note: risk1r checked 28767.4 144720 52387.3  
  C++ Note: risk2r checked 28767.4 514964 151495  
  C++ Note: riskl checked 498.666  
  C++ Note: risk1l checked 304.226 1582.04 793.308  
  C++ Note: risk2l checked 304.226 5554.38 2609.55  
  C++ Note: df101 -124.812 -124.812 -124.812  
  C++ Note: df102 -0.467622 -22.6674 2.97163  
  C++ Note: df103 -6.02126 -30.6469 -1.27345  
  C++ Note: df104 0.426096 0.646539 0.157278  
  C++ Note: df105 0.0776618 0.739632 -2.33354  
  C++ Note: df106 266.907 5.50621 -42.001  
  C++ Note: Starting Halves
  C++ Note: df501 -118.395
  C++ Note: df504 0.6007434 0.09652814 1.157278  
  C++ Note: values checked 0.600743 0.0965281 1.15728  
  C++ Note: sums checked 1773.98 1773.98 32135.8  
  C++ Note: derivs checked 1194.6 4043.19 134742  
  C++ Note: second derivs checked 1194.6 12805.3 616015  
  C++ Note: dose checked 1000 1000  
  C++ Note: non-dose checked 1773.98 32135.8  
  C++ Note: LIN_non-dose checked 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000  
  C++ Note: LOGLIN_non-dose checked 1773.98 32135.8  
  C++ Note: risk checked 58026.5  
  C++ Note: risk1 checked 37651.2 135360 236019  
  C++ Note: risk2 checked 37651.2 427814 1.08252e+06  
  C++ Note: riskr checked 119495  
  C++ Note: risk1r checked 76635.5 283568 429089  
  C++ Note: risk2r checked 76635.5 896488 1.77407e+06  
  C++ Note: riskl checked 1711.94  
  C++ Note: risk1l checked 1027.65 4618.5 6140.17  
  C++ Note: risk2l checked 1027.65 15652.6 24115.3  
  C++ Note: df101 -118.395 -118.395 -118.395  
  C++ Note: df102 -0.782638 -0.410558 -4.43759  
  C++ Note: df103 -5.94091 -49.8573 -9.26764  
  C++ Note: df104 0.600743 0.0965281 1.15728  
  C++ Note: df105 0.131737 0.00823466 0.478826  
  C++ Note: df106 151.277 288.376 26.68  
  C++ Note: df100 21188 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:53 2024
  
  C++ Note: values checked 0.51342 0.371534 0.657278  
  C++ Note: sums checked 3370.53 3370.53 4972.82  
  C++ Note: derivs checked 2201.24 9415.6 15965.6  
  C++ Note: second derivs checked 2201.24 31933.3 62675  
  C++ Note: dose checked 1000 1000  
  C++ Note: non-dose checked 3370.53 4972.82  
  C++ Note: LIN_non-dose checked 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000  
  C++ Note: LOGLIN_non-dose checked 3370.53 4972.82  
  C++ Note: risk checked 20026.8  
  C++ Note: risk1 checked 12767.6 55905.5 53475  
  C++ Note: risk2 checked 12767.6 188523 210555  
  C++ Note: riskr checked 50427.9  
  C++ Note: risk1r checked 32128.2 141448 121549  
  C++ Note: risk2r checked 32128.2 477449 432448  
  C++ Note: riskl checked 694.008  
  C++ Note: risk1l checked 419.149 2059.62 1976.96  
  C++ Note: risk2l checked 419.149 7123.47 7257.54  
  C++ Note: df101 -119.04 -119.04 -119.04  
  C++ Note: df102 -0.595098 -12.7024 -0.0570081  
  C++ Note: df103 -5.99518 -41.9658 -9.15921  
  C++ Note: df104 0.51342 0.371534 0.657278  
  C++ Note: df105 0.0992627 0.302686 0.00622413  
  C++ Note: df106 200.035 9.37145 2088.13  
  C++ Note: df100 23459 2 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:53 2024
  
  C++ Note: Changing back to best
  C++ Note: values checked 0.426096 0.646539 0.157278  
  C++ Note: sums checked 7274.1 7274.1 1341.83  
  C++ Note: derivs checked 4601.97 23182.6 2733.27  
  C++ Note: second derivs checked 4601.97 82544.2 8524.37  
  C++ Note: dose checked 1000 1000  
  C++ Note: non-dose checked 7274.1 1341.83  
  C++ Note: LIN_non-dose checked 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000  
  C++ Note: LOGLIN_non-dose checked 7274.1 1341.83  
  C++ Note: risk checked 17001  
  C++ Note: risk1 checked 10706.4 54122.7 19625.6  
  C++ Note: risk2 checked 10706.4 192502 61415.9  
  C++ Note: riskr checked 45411.7  
  C++ Note: risk1r checked 28767.4 144720 52387.3  
  C++ Note: risk2r checked 28767.4 514964 151495  
  C++ Note: riskl checked 498.666  
  C++ Note: risk1l checked 304.226 1582.04 793.308  
  C++ Note: risk2l checked 304.226 5554.38 2609.55  
  C++ Note: df101 -124.812 -124.812 -124.812  
  C++ Note: df102 -0.467622 -22.6674 2.97163  
  C++ Note: df103 -6.02126 -30.6469 -1.27345  
  C++ Note: df104 0.426096 0.646539 0.157278  
  C++ Note: df105 0.0776618 0.739632 -2.33354  
  C++ Note: df106 266.907 5.50621 -42.001  
  C++ Note: ending guess 1
  C++ Note: df501 -118.395
  C++ Note: df504 0.6007434 0.09652814 1.157278  
  C++ Note: starting subterms 2 in guess 2
  C++ Note: values checked 0.426096 0.646539 0.157278  
  C++ Note: sums checked 7274.1 7274.1 1341.83  
  C++ Note: derivs checked 4601.97 23182.6 2733.27  
  C++ Note: second derivs checked 4601.97 82544.2 8524.37  
  C++ Note: dose checked 1000 1000  
  C++ Note: non-dose checked 7274.1 1341.83  
  C++ Note: LIN_non-dose checked 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000  
  C++ Note: LOGLIN_non-dose checked 7274.1 1341.83  
  C++ Note: risk checked 17001  
  C++ Note: risk1 checked 10706.4 54122.7 19625.6  
  C++ Note: risk2 checked 10706.4 192502 61415.9  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 45411.7  
  C++ Note: risk1r checked 28767.4 144720 52387.3  
  C++ Note: risk2r checked 28767.4 514964 151495  
  C++ Note: riskl checked 498.666  
  C++ Note: risk1l checked 304.226 1582.04 793.308  
  C++ Note: risk2l checked 304.226 5554.38 2609.55  
  C++ Note: df101 -124.812 -124.812 -124.812  
  C++ Note: df102 -0.467622 -22.6674 2.97163  
  C++ Note: df103 -6.02126 -30.6469 -1.27345  
  C++ Note: df104 0.426096 0.646539 0.157278  
  C++ Note: df105 0.0776618 0.739632 -2.33354  
  C++ Note: df106 266.907 5.50621 -42.001  
  C++ Note: Starting Halves
  C++ Note: df501 -118.395
  C++ Note: df504 0.6007434 0.09652814 1.157278  
  C++ Note: values checked 0.600743 0.0965281 1.15728  
  C++ Note: sums checked 1773.98 1773.98 32135.8  
  C++ Note: derivs checked 1194.6 4043.19 134742  
  C++ Note: second derivs checked 1194.6 12805.3 616015  
  C++ Note: dose checked 1000 1000  
  C++ Note: non-dose checked 1773.98 32135.8  
  C++ Note: LIN_non-dose checked 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000  
  C++ Note: LOGLIN_non-dose checked 1773.98 32135.8  
  C++ Note: risk checked 58026.5  
  C++ Note: risk1 checked 37651.2 135360 236019  
  C++ Note: risk2 checked 37651.2 427814 1.08252e+06  
  C++ Note: riskr checked 119495  
  C++ Note: risk1r checked 76635.5 283568 429089  
  C++ Note: risk2r checked 76635.5 896488 1.77407e+06  
  C++ Note: riskl checked 1711.94  
  C++ Note: risk1l checked 1027.65 4618.5 6140.17  
  C++ Note: risk2l checked 1027.65 15652.6 24115.3  
  C++ Note: df101 -118.395 -118.395 -118.395  
  C++ Note: df102 -0.782638 -0.410558 -4.43759  
  C++ Note: df103 -5.94091 -49.8573 -9.26764  
  C++ Note: df104 0.600743 0.0965281 1.15728  
  C++ Note: df105 0.131737 0.00823466 0.478826  
  C++ Note: df106 151.277 288.376 26.68  
  C++ Note: df100 46128 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:53 2024
  
  C++ Note: values checked 0.51342 0.371534 0.657278  
  C++ Note: sums checked 3370.53 3370.53 4972.82  
  C++ Note: derivs checked 2201.24 9415.6 15965.6  
  C++ Note: second derivs checked 2201.24 31933.3 62675  
  C++ Note: dose checked 1000 1000  
  C++ Note: non-dose checked 3370.53 4972.82  
  C++ Note: LIN_non-dose checked 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000  
  C++ Note: LOGLIN_non-dose checked 3370.53 4972.82  
  C++ Note: risk checked 20026.8  
  C++ Note: risk1 checked 12767.6 55905.5 53475  
  C++ Note: risk2 checked 12767.6 188523 210555  
  C++ Note: riskr checked 50427.9  
  C++ Note: risk1r checked 32128.2 141448 121549  
  C++ Note: risk2r checked 32128.2 477449 432448  
  C++ Note: riskl checked 694.008  
  C++ Note: risk1l checked 419.149 2059.62 1976.96  
  C++ Note: risk2l checked 419.149 7123.47 7257.54  
  C++ Note: df101 -119.04 -119.04 -119.04  
  C++ Note: df102 -0.595098 -12.7024 -0.0570081  
  C++ Note: df103 -5.99518 -41.9658 -9.15921  
  C++ Note: df104 0.51342 0.371534 0.657278  
  C++ Note: df105 0.0992627 0.302686 0.00622413  
  C++ Note: df106 200.035 9.37145 2088.13  
  C++ Note: df100 48386 2 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:53 2024
  
  C++ Note: Changing back to best
  C++ Note: values checked 0.426096 0.646539 0.157278  
  C++ Note: sums checked 7274.1 7274.1 1341.83  
  C++ Note: derivs checked 4601.97 23182.6 2733.27  
  C++ Note: second derivs checked 4601.97 82544.2 8524.37  
  C++ Note: dose checked 1000 1000  
  C++ Note: non-dose checked 7274.1 1341.83  
  C++ Note: LIN_non-dose checked 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000  
  C++ Note: LOGLIN_non-dose checked 7274.1 1341.83  
  C++ Note: risk checked 17001  
  C++ Note: risk1 checked 10706.4 54122.7 19625.6  
  C++ Note: risk2 checked 10706.4 192502 61415.9  
  C++ Note: riskr checked 45411.7  
  C++ Note: risk1r checked 28767.4 144720 52387.3  
  C++ Note: risk2r checked 28767.4 514964 151495  
  C++ Note: riskl checked 498.666  
  C++ Note: risk1l checked 304.226 1582.04 793.308  
  C++ Note: risk2l checked 304.226 5554.38 2609.55  
  C++ Note: df101 -124.812 -124.812 -124.812  
  C++ Note: df102 -0.467622 -22.6674 2.97163  
  C++ Note: df103 -6.02126 -30.6469 -1.27345  
  C++ Note: df104 0.426096 0.646539 0.157278  
  C++ Note: df105 0.0776618 0.739632 -2.33354  
  C++ Note: df106 266.907 5.50621 -42.001  
  C++ Note: ending guess 2
  C++ Note: df501 -118.395
  C++ Note: df504 0.6007434 0.09652814 1.157278  
  C++ Note: Refreshing matrices after all guesses
  C++ Note: Guess Results
  Guess number, parameter values, Log-Likelihood
  0, 0.6007434 0.09652814 1.157278, -118.395<-- Best Guess
  1, 0.4260961 0.646539 0.1572781, -124.8115
  2, 0.4260961 0.646539 0.1572781, -124.8115
  C++ Note: starting subterms 2 in best guess 0
  C++ Note: values checked 0.600743 0.0965281 1.15728  
  C++ Note: sums checked 1773.98 1773.98 32135.8  
  C++ Note: derivs checked 1194.6 4043.19 134742  
  C++ Note: second derivs checked 1194.6 12805.3 616015  
  C++ Note: dose checked 1000 1000  
  C++ Note: non-dose checked 1773.98 32135.8  
  C++ Note: LIN_non-dose checked 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000  
  C++ Note: LOGLIN_non-dose checked 1773.98 32135.8  
  C++ Note: risk checked 58026.5  
  C++ Note: risk1 checked 37651.2 135360 236019  
  C++ Note: risk2 checked 37651.2 427814 1.08252e+06  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 119495  
  C++ Note: risk1r checked 76635.5 283568 429089  
  C++ Note: risk2r checked 76635.5 896488 1.77407e+06  
  C++ Note: riskl checked 1711.94  
  C++ Note: risk1l checked 1027.65 4618.5 6140.17  
  C++ Note: risk2l checked 1027.65 15652.6 24115.3  
  C++ Note: df101 -118.395 -118.395 -118.395  
  C++ Note: df102 -0.782638 -0.410558 -4.43759  
  C++ Note: df103 -5.94091 -49.8573 -9.26764  
  C++ Note: df104 0.600743 0.0965281 1.15728  
  C++ Note: df105 0.131737 0.00823466 0.478826  
  C++ Note: df106 151.277 288.376 26.68  
  C++ Note: Starting Halves
  C++ Note: df501 -118.395
  C++ Note: df504 0.6007434 0.09652814 1.157278  
  C++ Note: values checked 0.469257 0.102151 0.78977  
  C++ Note: sums checked 1647.84 1647.84 7760.94  
  C++ Note: derivs checked 1060.93 3775.1 27203.7  
  C++ Note: second derivs checked 1060.93 11977.1 111988  
  C++ Note: dose checked 1000 1000  
  C++ Note: non-dose checked 1647.84 7760.94  
  C++ Note: LIN_non-dose checked 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000  
  C++ Note: LOGLIN_non-dose checked 1647.84 7760.94  
  C++ Note: risk checked 14328.5  
  C++ Note: risk1 checked 8953.84 33119.7 44341.6  
  C++ Note: risk2 checked 8953.84 104570 182492  
  C++ Note: riskr checked 34488.8  
  C++ Note: risk1r checked 21529.9 80578.6 94839.5  
  C++ Note: risk2r checked 21529.9 254610 351090  
  C++ Note: riskl checked 470.725  
  C++ Note: risk1l checked 299.436 1220.36 1425.98  
  C++ Note: risk2l checked 299.436 4016.13 5259.82  
  C++ Note: df101 -117.31 -117.31 -117.31  
  C++ Note: df102 -0.252504 -0.212118 -1.1189  
  C++ Note: df103 -6.08937 -50.5934 -9.22555  
  C++ Note: df104 0.469257 0.102151 0.78977  
  C++ Note: df105 0.0414663 0.00419259 0.121283  
  C++ Note: df106 464.589 553.044 104.844  
  C++ Note: df100 55371 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:53 2024
  
  C++ Note: riskr checked 34488.8  
  C++ Note: risk1r checked 21529.9 80578.6 94839.5  
  C++ Note: risk2r checked 21529.9 254610 351090  
  C++ Note: riskl checked 470.725  
  C++ Note: risk1l checked 299.436 1220.36 1425.98  
  C++ Note: risk2l checked 299.436 4016.13 5259.82  
  C++ Note: df101 -117.31 -117.31 -117.31  
  C++ Note: df102 -0.252504 -0.212118 -1.1189  
  C++ Note: df103 -6.08937 -50.5934 -9.22555  
  C++ Note: df104 0.469257 0.102151 0.78977  
  C++ Note: df105 0.0414663 0.00419259 0.121283  
  C++ Note: df106 464.589 553.044 104.844  
  C++ Note: riskr checked 34488.8  
  C++ Note: risk1r checked 21529.9 80578.6 94839.5  
  C++ Note: risk2r checked 21529.9 254610 351090  
  C++ Note: riskl checked 470.725  
  C++ Note: risk1l checked 299.436 1220.36 1425.98  
  C++ Note: risk2l checked 299.436 4016.13 5259.82  
  C++ Note: df101 -117.31 -117.31 -117.31  
  C++ Note: df102 -0.252504 -0.212118 -1.1189  
  C++ Note: df103 -6.08937 -50.5934 -9.22555  
  C++ Note: df104 0.469257 0.102151 0.78977  
  C++ Note: df105 0.0414663 0.00419259 0.121283  
  C++ Note: df106 464.589 553.044 104.844  
  C++ Note: Exiting Regression
  C++ Note: df501 -117.3104
  C++ Note: df504 0.4692569 0.1021509 0.7897698  
  Warning: model covariate order changed
  Note: 26 risk groups
  Error: guesses: 50 , iterations per guess: c(1, 1)
  Warning: model covariate order changed
  Note: 26 risk groups
  C++ Note: START_COX_GUESS
  C++ Note: Current Time, Fri Feb 23 05:58:53 2024
  
  C++ Note: Term checked 0 0 1  
  C++ Note: df99,68,Starting
  C++ Note: Current Time, Fri Feb 23 05:58:53 2024
  
  C++ Note: Grouping Start
  C++ Note: df100 394 0 0 -1,Prep_List
  C++ Note: Current Time, Fri Feb 23 05:58:53 2024
  
  C++ Note: starting subterms 2 in guess 0
  C++ Note: values checked 0.426096 0.646539 0.157278  
  C++ Note: sums checked 7274.1 7274.1 1341.83  
  C++ Note: derivs checked 4601.97 23182.6 2733.27  
  C++ Note: second derivs checked 4601.97 82544.2 8524.37  
  C++ Note: dose checked 1000 1000  
  C++ Note: non-dose checked 7274.1 1341.83  
  C++ Note: LIN_non-dose checked 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000  
  C++ Note: LOGLIN_non-dose checked 7274.1 1341.83  
  C++ Note: risk checked 17001  
  C++ Note: risk1 checked 10706.4 54122.7 19625.6  
  C++ Note: risk2 checked 10706.4 192502 61415.9  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 45411.7  
  C++ Note: risk1r checked 28767.4 144720 52387.3  
  C++ Note: risk2r checked 28767.4 514964 151495  
  C++ Note: riskl checked 498.666  
  C++ Note: risk1l checked 304.226 1582.04 793.308  
  C++ Note: risk2l checked 304.226 5554.38 2609.55  
  C++ Note: df101 -124.812 -124.812 -124.812  
  C++ Note: df102 -0.467622 -22.6674 2.97163  
  C++ Note: df103 -6.02126 -30.6469 -1.27345  
  C++ Note: df104 0.426096 0.646539 0.157278  
  C++ Note: df105 0.0776618 0.739632 -2.33354  
  C++ Note: df106 266.907 5.50621 -42.001  
  C++ Note: Starting Halves
  C++ Note: df501 -124.8115
  C++ Note: df504 0.4260961 0.646539 0.1572781  
  C++ Note: values checked 0.600743 0.0965281 1.15728  
  C++ Note: sums checked 1773.98 1773.98 32135.8  
  C++ Note: derivs checked 1194.6 4043.19 134742  
  C++ Note: second derivs checked 1194.6 12805.3 616015  
  C++ Note: dose checked 1000 1000  
  C++ Note: non-dose checked 1773.98 32135.8  
  C++ Note: LIN_non-dose checked 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000  
  C++ Note: LOGLIN_non-dose checked 1773.98 32135.8  
  C++ Note: risk checked 58026.5  
  C++ Note: risk1 checked 37651.2 135360 236019  
  C++ Note: risk2 checked 37651.2 427814 1.08252e+06  
  C++ Note: riskr checked 119495  
  C++ Note: risk1r checked 76635.5 283568 429089  
  C++ Note: risk2r checked 76635.5 896488 1.77407e+06  
  C++ Note: riskl checked 1711.94  
  C++ Note: risk1l checked 1027.65 4618.5 6140.17  
  C++ Note: risk2l checked 1027.65 15652.6 24115.3  
  C++ Note: df101 -118.395 -118.395 -118.395  
  C++ Note: df102 -0.782638 -0.410558 -4.43759  
  C++ Note: df103 -5.94091 -49.8573 -9.26764  
  C++ Note: df104 0.600743 0.0965281 1.15728  
  C++ Note: df105 0.131737 0.00823466 0.478826  
  C++ Note: df106 151.277 288.376 26.68  
  C++ Note: df100 4085 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:53 2024
  
  C++ Note: riskr checked 119495  
  C++ Note: risk1r checked 76635.5 283568 429089  
  C++ Note: risk2r checked 76635.5 896488 1.77407e+06  
  C++ Note: riskl checked 1711.94  
  C++ Note: risk1l checked 1027.65 4618.5 6140.17  
  C++ Note: risk2l checked 1027.65 15652.6 24115.3  
  C++ Note: df101 -118.395 -118.395 -118.395  
  C++ Note: df102 -0.782638 -0.410558 -4.43759  
  C++ Note: df103 -5.94091 -49.8573 -9.26764  
  C++ Note: df104 0.600743 0.0965281 1.15728  
  C++ Note: df105 0.131737 0.00823466 0.478826  
  C++ Note: df106 151.277 288.376 26.68  
  C++ Note: ending guess 0
  C++ Note: df501 -118.395
  C++ Note: df504 0.6007434 0.09652814 1.157278  
  C++ Note: Refreshing matrices after all guesses
  C++ Note: Guess Results
  Guess number, parameter values, Log-Likelihood
  0, 0.6007434 0.09652814 1.157278, -118.395<-- Best Guess
  C++ Note: starting subterms 2 in best guess 0
  C++ Note: values checked 0.600743 0.0965281 1.15728  
  C++ Note: sums checked 1773.98 1773.98 32135.8  
  C++ Note: derivs checked 1194.6 4043.19 134742  
  C++ Note: second derivs checked 1194.6 12805.3 616015  
  C++ Note: dose checked 1000 1000  
  C++ Note: non-dose checked 1773.98 32135.8  
  C++ Note: LIN_non-dose checked 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000  
  C++ Note: LOGLIN_non-dose checked 1773.98 32135.8  
  C++ Note: risk checked 58026.5  
  C++ Note: risk1 checked 37651.2 135360 236019  
  C++ Note: risk2 checked 37651.2 427814 1.08252e+06  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 119495  
  C++ Note: risk1r checked 76635.5 283568 429089  
  C++ Note: risk2r checked 76635.5 896488 1.77407e+06  
  C++ Note: riskl checked 1711.94  
  C++ Note: risk1l checked 1027.65 4618.5 6140.17  
  C++ Note: risk2l checked 1027.65 15652.6 24115.3  
  C++ Note: df101 -118.395 -118.395 -118.395  
  C++ Note: df102 -0.782638 -0.410558 -4.43759  
  C++ Note: df103 -5.94091 -49.8573 -9.26764  
  C++ Note: df104 0.600743 0.0965281 1.15728  
  C++ Note: df105 0.131737 0.00823466 0.478826  
  C++ Note: df106 151.277 288.376 26.68  
  C++ Note: Starting Halves
  C++ Note: df501 -118.395
  C++ Note: df504 0.6007434 0.09652814 1.157278  
  C++ Note: values checked 0.469257 0.102151 0.78977  
  C++ Note: sums checked 1647.84 1647.84 7760.94  
  C++ Note: derivs checked 1060.93 3775.1 27203.7  
  C++ Note: second derivs checked 1060.93 11977.1 111988  
  C++ Note: dose checked 1000 1000  
  C++ Note: non-dose checked 1647.84 7760.94  
  C++ Note: LIN_non-dose checked 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000  
  C++ Note: LOGLIN_non-dose checked 1647.84 7760.94  
  C++ Note: risk checked 14328.5  
  C++ Note: risk1 checked 8953.84 33119.7 44341.6  
  C++ Note: risk2 checked 8953.84 104570 182492  
  C++ Note: riskr checked 34488.8  
  C++ Note: risk1r checked 21529.9 80578.6 94839.5  
  C++ Note: risk2r checked 21529.9 254610 351090  
  C++ Note: riskl checked 470.725  
  C++ Note: risk1l checked 299.436 1220.36 1425.98  
  C++ Note: risk2l checked 299.436 4016.13 5259.82  
  C++ Note: df101 -117.31 -117.31 -117.31  
  C++ Note: df102 -0.252504 -0.212118 -1.1189  
  C++ Note: df103 -6.08937 -50.5934 -9.22555  
  C++ Note: df104 0.469257 0.102151 0.78977  
  C++ Note: df105 0.0414663 0.00419259 0.121283  
  C++ Note: df106 464.589 553.044 104.844  
  C++ Note: df100 20073 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:53 2024
  
  C++ Note: riskr checked 34488.8  
  C++ Note: risk1r checked 21529.9 80578.6 94839.5  
  C++ Note: risk2r checked 21529.9 254610 351090  
  C++ Note: riskl checked 470.725  
  C++ Note: risk1l checked 299.436 1220.36 1425.98  
  C++ Note: risk2l checked 299.436 4016.13 5259.82  
  C++ Note: df101 -117.31 -117.31 -117.31  
  C++ Note: df102 -0.252504 -0.212118 -1.1189  
  C++ Note: df103 -6.08937 -50.5934 -9.22555  
  C++ Note: df104 0.469257 0.102151 0.78977  
  C++ Note: df105 0.0414663 0.00419259 0.121283  
  C++ Note: df106 464.589 553.044 104.844  
  C++ Note: riskr checked 34488.8  
  C++ Note: risk1r checked 21529.9 80578.6 94839.5  
  C++ Note: risk2r checked 21529.9 254610 351090  
  C++ Note: riskl checked 470.725  
  C++ Note: risk1l checked 299.436 1220.36 1425.98  
  C++ Note: risk2l checked 299.436 4016.13 5259.82  
  C++ Note: df101 -117.31 -117.31 -117.31  
  C++ Note: df102 -0.252504 -0.212118 -1.1189  
  C++ Note: df103 -6.08937 -50.5934 -9.22555  
  C++ Note: df104 0.469257 0.102151 0.78977  
  C++ Note: df105 0.0414663 0.00419259 0.121283  
  C++ Note: df106 464.589 553.044 104.844  
  C++ Note: Exiting Regression
  C++ Note: df501 -117.3104
  C++ Note: df504 0.4692569 0.1021509 0.7897698  
  Warning: model covariate order changed
  Note: 26 risk groups
  C++ Note: START_COX_GUESS
  C++ Note: Current Time, Fri Feb 23 05:58:53 2024
  
  C++ Note: Term checked 0 0 1  
  C++ Note: df99,77,Starting
  C++ Note: Current Time, Fri Feb 23 05:58:53 2024
  
  C++ Note: Grouping Start
  C++ Note: df100 531 0 0 -1,Prep_List
  C++ Note: Current Time, Fri Feb 23 05:58:53 2024
  
  C++ Note: starting subterms 2 in guess 0
  C++ Note: values checked 0.426096 0.646539 0.157278  
  C++ Note: sums checked 7274.1 7274.1 1341.83  
  C++ Note: derivs checked 4601.97 23182.6 2733.27  
  C++ Note: second derivs checked 4601.97 82544.2 8524.37  
  C++ Note: dose checked 1000 1000  
  C++ Note: non-dose checked 7274.1 1341.83  
  C++ Note: LIN_non-dose checked 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000  
  C++ Note: LOGLIN_non-dose checked 7274.1 1341.83  
  C++ Note: risk checked 17001  
  C++ Note: risk1 checked 10706.4 54122.7 19625.6  
  C++ Note: risk2 checked 10706.4 192502 61415.9  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 45411.7  
  C++ Note: risk1r checked 28767.4 144720 52387.3  
  C++ Note: risk2r checked 28767.4 514964 151495  
  C++ Note: riskl checked 498.666  
  C++ Note: risk1l checked 304.226 1582.04 793.308  
  C++ Note: risk2l checked 304.226 5554.38 2609.55  
  C++ Note: df101 -124.812 -124.812 -124.812  
  C++ Note: df102 -0.467622 -22.6674 2.97163  
  C++ Note: df103 -6.02126 -30.6469 -1.27345  
  C++ Note: df104 0.426096 0.646539 0.157278  
  C++ Note: df105 0.0776618 0.739632 -2.33354  
  C++ Note: df106 266.907 5.50621 -42.001  
  C++ Note: Starting Halves
  C++ Note: df501 -124.8115
  C++ Note: df504 0.4260961 0.646539 0.1572781  
  C++ Note: values checked 0.600743 0.0965281 1.15728  
  C++ Note: sums checked 1773.98 1773.98 32135.8  
  C++ Note: derivs checked 1194.6 4043.19 134742  
  C++ Note: second derivs checked 1194.6 12805.3 616015  
  C++ Note: dose checked 1000 1000  
  C++ Note: non-dose checked 1773.98 32135.8  
  C++ Note: LIN_non-dose checked 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000  
  C++ Note: LOGLIN_non-dose checked 1773.98 32135.8  
  C++ Note: risk checked 58026.5  
  C++ Note: risk1 checked 37651.2 135360 236019  
  C++ Note: risk2 checked 37651.2 427814 1.08252e+06  
  C++ Note: riskr checked 119495  
  C++ Note: risk1r checked 76635.5 283568 429089  
  C++ Note: risk2r checked 76635.5 896488 1.77407e+06  
  C++ Note: riskl checked 1711.94  
  C++ Note: risk1l checked 1027.65 4618.5 6140.17  
  C++ Note: risk2l checked 1027.65 15652.6 24115.3  
  C++ Note: df101 -118.395 -118.395 -118.395  
  C++ Note: df102 -0.782638 -0.410558 -4.43759  
  C++ Note: df103 -5.94091 -49.8573 -9.26764  
  C++ Note: df104 0.600743 0.0965281 1.15728  
  C++ Note: df105 0.131737 0.00823466 0.478826  
  C++ Note: df106 151.277 288.376 26.68  
  C++ Note: df100 4250 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:53 2024
  
  C++ Note: riskr checked 119495  
  C++ Note: risk1r checked 76635.5 283568 429089  
  C++ Note: risk2r checked 76635.5 896488 1.77407e+06  
  C++ Note: riskl checked 1711.94  
  C++ Note: risk1l checked 1027.65 4618.5 6140.17  
  C++ Note: risk2l checked 1027.65 15652.6 24115.3  
  C++ Note: df101 -118.395 -118.395 -118.395  
  C++ Note: df102 -0.782638 -0.410558 -4.43759  
  C++ Note: df103 -5.94091 -49.8573 -9.26764  
  C++ Note: df104 0.600743 0.0965281 1.15728  
  C++ Note: df105 0.131737 0.00823466 0.478826  
  C++ Note: df106 151.277 288.376 26.68  
  C++ Note: ending guess 0
  C++ Note: df501 -118.395
  C++ Note: df504 0.6007434 0.09652814 1.157278  
  C++ Note: Refreshing matrices after all guesses
  C++ Note: Guess Results
  Guess number, parameter values, Log-Likelihood
  0, 0.6007434 0.09652814 1.157278, -118.395<-- Best Guess
  C++ Note: starting subterms 2 in best guess 0
  C++ Note: values checked 0.600743 0.0965281 1.15728  
  C++ Note: sums checked 1773.98 1773.98 32135.8  
  C++ Note: derivs checked 1194.6 4043.19 134742  
  C++ Note: second derivs checked 1194.6 12805.3 616015  
  C++ Note: dose checked 1000 1000  
  C++ Note: non-dose checked 1773.98 32135.8  
  C++ Note: LIN_non-dose checked 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000  
  C++ Note: LOGLIN_non-dose checked 1773.98 32135.8  
  C++ Note: risk checked 58026.5  
  C++ Note: risk1 checked 37651.2 135360 236019  
  C++ Note: risk2 checked 37651.2 427814 1.08252e+06  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 119495  
  C++ Note: risk1r checked 76635.5 283568 429089  
  C++ Note: risk2r checked 76635.5 896488 1.77407e+06  
  C++ Note: riskl checked 1711.94  
  C++ Note: risk1l checked 1027.65 4618.5 6140.17  
  C++ Note: risk2l checked 1027.65 15652.6 24115.3  
  C++ Note: df101 -118.395 -118.395 -118.395  
  C++ Note: df102 -0.782638 -0.410558 -4.43759  
  C++ Note: df103 -5.94091 -49.8573 -9.26764  
  C++ Note: df104 0.600743 0.0965281 1.15728  
  C++ Note: df105 0.131737 0.00823466 0.478826  
  C++ Note: df106 151.277 288.376 26.68  
  C++ Note: Starting Halves
  C++ Note: df501 -118.395
  C++ Note: df504 0.6007434 0.09652814 1.157278  
  C++ Note: values checked 0.469257 0.102151 0.78977  
  C++ Note: sums checked 1647.84 1647.84 7760.94  
  C++ Note: derivs checked 1060.93 3775.1 27203.7  
  C++ Note: second derivs checked 1060.93 11977.1 111988  
  C++ Note: dose checked 1000 1000  
  C++ Note: non-dose checked 1647.84 7760.94  
  C++ Note: LIN_non-dose checked 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000  
  C++ Note: LOGLIN_non-dose checked 1647.84 7760.94  
  C++ Note: risk checked 14328.5  
  C++ Note: risk1 checked 8953.84 33119.7 44341.6  
  C++ Note: risk2 checked 8953.84 104570 182492  
  C++ Note: riskr checked 34488.8  
  C++ Note: risk1r checked 21529.9 80578.6 94839.5  
  C++ Note: risk2r checked 21529.9 254610 351090  
  C++ Note: riskl checked 470.725  
  C++ Note: risk1l checked 299.436 1220.36 1425.98  
  C++ Note: risk2l checked 299.436 4016.13 5259.82  
  C++ Note: df101 -117.31 -117.31 -117.31  
  C++ Note: df102 -0.252504 -0.212118 -1.1189  
  C++ Note: df103 -6.08937 -50.5934 -9.22555  
  C++ Note: df104 0.469257 0.102151 0.78977  
  C++ Note: df105 0.0414663 0.00419259 0.121283  
  C++ Note: df106 464.589 553.044 104.844  
  C++ Note: df100 32021 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:53 2024
  
  C++ Note: riskr checked 34488.8  
  C++ Note: risk1r checked 21529.9 80578.6 94839.5  
  C++ Note: risk2r checked 21529.9 254610 351090  
  C++ Note: riskl checked 470.725  
  C++ Note: risk1l checked 299.436 1220.36 1425.98  
  C++ Note: risk2l checked 299.436 4016.13 5259.82  
  C++ Note: df101 -117.31 -117.31 -117.31  
  C++ Note: df102 -0.252504 -0.212118 -1.1189  
  C++ Note: df103 -6.08937 -50.5934 -9.22555  
  C++ Note: df104 0.469257 0.102151 0.78977  
  C++ Note: df105 0.0414663 0.00419259 0.121283  
  C++ Note: df106 464.589 553.044 104.844  
  C++ Note: riskr checked 34488.8  
  C++ Note: risk1r checked 21529.9 80578.6 94839.5  
  C++ Note: risk2r checked 21529.9 254610 351090  
  C++ Note: riskl checked 470.725  
  C++ Note: risk1l checked 299.436 1220.36 1425.98  
  C++ Note: risk2l checked 299.436 4016.13 5259.82  
  C++ Note: df101 -117.31 -117.31 -117.31  
  C++ Note: df102 -0.252504 -0.212118 -1.1189  
  C++ Note: df103 -6.08937 -50.5934 -9.22555  
  C++ Note: df104 0.469257 0.102151 0.78977  
  C++ Note: df105 0.0414663 0.00419259 0.121283  
  C++ Note: df106 464.589 553.044 104.844  
  C++ Note: Exiting Regression
  C++ Note: df501 -117.3104
  C++ Note: df504 0.4692569 0.1021509 0.7897698  
  Warning: model covariate order changed
  Note: 26 risk groups
  C++ Note: START_COX_GUESS
  C++ Note: Current Time, Fri Feb 23 05:58:53 2024
  
  C++ Note: Term checked 0 0 1  
  C++ Note: df99,86,Starting
  C++ Note: Current Time, Fri Feb 23 05:58:53 2024
  
  C++ Note: Grouping Start
  C++ Note: df100 441 0 0 -1,Prep_List
  C++ Note: Current Time, Fri Feb 23 05:58:53 2024
  
  C++ Note: starting subterms 2 in guess 0
  C++ Note: values checked -0.1 -0.1 0.2  
  C++ Note: sums checked -261.4 -261.4 341.682  
  C++ Note: derivs checked 531 2083 1708.41  
  C++ Note: second derivs checked 0 0 0  
  C++ Note: dose checked 1000 1000  
  C++ Note: non-dose checked -261.4 341.682  
  C++ Note: LIN_non-dose checked -261.4 341.682  
  C++ Note: PLIN_non-dose checked 1000 1000  
  C++ Note: LOGLIN_non-dose checked 1000 1000  
  C++ Error: A non-positive risk was detected: -1.111148
  C++ Warning: final failing values -0.1 -0.1 0.2  
  Invalid risk
  Warning: model covariate order changed
  C++ Note: START_POIS_GUESS
  C++ Note: Current Time, Fri Feb 23 05:58:54 2024
  
  C++ Note: Term checked 0 0 1  
  C++ Note: df99,91,Starting
  C++ Note: Current Time, Fri Feb 23 05:58:54 2024
  
  C++ Note: starting subterms 2 in guess 0
  C++ Note: values checked 0.426096 0.646539 0.157278  
  C++ Note: sums checked 7274.1 7274.1 1341.83  
  C++ Note: derivs checked 4601.97 23182.6 2733.27  
  C++ Note: second derivs checked 4601.97 82544.2 8524.37  
  C++ Note: dose checked 1000 1000  
  C++ Note: non-dose checked 7274.1 1341.83  
  C++ Note: LIN_non-dose checked 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000  
  C++ Note: LOGLIN_non-dose checked 7274.1 1341.83  
  C++ Note: risk checked 17001  
  C++ Note: risk1 checked 10706.4 54122.7 19625.6  
  C++ Note: risk2 checked 10706.4 192502 61415.9  
  C++ Note: df101 -18942.2 -18942.2 -18942.2  
  C++ Note: df102 -12053.5 -60927.3 -21843.1  
  C++ Note: df103 -12141.5 -218114 -69007.6  
  C++ Note: df104 0.426096 0.646539 0.157278  
  C++ Note: Checking Deviance 37742.9
  C++ Note: df105 0.992752 0.279337 0.316532  
  C++ Note: df106 1.57151 0.310899 0.867193  
  C++ Note: Starting Halves
  C++ Note: df501 -18942.23
  C++ Note: df504 0.4260961 0.646539 0.1572781  
  C++ Note: values checked 0.254195 0.478304 0.123322  
  C++ Note: sums checked 3900.36 3900.36 1253.74  
  C++ Note: derivs checked 2309.18 11554.8 2460.98  
  C++ Note: second derivs checked 2309.18 40015.3 7535.66  
  C++ Note: dose checked 1000 1000  
  C++ Note: non-dose checked 3900.36 1253.74  
  C++ Note: LIN_non-dose checked 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000  
  C++ Note: LOGLIN_non-dose checked 3900.36 1253.74  
  C++ Note: risk checked 8783.44  
  C++ Note: risk1 checked 5182.78 26003.4 9537.67  
  C++ Note: risk2 checked 5182.78 89978.1 29321.3  
  C++ Note: df101 -9722.07 -9722.07 -9722.07  
  C++ Note: df102 -5791.51 -29075 -10520.7  
  C++ Note: df103 -5879.51 -101991 -32827.7  
  C++ Note: df104 0.254195 0.478304 0.123322  
  C++ Note: Checking Deviance 19302.5
  C++ Note: df105 0.985033 0.285074 0.320482  
  C++ Note: df106 1.67868 0.334379 0.924092  
  C++ Note: df100 2625 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:54 2024
  
  C++ Note: df100 2708 0 0 0,Update_Calc
  C++ Note: Current Time, Fri Feb 23 05:58:54 2024
  
  C++ Note: df101 -9722.072 -9722.072 -9722.072  
  C++ Note: df102 -5791.513 -29075.02 -10520.68  
  C++ Note: df103 -5879.513 -101991.2 -32827.7  
  C++ Note: df104 0.2541947 0.4783037 0.1233221  
  C++ Note: Checking Deviance 19302.54
  C++ Note: df105 0.9850328 0.2850738 0.3204818  
  C++ Note: df106 1.678676 0.3343789 0.9240916  
  C++ Note: df101 -9722.07 -9722.07 -9722.07  
  C++ Note: df102 -5791.51 -29075 -10520.7  
  C++ Note: df103 -5879.51 -101991 -32827.7  
  C++ Note: df104 0.254195 0.478304 0.123322  
  C++ Note: Checking Deviance 19302.5
  C++ Note: df105 0.985033 0.285074 0.320482  
  C++ Note: df106 1.67868 0.334379 0.924092  
  C++ Note: ending guess 0
  C++ Note: df501 -9722.072
  C++ Note: df504 0.2541947 0.4783037 0.1233221  
  C++ Note: Refreshing matrices after all guesses
  C++ Note: Guess Results
  Guess number, parameter values, Log-Likelihood
  0, 0.2541947 0.4783037 0.1233221, -9722.072<-- Best Guess
  C++ Note: starting subterms 2 in best guess 0
  C++ Note: values checked 0.254195 0.478304 0.123322  
  C++ Note: sums checked 3900.36 3900.36 1253.74  
  C++ Note: derivs checked 2309.18 11554.8 2460.98  
  C++ Note: second derivs checked 2309.18 40015.3 7535.66  
  C++ Note: dose checked 1000 1000  
  C++ Note: non-dose checked 3900.36 1253.74  
  C++ Note: LIN_non-dose checked 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000  
  C++ Note: LOGLIN_non-dose checked 3900.36 1253.74  
  C++ Note: risk checked 8783.44  
  C++ Note: risk1 checked 5182.78 26003.4 9537.67  
  C++ Note: risk2 checked 5182.78 89978.1 29321.3  
  C++ Note: Made Risk Side Lists
  C++ Note: df101 -9722.07 -9722.07 -9722.07  
  C++ Note: df102 -5791.51 -29075 -10520.7  
  C++ Note: df103 -5879.51 -101991 -32827.7  
  C++ Note: df104 0.254195 0.478304 0.123322  
  C++ Note: Checking Deviance 19302.5
  C++ Note: df105 0.985033 0.285074 0.320482  
  C++ Note: df106 1.67868 0.334379 0.924092  
  C++ Note: Starting Halves
  C++ Note: df501 -9722.072
  C++ Note: df504 0.2541947 0.4783037 0.1233221  
  C++ Note: values checked 0.0500616 0.312566 0.0802485  
  C++ Note: sums checked 2172.57 2172.57 1154.38  
  C++ Note: derivs checked 1178.37 5851.84 2160.22  
  C++ Note: second derivs checked 1178.37 19594.1 6459.87  
  C++ Note: dose checked 1000 1000  
  C++ Note: non-dose checked 2172.57 1154.38  
  C++ Note: LIN_non-dose checked 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000  
  C++ Note: LOGLIN_non-dose checked 2172.57 1154.38  
  C++ Note: risk checked 4679.98  
  C++ Note: risk1 checked 2533.3 12602.3 4687.51  
  C++ Note: risk2 checked 2533.3 42177.5 14076.6  
  C++ Note: df101 -5164.53 -5164.53 -5164.53  
  C++ Note: df102 -2787.43 -13890.9 -5084.88  
  C++ Note: df103 -2875.43 -47831.4 -15650.9  
  C++ Note: df104 0.0500616 0.312566 0.0802485  
  C++ Note: Checking Deviance 10187.5
  C++ Note: df105 0.969396 0.290413 0.324893  
  C++ Note: df106 1.85279 0.371793 1.01567  
  C++ Note: df100 5739 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:54 2024
  
  C++ Note: df100 5817 0 0 0,Update_Calc
  C++ Note: Current Time, Fri Feb 23 05:58:54 2024
  
  C++ Note: df101 -5164.534 -5164.534 -5164.534  
  C++ Note: df102 -2787.432 -13890.89 -5084.875  
  C++ Note: df103 -2875.432 -47831.43 -15650.91  
  C++ Note: df104 0.05006156 0.3125659 0.0802485  
  C++ Note: Checking Deviance 10187.47
  C++ Note: df105 0.9693959 0.2904134 0.3248932  
  C++ Note: df106 1.852793 0.371793 1.015666  
  C++ Note: df101 -5164.53 -5164.53 -5164.53  
  C++ Note: df102 -2787.43 -13890.9 -5084.88  
  C++ Note: df103 -2875.43 -47831.4 -15650.9  
  C++ Note: df104 0.0500616 0.312566 0.0802485  
  C++ Note: Checking Deviance 10187.5
  C++ Note: df105 0.969396 0.290413 0.324893  
  C++ Note: df106 1.85279 0.371793 1.01567  
  C++ Note: df501 -5164.534
  C++ Note: df504 0.05006156 0.3125659 0.0802485  
  Error: Atleast one parameter must be free
  Warning: model covariate order changed
  Error: no events
  Warning: model covariate order changed
  Note: Initial starts: 1 , Number of iterations provided: 4 . Colossus requires one more iteration counts than number of guesses (for best guess)
  C++ Note: START_POIS_GUESS
  C++ Note: Current Time, Fri Feb 23 05:58:54 2024
  
  C++ Note: Term checked 0 0 1  
  C++ Note: df99,81,Starting
  C++ Note: Current Time, Fri Feb 23 05:58:54 2024
  
  C++ Note: starting subterms 2 in guess 0
  C++ Note: values checked 0.426096 0.646539 0.157278  
  C++ Note: sums checked 7274.1 7274.1 1341.83  
  C++ Note: derivs checked 4601.97 23182.6 2733.27  
  C++ Note: second derivs checked 4601.97 82544.2 8524.37  
  C++ Note: dose checked 1000 1000  
  C++ Note: non-dose checked 7274.1 1341.83  
  C++ Note: LIN_non-dose checked 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000  
  C++ Note: LOGLIN_non-dose checked 7274.1 1341.83  
  C++ Note: risk checked 17001  
  C++ Note: risk1 checked 10706.4 54122.7 19625.6  
  C++ Note: risk2 checked 10706.4 192502 61415.9  
  C++ Note: df101 -18942.2 -18942.2 -18942.2  
  C++ Note: df102 -12053.5 -60927.3 -21843.1  
  C++ Note: df103 -12141.5 -218114 -69007.6  
  C++ Note: df104 0.426096 0.646539 0.157278  
  C++ Note: Checking Deviance 37742.9
  C++ Note: df105 0.992752 0.279337 0.316532  
  C++ Note: df106 1.57151 0.310899 0.867193  
  C++ Note: Starting Halves
  C++ Note: df501 -18942.23
  C++ Note: df504 0.4260961 0.646539 0.1572781  
  C++ Note: values checked 0.254195 0.478304 0.123322  
  C++ Note: sums checked 3900.36 3900.36 1253.74  
  C++ Note: derivs checked 2309.18 11554.8 2460.98  
  C++ Note: second derivs checked 2309.18 40015.3 7535.66  
  C++ Note: dose checked 1000 1000  
  C++ Note: non-dose checked 3900.36 1253.74  
  C++ Note: LIN_non-dose checked 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000  
  C++ Note: LOGLIN_non-dose checked 3900.36 1253.74  
  C++ Note: risk checked 8783.44  
  C++ Note: risk1 checked 5182.78 26003.4 9537.67  
  C++ Note: risk2 checked 5182.78 89978.1 29321.3  
  C++ Note: df101 -9722.07 -9722.07 -9722.07  
  C++ Note: df102 -5791.51 -29075 -10520.7  
  C++ Note: df103 -5879.51 -101991 -32827.7  
  C++ Note: df104 0.254195 0.478304 0.123322  
  C++ Note: Checking Deviance 19302.5
  C++ Note: df105 0.985033 0.285074 0.320482  
  C++ Note: df106 1.67868 0.334379 0.924092  
  C++ Note: df100 2800 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:54 2024
  
  C++ Note: df100 2897 0 0 0,Update_Calc
  C++ Note: Current Time, Fri Feb 23 05:58:54 2024
  
  C++ Note: df101 -9722.072 -9722.072 -9722.072  
  C++ Note: df102 -5791.513 -29075.02 -10520.68  
  C++ Note: df103 -5879.513 -101991.2 -32827.7  
  C++ Note: df104 0.2541947 0.4783037 0.1233221  
  C++ Note: Checking Deviance 19302.54
  C++ Note: df105 0.9850328 0.2850738 0.3204818  
  C++ Note: df106 1.678676 0.3343789 0.9240916  
  C++ Note: df101 -9722.07 -9722.07 -9722.07  
  C++ Note: df102 -5791.51 -29075 -10520.7  
  C++ Note: df103 -5879.51 -101991 -32827.7  
  C++ Note: df104 0.254195 0.478304 0.123322  
  C++ Note: Checking Deviance 19302.5
  C++ Note: df105 0.985033 0.285074 0.320482  
  C++ Note: df106 1.67868 0.334379 0.924092  
  C++ Note: ending guess 0
  C++ Note: df501 -9722.072
  C++ Note: df504 0.2541947 0.4783037 0.1233221  
  C++ Note: Refreshing matrices after all guesses
  C++ Note: Guess Results
  Guess number, parameter values, Log-Likelihood
  0, 0.2541947 0.4783037 0.1233221, -9722.072<-- Best Guess
  C++ Note: starting subterms 2 in best guess 0
  C++ Note: values checked 0.254195 0.478304 0.123322  
  C++ Note: sums checked 3900.36 3900.36 1253.74  
  C++ Note: derivs checked 2309.18 11554.8 2460.98  
  C++ Note: second derivs checked 2309.18 40015.3 7535.66  
  C++ Note: dose checked 1000 1000  
  C++ Note: non-dose checked 3900.36 1253.74  
  C++ Note: LIN_non-dose checked 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000  
  C++ Note: LOGLIN_non-dose checked 3900.36 1253.74  
  C++ Note: risk checked 8783.44  
  C++ Note: risk1 checked 5182.78 26003.4 9537.67  
  C++ Note: risk2 checked 5182.78 89978.1 29321.3  
  C++ Note: Made Risk Side Lists
  C++ Note: df101 -9722.07 -9722.07 -9722.07  
  C++ Note: df102 -5791.51 -29075 -10520.7  
  C++ Note: df103 -5879.51 -101991 -32827.7  
  C++ Note: df104 0.254195 0.478304 0.123322  
  C++ Note: Checking Deviance 19302.5
  C++ Note: df105 0.985033 0.285074 0.320482  
  C++ Note: df106 1.67868 0.334379 0.924092  
  C++ Note: Starting Halves
  C++ Note: df501 -9722.072
  C++ Note: df504 0.2541947 0.4783037 0.1233221  
  C++ Note: values checked 0.0500616 0.312566 0.0802485  
  C++ Note: sums checked 2172.57 2172.57 1154.38  
  C++ Note: derivs checked 1178.37 5851.84 2160.22  
  C++ Note: second derivs checked 1178.37 19594.1 6459.87  
  C++ Note: dose checked 1000 1000  
  C++ Note: non-dose checked 2172.57 1154.38  
  C++ Note: LIN_non-dose checked 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000  
  C++ Note: LOGLIN_non-dose checked 2172.57 1154.38  
  C++ Note: risk checked 4679.98  
  C++ Note: risk1 checked 2533.3 12602.3 4687.51  
  C++ Note: risk2 checked 2533.3 42177.5 14076.6  
  C++ Note: df101 -5164.53 -5164.53 -5164.53  
  C++ Note: df102 -2787.43 -13890.9 -5084.88  
  C++ Note: df103 -2875.43 -47831.4 -15650.9  
  C++ Note: df104 0.0500616 0.312566 0.0802485  
  C++ Note: Checking Deviance 10187.5
  C++ Note: df105 0.969396 0.290413 0.324893  
  C++ Note: df106 1.85279 0.371793 1.01567  
  C++ Note: df100 6204 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:54 2024
  
  C++ Note: df100 6287 0 0 0,Update_Calc
  C++ Note: Current Time, Fri Feb 23 05:58:54 2024
  
  C++ Note: df101 -5164.534 -5164.534 -5164.534  
  C++ Note: df102 -2787.432 -13890.89 -5084.875  
  C++ Note: df103 -2875.432 -47831.43 -15650.91  
  C++ Note: df104 0.05006156 0.3125659 0.0802485  
  C++ Note: Checking Deviance 10187.47
  C++ Note: df105 0.9693959 0.2904134 0.3248932  
  C++ Note: df106 1.852793 0.371793 1.015666  
  C++ Note: df101 -5164.53 -5164.53 -5164.53  
  C++ Note: df102 -2787.43 -13890.9 -5084.88  
  C++ Note: df103 -2875.43 -47831.4 -15650.9  
  C++ Note: df104 0.0500616 0.312566 0.0802485  
  C++ Note: Checking Deviance 10187.5
  C++ Note: df105 0.969396 0.290413 0.324893  
  C++ Note: df106 1.85279 0.371793 1.01567  
  C++ Note: df501 -5164.534
  C++ Note: df504 0.05006156 0.3125659 0.0802485  
  Warning: model covariate order changed
  Note: Initial starts: 3 , Number of iterations provided: 2 . Colossus requires one more iteration counts than number of guesses (for best guess)
  C++ Note: START_POIS_GUESS
  C++ Note: Current Time, Fri Feb 23 05:58:54 2024
  
  C++ Note: Term checked 0 0 1  
  C++ Note: df99,68,Starting
  C++ Note: Current Time, Fri Feb 23 05:58:54 2024
  
  C++ Note: starting subterms 2 in guess 0
  C++ Note: values checked 0.426096 0.646539 0.157278  
  C++ Note: sums checked 7274.1 7274.1 1341.83  
  C++ Note: derivs checked 4601.97 23182.6 2733.27  
  C++ Note: second derivs checked 4601.97 82544.2 8524.37  
  C++ Note: dose checked 1000 1000  
  C++ Note: non-dose checked 7274.1 1341.83  
  C++ Note: LIN_non-dose checked 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000  
  C++ Note: LOGLIN_non-dose checked 7274.1 1341.83  
  C++ Note: risk checked 17001  
  C++ Note: risk1 checked 10706.4 54122.7 19625.6  
  C++ Note: risk2 checked 10706.4 192502 61415.9  
  C++ Note: df101 -18942.2 -18942.2 -18942.2  
  C++ Note: df102 -12053.5 -60927.3 -21843.1  
  C++ Note: df103 -12141.5 -218114 -69007.6  
  C++ Note: df104 0.426096 0.646539 0.157278  
  C++ Note: Checking Deviance 37742.9
  C++ Note: df105 0.992752 0.279337 0.316532  
  C++ Note: df106 1.57151 0.310899 0.867193  
  C++ Note: Starting Halves
  C++ Note: df501 -18942.23
  C++ Note: df504 0.4260961 0.646539 0.1572781  
  C++ Note: values checked 0.254195 0.478304 0.123322  
  C++ Note: sums checked 3900.36 3900.36 1253.74  
  C++ Note: derivs checked 2309.18 11554.8 2460.98  
  C++ Note: second derivs checked 2309.18 40015.3 7535.66  
  C++ Note: dose checked 1000 1000  
  C++ Note: non-dose checked 3900.36 1253.74  
  C++ Note: LIN_non-dose checked 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000  
  C++ Note: LOGLIN_non-dose checked 3900.36 1253.74  
  C++ Note: risk checked 8783.44  
  C++ Note: risk1 checked 5182.78 26003.4 9537.67  
  C++ Note: risk2 checked 5182.78 89978.1 29321.3  
  C++ Note: df101 -9722.07 -9722.07 -9722.07  
  C++ Note: df102 -5791.51 -29075 -10520.7  
  C++ Note: df103 -5879.51 -101991 -32827.7  
  C++ Note: df104 0.254195 0.478304 0.123322  
  C++ Note: Checking Deviance 19302.5
  C++ Note: df105 0.985033 0.285074 0.320482  
  C++ Note: df106 1.67868 0.334379 0.924092  
  C++ Note: df100 2623 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:54 2024
  
  C++ Note: df100 2707 0 0 0,Update_Calc
  C++ Note: Current Time, Fri Feb 23 05:58:54 2024
  
  C++ Note: df101 -9722.072 -9722.072 -9722.072  
  C++ Note: df102 -5791.513 -29075.02 -10520.68  
  C++ Note: df103 -5879.513 -101991.2 -32827.7  
  C++ Note: df104 0.2541947 0.4783037 0.1233221  
  C++ Note: Checking Deviance 19302.54
  C++ Note: df105 0.9850328 0.2850738 0.3204818  
  C++ Note: df106 1.678676 0.3343789 0.9240916  
  C++ Note: df101 -9722.07 -9722.07 -9722.07  
  C++ Note: df102 -5791.51 -29075 -10520.7  
  C++ Note: df103 -5879.51 -101991 -32827.7  
  C++ Note: df104 0.254195 0.478304 0.123322  
  C++ Note: Checking Deviance 19302.5
  C++ Note: df105 0.985033 0.285074 0.320482  
  C++ Note: df106 1.67868 0.334379 0.924092  
  C++ Note: ending guess 0
  C++ Note: df501 -9722.072
  C++ Note: df504 0.2541947 0.4783037 0.1233221  
  C++ Note: starting subterms 2 in guess 1
  C++ Note: values checked 0.426096 0.646539 0.157278  
  C++ Note: sums checked 7274.1 7274.1 1341.83  
  C++ Note: derivs checked 4601.97 23182.6 2733.27  
  C++ Note: second derivs checked 4601.97 82544.2 8524.37  
  C++ Note: dose checked 1000 1000  
  C++ Note: non-dose checked 7274.1 1341.83  
  C++ Note: LIN_non-dose checked 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000  
  C++ Note: LOGLIN_non-dose checked 7274.1 1341.83  
  C++ Note: risk checked 17001  
  C++ Note: risk1 checked 10706.4 54122.7 19625.6  
  C++ Note: risk2 checked 10706.4 192502 61415.9  
  C++ Note: df101 -18942.2 -18942.2 -18942.2  
  C++ Note: df102 -12053.5 -60927.3 -21843.1  
  C++ Note: df103 -12141.5 -218114 -69007.6  
  C++ Note: df104 0.426096 0.646539 0.157278  
  C++ Note: Checking Deviance 37742.9
  C++ Note: df105 0.992752 0.279337 0.316532  
  C++ Note: df106 1.57151 0.310899 0.867193  
  C++ Note: Starting Halves
  C++ Note: df501 -9722.072
  C++ Note: df504 0.2541947 0.4783037 0.1233221  
  C++ Note: values checked 0.254195 0.478304 0.123322  
  C++ Note: sums checked 3900.36 3900.36 1253.74  
  C++ Note: derivs checked 2309.18 11554.8 2460.98  
  C++ Note: second derivs checked 2309.18 40015.3 7535.66  
  C++ Note: dose checked 1000 1000  
  C++ Note: non-dose checked 3900.36 1253.74  
  C++ Note: LIN_non-dose checked 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000  
  C++ Note: LOGLIN_non-dose checked 3900.36 1253.74  
  C++ Note: risk checked 8783.44  
  C++ Note: risk1 checked 5182.78 26003.4 9537.67  
  C++ Note: risk2 checked 5182.78 89978.1 29321.3  
  C++ Note: df101 -9722.07 -9722.07 -9722.07  
  C++ Note: df102 -5791.51 -29075 -10520.7  
  C++ Note: df103 -5879.51 -101991 -32827.7  
  C++ Note: df104 0.254195 0.478304 0.123322  
  C++ Note: Checking Deviance 19302.5
  C++ Note: df105 0.985033 0.285074 0.320482  
  C++ Note: df106 1.67868 0.334379 0.924092  
  C++ Note: df100 5626 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:54 2024
  
  C++ Note: values checked 0.340145 0.562421 0.1403  
  C++ Note: sums checked 5296.79 5296.79 1296.63  
  C++ Note: derivs checked 3244.35 16318.8 2592.93  
  C++ Note: second derivs checked 3244.35 57346.2 8013.16  
  C++ Note: dose checked 1000 1000  
  C++ Note: non-dose checked 5296.79 1296.63  
  C++ Note: LIN_non-dose checked 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000  
  C++ Note: LOGLIN_non-dose checked 5296.79 1296.63  
  C++ Note: risk checked 12148.9  
  C++ Note: risk1 checked 7411.88 37396.1 13604.8  
  C++ Note: risk2 checked 7411.88 131289 42203  
  C++ Note: df101 -13490.5 -13490.5 -13490.5  
  C++ Note: df102 -8318.73 -41981.5 -15084.1  
  C++ Note: df103 -8406.73 -148787 -47345.2  
  C++ Note: df104 0.340145 0.562421 0.1403  
  C++ Note: Checking Deviance 26839.3
  C++ Note: df105 0.989532 0.282158 0.318597  
  C++ Note: df106 1.6217 0.321343 0.894353  
  C++ Note: df100 6776 2 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:54 2024
  
  C++ Note: Changing back to best
  C++ Note: values checked 0.426096 0.646539 0.157278  
  C++ Note: sums checked 7274.1 7274.1 1341.83  
  C++ Note: derivs checked 4601.97 23182.6 2733.27  
  C++ Note: second derivs checked 4601.97 82544.2 8524.37  
  C++ Note: dose checked 1000 1000  
  C++ Note: non-dose checked 7274.1 1341.83  
  C++ Note: LIN_non-dose checked 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000  
  C++ Note: LOGLIN_non-dose checked 7274.1 1341.83  
  C++ Note: risk checked 17001  
  C++ Note: risk1 checked 10706.4 54122.7 19625.6  
  C++ Note: risk2 checked 10706.4 192502 61415.9  
  C++ Note: df101 -18942.2 -18942.2 -18942.2  
  C++ Note: df102 -12053.5 -60927.3 -21843.1  
  C++ Note: df103 -12141.5 -218114 -69007.6  
  C++ Note: df104 0.426096 0.646539 0.157278  
  C++ Note: Checking Deviance 37742.9
  C++ Note: df105 0.992752 0.279337 0.316532  
  C++ Note: df106 1.57151 0.310899 0.867193  
  C++ Note: df100 8279 0 0 0,Update_Calc
  C++ Note: Current Time, Fri Feb 23 05:58:54 2024
  
  C++ Note: df101 -18942.23 -18942.23 -18942.23  
  C++ Note: df102 -12053.55 -60927.32 -21843.14  
  C++ Note: df103 -12141.55 -218114.1 -69007.65  
  C++ Note: df104 0.4260961 0.646539 0.1572781  
  C++ Note: Checking Deviance 37742.86
  C++ Note: df105 0.9927522 0.2793369 0.3165322  
  C++ Note: df106 1.571507 0.3108988 0.8671935  
  C++ Note: df101 -18942.2 -18942.2 -18942.2  
  C++ Note: df102 -12053.5 -60927.3 -21843.1  
  C++ Note: df103 -12141.5 -218114 -69007.6  
  C++ Note: df104 0.426096 0.646539 0.157278  
  C++ Note: Checking Deviance 37742.9
  C++ Note: df105 0.992752 0.279337 0.316532  
  C++ Note: df106 1.57151 0.310899 0.867193  
  C++ Note: ending guess 1
  C++ Note: df501 -9722.072
  C++ Note: df504 0.2541947 0.4783037 0.1233221  
  C++ Note: starting subterms 2 in guess 2
  C++ Note: values checked 0.426096 0.646539 0.157278  
  C++ Note: sums checked 7274.1 7274.1 1341.83  
  C++ Note: derivs checked 4601.97 23182.6 2733.27  
  C++ Note: second derivs checked 4601.97 82544.2 8524.37  
  C++ Note: dose checked 1000 1000  
  C++ Note: non-dose checked 7274.1 1341.83  
  C++ Note: LIN_non-dose checked 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000  
  C++ Note: LOGLIN_non-dose checked 7274.1 1341.83  
  C++ Note: risk checked 17001  
  C++ Note: risk1 checked 10706.4 54122.7 19625.6  
  C++ Note: risk2 checked 10706.4 192502 61415.9  
  C++ Note: df101 -18942.2 -18942.2 -18942.2  
  C++ Note: df102 -12053.5 -60927.3 -21843.1  
  C++ Note: df103 -12141.5 -218114 -69007.6  
  C++ Note: df104 0.426096 0.646539 0.157278  
  C++ Note: Checking Deviance 37742.9
  C++ Note: df105 0.992752 0.279337 0.316532  
  C++ Note: df106 1.57151 0.310899 0.867193  
  C++ Note: Starting Halves
  C++ Note: df501 -9722.072
  C++ Note: df504 0.2541947 0.4783037 0.1233221  
  C++ Note: values checked 0.254195 0.478304 0.123322  
  C++ Note: sums checked 3900.36 3900.36 1253.74  
  C++ Note: derivs checked 2309.18 11554.8 2460.98  
  C++ Note: second derivs checked 2309.18 40015.3 7535.66  
  C++ Note: dose checked 1000 1000  
  C++ Note: non-dose checked 3900.36 1253.74  
  C++ Note: LIN_non-dose checked 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000  
  C++ Note: LOGLIN_non-dose checked 3900.36 1253.74  
  C++ Note: risk checked 8783.44  
  C++ Note: risk1 checked 5182.78 26003.4 9537.67  
  C++ Note: risk2 checked 5182.78 89978.1 29321.3  
  C++ Note: df101 -9722.07 -9722.07 -9722.07  
  C++ Note: df102 -5791.51 -29075 -10520.7  
  C++ Note: df103 -5879.51 -101991 -32827.7  
  C++ Note: df104 0.254195 0.478304 0.123322  
  C++ Note: Checking Deviance 19302.5
  C++ Note: df105 0.985033 0.285074 0.320482  
  C++ Note: df106 1.67868 0.334379 0.924092  
  C++ Note: df100 11272 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:54 2024
  
  C++ Note: values checked 0.340145 0.562421 0.1403  
  C++ Note: sums checked 5296.79 5296.79 1296.63  
  C++ Note: derivs checked 3244.35 16318.8 2592.93  
  C++ Note: second derivs checked 3244.35 57346.2 8013.16  
  C++ Note: dose checked 1000 1000  
  C++ Note: non-dose checked 5296.79 1296.63  
  C++ Note: LIN_non-dose checked 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000  
  C++ Note: LOGLIN_non-dose checked 5296.79 1296.63  
  C++ Note: risk checked 12148.9  
  C++ Note: risk1 checked 7411.88 37396.1 13604.8  
  C++ Note: risk2 checked 7411.88 131289 42203  
  C++ Note: df101 -13490.5 -13490.5 -13490.5  
  C++ Note: df102 -8318.73 -41981.5 -15084.1  
  C++ Note: df103 -8406.73 -148787 -47345.2  
  C++ Note: df104 0.340145 0.562421 0.1403  
  C++ Note: Checking Deviance 26839.3
  C++ Note: df105 0.989532 0.282158 0.318597  
  C++ Note: df106 1.6217 0.321343 0.894353  
  C++ Note: df100 12363 2 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:54 2024
  
  C++ Note: Changing back to best
  C++ Note: values checked 0.426096 0.646539 0.157278  
  C++ Note: sums checked 7274.1 7274.1 1341.83  
  C++ Note: derivs checked 4601.97 23182.6 2733.27  
  C++ Note: second derivs checked 4601.97 82544.2 8524.37  
  C++ Note: dose checked 1000 1000  
  C++ Note: non-dose checked 7274.1 1341.83  
  C++ Note: LIN_non-dose checked 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000  
  C++ Note: LOGLIN_non-dose checked 7274.1 1341.83  
  C++ Note: risk checked 17001  
  C++ Note: risk1 checked 10706.4 54122.7 19625.6  
  C++ Note: risk2 checked 10706.4 192502 61415.9  
  C++ Note: df101 -18942.2 -18942.2 -18942.2  
  C++ Note: df102 -12053.5 -60927.3 -21843.1  
  C++ Note: df103 -12141.5 -218114 -69007.6  
  C++ Note: df104 0.426096 0.646539 0.157278  
  C++ Note: Checking Deviance 37742.9
  C++ Note: df105 0.992752 0.279337 0.316532  
  C++ Note: df106 1.57151 0.310899 0.867193  
  C++ Note: df100 13418 0 0 0,Update_Calc
  C++ Note: Current Time, Fri Feb 23 05:58:54 2024
  
  C++ Note: df101 -18942.23 -18942.23 -18942.23  
  C++ Note: df102 -12053.55 -60927.32 -21843.14  
  C++ Note: df103 -12141.55 -218114.1 -69007.65  
  C++ Note: df104 0.4260961 0.646539 0.1572781  
  C++ Note: Checking Deviance 37742.86
  C++ Note: df105 0.9927522 0.2793369 0.3165322  
  C++ Note: df106 1.571507 0.3108988 0.8671935  
  C++ Note: df101 -18942.2 -18942.2 -18942.2  
  C++ Note: df102 -12053.5 -60927.3 -21843.1  
  C++ Note: df103 -12141.5 -218114 -69007.6  
  C++ Note: df104 0.426096 0.646539 0.157278  
  C++ Note: Checking Deviance 37742.9
  C++ Note: df105 0.992752 0.279337 0.316532  
  C++ Note: df106 1.57151 0.310899 0.867193  
  C++ Note: ending guess 2
  C++ Note: df501 -9722.072
  C++ Note: df504 0.2541947 0.4783037 0.1233221  
  C++ Note: Refreshing matrices after all guesses
  C++ Note: Guess Results
  Guess number, parameter values, Log-Likelihood
  0, 0.2541947 0.4783037 0.1233221, -9722.072<-- Best Guess
  1, 0.4260961 0.646539 0.1572781, -18942.23
  2, 0.4260961 0.646539 0.1572781, -18942.23
  C++ Note: starting subterms 2 in best guess 0
  C++ Note: values checked 0.254195 0.478304 0.123322  
  C++ Note: sums checked 3900.36 3900.36 1253.74  
  C++ Note: derivs checked 2309.18 11554.8 2460.98  
  C++ Note: second derivs checked 2309.18 40015.3 7535.66  
  C++ Note: dose checked 1000 1000  
  C++ Note: non-dose checked 3900.36 1253.74  
  C++ Note: LIN_non-dose checked 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000  
  C++ Note: LOGLIN_non-dose checked 3900.36 1253.74  
  C++ Note: risk checked 8783.44  
  C++ Note: risk1 checked 5182.78 26003.4 9537.67  
  C++ Note: risk2 checked 5182.78 89978.1 29321.3  
  C++ Note: Made Risk Side Lists
  C++ Note: df101 -9722.07 -9722.07 -9722.07  
  C++ Note: df102 -5791.51 -29075 -10520.7  
  C++ Note: df103 -5879.51 -101991 -32827.7  
  C++ Note: df104 0.254195 0.478304 0.123322  
  C++ Note: Checking Deviance 19302.5
  C++ Note: df105 0.985033 0.285074 0.320482  
  C++ Note: df106 1.67868 0.334379 0.924092  
  C++ Note: Starting Halves
  C++ Note: df501 -9722.072
  C++ Note: df504 0.2541947 0.4783037 0.1233221  
  C++ Note: values checked 0.0500616 0.312566 0.0802485  
  C++ Note: sums checked 2172.57 2172.57 1154.38  
  C++ Note: derivs checked 1178.37 5851.84 2160.22  
  C++ Note: second derivs checked 1178.37 19594.1 6459.87  
  C++ Note: dose checked 1000 1000  
  C++ Note: non-dose checked 2172.57 1154.38  
  C++ Note: LIN_non-dose checked 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000  
  C++ Note: LOGLIN_non-dose checked 2172.57 1154.38  
  C++ Note: risk checked 4679.98  
  C++ Note: risk1 checked 2533.3 12602.3 4687.51  
  C++ Note: risk2 checked 2533.3 42177.5 14076.6  
  C++ Note: df101 -5164.53 -5164.53 -5164.53  
  C++ Note: df102 -2787.43 -13890.9 -5084.88  
  C++ Note: df103 -2875.43 -47831.4 -15650.9  
  C++ Note: df104 0.0500616 0.312566 0.0802485  
  C++ Note: Checking Deviance 10187.5
  C++ Note: df105 0.969396 0.290413 0.324893  
  C++ Note: df106 1.85279 0.371793 1.01567  
  C++ Note: df100 32649 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:54 2024
  
  C++ Note: df100 32738 0 0 0,Update_Calc
  C++ Note: Current Time, Fri Feb 23 05:58:54 2024
  
  C++ Note: df101 -5164.534 -5164.534 -5164.534  
  C++ Note: df102 -2787.432 -13890.89 -5084.875  
  C++ Note: df103 -2875.432 -47831.43 -15650.91  
  C++ Note: df104 0.05006156 0.3125659 0.0802485  
  C++ Note: Checking Deviance 10187.47
  C++ Note: df105 0.9693959 0.2904134 0.3248932  
  C++ Note: df106 1.852793 0.371793 1.015666  
  C++ Note: df101 -5164.53 -5164.53 -5164.53  
  C++ Note: df102 -2787.43 -13890.9 -5084.88  
  C++ Note: df103 -2875.43 -47831.4 -15650.9  
  C++ Note: df104 0.0500616 0.312566 0.0802485  
  C++ Note: Checking Deviance 10187.5
  C++ Note: df105 0.969396 0.290413 0.324893  
  C++ Note: df106 1.85279 0.371793 1.01567  
  C++ Note: df501 -5164.534
  C++ Note: df504 0.05006156 0.3125659 0.0802485  
  Warning: model covariate order changed
  Error: guesses: 50 , iterations per guess: c(1, 1)
  Warning: model covariate order changed
  C++ Note: START_POIS_GUESS
  C++ Note: Current Time, Fri Feb 23 05:58:54 2024
  
  C++ Note: Term checked 0 0 1  
  C++ Note: df99,86,Starting
  C++ Note: Current Time, Fri Feb 23 05:58:54 2024
  
  C++ Note: starting subterms 2 in guess 0
  C++ Note: values checked 0.426096 0.646539 0.157278  
  C++ Note: sums checked 7274.1 7274.1 1341.83  
  C++ Note: derivs checked 4601.97 23182.6 2733.27  
  C++ Note: second derivs checked 4601.97 82544.2 8524.37  
  C++ Note: dose checked 1000 1000  
  C++ Note: non-dose checked 7274.1 1341.83  
  C++ Note: LIN_non-dose checked 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000  
  C++ Note: LOGLIN_non-dose checked 7274.1 1341.83  
  C++ Note: risk checked 17001  
  C++ Note: risk1 checked 10706.4 54122.7 19625.6  
  C++ Note: risk2 checked 10706.4 192502 61415.9  
  C++ Note: df101 -18942.2 -18942.2 -18942.2  
  C++ Note: df102 -12053.5 -60927.3 -21843.1  
  C++ Note: df103 -12141.5 -218114 -69007.6  
  C++ Note: df104 0.426096 0.646539 0.157278  
  C++ Note: Checking Deviance 37742.9
  C++ Note: df105 0.992752 0.279337 0.316532  
  C++ Note: df106 1.57151 0.310899 0.867193  
  C++ Note: Starting Halves
  C++ Note: df501 -18942.23
  C++ Note: df504 0.4260961 0.646539 0.1572781  
  C++ Note: values checked 0.254195 0.478304 0.123322  
  C++ Note: sums checked 3900.36 3900.36 1253.74  
  C++ Note: derivs checked 2309.18 11554.8 2460.98  
  C++ Note: second derivs checked 2309.18 40015.3 7535.66  
  C++ Note: dose checked 1000 1000  
  C++ Note: non-dose checked 3900.36 1253.74  
  C++ Note: LIN_non-dose checked 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000  
  C++ Note: LOGLIN_non-dose checked 3900.36 1253.74  
  C++ Note: risk checked 8783.44  
  C++ Note: risk1 checked 5182.78 26003.4 9537.67  
  C++ Note: risk2 checked 5182.78 89978.1 29321.3  
  C++ Note: df101 -9722.07 -9722.07 -9722.07  
  C++ Note: df102 -5791.51 -29075 -10520.7  
  C++ Note: df103 -5879.51 -101991 -32827.7  
  C++ Note: df104 0.254195 0.478304 0.123322  
  C++ Note: Checking Deviance 19302.5
  C++ Note: df105 0.985033 0.285074 0.320482  
  C++ Note: df106 1.67868 0.334379 0.924092  
  C++ Note: df100 9778 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:54 2024
  
  C++ Note: df100 9862 0 0 0,Update_Calc
  C++ Note: Current Time, Fri Feb 23 05:58:54 2024
  
  C++ Note: df101 -9722.072 -9722.072 -9722.072  
  C++ Note: df102 -5791.513 -29075.02 -10520.68  
  C++ Note: df103 -5879.513 -101991.2 -32827.7  
  C++ Note: df104 0.2541947 0.4783037 0.1233221  
  C++ Note: Checking Deviance 19302.54
  C++ Note: df105 0.9850328 0.2850738 0.3204818  
  C++ Note: df106 1.678676 0.3343789 0.9240916  
  C++ Note: df101 -9722.07 -9722.07 -9722.07  
  C++ Note: df102 -5791.51 -29075 -10520.7  
  C++ Note: df103 -5879.51 -101991 -32827.7  
  C++ Note: df104 0.254195 0.478304 0.123322  
  C++ Note: Checking Deviance 19302.5
  C++ Note: df105 0.985033 0.285074 0.320482  
  C++ Note: df106 1.67868 0.334379 0.924092  
  C++ Note: ending guess 0
  C++ Note: df501 -9722.072
  C++ Note: df504 0.2541947 0.4783037 0.1233221  
  C++ Note: Refreshing matrices after all guesses
  C++ Note: Guess Results
  Guess number, parameter values, Log-Likelihood
  0, 0.2541947 0.4783037 0.1233221, -9722.072<-- Best Guess
  C++ Note: starting subterms 2 in best guess 0
  C++ Note: values checked 0.254195 0.478304 0.123322  
  C++ Note: sums checked 3900.36 3900.36 1253.74  
  C++ Note: derivs checked 2309.18 11554.8 2460.98  
  C++ Note: second derivs checked 2309.18 40015.3 7535.66  
  C++ Note: dose checked 1000 1000  
  C++ Note: non-dose checked 3900.36 1253.74  
  C++ Note: LIN_non-dose checked 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000  
  C++ Note: LOGLIN_non-dose checked 3900.36 1253.74  
  C++ Note: risk checked 8783.44  
  C++ Note: risk1 checked 5182.78 26003.4 9537.67  
  C++ Note: risk2 checked 5182.78 89978.1 29321.3  
  C++ Note: Made Risk Side Lists
  C++ Note: df101 -9722.07 -9722.07 -9722.07  
  C++ Note: df102 -5791.51 -29075 -10520.7  
  C++ Note: df103 -5879.51 -101991 -32827.7  
  C++ Note: df104 0.254195 0.478304 0.123322  
  C++ Note: Checking Deviance 19302.5
  C++ Note: df105 0.985033 0.285074 0.320482  
  C++ Note: df106 1.67868 0.334379 0.924092  
  C++ Note: Starting Halves
  C++ Note: df501 -9722.072
  C++ Note: df504 0.2541947 0.4783037 0.1233221  
  C++ Note: values checked 0.0500616 0.312566 0.0802485  
  C++ Note: sums checked 2172.57 2172.57 1154.38  
  C++ Note: derivs checked 1178.37 5851.84 2160.22  
  C++ Note: second derivs checked 1178.37 19594.1 6459.87  
  C++ Note: dose checked 1000 1000  
  C++ Note: non-dose checked 2172.57 1154.38  
  C++ Note: LIN_non-dose checked 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000  
  C++ Note: LOGLIN_non-dose checked 2172.57 1154.38  
  C++ Note: risk checked 4679.98  
  C++ Note: risk1 checked 2533.3 12602.3 4687.51  
  C++ Note: risk2 checked 2533.3 42177.5 14076.6  
  C++ Note: df101 -5164.53 -5164.53 -5164.53  
  C++ Note: df102 -2787.43 -13890.9 -5084.88  
  C++ Note: df103 -2875.43 -47831.4 -15650.9  
  C++ Note: df104 0.0500616 0.312566 0.0802485  
  C++ Note: Checking Deviance 10187.5
  C++ Note: df105 0.969396 0.290413 0.324893  
  C++ Note: df106 1.85279 0.371793 1.01567  
  C++ Note: df100 13053 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:54 2024
  
  C++ Note: df100 13136 0 0 0,Update_Calc
  C++ Note: Current Time, Fri Feb 23 05:58:54 2024
  
  C++ Note: df101 -5164.534 -5164.534 -5164.534  
  C++ Note: df102 -2787.432 -13890.89 -5084.875  
  C++ Note: df103 -2875.432 -47831.43 -15650.91  
  C++ Note: df104 0.05006156 0.3125659 0.0802485  
  C++ Note: Checking Deviance 10187.47
  C++ Note: df105 0.9693959 0.2904134 0.3248932  
  C++ Note: df106 1.852793 0.371793 1.015666  
  C++ Note: df101 -5164.53 -5164.53 -5164.53  
  C++ Note: df102 -2787.43 -13890.9 -5084.88  
  C++ Note: df103 -2875.43 -47831.4 -15650.9  
  C++ Note: df104 0.0500616 0.312566 0.0802485  
  C++ Note: Checking Deviance 10187.5
  C++ Note: df105 0.969396 0.290413 0.324893  
  C++ Note: df106 1.85279 0.371793 1.01567  
  C++ Note: df501 -5164.534
  C++ Note: df504 0.05006156 0.3125659 0.0802485  
  Warning: model covariate order changed
  C++ Note: START_POIS_GUESS
  C++ Note: Current Time, Fri Feb 23 05:58:54 2024
  
  C++ Note: Term checked 0 0 1  
  C++ Note: df99,82,Starting
  C++ Note: Current Time, Fri Feb 23 05:58:54 2024
  
  C++ Note: starting subterms 2 in guess 0
  C++ Note: values checked 0.426096 0.646539 0.157278  
  C++ Note: sums checked 7274.1 7274.1 1341.83  
  C++ Note: derivs checked 4601.97 23182.6 2733.27  
  C++ Note: second derivs checked 4601.97 82544.2 8524.37  
  C++ Note: dose checked 1000 1000  
  C++ Note: non-dose checked 7274.1 1341.83  
  C++ Note: LIN_non-dose checked 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000  
  C++ Note: LOGLIN_non-dose checked 7274.1 1341.83  
  C++ Note: risk checked 17001  
  C++ Note: risk1 checked 10706.4 54122.7 19625.6  
  C++ Note: risk2 checked 10706.4 192502 61415.9  
  C++ Note: df101 -18942.2 -18942.2 -18942.2  
  C++ Note: df102 -12053.5 -60927.3 -21843.1  
  C++ Note: df103 -12141.5 -218114 -69007.6  
  C++ Note: df104 0.426096 0.646539 0.157278  
  C++ Note: Checking Deviance 37742.9
  C++ Note: df105 0.992752 0.279337 0.316532  
  C++ Note: df106 1.57151 0.310899 0.867193  
  C++ Note: Starting Halves
  C++ Note: df501 -18942.23
  C++ Note: df504 0.4260961 0.646539 0.1572781  
  C++ Note: values checked 0.254195 0.478304 0.123322  
  C++ Note: sums checked 3900.36 3900.36 1253.74  
  C++ Note: derivs checked 2309.18 11554.8 2460.98  
  C++ Note: second derivs checked 2309.18 40015.3 7535.66  
  C++ Note: dose checked 1000 1000  
  C++ Note: non-dose checked 3900.36 1253.74  
  C++ Note: LIN_non-dose checked 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000  
  C++ Note: LOGLIN_non-dose checked 3900.36 1253.74  
  C++ Note: risk checked 8783.44  
  C++ Note: risk1 checked 5182.78 26003.4 9537.67  
  C++ Note: risk2 checked 5182.78 89978.1 29321.3  
  C++ Note: df101 -9722.07 -9722.07 -9722.07  
  C++ Note: df102 -5791.51 -29075 -10520.7  
  C++ Note: df103 -5879.51 -101991 -32827.7  
  C++ Note: df104 0.254195 0.478304 0.123322  
  C++ Note: Checking Deviance 19302.5
  C++ Note: df105 0.985033 0.285074 0.320482  
  C++ Note: df106 1.67868 0.334379 0.924092  
  C++ Note: df100 2580 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:54 2024
  
  C++ Note: df100 2664 0 0 0,Update_Calc
  C++ Note: Current Time, Fri Feb 23 05:58:54 2024
  
  C++ Note: df101 -9722.072 -9722.072 -9722.072  
  C++ Note: df102 -5791.513 -29075.02 -10520.68  
  C++ Note: df103 -5879.513 -101991.2 -32827.7  
  C++ Note: df104 0.2541947 0.4783037 0.1233221  
  C++ Note: Checking Deviance 19302.54
  C++ Note: df105 0.9850328 0.2850738 0.3204818  
  C++ Note: df106 1.678676 0.3343789 0.9240916  
  C++ Note: df101 -9722.07 -9722.07 -9722.07  
  C++ Note: df102 -5791.51 -29075 -10520.7  
  C++ Note: df103 -5879.51 -101991 -32827.7  
  C++ Note: df104 0.254195 0.478304 0.123322  
  C++ Note: Checking Deviance 19302.5
  C++ Note: df105 0.985033 0.285074 0.320482  
  C++ Note: df106 1.67868 0.334379 0.924092  
  C++ Note: ending guess 0
  C++ Note: df501 -9722.072
  C++ Note: df504 0.2541947 0.4783037 0.1233221  
  C++ Note: Refreshing matrices after all guesses
  C++ Note: Guess Results
  Guess number, parameter values, Log-Likelihood
  0, 0.2541947 0.4783037 0.1233221, -9722.072<-- Best Guess
  C++ Note: starting subterms 2 in best guess 0
  C++ Note: values checked 0.254195 0.478304 0.123322  
  C++ Note: sums checked 3900.36 3900.36 1253.74  
  C++ Note: derivs checked 2309.18 11554.8 2460.98  
  C++ Note: second derivs checked 2309.18 40015.3 7535.66  
  C++ Note: dose checked 1000 1000  
  C++ Note: non-dose checked 3900.36 1253.74  
  C++ Note: LIN_non-dose checked 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000  
  C++ Note: LOGLIN_non-dose checked 3900.36 1253.74  
  C++ Note: risk checked 8783.44  
  C++ Note: risk1 checked 5182.78 26003.4 9537.67  
  C++ Note: risk2 checked 5182.78 89978.1 29321.3  
  C++ Note: Made Risk Side Lists
  C++ Note: df101 -9722.07 -9722.07 -9722.07  
  C++ Note: df102 -5791.51 -29075 -10520.7  
  C++ Note: df103 -5879.51 -101991 -32827.7  
  C++ Note: df104 0.254195 0.478304 0.123322  
  C++ Note: Checking Deviance 19302.5
  C++ Note: df105 0.985033 0.285074 0.320482  
  C++ Note: df106 1.67868 0.334379 0.924092  
  C++ Note: Starting Halves
  C++ Note: df501 -9722.072
  C++ Note: df504 0.2541947 0.4783037 0.1233221  
  C++ Note: values checked 0.0500616 0.312566 0.0802485  
  C++ Note: sums checked 2172.57 2172.57 1154.38  
  C++ Note: derivs checked 1178.37 5851.84 2160.22  
  C++ Note: second derivs checked 1178.37 19594.1 6459.87  
  C++ Note: dose checked 1000 1000  
  C++ Note: non-dose checked 2172.57 1154.38  
  C++ Note: LIN_non-dose checked 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000  
  C++ Note: LOGLIN_non-dose checked 2172.57 1154.38  
  C++ Note: risk checked 4679.98  
  C++ Note: risk1 checked 2533.3 12602.3 4687.51  
  C++ Note: risk2 checked 2533.3 42177.5 14076.6  
  C++ Note: df101 -5164.53 -5164.53 -5164.53  
  C++ Note: df102 -2787.43 -13890.9 -5084.88  
  C++ Note: df103 -2875.43 -47831.4 -15650.9  
  C++ Note: df104 0.0500616 0.312566 0.0802485  
  C++ Note: Checking Deviance 10187.5
  C++ Note: df105 0.969396 0.290413 0.324893  
  C++ Note: df106 1.85279 0.371793 1.01567  
  C++ Note: df100 19254 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:54 2024
  
  C++ Note: df100 19336 0 0 0,Update_Calc
  C++ Note: Current Time, Fri Feb 23 05:58:54 2024
  
  C++ Note: df101 -5164.534 -5164.534 -5164.534  
  C++ Note: df102 -2787.432 -13890.89 -5084.875  
  C++ Note: df103 -2875.432 -47831.43 -15650.91  
  C++ Note: df104 0.05006156 0.3125659 0.0802485  
  C++ Note: Checking Deviance 10187.47
  C++ Note: df105 0.9693959 0.2904134 0.3248932  
  C++ Note: df106 1.852793 0.371793 1.015666  
  C++ Note: df101 -5164.53 -5164.53 -5164.53  
  C++ Note: df102 -2787.43 -13890.9 -5084.88  
  C++ Note: df103 -2875.43 -47831.4 -15650.9  
  C++ Note: df104 0.0500616 0.312566 0.0802485  
  C++ Note: Checking Deviance 10187.5
  C++ Note: df105 0.969396 0.290413 0.324893  
  C++ Note: df106 1.85279 0.371793 1.01567  
  C++ Note: df501 -5164.534
  C++ Note: df504 0.05006156 0.3125659 0.0802485  
  Warning: model covariate order changed
  C++ Note: START_POIS_GUESS
  C++ Note: Current Time, Fri Feb 23 05:58:54 2024
  
  C++ Note: Term checked 0 0 1  
  C++ Note: df99,81,Starting
  C++ Note: Current Time, Fri Feb 23 05:58:54 2024
  
  C++ Note: starting subterms 2 in guess 0
  C++ Note: values checked -0.1 -0.1 0.2  
  C++ Note: sums checked -261.4 -261.4 341.682  
  C++ Note: derivs checked 531 2083 1708.41  
  C++ Note: second derivs checked 0 0 0  
  C++ Note: dose checked 1000 1000  
  C++ Note: non-dose checked -261.4 341.682  
  C++ Note: LIN_non-dose checked -261.4 341.682  
  C++ Note: PLIN_non-dose checked 1000 1000  
  C++ Note: LOGLIN_non-dose checked 1000 1000  
  C++ Error: A non-positive risk was detected: -1.111148
  C++ Warning: final failing values -0.1 -0.1 0.2  
  C++ Warning: final failing terms lin lin lin  
  Invalid risk
  Error: Atleast one parameter must be free
  Note: 2 risk groups
  C++ Note: START_RISK_CHECK
  C++ Note: Current Time, Fri Feb 23 05:58:54 2024
  
  C++ Note: Term checked 0 1 1 2  
  C++ Note: df99,72,Starting
  C++ Note: Current Time, Fri Feb 23 05:58:54 2024
  
  C++ Note: starting subterms 3
  C++ Note: values checked 0.1 0.1 0.1 0.1  
  C++ Note: sums checked 7.420684 1.45 1.45 7.4  
  C++ Note: dose checked 7 7 7  
  C++ Note: non-dose checked 7.420684 1.45 7.4  
  C++ Note: LIN_non-dose checked 7 1.45 7  
  C++ Note: PLIN_non-dose checked 7 7 7.4  
  C++ Note: LOGLIN_non-dose checked 7.420684 7 7  
  C++ Note: df99,439,Prep_Terms
  C++ Note: Current Time, Fri Feb 23 05:58:54 2024
  
  Error: no events
  Error: Atleast one parameter must be free
  C++ Note: START_RISK_CHECK
  C++ Note: Current Time, Fri Feb 23 05:58:55 2024
  
  C++ Note: Term checked 0 1 1 2  
  C++ Note: df99,80,Starting
  C++ Note: Current Time, Fri Feb 23 05:58:55 2024
  
  C++ Note: starting subterms 3
  C++ Note: values checked 0.1 0.1 0.1 0.1  
  C++ Note: sums checked 7.420684 1.45 1.45 7.4  
  C++ Note: dose checked 7 7 7  
  C++ Note: non-dose checked 7.420684 1.45 7.4  
  C++ Note: LIN_non-dose checked 7 1.45 7  
  C++ Note: PLIN_non-dose checked 7 7 7.4  
  C++ Note: LOGLIN_non-dose checked 7.420684 7 7  
  C++ Note: df99,550,Prep_Terms
  C++ Note: Current Time, Fri Feb 23 05:58:55 2024
  
  Error: no events
  Error: Atleast one parameter must be free
  C++ Note: START_PLOT
  C++ Note: Current Time, Fri Feb 23 05:58:55 2024
  
  C++ Note: Term checked 0 0  
  C++ Note: df99,67,Starting
  C++ Note: Current Time, Fri Feb 23 05:58:55 2024
  
  C++ Note: values checked 0.1 -0.1  
  C++ Note: sums checked 4.33113 4.33113  
  C++ Note: dose checked 7  
  C++ Note: non-dose checked 4.33113  
  C++ Note: LIN_non-dose checked 7  
  C++ Note: PLIN_non-dose checked 7  
  C++ Note: LOGLIN_non-dose checked 4.33113  
  C++ Note: risk checked 4.33113  
  Error: Atleast one parameter must be free
  Note: Starting Plot Function
  Note: Getting Plot Info
  Note: 2 risk groups
  Warning: model covariate order changed
  Note: 2 risk groups
  C++ Note: START_COX_GUESS
  C++ Note: Current Time, Fri Feb 23 05:58:55 2024
  
  C++ Note: Term checked 0 0  
  C++ Note: df99,69,Starting
  C++ Note: Current Time, Fri Feb 23 05:58:55 2024
  
  C++ Note: Grouping Start
  C++ Note: df100 178 0 0 -1,Prep_List
  C++ Note: Current Time, Fri Feb 23 05:58:55 2024
  
  C++ Note: starting subterms 1 in guess 0
  C++ Note: values checked 0.1 -0.1  
  C++ Note: sums checked 4.33113 4.33113  
  C++ Note: derivs checked 4.33113 24.2686  
  C++ Note: second derivs checked 4.33113 152.884  
  C++ Note: dose checked 7  
  C++ Note: non-dose checked 4.33113  
  C++ Note: LIN_non-dose checked 7  
  C++ Note: PLIN_non-dose checked 7  
  C++ Note: LOGLIN_non-dose checked 4.33113  
  C++ Note: risk checked 4.33113  
  C++ Note: risk1 checked 4.33113 24.2686  
  C++ Note: risk2 checked 4.33113 152.884  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 1.2374  
  C++ Note: risk1r checked 1.2374 6.93596  
  C++ Note: risk2r checked 1.2374 43.6346  
  C++ Note: riskl checked 1.2374  
  C++ Note: risk1l checked 1.2374 6.93596  
  C++ Note: risk2l checked 1.2374 43.6346  
  C++ Note: df101 0 0  
  C++ Note: df102 0 0  
  C++ Note: df103 0 0  
  C++ Note: df104 0.1 -0.1  
  C++ Note: df105 -nan -nan  
  C++ Note: df106 -nan -nan  
  C++ Note: riskr checked 1.2374  
  C++ Note: risk1r checked 1.2374 6.93596  
  C++ Note: risk2r checked 1.2374 43.6346  
  C++ Note: riskl checked 1.2374  
  C++ Note: risk1l checked 1.2374 6.93596  
  C++ Note: risk2l checked 1.2374 43.6346  
  C++ Note: df101 0 0  
  C++ Note: df102 0 0  
  C++ Note: df103 0 0  
  C++ Note: df104 0.1 -0.1  
  C++ Note: df105 -nan -nan  
  C++ Note: df106 -nan -nan  
  C++ Note: ending guess 0
  C++ Note: df501 0
  C++ Note: df504 0.1 -0.1  
  C++ Note: Refreshing matrices after all guesses
  C++ Note: Guess Results
  Guess number, parameter values, Log-Likelihood
  0, 0.1 -0.1, 0<-- Best Guess
  C++ Note: starting subterms 1 in best guess 0
  C++ Note: values checked 0.1 -0.1  
  C++ Note: sums checked 4.33113 4.33113  
  C++ Note: derivs checked 4.33113 24.2686  
  C++ Note: second derivs checked 4.33113 152.884  
  C++ Note: dose checked 7  
  C++ Note: non-dose checked 4.33113  
  C++ Note: LIN_non-dose checked 7  
  C++ Note: PLIN_non-dose checked 7  
  C++ Note: LOGLIN_non-dose checked 4.33113  
  C++ Note: risk checked 4.33113  
  C++ Note: risk1 checked 4.33113 24.2686  
  C++ Note: risk2 checked 4.33113 152.884  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 1.2374  
  C++ Note: risk1r checked 1.2374 6.93596  
  C++ Note: risk2r checked 1.2374 43.6346  
  C++ Note: riskl checked 1.2374  
  C++ Note: risk1l checked 1.2374 6.93596  
  C++ Note: risk2l checked 1.2374 43.6346  
  C++ Note: df101 0 0  
  C++ Note: df102 0 0  
  C++ Note: df103 0 0  
  C++ Note: df104 0.1 -0.1  
  C++ Note: df105 -nan -nan  
  C++ Note: df106 -nan -nan  
  C++ Note: riskr checked 1.2374  
  C++ Note: risk1r checked 1.2374 6.93596  
  C++ Note: risk2r checked 1.2374 43.6346  
  C++ Note: riskl checked 1.2374  
  C++ Note: risk1l checked 1.2374 6.93596  
  C++ Note: risk2l checked 1.2374 43.6346  
  C++ Note: df101 0 0  
  C++ Note: df102 0 0  
  C++ Note: df103 0 0  
  C++ Note: df104 0.1 -0.1  
  C++ Note: df105 -nan -nan  
  C++ Note: df106 -nan -nan  
  C++ Note: Exiting Regression
  C++ Note: df501 0
  C++ Note: df504 0.1 -0.1  
  Note: starting ph_plot
  Note: nonStratified survival curve calculation
  C++ Note: START_PLOT
  C++ Note: Current Time, Fri Feb 23 05:58:55 2024
  
  C++ Note: Term checked 0 0  
  C++ Note: df99,71,Starting
  C++ Note: Current Time, Fri Feb 23 05:58:55 2024
  
  C++ Note: values checked -0.1 0.1  
  C++ Note: sums checked 4.33113 4.33113  
  C++ Note: derivs checked 24.2686 4.33113  
  C++ Note: second derivs checked 152.884 4.33113  
  C++ Note: dose checked 7  
  C++ Note: non-dose checked 4.33113  
  C++ Note: LIN_non-dose checked 7  
  C++ Note: PLIN_non-dose checked 7  
  C++ Note: LOGLIN_non-dose checked 4.33113  
  C++ Note: risk checked 4.33113  
  C++ Note: risk1 checked 24.2686 4.33113  
  C++ Note: risk2 checked 152.884 4.33113  
  C++ Note: Grouping Start
  C++ Note: df100 611 0 0 -1,Prep_List
  C++ Note: Current Time, Fri Feb 23 05:58:55 2024
  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 1.2374  
  C++ Note: risk1r checked 6.93596 1.2374  
  C++ Note: risk2r checked 43.6346 1.2374  
  C++ Note: riskl checked 1.2374  
  C++ Note: risk1l checked 6.93596 1.2374  
  C++ Note: risk2l checked 43.6346 1.2374  
  C++ Note: df101 0 0  
  C++ Note: df102 0 0  
  C++ Note: df103 0 0  
  C++ Note: df104 -0.1 0.1  
  C++ Note: df105 -nan -nan  
  C++ Note: df106 -nan -nan  
  Note: writing survival data
  Note: Plotting Martingale Residuals
  Note: Martingale Plot: d
  Saving 7 x 7 in image
  Saving 7 x 7 in image
  Note: Starting Plot Function
  Note: Getting Plot Info
  Note: 2 risk groups
  Note: Starting Plot Function
  Note: Getting Plot Info
  Error: no events
  Error: Atleast one parameter must be free
  Warning: rmin/rmax not equal size, lin/loglin min/max used
  Warning: rmin and rmax lists not equal size, defaulting to lin and loglin min/max values
  C++ Note: START_RISK_CHECK
  C++ Note: Current Time, Fri Feb 23 05:58:56 2024
  
  C++ Note: Term checked 0  
  C++ Note: df99,66,Starting
  C++ Note: Current Time, Fri Feb 23 05:58:56 2024
  
  C++ Note: starting subterms 1
  C++ Note: values checked 0.01  
  C++ Note: sums checked 6437.949  
  C++ Note: dose checked 6400  
  C++ Note: non-dose checked 6437.949  
  C++ Note: LIN_non-dose checked 6400  
  C++ Note: PLIN_non-dose checked 6400  
  C++ Note: LOGLIN_non-dose checked 6437.949  
  C++ Note: df99,646,Prep_Terms
  C++ Note: Current Time, Fri Feb 23 05:58:56 2024
  
  Note: 86 risk groups
  C++ Note: START_COX_GUESS
  C++ Note: Current Time, Fri Feb 23 05:58:56 2024
  
  C++ Note: Term checked 0  
  C++ Note: df99,69,Starting
  C++ Note: Current Time, Fri Feb 23 05:58:56 2024
  
  C++ Note: Grouping Start
  C++ Note: df100 1843 0 0 -1,Prep_List
  C++ Note: Current Time, Fri Feb 23 05:58:56 2024
  
  C++ Note: starting subterms 1 in guess 0
  C++ Note: values checked 0.01  
  C++ Note: sums checked 6437.95  
  C++ Note: derivs checked 3813.95  
  C++ Note: second derivs checked 3813.95  
  C++ Note: dose checked 6400  
  C++ Note: non-dose checked 6437.95  
  C++ Note: LIN_non-dose checked 6400  
  C++ Note: PLIN_non-dose checked 6400  
  C++ Note: LOGLIN_non-dose checked 6437.95  
  C++ Note: risk checked 6437.95  
  C++ Note: risk1 checked 3813.95  
  C++ Note: risk2 checked 3813.95  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 4185.37  
  C++ Note: risk1r checked 2549.37  
  C++ Note: risk2r checked 2549.37  
  C++ Note: riskl checked 86.3317  
  C++ Note: risk1l checked 33.3317  
  C++ Note: risk2l checked 33.3317  
  C++ Note: df101 -313.163  
  C++ Note: df102 -21.7172  
  C++ Note: df103 -19.4313  
  C++ Note: df104 0.01  
  C++ Note: df105 1.11764  
  C++ Note: df106 14.42  
  C++ Note: Starting Halves
  C++ Note: df501 -313.1627
  C++ Note: df504 0.01  
  C++ Note: values checked -0.828233  
  C++ Note: sums checked 4273.43  
  C++ Note: derivs checked 1649.43  
  C++ Note: second derivs checked 1649.43  
  C++ Note: dose checked 6400  
  C++ Note: non-dose checked 4273.43  
  C++ Note: LIN_non-dose checked 6400  
  C++ Note: PLIN_non-dose checked 6400  
  C++ Note: LOGLIN_non-dose checked 4273.43  
  C++ Note: risk checked 4273.43  
  C++ Note: risk1 checked 1649.43  
  C++ Note: risk2 checked 1649.43  
  C++ Note: riskr checked 2738.53  
  C++ Note: risk1r checked 1102.53  
  C++ Note: risk2r checked 1102.53  
  C++ Note: riskl checked 67.4151  
  C++ Note: risk1l checked 14.4151  
  C++ Note: risk2l checked 14.4151  
  C++ Note: df101 -302.091  
  C++ Note: df102 -4.55996  
  C++ Note: df103 -20.4044  
  C++ Note: df104 -0.828233  
  C++ Note: df105 0.22348  
  C++ Note: df106 66.2487  
  C++ Note: df100 20265 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:56 2024
  
  C++ Note: Starting Halves
  C++ Note: df501 -302.0913
  C++ Note: df504 -0.828233  
  C++ Note: values checked -0.995843  
  C++ Note: sums checked 4018.9  
  C++ Note: derivs checked 1394.9  
  C++ Note: second derivs checked 1394.9  
  C++ Note: dose checked 6400  
  C++ Note: non-dose checked 4018.9  
  C++ Note: LIN_non-dose checked 6400  
  C++ Note: PLIN_non-dose checked 6400  
  C++ Note: LOGLIN_non-dose checked 4018.9  
  C++ Note: risk checked 4018.9  
  C++ Note: risk1 checked 1394.9  
  C++ Note: risk2 checked 1394.9  
  C++ Note: riskr checked 2568.4  
  C++ Note: risk1r checked 932.396  
  C++ Note: risk2r checked 932.396  
  C++ Note: riskl checked 65.1906  
  C++ Note: risk1l checked 12.1906  
  C++ Note: risk2l checked 12.1906  
  C++ Note: df101 -301.611  
  C++ Note: df102 -1.18635  
  C++ Note: df103 -19.8114  
  C++ Note: df104 -0.995843  
  C++ Note: df105 0.0598821  
  C++ Note: df106 254.236  
  C++ Note: df100 22264 1 2 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:56 2024
  
  C++ Note: Starting Halves
  C++ Note: df501 -301.6112
  C++ Note: df504 -0.9958427  
  C++ Note: values checked -1.04075  
  C++ Note: sums checked 3957.64  
  C++ Note: derivs checked 1333.64  
  C++ Note: second derivs checked 1333.64  
  C++ Note: dose checked 6400  
  C++ Note: non-dose checked 3957.64  
  C++ Note: LIN_non-dose checked 6400  
  C++ Note: PLIN_non-dose checked 6400  
  C++ Note: LOGLIN_non-dose checked 3957.64  
  C++ Note: risk checked 3957.64  
  C++ Note: risk1 checked 1333.64  
  C++ Note: risk2 checked 1333.64  
  C++ Note: riskr checked 2527.45  
  C++ Note: risk1r checked 891.447  
  C++ Note: risk2r checked 891.447  
  C++ Note: riskl checked 64.6552  
  C++ Note: risk1l checked 11.6552  
  C++ Note: risk2l checked 11.6552  
  C++ Note: df101 -301.578  
  C++ Note: df102 -0.300978  
  C++ Note: df103 -19.6132  
  C++ Note: df104 -1.04075  
  C++ Note: df105 0.0153457  
  C++ Note: df106 1001.99  
  C++ Note: df100 24076 1 3 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:56 2024
  
  C++ Note: Starting Halves
  C++ Note: df501 -301.5778
  C++ Note: df504 -1.040754  
  C++ Note: values checked -1.05226  
  C++ Note: sums checked 3942.38  
  C++ Note: derivs checked 1318.38  
  C++ Note: second derivs checked 1318.38  
  C++ Note: dose checked 6400  
  C++ Note: non-dose checked 3942.38  
  C++ Note: LIN_non-dose checked 6400  
  C++ Note: PLIN_non-dose checked 6400  
  C++ Note: LOGLIN_non-dose checked 3942.38  
  C++ Note: risk checked 3942.38  
  C++ Note: risk1 checked 1318.38  
  C++ Note: risk2 checked 1318.38  
  C++ Note: riskr checked 2517.25  
  C++ Note: risk1r checked 881.246  
  C++ Note: risk2r checked 881.246  
  C++ Note: riskl checked 64.5218  
  C++ Note: risk1l checked 11.5218  
  C++ Note: risk2l checked 11.5218  
  C++ Note: df101 -301.576  
  C++ Note: df102 -0.0755501  
  C++ Note: df103 -19.5599  
  C++ Note: df104 -1.05226  
  C++ Note: df105 0.0038625  
  C++ Note: df106 3991.73  
  C++ Note: df100 40868 1 4 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:56 2024
  
  C++ Note: Starting Halves
  C++ Note: df501 -301.5756
  C++ Note: df504 -1.052263  
  C++ Note: values checked -1.05516  
  C++ Note: sums checked 3938.56  
  C++ Note: derivs checked 1314.56  
  C++ Note: second derivs checked 1314.56  
  C++ Note: dose checked 6400  
  C++ Note: non-dose checked 3938.56  
  C++ Note: LIN_non-dose checked 6400  
  C++ Note: PLIN_non-dose checked 6400  
  C++ Note: LOGLIN_non-dose checked 3938.56  
  C++ Note: risk checked 3938.56  
  C++ Note: risk1 checked 1314.56  
  C++ Note: risk2 checked 1314.56  
  C++ Note: riskr checked 2514.7  
  C++ Note: risk1r checked 878.697  
  C++ Note: risk2r checked 878.697  
  C++ Note: riskl checked 64.4885  
  C++ Note: risk1l checked 11.4885  
  C++ Note: risk2l checked 11.4885  
  C++ Note: df101 -301.576  
  C++ Note: df102 -0.0189072  
  C++ Note: df103 -19.5463  
  C++ Note: df104 -1.05516  
  C++ Note: df105 0.0009673  
  C++ Note: df106 15950.3  
  C++ Note: df100 42524 1 5 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:56 2024
  
  C++ Note: riskr checked 2514.7  
  C++ Note: risk1r checked 878.697  
  C++ Note: risk2r checked 878.697  
  C++ Note: riskl checked 64.4885  
  C++ Note: risk1l checked 11.4885  
  C++ Note: risk2l checked 11.4885  
  C++ Note: df101 -301.576  
  C++ Note: df102 -0.0189072  
  C++ Note: df103 -19.5463  
  C++ Note: df104 -1.05516  
  C++ Note: df105 0.0009673  
  C++ Note: df106 15950.3  
  C++ Note: ending guess 0
  C++ Note: df501 -301.5755
  C++ Note: df504 -1.05516  
  C++ Note: Refreshing matrices after all guesses
  C++ Note: Guess Results
  Guess number, parameter values, Log-Likelihood
  0, -1.05516, -301.5755<-- Best Guess
  C++ Note: starting subterms 1 in best guess 0
  C++ Note: values checked -1.05516  
  C++ Note: sums checked 3938.56  
  C++ Note: derivs checked 1314.56  
  C++ Note: second derivs checked 1314.56  
  C++ Note: dose checked 6400  
  C++ Note: non-dose checked 3938.56  
  C++ Note: LIN_non-dose checked 6400  
  C++ Note: PLIN_non-dose checked 6400  
  C++ Note: LOGLIN_non-dose checked 3938.56  
  C++ Note: risk checked 3938.56  
  C++ Note: risk1 checked 1314.56  
  C++ Note: risk2 checked 1314.56  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 2514.7  
  C++ Note: risk1r checked 878.697  
  C++ Note: risk2r checked 878.697  
  C++ Note: riskl checked 64.4885  
  C++ Note: risk1l checked 11.4885  
  C++ Note: risk2l checked 11.4885  
  C++ Note: df101 -301.576  
  C++ Note: df102 -0.0189072  
  C++ Note: df103 -19.5463  
  C++ Note: df104 -1.05516  
  C++ Note: df105 0.0009673  
  C++ Note: df106 15950.3  
  C++ Note: Starting Halves
  C++ Note: df501 -301.5755
  C++ Note: df504 -1.05516  
  C++ Note: values checked -1.05589  
  C++ Note: sums checked 3937.61  
  C++ Note: derivs checked 1313.61  
  C++ Note: second derivs checked 1313.61  
  C++ Note: dose checked 6400  
  C++ Note: non-dose checked 3937.61  
  C++ Note: LIN_non-dose checked 6400  
  C++ Note: PLIN_non-dose checked 6400  
  C++ Note: LOGLIN_non-dose checked 3937.61  
  C++ Note: risk checked 3937.61  
  C++ Note: risk1 checked 1313.61  
  C++ Note: risk2 checked 1313.61  
  C++ Note: riskr checked 2514.06  
  C++ Note: risk1r checked 878.06  
  C++ Note: risk2r checked 878.06  
  C++ Note: riskl checked 64.4802  
  C++ Note: risk1l checked 11.4802  
  C++ Note: risk2l checked 11.4802  
  C++ Note: df101 -301.575  
  C++ Note: df102 -0.00472803  
  C++ Note: df103 -19.5429  
  C++ Note: df104 -1.05589  
  C++ Note: df105 0.00024193  
  C++ Note: df106 63784.6  
  C++ Note: df100 46790 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:56 2024
  
  C++ Note: riskr checked 2514.06  
  C++ Note: risk1r checked 878.06  
  C++ Note: risk2r checked 878.06  
  C++ Note: riskl checked 64.4802  
  C++ Note: risk1l checked 11.4802  
  C++ Note: risk2l checked 11.4802  
  C++ Note: df101 -301.575  
  C++ Note: df102 -0.00472803  
  C++ Note: df103 -19.5429  
  C++ Note: df104 -1.05589  
  C++ Note: df105 0.00024193  
  C++ Note: df106 63784.6  
  C++ Note: riskr checked 2514.06  
  C++ Note: risk1r checked 878.06  
  C++ Note: risk2r checked 878.06  
  C++ Note: riskl checked 64.4802  
  C++ Note: risk1l checked 11.4802  
  C++ Note: risk2l checked 11.4802  
  C++ Note: df101 -301.575  
  C++ Note: df102 -0.00472803  
  C++ Note: df103 -19.5429  
  C++ Note: df104 -1.05589  
  C++ Note: df105 0.00024193  
  C++ Note: df106 63784.6  
  C++ Note: Exiting Regression
  C++ Note: df501 -301.5755
  C++ Note: df504 -1.055886  
  Warning: rmin and rmax lists not equal size, defaulting to lin and loglin min/max values
  C++ Note: START_RISK_CHECK
  C++ Note: Current Time, Fri Feb 23 05:58:56 2024
  
  C++ Note: Term checked 0 1  
  C++ Note: df99,69,Starting
  C++ Note: Current Time, Fri Feb 23 05:58:56 2024
  
  C++ Note: starting subterms 2
  C++ Note: values checked -1.055886 -15  
  C++ Note: sums checked 3937.61 0.001957775  
  C++ Note: dose checked 6400 6400  
  C++ Note: non-dose checked 3937.61 0.001957775  
  C++ Note: LIN_non-dose checked 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400  
  C++ Note: LOGLIN_non-dose checked 3937.61 0.001957775  
  C++ Note: df99,15682,Prep_Terms
  C++ Note: Current Time, Fri Feb 23 05:58:56 2024
  
  Note: 86 risk groups
  C++ Note: START_COX_GUESS
  C++ Note: Current Time, Fri Feb 23 05:58:56 2024
  
  C++ Note: Term checked 0 1  
  C++ Note: df99,73,Starting
  C++ Note: Current Time, Fri Feb 23 05:58:56 2024
  
  C++ Note: Grouping Start
  C++ Note: df100 2048 0 0 -1,Prep_List
  C++ Note: Current Time, Fri Feb 23 05:58:56 2024
  
  C++ Note: starting subterms 2 in guess 0
  C++ Note: values checked -1.05589 -15  
  C++ Note: sums checked 3937.61 0.00195777  
  C++ Note: derivs checked 1313.61 0.00195777  
  C++ Note: second derivs checked 1313.61 0.00195777  
  C++ Note: dose checked 6400 6400  
  C++ Note: non-dose checked 3937.61 0.00195777  
  C++ Note: LIN_non-dose checked 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400  
  C++ Note: LOGLIN_non-dose checked 3937.61 0.00195777  
  C++ Note: risk checked 3937.61  
  C++ Note: risk1 checked 1313.61 0.00120452  
  C++ Note: risk2 checked 1313.61 0.00120452  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 2514.06  
  C++ Note: risk1r checked 878.06 0.000769057  
  C++ Note: risk2r checked 878.06 0.000769057  
  C++ Note: riskl checked 64.4802  
  C++ Note: risk1l checked 11.4802 1.97246e-05  
  C++ Note: risk2l checked 11.4802 1.97246e-05  
  C++ Note: df101 -301.575 -301.575  
  C++ Note: df102 -0.00472803 -1.08526e-20  
  C++ Note: df103 -19.5429 -9.74088e-21  
  C++ Note: df104 -1.05589 -15  
  C++ Note: df105 0.00024193 1.11413  
  C++ Note: df106 63784.6 2.77883e+22  
  C++ Note: Starting Halves
  C++ Note: df501 -301.5755
  C++ Note: df504 -1.055886 -15  
  C++ Note: values checked -1.05607 -15  
  C++ Note: sums checked 3937.37 0.00195777  
  C++ Note: derivs checked 1313.37 0.00195777  
  C++ Note: second derivs checked 1313.37 0.00195777  
  C++ Note: dose checked 6400 6400  
  C++ Note: non-dose checked 3937.37 0.00195777  
  C++ Note: LIN_non-dose checked 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400  
  C++ Note: LOGLIN_non-dose checked 3937.37 0.00195777  
  C++ Note: risk checked 3937.37  
  C++ Note: risk1 checked 1313.37 0.00120445  
  C++ Note: risk2 checked 1313.37 0.00120445  
  C++ Note: riskr checked 2513.9  
  C++ Note: risk1r checked 877.901 0.000769008  
  C++ Note: risk2r checked 877.901 0.000769008  
  C++ Note: riskl checked 64.4781  
  C++ Note: risk1l checked 11.4781 1.9724e-05  
  C++ Note: risk2l checked 11.4781 1.9724e-05  
  C++ Note: df101 -301.575 -301.575  
  C++ Note: df102 -0.00118208 -6.29981e-21  
  C++ Note: df103 -19.5421 -6.29981e-21  
  C++ Note: df104 -1.05607 -15  
  C++ Note: df105 6.04892e-05 1  
  C++ Note: df106 255122 4.78706e+22  
  C++ Note: df100 20294 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:56 2024
  
  C++ Note: riskr checked 2513.9  
  C++ Note: risk1r checked 877.901 0.000769008  
  C++ Note: risk2r checked 877.901 0.000769008  
  C++ Note: riskl checked 64.4781  
  C++ Note: risk1l checked 11.4781 1.9724e-05  
  C++ Note: risk2l checked 11.4781 1.9724e-05  
  C++ Note: df101 -301.575 -301.575  
  C++ Note: df102 -0.00118208 -6.29981e-21  
  C++ Note: df103 -19.5421 -6.29981e-21  
  C++ Note: df104 -1.05607 -15  
  C++ Note: df105 6.04892e-05 1  
  C++ Note: df106 255122 4.78706e+22  
  C++ Note: ending guess 0
  C++ Note: df501 -301.5755
  C++ Note: df504 -1.056067 -15  
  C++ Note: Refreshing matrices after all guesses
  C++ Note: Guess Results
  Guess number, parameter values, Log-Likelihood
  0, -1.056067 -15, -301.5755<-- Best Guess
  C++ Note: starting subterms 2 in best guess 0
  C++ Note: values checked -1.05607 -15  
  C++ Note: sums checked 3937.37 0.00195777  
  C++ Note: derivs checked 1313.37 0.00195777  
  C++ Note: second derivs checked 1313.37 0.00195777  
  C++ Note: dose checked 6400 6400  
  C++ Note: non-dose checked 3937.37 0.00195777  
  C++ Note: LIN_non-dose checked 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400  
  C++ Note: LOGLIN_non-dose checked 3937.37 0.00195777  
  C++ Note: risk checked 3937.37  
  C++ Note: risk1 checked 1313.37 0.00120445  
  C++ Note: risk2 checked 1313.37 0.00120445  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 2513.9  
  C++ Note: risk1r checked 877.901 0.000769008  
  C++ Note: risk2r checked 877.901 0.000769008  
  C++ Note: riskl checked 64.4781  
  C++ Note: risk1l checked 11.4781 1.9724e-05  
  C++ Note: risk2l checked 11.4781 1.9724e-05  
  C++ Note: df101 -301.575 -301.575  
  C++ Note: df102 -0.00118208 -6.29981e-21  
  C++ Note: df103 -19.5421 -6.29981e-21  
  C++ Note: df104 -1.05607 -15  
  C++ Note: df105 6.04892e-05 1  
  C++ Note: df106 255122 4.78706e+22  
  C++ Note: Starting Halves
  C++ Note: df501 -301.5755
  C++ Note: df504 -1.056067 -15  
  C++ Note: values checked -1.05611 -15  
  C++ Note: sums checked 3937.31 0.00195777  
  C++ Note: derivs checked 1313.31 0.00195777  
  C++ Note: second derivs checked 1313.31 0.00195777  
  C++ Note: dose checked 6400 6400  
  C++ Note: non-dose checked 3937.31 0.00195777  
  C++ Note: LIN_non-dose checked 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400  
  C++ Note: LOGLIN_non-dose checked 3937.31 0.00195777  
  C++ Note: risk checked 3937.31  
  C++ Note: risk1 checked 1313.31 0.00120443  
  C++ Note: risk2 checked 1313.31 0.00120443  
  C++ Note: riskr checked 2513.86  
  C++ Note: risk1r checked 877.861 0.000768996  
  C++ Note: risk2r checked 877.861 0.000768996  
  C++ Note: riskl checked 64.4776  
  C++ Note: risk1l checked 11.4776 1.97238e-05  
  C++ Note: risk2l checked 11.4776 1.97238e-05  
  C++ Note: df101 -301.575 -301.575  
  C++ Note: df102 -0.000295526 5.98217e-21  
  C++ Note: df103 -19.5419 5.82335e-21  
  C++ Note: df104 -1.05611 -15  
  C++ Note: df105 1.51227e-05 1.02727  
  C++ Note: df106 1.02047e+06 -5.04124e+22  
  C++ Note: df100 36405 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:56 2024
  
  C++ Note: riskr checked 2513.86  
  C++ Note: risk1r checked 877.861 0.000768996  
  C++ Note: risk2r checked 877.861 0.000768996  
  C++ Note: riskl checked 64.4776  
  C++ Note: risk1l checked 11.4776 1.97238e-05  
  C++ Note: risk2l checked 11.4776 1.97238e-05  
  C++ Note: df101 -301.575 -301.575  
  C++ Note: df102 -0.000295526 5.98217e-21  
  C++ Note: df103 -19.5419 5.82335e-21  
  C++ Note: df104 -1.05611 -15  
  C++ Note: df105 1.51227e-05 1.02727  
  C++ Note: df106 1.02047e+06 -5.04124e+22  
  C++ Note: riskr checked 2513.86  
  C++ Note: risk1r checked 877.861 0.000768996  
  C++ Note: risk2r checked 877.861 0.000768996  
  C++ Note: riskl checked 64.4776  
  C++ Note: risk1l checked 11.4776 1.97238e-05  
  C++ Note: risk2l checked 11.4776 1.97238e-05  
  C++ Note: df101 -301.575 -301.575  
  C++ Note: df102 -0.000295526 5.98217e-21  
  C++ Note: df103 -19.5419 5.82335e-21  
  C++ Note: df104 -1.05611 -15  
  C++ Note: df105 1.51227e-05 1.02727  
  C++ Note: df106 1.02047e+06 -5.04124e+22  
  C++ Note: Exiting Regression
  C++ Note: df501 -301.5755
  C++ Note: df504 -1.056113 -15  
  Error: guesses_control and model_control have different strata options
  Note: 2  strata used
  Note: 86 risk groups
  Warning: rmin and rmax lists not equal size, defaulting to lin and loglin min/max values
  C++ Note: START_RISK_CHECK
  C++ Note: Current Time, Fri Feb 23 05:58:56 2024
  
  C++ Note: Term checked 0 1  
  C++ Note: df99,61,Starting
  C++ Note: Current Time, Fri Feb 23 05:58:56 2024
  
  C++ Note: starting subterms 2
  C++ Note: values checked 0.01 -15  
  C++ Note: sums checked 6437.949 0.001957775  
  C++ Note: dose checked 6400 6400  
  C++ Note: non-dose checked 6437.949 0.001957775  
  C++ Note: LIN_non-dose checked 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400  
  C++ Note: LOGLIN_non-dose checked 6437.949 0.001957775  
  C++ Note: df99,12816,Prep_Terms
  C++ Note: Current Time, Fri Feb 23 05:58:56 2024
  
  Note: 1 valid guesses
  C++ Note: START_RISK_CHECK
  C++ Note: Current Time, Fri Feb 23 05:58:56 2024
  
  C++ Note: Term checked 0 1  
  C++ Note: df99,52,Starting
  C++ Note: Current Time, Fri Feb 23 05:58:56 2024
  
  C++ Note: starting subterms 2
  C++ Note: values checked -0.4291924 -15.30179  
  C++ Note: sums checked 5082.307 0.001447756  
  C++ Note: dose checked 6400 6400  
  C++ Note: non-dose checked 5082.307 0.001447756  
  C++ Note: LIN_non-dose checked 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400  
  C++ Note: LOGLIN_non-dose checked 5082.307 0.001447756  
  C++ Note: df99,991,Prep_Terms
  C++ Note: Current Time, Fri Feb 23 05:58:56 2024
  
  Note: 2  strata used
  Note: 86 risk groups
  C++ Note: START_COX_GUESS
  C++ Note: Current Time, Fri Feb 23 05:58:56 2024
  
  C++ Note: Term checked 0 1  
  C++ Note: df99,68,Starting
  C++ Note: Current Time, Fri Feb 23 05:58:56 2024
  
  C++ Note: Grouping Start
  C++ Note: df100 3116 0 0 -1,Prep_List
  C++ Note: Current Time, Fri Feb 23 05:58:56 2024
  
  C++ Note: starting subterms 2 in guess 0
  C++ Note: values checked 0.01 -15  
  C++ Note: sums checked 6437.95 0.00195777  
  C++ Note: derivs checked 3813.95 0.00195777  
  C++ Note: second derivs checked 3813.95 0.00195777  
  C++ Note: dose checked 6400 6400  
  C++ Note: non-dose checked 6437.95 0.00195777  
  C++ Note: LIN_non-dose checked 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400  
  C++ Note: LOGLIN_non-dose checked 6437.95 0.00195777  
  C++ Note: risk checked 6437.95  
  C++ Note: risk1 checked 3813.95 0.00196938  
  C++ Note: risk2 checked 3813.95 0.00196938  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 1135 832.282  
  C++ Note: riskl checked 53 33.3317  
  C++ Note: df101 -248.958 -248.958  
  C++ Note: df102 2.22045e-16 -1.53525e-21  
  C++ Note: df103 -2.22045e-16 -1.53525e-21  
  C++ Note: df104 0.01 -15  
  C++ Note: df105 -1 1  
  C++ Note: df106 -1.12121e+18 1.62162e+23  
  C++ Note: Starting Halves
  C++ Note: df501 -248.9581
  C++ Note: df504 0.01 -15  
  C++ Note: values checked 0.76 -15.8017  
  C++ Note: sums checked 10698.1 0.00087817  
  C++ Note: derivs checked 8074.13 0.00087817  
  C++ Note: second derivs checked 8074.13 0.00087817  
  C++ Note: dose checked 6400 6400  
  C++ Note: non-dose checked 10698.1 0.00087817  
  C++ Note: LIN_non-dose checked 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400  
  C++ Note: LOGLIN_non-dose checked 10698.1 0.00087817  
  C++ Note: risk checked 10698.1  
  C++ Note: risk1 checked 8074.14 0.00146793  
  C++ Note: risk2 checked 8074.14 0.00146793  
  C++ Note: riskr checked 1135 1761.94  
  C++ Note: riskl checked 53 70.5632  
  C++ Note: df101 -248.958 -248.958  
  C++ Note: df102 8.88178e-16 -1.1382e-21  
  C++ Note: df103 -8.88178e-16 -1.1382e-21  
  C++ Note: df104 0.76 -15.8017  
  C++ Note: df105 -1 1  
  C++ Note: df106 -2.80302e+17 2.1873e+23  
  C++ Note: df100 44392 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:57 2024
  
  C++ Note: values checked 0.385 -15.4009  
  C++ Note: sums checked 8173.26 0.0013112  
  C++ Note: derivs checked 5549.26 0.0013112  
  C++ Note: second derivs checked 5549.26 0.0013112  
  C++ Note: dose checked 6400 6400  
  C++ Note: non-dose checked 8173.26 0.0013112  
  C++ Note: LIN_non-dose checked 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400  
  C++ Note: LOGLIN_non-dose checked 8173.26 0.0013112  
  C++ Note: risk checked 8173.27  
  C++ Note: risk1 checked 5549.27 0.0016745  
  C++ Note: risk2 checked 5549.27 0.0016745  
  C++ Note: riskr checked 1135 1210.96  
  C++ Note: riskl checked 53 48.4973  
  C++ Note: df101 -248.958 -248.958  
  C++ Note: df102 3.33067e-16 -2.30287e-21  
  C++ Note: df103 -3.33067e-16 -2.30287e-21  
  C++ Note: df104 0.385 -15.4009  
  C++ Note: df105 -1 1  
  C++ Note: df106 -7.47472e+17 1.08108e+23  
  C++ Note: df100 61417 2 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:57 2024
  
  C++ Note: values checked 0.1975 -15.2004  
  C++ Note: sums checked 7224.5 0.0016022  
  C++ Note: derivs checked 4600.5 0.0016022  
  C++ Note: second derivs checked 4600.5 0.0016022  
  C++ Note: dose checked 6400 6400  
  C++ Note: non-dose checked 7224.5 0.0016022  
  C++ Note: LIN_non-dose checked 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400  
  C++ Note: LOGLIN_non-dose checked 7224.5 0.0016022  
  C++ Note: risk checked 7224.5  
  C++ Note: risk1 checked 4600.5 0.00180861  
  C++ Note: risk2 checked 4600.5 0.00180861  
  C++ Note: riskr checked 1135 1003.92  
  C++ Note: riskl checked 53 40.2057  
  C++ Note: df101 -248.958 -248.958  
  C++ Note: df102 4.44089e-16 1.90582e-21  
  C++ Note: df103 -4.44089e-16 -1.79995e-21  
  C++ Note: df104 0.1975 -15.2004  
  C++ Note: df105 -1 -1.05882  
  C++ Note: df106 -5.60604e+17 -1.3063e+23  
  C++ Note: df100 65749 3 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:57 2024
  
  C++ Note: riskr checked 1135 1003.92  
  C++ Note: riskl checked 53 40.2057  
  C++ Note: df101 -497.916 -497.916  
  C++ Note: df102 8.88178e-16 3.81165e-21  
  C++ Note: df103 -8.88178e-16 -3.59989e-21  
  C++ Note: df104 0.1975 -15.2004  
  C++ Note: df105 -1 -1.05882  
  C++ Note: df106 -5.60604e+17 -1.3063e+23  
  C++ Note: ending guess 0
  C++ Note: df501 -248.9581
  C++ Note: df504 0.01 -15  
  C++ Note: starting subterms 2 in guess 1
  C++ Note: values checked -0.429192 -15.3018  
  C++ Note: sums checked 5082.31 0.00144776  
  C++ Note: derivs checked 2458.31 0.00144776  
  C++ Note: second derivs checked 2458.31 0.00144776  
  C++ Note: dose checked 6400 6400  
  C++ Note: non-dose checked 5082.31 0.00144776  
  C++ Note: LIN_non-dose checked 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400  
  C++ Note: LOGLIN_non-dose checked 5082.31 0.00144776  
  C++ Note: risk checked 5082.31  
  C++ Note: risk1 checked 2458.31 0.00114968  
  C++ Note: risk2 checked 2458.31 0.00114968  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 1135 536.453  
  C++ Note: riskl checked 53 21.4841  
  C++ Note: df101 -248.958 -248.958  
  C++ Note: df102 5.55112e-16 -3.70577e-22  
  C++ Note: df103 -5.55112e-16 -3.70577e-22  
  C++ Note: df104 -0.429192 -15.3018  
  C++ Note: df105 -1 1  
  C++ Note: df106 -4.48483e+17 6.71812e+23  
  C++ Note: Starting Halves
  C++ Note: df501 -248.9581
  C++ Note: df504 -0.4291924 -15.30179  
  C++ Note: values checked 0.320808 -16.3018  
  C++ Note: sums checked 7828.24 0.0005326  
  C++ Note: derivs checked 5204.24 0.0005326  
  C++ Note: second derivs checked 5204.24 0.0005326  
  C++ Note: dose checked 6400 6400  
  C++ Note: non-dose checked 7828.24 0.0005326  
  C++ Note: LIN_non-dose checked 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400  
  C++ Note: LOGLIN_non-dose checked 7828.24 0.0005326  
  C++ Note: risk checked 7828.24  
  C++ Note: risk1 checked 5204.24 0.000651456  
  C++ Note: risk2 checked 5204.24 0.000651456  
  C++ Note: riskr checked 1135 1135.67  
  C++ Note: riskl checked 53 45.4819  
  C++ Note: df101 -248.958 -248.958  
  C++ Note: df102 3.33067e-16 4.49986e-22  
  C++ Note: df103 -3.33067e-16 4.49986e-22  
  C++ Note: df104 0.320808 -16.3018  
  C++ Note: df105 -1 1  
  C++ Note: df106 -7.47472e+17 -5.53257e+23  
  C++ Note: df100 98605 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:57 2024
  
  C++ Note: values checked -0.0541923 -15.8018  
  C++ Note: sums checked 6200.82 0.000878109  
  C++ Note: derivs checked 3576.82 0.000878109  
  C++ Note: second derivs checked 3576.82 0.000878109  
  C++ Note: dose checked 6400 6400  
  C++ Note: non-dose checked 6200.82 0.000878109  
  C++ Note: LIN_non-dose checked 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400  
  C++ Note: LOGLIN_non-dose checked 6200.82 0.000878109  
  C++ Note: risk checked 6200.82  
  C++ Note: risk1 checked 3576.82 0.00085078  
  C++ Note: risk2 checked 3576.82 0.00085078  
  C++ Note: riskr checked 1135 780.534  
  C++ Note: riskl checked 53 31.2593  
  C++ Note: df101 -248.958 -248.958  
  C++ Note: df102 -3.33067e-15 -1.05879e-21  
  C++ Note: df103 3.33067e-15 -9.52912e-22  
  C++ Note: df104 -0.0541923 -15.8018  
  C++ Note: df105 -1 1.11111  
  C++ Note: df106 7.47472e+16 2.35134e+23  
  C++ Note: df100 113516 2 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:57 2024
  
  C++ Note: values checked -0.241692 -15.5518  
  C++ Note: sums checked 5589.28 0.00112751  
  C++ Note: derivs checked 2965.28 0.00112751  
  C++ Note: second derivs checked 2965.28 0.00112751  
  C++ Note: dose checked 6400 6400  
  C++ Note: non-dose checked 5589.28 0.00112751  
  C++ Note: LIN_non-dose checked 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400  
  C++ Note: LOGLIN_non-dose checked 5589.28 0.00112751  
  C++ Note: risk checked 5589.29  
  C++ Note: risk1 checked 2965.28 0.000984687  
  C++ Note: risk2 checked 2965.28 0.000984687  
  C++ Note: riskr checked 1135 647.085  
  C++ Note: riskl checked 53 25.9148  
  C++ Note: df101 -248.958 -248.958  
  C++ Note: df102 4.21885e-15 2.35581e-21  
  C++ Note: df103 -7.99361e-15 2.35581e-21  
  C++ Note: df104 -0.241692 -15.5518  
  C++ Note: df105 -0.527778 1  
  C++ Note: df106 -5.90109e+16 -1.05678e+23  
  C++ Note: df100 129370 3 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:57 2024
  
  C++ Note: values checked -0.335442 -15.4268  
  C++ Note: sums checked 5323.92 0.00127764  
  C++ Note: derivs checked 2699.92 0.00127764  
  C++ Note: second derivs checked 2699.92 0.00127764  
  C++ Note: dose checked 6400 6400  
  C++ Note: non-dose checked 5323.92 0.00127764  
  C++ Note: LIN_non-dose checked 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400  
  C++ Note: LOGLIN_non-dose checked 5323.92 0.00127764  
  C++ Note: risk checked 5323.92  
  C++ Note: risk1 checked 2699.92 0.00106282  
  C++ Note: risk2 checked 2699.92 0.00106282  
  C++ Note: riskr checked 1135 589.178  
  C++ Note: riskl checked 53 23.5957  
  C++ Note: df101 -248.958 -248.958  
  C++ Note: df102 3.33067e-16 1.16467e-21  
  C++ Note: df103 -3.33067e-16 1.6676e-21  
  C++ Note: df104 -0.335442 -15.4268  
  C++ Note: df105 -1 0.698413  
  C++ Note: df106 -7.47472e+17 -2.13758e+23  
  C++ Note: df100 133945 4 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:57 2024
  
  C++ Note: values checked -0.382317 -15.3643  
  C++ Note: sums checked 5200.28 0.00136004  
  C++ Note: derivs checked 2576.28 0.00136004  
  C++ Note: second derivs checked 2576.28 0.00136004  
  C++ Note: dose checked 6400 6400  
  C++ Note: non-dose checked 5200.28 0.00136004  
  C++ Note: LIN_non-dose checked 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400  
  C++ Note: LOGLIN_non-dose checked 5200.28 0.00136004  
  C++ Note: risk checked 5200.28  
  C++ Note: risk1 checked 2576.28 0.00110509  
  C++ Note: risk2 checked 2576.28 0.00110509  
  C++ Note: riskr checked 1135 562.198  
  C++ Note: riskl checked 53 22.5152  
  C++ Note: df101 -248.958 -248.958  
  C++ Note: df102 5.55112e-16 -1.21761e-21  
  C++ Note: df103 -5.55112e-16 -1.21761e-21  
  C++ Note: df104 -0.382317 -15.3643  
  C++ Note: df105 -1 1  
  C++ Note: df106 -4.48483e+17 2.04465e+23  
  C++ Note: df100 138535 5 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:57 2024
  
  C++ Note: Changing back to best
  C++ Note: values checked -0.429192 -15.3018  
  C++ Note: sums checked 5082.31 0.00144776  
  C++ Note: derivs checked 2458.31 0.00144776  
  C++ Note: second derivs checked 2458.31 0.00144776  
  C++ Note: dose checked 6400 6400  
  C++ Note: non-dose checked 5082.31 0.00144776  
  C++ Note: LIN_non-dose checked 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400  
  C++ Note: LOGLIN_non-dose checked 5082.31 0.00144776  
  C++ Note: risk checked 5082.31  
  C++ Note: risk1 checked 2458.31 0.00114968  
  C++ Note: risk2 checked 2458.31 0.00114968  
  C++ Note: riskr checked 1135 536.453  
  C++ Note: riskl checked 53 21.4841  
  C++ Note: df101 -497.916 -497.916  
  C++ Note: df102 1.11022e-15 -7.41154e-22  
  C++ Note: df103 -1.11022e-15 -7.41154e-22  
  C++ Note: df104 -0.429192 -15.3018  
  C++ Note: df105 -1 1  
  C++ Note: df106 -4.48483e+17 6.71812e+23  
  C++ Note: ending guess 1
  C++ Note: df501 -248.9581
  C++ Note: df504 -0.4291924 -15.30179  
  C++ Note: Refreshing matrices after all guesses
  C++ Note: Guess Results
  Guess number, parameter values, Log-Likelihood
  0, 0.1975001 -15.20043, -497.9161
  1, -0.4291924 -15.30179, -497.9161<-- Best Guess
  C++ Note: starting subterms 2 in best guess 1
  C++ Note: values checked -0.429192 -15.3018  
  C++ Note: sums checked 5082.31 0.00144776  
  C++ Note: derivs checked 2458.31 0.00144776  
  C++ Note: second derivs checked 2458.31 0.00144776  
  C++ Note: dose checked 6400 6400  
  C++ Note: non-dose checked 5082.31 0.00144776  
  C++ Note: LIN_non-dose checked 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400  
  C++ Note: LOGLIN_non-dose checked 5082.31 0.00144776  
  C++ Note: risk checked 5082.31  
  C++ Note: risk1 checked 2458.31 0.00114968  
  C++ Note: risk2 checked 2458.31 0.00114968  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 1135 536.453  
  C++ Note: riskl checked 53 21.4841  
  C++ Note: df101 -248.958 -248.958  
  C++ Note: df102 5.55112e-16 -3.70577e-22  
  C++ Note: df103 -5.55112e-16 -3.70577e-22  
  C++ Note: df104 -0.429192 -15.3018  
  C++ Note: df105 -1 1  
  C++ Note: df106 -4.48483e+17 6.71812e+23  
  C++ Note: Starting Halves
  C++ Note: df501 -248.9581
  C++ Note: df504 -0.4291924 -15.30179  
  C++ Note: values checked 0.320808 -16.3018  
  C++ Note: sums checked 7828.24 0.0005326  
  C++ Note: derivs checked 5204.24 0.0005326  
  C++ Note: second derivs checked 5204.24 0.0005326  
  C++ Note: dose checked 6400 6400  
  C++ Note: non-dose checked 7828.24 0.0005326  
  C++ Note: LIN_non-dose checked 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400  
  C++ Note: LOGLIN_non-dose checked 7828.24 0.0005326  
  C++ Note: risk checked 7828.24  
  C++ Note: risk1 checked 5204.24 0.000651456  
  C++ Note: risk2 checked 5204.24 0.000651456  
  C++ Note: riskr checked 1135 1135.67  
  C++ Note: riskl checked 53 45.4819  
  C++ Note: df101 -248.958 -248.958  
  C++ Note: df102 3.33067e-16 4.49986e-22  
  C++ Note: df103 -3.33067e-16 4.49986e-22  
  C++ Note: df104 0.320808 -16.3018  
  C++ Note: df105 -1 1  
  C++ Note: df106 -7.47472e+17 -5.53257e+23  
  C++ Note: df100 197455 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:57 2024
  
  C++ Note: values checked -0.0541923 -15.8018  
  C++ Note: sums checked 6200.82 0.000878109  
  C++ Note: derivs checked 3576.82 0.000878109  
  C++ Note: second derivs checked 3576.82 0.000878109  
  C++ Note: dose checked 6400 6400  
  C++ Note: non-dose checked 6200.82 0.000878109  
  C++ Note: LIN_non-dose checked 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400  
  C++ Note: LOGLIN_non-dose checked 6200.82 0.000878109  
  C++ Note: risk checked 6200.82  
  C++ Note: risk1 checked 3576.82 0.00085078  
  C++ Note: risk2 checked 3576.82 0.00085078  
  C++ Note: riskr checked 1135 780.534  
  C++ Note: riskl checked 53 31.2593  
  C++ Note: df101 -248.958 -248.958  
  C++ Note: df102 -3.33067e-15 -1.05879e-21  
  C++ Note: df103 3.33067e-15 -9.52912e-22  
  C++ Note: df104 -0.0541923 -15.8018  
  C++ Note: df105 -1 1.11111  
  C++ Note: df106 7.47472e+16 2.35134e+23  
  C++ Note: df100 201852 2 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:57 2024
  
  C++ Note: values checked -0.241692 -15.5518  
  C++ Note: sums checked 5589.28 0.00112751  
  C++ Note: derivs checked 2965.28 0.00112751  
  C++ Note: second derivs checked 2965.28 0.00112751  
  C++ Note: dose checked 6400 6400  
  C++ Note: non-dose checked 5589.28 0.00112751  
  C++ Note: LIN_non-dose checked 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400  
  C++ Note: LOGLIN_non-dose checked 5589.28 0.00112751  
  C++ Note: risk checked 5589.29  
  C++ Note: risk1 checked 2965.28 0.000984687  
  C++ Note: risk2 checked 2965.28 0.000984687  
  C++ Note: riskr checked 1135 647.085  
  C++ Note: riskl checked 53 25.9148  
  C++ Note: df101 -248.958 -248.958  
  C++ Note: df102 4.21885e-15 2.35581e-21  
  C++ Note: df103 -7.99361e-15 2.35581e-21  
  C++ Note: df104 -0.241692 -15.5518  
  C++ Note: df105 -0.527778 1  
  C++ Note: df106 -5.90109e+16 -1.05678e+23  
  C++ Note: df100 217564 3 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:57 2024
  
  C++ Note: values checked -0.335442 -15.4268  
  C++ Note: sums checked 5323.92 0.00127764  
  C++ Note: derivs checked 2699.92 0.00127764  
  C++ Note: second derivs checked 2699.92 0.00127764  
  C++ Note: dose checked 6400 6400  
  C++ Note: non-dose checked 5323.92 0.00127764  
  C++ Note: LIN_non-dose checked 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400  
  C++ Note: LOGLIN_non-dose checked 5323.92 0.00127764  
  C++ Note: risk checked 5323.92  
  C++ Note: risk1 checked 2699.92 0.00106282  
  C++ Note: risk2 checked 2699.92 0.00106282  
  C++ Note: riskr checked 1135 589.178  
  C++ Note: riskl checked 53 23.5957  
  C++ Note: df101 -248.958 -248.958  
  C++ Note: df102 3.33067e-16 1.16467e-21  
  C++ Note: df103 -3.33067e-16 1.6676e-21  
  C++ Note: df104 -0.335442 -15.4268  
  C++ Note: df105 -1 0.698413  
  C++ Note: df106 -7.47472e+17 -2.13758e+23  
  C++ Note: df100 222004 4 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:57 2024
  
  C++ Note: values checked -0.382317 -15.3643  
  C++ Note: sums checked 5200.28 0.00136004  
  C++ Note: derivs checked 2576.28 0.00136004  
  C++ Note: second derivs checked 2576.28 0.00136004  
  C++ Note: dose checked 6400 6400  
  C++ Note: non-dose checked 5200.28 0.00136004  
  C++ Note: LIN_non-dose checked 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400  
  C++ Note: LOGLIN_non-dose checked 5200.28 0.00136004  
  C++ Note: risk checked 5200.28  
  C++ Note: risk1 checked 2576.28 0.00110509  
  C++ Note: risk2 checked 2576.28 0.00110509  
  C++ Note: riskr checked 1135 562.198  
  C++ Note: riskl checked 53 22.5152  
  C++ Note: df101 -248.958 -248.958  
  C++ Note: df102 5.55112e-16 -1.21761e-21  
  C++ Note: df103 -5.55112e-16 -1.21761e-21  
  C++ Note: df104 -0.382317 -15.3643  
  C++ Note: df105 -1 1  
  C++ Note: df106 -4.48483e+17 2.04465e+23  
  C++ Note: df100 237489 5 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:57 2024
  
  C++ Note: Changing back to best
  C++ Note: values checked -0.429192 -15.3018  
  C++ Note: sums checked 5082.31 0.00144776  
  C++ Note: derivs checked 2458.31 0.00144776  
  C++ Note: second derivs checked 2458.31 0.00144776  
  C++ Note: dose checked 6400 6400  
  C++ Note: non-dose checked 5082.31 0.00144776  
  C++ Note: LIN_non-dose checked 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400  
  C++ Note: LOGLIN_non-dose checked 5082.31 0.00144776  
  C++ Note: risk checked 5082.31  
  C++ Note: risk1 checked 2458.31 0.00114968  
  C++ Note: risk2 checked 2458.31 0.00114968  
  C++ Note: riskr checked 1135 536.453  
  C++ Note: riskl checked 53 21.4841  
  C++ Note: df101 -248.958 -248.958  
  C++ Note: df102 5.55112e-16 -3.70577e-22  
  C++ Note: df103 -5.55112e-16 -3.70577e-22  
  C++ Note: df104 -0.429192 -15.3018  
  C++ Note: df105 -1 1  
  C++ Note: df106 -4.48483e+17 6.71812e+23  
  C++ Note: Starting Halves
  C++ Note: df501 -248.9581
  C++ Note: df504 -0.4291924 -15.30179  
  C++ Note: values checked -0.397942 -15.333  
  C++ Note: sums checked 5160.34 0.00140321  
  C++ Note: derivs checked 2536.34 0.00140321  
  C++ Note: second derivs checked 2536.34 0.00140321  
  C++ Note: dose checked 6400 6400  
  C++ Note: non-dose checked 5160.34 0.00140321  
  C++ Note: LIN_non-dose checked 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400  
  C++ Note: LOGLIN_non-dose checked 5160.34 0.00140321  
  C++ Note: risk checked 5160.34  
  C++ Note: risk1 checked 2536.34 0.00113142  
  C++ Note: risk2 checked 2536.34 0.00113142  
  C++ Note: riskr checked 1135 553.481  
  C++ Note: riskl checked 53 22.1661  
  C++ Note: df101 -248.958 -248.958  
  C++ Note: df102 -4.77396e-15 -3.17637e-22  
  C++ Note: df103 9.65894e-15 1.29702e-21  
  C++ Note: df104 -0.397942 -15.333  
  C++ Note: df105 -0.494253 -0.244898  
  C++ Note: df106 5.21492e+16 7.83781e+23  
  C++ Note: df100 246511 1 2 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:57 2024
  
  C++ Note: values checked -0.413567 -15.3174  
  C++ Note: sums checked 5121.02 0.00142531  
  C++ Note: derivs checked 2497.02 0.00142531  
  C++ Note: second derivs checked 2497.02 0.00142531  
  C++ Note: dose checked 6400 6400  
  C++ Note: non-dose checked 5121.02 0.00142531  
  C++ Note: LIN_non-dose checked 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400  
  C++ Note: LOGLIN_non-dose checked 5121.02 0.00142531  
  C++ Note: risk checked 5121.02  
  C++ Note: risk1 checked 2497.02 0.00114048  
  C++ Note: risk2 checked 2497.02 0.00114048  
  C++ Note: riskr checked 1135 544.901  
  C++ Note: riskl checked 53 21.8225  
  C++ Note: df101 -248.958 -248.958  
  C++ Note: df102 5.55112e-16 -8.73503e-22  
  C++ Note: df103 -5.55112e-16 -8.73503e-22  
  C++ Note: df104 -0.413567 -15.3174  
  C++ Note: df105 -1 1  
  C++ Note: df106 -4.48483e+17 2.85011e+23  
  C++ Note: df100 261401 2 2 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:57 2024
  
  C++ Note: values checked -0.42138 -15.3096  
  C++ Note: sums checked 5101.59 0.00143649  
  C++ Note: derivs checked 2477.59 0.00143649  
  C++ Note: second derivs checked 2477.59 0.00143649  
  C++ Note: dose checked 6400 6400  
  C++ Note: non-dose checked 5101.59 0.00143649  
  C++ Note: LIN_non-dose checked 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400  
  C++ Note: LOGLIN_non-dose checked 5101.59 0.00143649  
  C++ Note: risk checked 5101.59  
  C++ Note: risk1 checked 2477.59 0.00114506  
  C++ Note: risk2 checked 2477.59 0.00114506  
  C++ Note: riskr checked 1135 540.66  
  C++ Note: riskl checked 53 21.6526  
  C++ Note: df101 -248.958 -248.958  
  C++ Note: df102 5.55112e-16 1.03232e-21  
  C++ Note: df103 -5.55112e-16 7.41154e-22  
  C++ Note: df104 -0.42138 -15.3096  
  C++ Note: df105 -1 1.39286  
  C++ Note: df106 -4.48483e+17 -2.41163e+23  
  C++ Note: df100 277451 3 2 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:57 2024
  
  C++ Note: values checked -0.425286 -15.3057  
  C++ Note: sums checked 5091.93 0.00144211  
  C++ Note: derivs checked 2467.93 0.00144211  
  C++ Note: second derivs checked 2467.93 0.00144211  
  C++ Note: dose checked 6400 6400  
  C++ Note: non-dose checked 5091.93 0.00144211  
  C++ Note: LIN_non-dose checked 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400  
  C++ Note: LOGLIN_non-dose checked 5091.93 0.00144211  
  C++ Note: risk checked 5091.93  
  C++ Note: risk1 checked 2467.93 0.00114736  
  C++ Note: risk2 checked 2467.93 0.00114736  
  C++ Note: riskr checked 1135 538.552  
  C++ Note: riskl checked 53 21.5682  
  C++ Note: df101 -248.958 -248.958  
  C++ Note: df102 1.22125e-15 -2.62051e-21  
  C++ Note: df103 -1.88738e-15 -1.45584e-21  
  C++ Note: df104 -0.425286 -15.3057  
  C++ Note: df105 -0.647059 1.8  
  C++ Note: df106 -2.03856e+17 9.50037e+22  
  C++ Note: df100 281800 4 2 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:57 2024
  
  C++ Note: values checked -0.427239 -15.3037  
  C++ Note: sums checked 5087.11 0.00144493  
  C++ Note: derivs checked 2463.11 0.00144493  
  C++ Note: second derivs checked 2463.11 0.00144493  
  C++ Note: dose checked 6400 6400  
  C++ Note: non-dose checked 5087.11 0.00144493  
  C++ Note: LIN_non-dose checked 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400  
  C++ Note: LOGLIN_non-dose checked 5087.11 0.00144493  
  C++ Note: risk checked 5087.11  
  C++ Note: risk1 checked 2463.11 0.00114852  
  C++ Note: risk2 checked 2463.11 0.00114852  
  C++ Note: riskr checked 1135 537.501  
  C++ Note: riskl checked 53 21.5261  
  C++ Note: df101 -497.916 -497.916  
  C++ Note: df102 1.11022e-15 3.28225e-21  
  C++ Note: df103 -1.11022e-15 4.60574e-21  
  C++ Note: df104 -0.427239 -15.3037  
  C++ Note: df105 -1 0.712644  
  C++ Note: df106 -4.48483e+17 -1.517e+23  
  C++ Note: df100 297596 5 2 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:57 2024
  
  C++ Note: Changing back to best
  C++ Note: values checked -0.429192 -15.3018  
  C++ Note: sums checked 5082.31 0.00144776  
  C++ Note: derivs checked 2458.31 0.00144776  
  C++ Note: second derivs checked 2458.31 0.00144776  
  C++ Note: dose checked 6400 6400  
  C++ Note: non-dose checked 5082.31 0.00144776  
  C++ Note: LIN_non-dose checked 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400  
  C++ Note: LOGLIN_non-dose checked 5082.31 0.00144776  
  C++ Note: risk checked 5082.31  
  C++ Note: risk1 checked 2458.31 0.00114968  
  C++ Note: risk2 checked 2458.31 0.00114968  
  C++ Note: riskr checked 1135 536.453  
  C++ Note: riskl checked 53 21.4841  
  C++ Note: df101 -248.958 -248.958  
  C++ Note: df102 5.55112e-16 -3.70577e-22  
  C++ Note: df103 -5.55112e-16 -3.70577e-22  
  C++ Note: df104 -0.429192 -15.3018  
  C++ Note: df105 -1 1  
  C++ Note: df106 -4.48483e+17 6.71812e+23  
  C++ Note: Starting Halves
  C++ Note: df501 -248.9581
  C++ Note: df504 -0.4291924 -15.30179  
  C++ Note: values checked -0.428216 -15.3028  
  C++ Note: sums checked 5084.71 0.00144634  
  C++ Note: derivs checked 2460.71 0.00144634  
  C++ Note: second derivs checked 2460.71 0.00144634  
  C++ Note: dose checked 6400 6400  
  C++ Note: non-dose checked 5084.71 0.00144634  
  C++ Note: LIN_non-dose checked 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400  
  C++ Note: LOGLIN_non-dose checked 5084.71 0.00144634  
  C++ Note: risk checked 5084.71  
  C++ Note: risk1 checked 2460.71 0.0011491  
  C++ Note: risk2 checked 2460.71 0.0011491  
  C++ Note: riskr checked 1135 536.977  
  C++ Note: riskl checked 53 21.5051  
  C++ Note: df101 -248.958 -248.958  
  C++ Note: df102 -5.9952e-15 -4.49986e-21  
  C++ Note: df103 1.19904e-14 -4.49986e-21  
  C++ Note: df104 -0.428216 -15.3028  
  C++ Note: df105 -0.5 1  
  C++ Note: df106 4.15262e+16 5.53257e+22  
  C++ Note: df100 306051 1 3 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:57 2024
  
  C++ Note: values checked -0.428704 -15.3023  
  C++ Note: sums checked 5083.51 0.00144705  
  C++ Note: derivs checked 2459.51 0.00144705  
  C++ Note: second derivs checked 2459.51 0.00144705  
  C++ Note: dose checked 6400 6400  
  C++ Note: non-dose checked 5083.51 0.00144705  
  C++ Note: LIN_non-dose checked 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400  
  C++ Note: LOGLIN_non-dose checked 5083.51 0.00144705  
  C++ Note: risk checked 5083.51  
  C++ Note: risk1 checked 2459.51 0.00114939  
  C++ Note: risk2 checked 2459.51 0.00114939  
  C++ Note: riskr checked 1135 536.715  
  C++ Note: riskl checked 53 21.4946  
  C++ Note: df101 -248.958 -248.958  
  C++ Note: df102 8.88178e-16 -8.20563e-22  
  C++ Note: df103 -8.88178e-16 7.94093e-23  
  C++ Note: df104 -0.428704 -15.3023  
  C++ Note: df105 -1 -10.3333  
  C++ Note: df106 -2.80302e+17 3.03399e+23  
  C++ Note: df100 325189 2 3 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:57 2024
  
  C++ Note: values checked -0.428948 -15.302  
  C++ Note: sums checked 5082.91 0.0014474  
  C++ Note: derivs checked 2458.91 0.0014474  
  C++ Note: second derivs checked 2458.91 0.0014474  
  C++ Note: dose checked 6400 6400  
  C++ Note: non-dose checked 5082.91 0.0014474  
  C++ Note: LIN_non-dose checked 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400  
  C++ Note: LOGLIN_non-dose checked 5082.91 0.0014474  
  C++ Note: risk checked 5082.91  
  C++ Note: risk1 checked 2458.91 0.00114953  
  C++ Note: risk2 checked 2458.91 0.00114953  
  C++ Note: riskr checked 1135 536.584  
  C++ Note: riskl checked 53 21.4894  
  C++ Note: df101 -248.958 -248.958  
  C++ Note: df102 -5.55112e-15 -3.20284e-21  
  C++ Note: df103 7.88258e-15 -2.72639e-21  
  C++ Note: df104 -0.428948 -15.302  
  C++ Note: df105 -0.704225 1.17476  
  C++ Note: df106 4.48483e+16 7.77303e+22  
  C++ Note: df100 329408 3 3 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:57 2024
  
  C++ Note: values checked -0.42907 -15.3019  
  C++ Note: sums checked 5082.61 0.00144758  
  C++ Note: derivs checked 2458.61 0.00144758  
  C++ Note: second derivs checked 2458.61 0.00144758  
  C++ Note: dose checked 6400 6400  
  C++ Note: non-dose checked 5082.61 0.00144758  
  C++ Note: LIN_non-dose checked 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400  
  C++ Note: LOGLIN_non-dose checked 5082.61 0.00144758  
  C++ Note: risk checked 5082.61  
  C++ Note: risk1 checked 2458.61 0.00114961  
  C++ Note: risk2 checked 2458.61 0.00114961  
  C++ Note: riskr checked 1135 536.518  
  C++ Note: riskl checked 53 21.4868  
  C++ Note: df101 -248.958 -248.958  
  C++ Note: df102 6.66134e-16 2.48816e-21  
  C++ Note: df103 -6.66134e-16 2.48816e-21  
  C++ Note: df104 -0.42907 -15.3019  
  C++ Note: df105 -1 1  
  C++ Note: df106 -3.73736e+17 -1.00057e+23  
  C++ Note: df100 345303 4 3 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:57 2024
  
  C++ Note: values checked -0.429131 -15.3019  
  C++ Note: sums checked 5082.46 0.00144767  
  C++ Note: derivs checked 2458.46 0.00144767  
  C++ Note: second derivs checked 2458.46 0.00144767  
  C++ Note: dose checked 6400 6400  
  C++ Note: non-dose checked 5082.46 0.00144767  
  C++ Note: LIN_non-dose checked 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400  
  C++ Note: LOGLIN_non-dose checked 5082.46 0.00144767  
  C++ Note: risk checked 5082.46  
  C++ Note: risk1 checked 2458.46 0.00114964  
  C++ Note: risk2 checked 2458.46 0.00114964  
  C++ Note: riskr checked 1135 536.485  
  C++ Note: riskl checked 53 21.4855  
  C++ Note: df101 -248.958 -248.958  
  C++ Note: df102 3.33067e-16 -2.11758e-22  
  C++ Note: df103 -3.33067e-16 -1.32349e-21  
  C++ Note: df104 -0.429131 -15.3019  
  C++ Note: df105 -1 0.16  
  C++ Note: df106 -7.47472e+17 1.17567e+24  
  C++ Note: df100 349618 5 3 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:57 2024
  
  C++ Note: Changing back to best
  C++ Note: values checked -0.429192 -15.3018  
  C++ Note: sums checked 5082.31 0.00144776  
  C++ Note: derivs checked 2458.31 0.00144776  
  C++ Note: second derivs checked 2458.31 0.00144776  
  C++ Note: dose checked 6400 6400  
  C++ Note: non-dose checked 5082.31 0.00144776  
  C++ Note: LIN_non-dose checked 6400 6400  
  C++ Note: PLIN_non-dose checked 6400 6400  
  C++ Note: LOGLIN_non-dose checked 5082.31 0.00144776  
  C++ Note: risk checked 5082.31  
  C++ Note: risk1 checked 2458.31 0.00114968  
  C++ Note: risk2 checked 2458.31 0.00114968  
  C++ Note: riskr checked 1135 536.453  
  C++ Note: riskl checked 53 21.4841  
  C++ Note: df101 -248.958 -248.958  
  C++ Note: df102 5.55112e-16 -3.70577e-22  
  C++ Note: df103 -5.55112e-16 -3.70577e-22  
  C++ Note: df104 -0.429192 -15.3018  
  C++ Note: df105 -1 1  
  C++ Note: df106 -4.48483e+17 6.71812e+23  
  C++ Note: riskr checked 1135 536.453  
  C++ Note: riskl checked 53 21.4841  
  C++ Note: df101 -248.958 -248.958  
  C++ Note: df102 5.55112e-16 -3.70577e-22  
  C++ Note: df103 -5.55112e-16 -3.70577e-22  
  C++ Note: df104 -0.429192 -15.3018  
  C++ Note: df105 -1 1  
  C++ Note: df106 -4.48483e+17 6.71812e+23  
  C++ Note: Exiting Regression
  C++ Note: df501 -248.9581
  C++ Note: df504 -0.4291924 -15.30179  
  Error: Atleast one parameter must be free
  Error: no events
  Error: Default Parameters used: 4, Covariates used: 6
  Warning: rmin and rmax lists not equal size, defaulting to lin and loglin min/max values
  C++ Note: START_RISK_CHECK
  C++ Note: Current Time, Fri Feb 23 05:58:57 2024
  
  C++ Note: Term checked 0 0 0 0  
  C++ Note: df99,89,Starting
  C++ Note: Current Time, Fri Feb 23 05:58:57 2024
  
  C++ Note: starting subterms 1
  C++ Note: values checked -0.1 6 0.1 0.1  
  C++ Note: sums checked 254.8 254.8 8.4 8.4  
  C++ Note: dose checked 7  
  C++ Note: non-dose checked 338.8  
  C++ Note: LIN_non-dose checked 8.4  
  C++ Note: PLIN_non-dose checked 254.8  
  C++ Note: LOGLIN_non-dose checked 7  
  C++ Note: df99,452,Prep_Terms
  C++ Note: Current Time, Fri Feb 23 05:58:57 2024
  
  Note: 1 valid guesses
  C++ Note: START_RISK_CHECK
  C++ Note: Current Time, Fri Feb 23 05:58:57 2024
  
  C++ Note: Term checked 0 0 0 0  
  C++ Note: df99,93,Starting
  C++ Note: Current Time, Fri Feb 23 05:58:57 2024
  
  C++ Note: starting subterms 1
  C++ Note: values checked 0.2215742 6.617788 0.7390184 0.9740044  
  C++ Note: sums checked 294.2532 294.2532 71.94696 71.94696  
  C++ Note: dose checked 7  
  C++ Note: non-dose checked 3352.422  
  C++ Note: LIN_non-dose checked 71.94696  
  C++ Note: PLIN_non-dose checked 294.2532  
  C++ Note: LOGLIN_non-dose checked 7  
  C++ Note: df99,449,Prep_Terms
  C++ Note: Current Time, Fri Feb 23 05:58:57 2024
  
  Note: 2 valid guesses
  C++ Note: START_RISK_CHECK
  C++ Note: Current Time, Fri Feb 23 05:58:57 2024
  
  C++ Note: Term checked 0 0 0 0  
  C++ Note: df99,86,Starting
  C++ Note: Current Time, Fri Feb 23 05:58:57 2024
  
  C++ Note: starting subterms 1
  C++ Note: values checked 0.5654312 6.279162 0.3661973 1.023089  
  C++ Note: sums checked 294.4729 294.4729 58.35 58.35  
  C++ Note: dose checked 7  
  C++ Note: non-dose checked 2720.897  
  C++ Note: LIN_non-dose checked 58.35  
  C++ Note: PLIN_non-dose checked 294.4729  
  C++ Note: LOGLIN_non-dose checked 7  
  C++ Note: df99,455,Prep_Terms
  C++ Note: Current Time, Fri Feb 23 05:58:57 2024
  
  Note: 3 valid guesses
  C++ Note: START_RISK_CHECK
  C++ Note: Current Time, Fri Feb 23 05:58:57 2024
  
  C++ Note: Term checked 0 0 0 0  
  C++ Note: df99,83,Starting
  C++ Note: Current Time, Fri Feb 23 05:58:57 2024
  
  C++ Note: starting subterms 1
  C++ Note: values checked 0.4540596 6.915258 0.7989374 1.006046  
  C++ Note: sums checked 316.5113 316.5113 75.80929 75.80929  
  C++ Note: dose checked 7  
  C++ Note: non-dose checked 3800.228  
  C++ Note: LIN_non-dose checked 75.80929  
  C++ Note: PLIN_non-dose checked 316.5113  
  C++ Note: LOGLIN_non-dose checked 7  
  C++ Note: df99,445,Prep_Terms
  C++ Note: Current Time, Fri Feb 23 05:58:57 2024
  
  Note: 4 valid guesses
  C++ Note: START_RISK_CHECK
  C++ Note: Current Time, Fri Feb 23 05:58:57 2024
  
  C++ Note: Term checked 0 0 0 0  
  C++ Note: df99,89,Starting
  C++ Note: Current Time, Fri Feb 23 05:58:57 2024
  
  C++ Note: starting subterms 1
  C++ Note: values checked 0.005602757 6.392582 0.9584111 0.8517844  
  C++ Note: sums checked 275.7237 275.7237 76.02821 76.02821  
  C++ Note: dose checked 7  
  C++ Note: non-dose checked 3318.978  
  C++ Note: LIN_non-dose checked 76.02821  
  C++ Note: PLIN_non-dose checked 275.7237  
  C++ Note: LOGLIN_non-dose checked 7  
  C++ Note: df99,478,Prep_Terms
  C++ Note: Current Time, Fri Feb 23 05:58:57 2024
  
  Note: 5 valid guesses
  C++ Note: START_RISK_CHECK
  C++ Note: Current Time, Fri Feb 23 05:58:57 2024
  
  C++ Note: Term checked 0 0 0 0  
  C++ Note: df99,92,Starting
  C++ Note: Current Time, Fri Feb 23 05:58:57 2024
  
  C++ Note: starting subterms 1
  C++ Note: values checked 0.4204453 6.836265 0.9252424 0.4260211  
  C++ Note: sums checked 311.7818 311.7818 56.75307 56.75307  
  C++ Note: dose checked 7  
  C++ Note: non-dose checked 2802.357  
  C++ Note: LIN_non-dose checked 56.75307  
  C++ Note: PLIN_non-dose checked 311.7818  
  C++ Note: LOGLIN_non-dose checked 7  
  C++ Note: df99,454,Prep_Terms
  C++ Note: Current Time, Fri Feb 23 05:58:57 2024
  
  Note: 6 valid guesses
  C++ Note: START_RISK_CHECK
  C++ Note: Current Time, Fri Feb 23 05:58:57 2024
  
  C++ Note: Term checked 0 0 0 0  
  C++ Note: df99,81,Starting
  C++ Note: Current Time, Fri Feb 23 05:58:57 2024
  
  C++ Note: starting subterms 1
  C++ Note: values checked 0.05800769 6.850922 0.6988397 0.5647598  
  C++ Note: sums checked 297.175 297.175 53.07118 53.07118  
  C++ Note: dose checked 7  
  C++ Note: non-dose checked 2497.505  
  C++ Note: LIN_non-dose checked 53.07118  
  C++ Note: PLIN_non-dose checked 297.175  
  C++ Note: LOGLIN_non-dose checked 7  
  C++ Note: df99,432,Prep_Terms
  C++ Note: Current Time, Fri Feb 23 05:58:57 2024
  
  Note: 7 valid guesses
  C++ Note: START_RISK_CHECK
  C++ Note: Current Time, Fri Feb 23 05:58:57 2024
  
  C++ Note: Term checked 0 0 0 0  
  C++ Note: df99,68,Starting
  C++ Note: Current Time, Fri Feb 23 05:58:57 2024
  
  C++ Note: starting subterms 1
  C++ Note: values checked 0.5803103 6.831288 0.469853 0.5463882  
  C++ Note: sums checked 318.2871 318.2871 42.68213 42.68213  
  C++ Note: dose checked 7  
  C++ Note: non-dose checked 2151.634  
  C++ Note: LIN_non-dose checked 42.68213  
  C++ Note: PLIN_non-dose checked 318.2871  
  C++ Note: LOGLIN_non-dose checked 7  
  C++ Note: df99,368,Prep_Terms
  C++ Note: Current Time, Fri Feb 23 05:58:57 2024
  
  Note: 8 valid guesses
  C++ Note: START_RISK_CHECK
  C++ Note: Current Time, Fri Feb 23 05:58:57 2024
  
  C++ Note: Term checked 0 0 0 0  
  C++ Note: df99,73,Starting
  C++ Note: Current Time, Fri Feb 23 05:58:57 2024
  
  C++ Note: starting subterms 1
  C++ Note: values checked 0.004723529 6.147166 1.021718 0.6426009  
  C++ Note: sums checked 265.3794 265.3794 69.9014 69.9014  
  C++ Note: dose checked 7  
  C++ Note: non-dose checked 2936.739  
  C++ Note: LIN_non-dose checked 69.9014  
  C++ Note: PLIN_non-dose checked 265.3794  
  C++ Note: LOGLIN_non-dose checked 7  
  C++ Note: df99,388,Prep_Terms
  C++ Note: Current Time, Fri Feb 23 05:58:57 2024
  
  Note: 9 valid guesses
  C++ Note: START_RISK_CHECK
  C++ Note: Current Time, Fri Feb 23 05:58:57 2024
  
  C++ Note: Term checked 0 0 0 0  
  C++ Note: df99,60,Starting
  C++ Note: Current Time, Fri Feb 23 05:58:57 2024
  
  C++ Note: starting subterms 1
  C++ Note: values checked 0.569784 6.401194 1.070144 0.3297178  
  C++ Note: sums checked 299.7811 299.7811 58.7942 58.7942  
  C++ Note: dose checked 7  
  C++ Note: non-dose checked 2791.148  
  C++ Note: LIN_non-dose checked 58.7942  
  C++ Note: PLIN_non-dose checked 299.7811  
  C++ Note: LOGLIN_non-dose checked 7  
  C++ Note: df99,359,Prep_Terms
  C++ Note: Current Time, Fri Feb 23 05:58:57 2024
  
  Error: tform not implemented Not
  Warning: rmin and rmax lists not equal size, defaulting to lin and loglin min/max values
  C++ Note: START_RISK_CHECK
  C++ Note: Current Time, Fri Feb 23 05:58:57 2024
  
  C++ Note: Term checked 0 0 0 0  
  C++ Note: df99,88,Starting
  C++ Note: Current Time, Fri Feb 23 05:58:57 2024
  
  C++ Note: starting subterms 1
  C++ Note: values checked -0.1 6 0.1 0.1  
  C++ Note: sums checked 6.978181e+23 6.978181e+23 6.978181e+23 6.978181e+23  
  C++ Note: dose checked 7  
  C++ Note: non-dose checked 6.978181e+23  
  C++ Note: LIN_non-dose checked 7  
  C++ Note: PLIN_non-dose checked 7  
  C++ Note: LOGLIN_non-dose checked 6.978181e+23  
  C++ Note: df99,442,Prep_Terms
  C++ Note: Current Time, Fri Feb 23 05:58:57 2024
  
  Note: 1 valid guesses
  C++ Note: START_RISK_CHECK
  C++ Note: Current Time, Fri Feb 23 05:58:57 2024
  
  C++ Note: Term checked 0 0 0 0  
  C++ Note: df99,88,Starting
  C++ Note: Current Time, Fri Feb 23 05:58:57 2024
  
  C++ Note: starting subterms 1
  C++ Note: values checked -1.078912 6.381868 -0.6204552 0.1403137  
  C++ Note: sums checked 7.148279e+18 7.148279e+18 7.148279e+18 7.148279e+18  
  C++ Note: dose checked 7  
  C++ Note: non-dose checked 7.148279e+18  
  C++ Note: LIN_non-dose checked 7  
  C++ Note: PLIN_non-dose checked 7  
  C++ Note: LOGLIN_non-dose checked 7.148279e+18  
  C++ Note: df99,395,Prep_Terms
  C++ Note: Current Time, Fri Feb 23 05:58:57 2024
  
  Note: 2 valid guesses
  C++ Note: START_RISK_CHECK
  C++ Note: Current Time, Fri Feb 23 05:58:57 2024
  
  C++ Note: Term checked 0 0 0 0  
  C++ Note: df99,74,Starting
  C++ Note: Current Time, Fri Feb 23 05:58:57 2024
  
  C++ Note: starting subterms 1
  C++ Note: values checked 0.124094 5.233358 0.7481482 0.8674378  
  C++ Note: sums checked 1.801258e+27 1.801258e+27 1.801258e+27 1.801258e+27  
  C++ Note: dose checked 7  
  C++ Note: non-dose checked 1.801258e+27  
  C++ Note: LIN_non-dose checked 7  
  C++ Note: PLIN_non-dose checked 7  
  C++ Note: LOGLIN_non-dose checked 1.801258e+27  
  C++ Note: df99,395,Prep_Terms
  C++ Note: Current Time, Fri Feb 23 05:58:57 2024
  
  Note: 3 valid guesses
  C++ Note: START_RISK_CHECK
  C++ Note: Current Time, Fri Feb 23 05:58:57 2024
  
  C++ Note: Term checked 0 0 0 0  
  C++ Note: df99,71,Starting
  C++ Note: Current Time, Fri Feb 23 05:58:57 2024
  
  C++ Note: starting subterms 1
  C++ Note: values checked 0.723155 5.889726 0.2044639 -0.4021117  
  C++ Note: sums checked 1.190181e+25 1.190181e+25 1.190181e+25 1.190181e+25  
  C++ Note: dose checked 7  
  C++ Note: non-dose checked 1.190181e+25  
  C++ Note: LIN_non-dose checked 7  
  C++ Note: PLIN_non-dose checked 7  
  C++ Note: LOGLIN_non-dose checked 1.190181e+25  
  C++ Note: df99,387,Prep_Terms
  C++ Note: Current Time, Fri Feb 23 05:58:57 2024
  
  Note: 4 valid guesses
  C++ Note: START_RISK_CHECK
  C++ Note: Current Time, Fri Feb 23 05:58:57 2024
  
  C++ Note: Term checked 0 0 0 0  
  C++ Note: df99,73,Starting
  C++ Note: Current Time, Fri Feb 23 05:58:57 2024
  
  C++ Note: starting subterms 1
  C++ Note: values checked -0.9384565 5.491963 -0.4929961 0.02297141  
  C++ Note: sums checked 9.295681e+15 9.295681e+15 9.295681e+15 9.295681e+15  
  C++ Note: dose checked 7  
  C++ Note: non-dose checked 9.295681e+15  
  C++ Note: LIN_non-dose checked 7  
  C++ Note: PLIN_non-dose checked 7  
  C++ Note: LOGLIN_non-dose checked 9.295681e+15  
  C++ Note: df99,389,Prep_Terms
  C++ Note: Current Time, Fri Feb 23 05:58:57 2024
  
  Note: 5 valid guesses
  C++ Note: START_RISK_CHECK
  C++ Note: Current Time, Fri Feb 23 05:58:57 2024
  
  C++ Note: Term checked 0 0 0 0  
  C++ Note: df99,72,Starting
  C++ Note: Current Time, Fri Feb 23 05:58:57 2024
  
  C++ Note: starting subterms 1
  C++ Note: values checked 0.7582357 5.622153 0.1475021 -0.6665197  
  C++ Note: sums checked 8.152489e+22 8.152489e+22 8.152489e+22 8.152489e+22  
  C++ Note: dose checked 7  
  C++ Note: non-dose checked 8.152489e+22  
  C++ Note: LIN_non-dose checked 7  
  C++ Note: PLIN_non-dose checked 7  
  C++ Note: LOGLIN_non-dose checked 8.152489e+22  
  C++ Note: df99,378,Prep_Terms
  C++ Note: Current Time, Fri Feb 23 05:58:57 2024
  
  Note: 6 valid guesses
  C++ Note: START_RISK_CHECK
  C++ Note: Current Time, Fri Feb 23 05:58:57 2024
  
  C++ Note: Term checked 0 0 0 0  
  C++ Note: df99,63,Starting
  C++ Note: Current Time, Fri Feb 23 05:58:57 2024
  
  C++ Note: starting subterms 1
  C++ Note: values checked -0.3285743 6.883413 -0.7341383 -0.6765644  
  C++ Note: sums checked 1.285792e+20 1.285792e+20 1.285792e+20 1.285792e+20  
  C++ Note: dose checked 7  
  C++ Note: non-dose checked 1.285792e+20  
  C++ Note: LIN_non-dose checked 7  
  C++ Note: PLIN_non-dose checked 7  
  C++ Note: LOGLIN_non-dose checked 1.285792e+20  
  C++ Note: df99,341,Prep_Terms
  C++ Note: Current Time, Fri Feb 23 05:58:57 2024
  
  Note: 7 valid guesses
  C++ Note: START_RISK_CHECK
  C++ Note: Current Time, Fri Feb 23 05:58:57 2024
  
  C++ Note: Term checked 0 0 0 0  
  C++ Note: df99,72,Starting
  C++ Note: Current Time, Fri Feb 23 05:58:57 2024
  
  C++ Note: starting subterms 1
  C++ Note: values checked -0.3835654 5.580549 0.8623136 0.6676176  
  C++ Note: sums checked 1.966433e+26 1.966433e+26 1.966433e+26 1.966433e+26  
  C++ Note: dose checked 7  
  C++ Note: non-dose checked 1.966433e+26  
  C++ Note: LIN_non-dose checked 7  
  C++ Note: PLIN_non-dose checked 7  
  C++ Note: LOGLIN_non-dose checked 1.966433e+26  
  C++ Note: df99,411,Prep_Terms
  C++ Note: Current Time, Fri Feb 23 05:58:57 2024
  
  Note: 8 valid guesses
  C++ Note: START_RISK_CHECK
  C++ Note: Current Time, Fri Feb 23 05:58:57 2024
  
  C++ Note: Term checked 0 0 0 0  
  C++ Note: df99,72,Starting
  C++ Note: Current Time, Fri Feb 23 05:58:57 2024
  
  C++ Note: starting subterms 1
  C++ Note: values checked 0.5220103 6.580932 0.07026672 0.2925053  
  C++ Note: sums checked 1.517451e+29 1.517451e+29 1.517451e+29 1.517451e+29  
  C++ Note: dose checked 7  
  C++ Note: non-dose checked 1.517451e+29  
  C++ Note: LIN_non-dose checked 7  
  C++ Note: PLIN_non-dose checked 7  
  C++ Note: LOGLIN_non-dose checked 1.517451e+29  
  C++ Note: df99,386,Prep_Terms
  C++ Note: Current Time, Fri Feb 23 05:58:57 2024
  
  Note: 9 valid guesses
  C++ Note: START_RISK_CHECK
  C++ Note: Current Time, Fri Feb 23 05:58:57 2024
  
  C++ Note: Term checked 0 0 0 0  
  C++ Note: df99,74,Starting
  C++ Note: Current Time, Fri Feb 23 05:58:57 2024
  
  C++ Note: starting subterms 1
  C++ Note: values checked -0.7559232 5.684553 -0.3870322 -0.194844  
  C++ Note: sums checked 9.899231e+16 9.899231e+16 9.899231e+16 9.899231e+16  
  C++ Note: dose checked 7  
  C++ Note: non-dose checked 9.899231e+16  
  C++ Note: LIN_non-dose checked 7  
  C++ Note: PLIN_non-dose checked 7  
  C++ Note: LOGLIN_non-dose checked 9.899231e+16  
  C++ Note: df99,385,Prep_Terms
  C++ Note: Current Time, Fri Feb 23 05:58:57 2024
  
  Error: verbosity arguement not valid
  Error: verbosity arguement not valid
  Error: a0 arguement was not a number
  Error: a0 arguement was not a number
  Error: a0 arguement was not a number
  Error: item e1 in name_list has 1 items, but same item in Term_n_list has 6 items. Omit entry in Term_n_list to set to default of term 0 or add missing values
  Error: item e1 in name_list has 1 items, but same item in tform_list has 6 items. Omit entry in tform_list to set to default of 'loglin' or add missing values
  Error: item e1 in name_list has 1 items, but same item in keep_constant_list has 6 items. Omit entry in tform_list to set to default of 0 or add missing values
  Error: item e1 in name_list has 1 items, but same item in a_n_list has 6 items. Omit entry in a_n_list to set to default of 0 or add missing values
  Note: 2  strata used
  Note: 114 risk groups
  C++ Note: START_COX_GUESS
  C++ Note: Current Time, Fri Feb 23 05:58:58 2024
  
  C++ Note: Grouping Start
  C++ Note: df100 1550 0 0 -1,Prep_List
  C++ Note: Current Time, Fri Feb 23 05:58:58 2024
  
  C++ Note: riskr checked 3237  
  C++ Note: riskl checked 59  
  Note: 2  strata used
  Note: 114 risk groups
  C++ Note: START_COX_GUESS
  C++ Note: Current Time, Fri Feb 23 05:58:58 2024
  
  C++ Note: Term checked 0  
  C++ Note: df99,58,Starting
  C++ Note: Current Time, Fri Feb 23 05:58:58 2024
  
  C++ Note: Grouping Start
  C++ Note: df100 1386 0 0 -1,Prep_List
  C++ Note: Current Time, Fri Feb 23 05:58:58 2024
  
  C++ Note: starting subterms 1 in guess 0
  C++ Note: values checked 0.01  
  C++ Note: sums checked 1016.5  
  C++ Note: risk checked 1016.5  
  C++ Note: risk1 checked 1673.67  
  C++ Note: risk2 checked 4753.83  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 3284.26 2905.4  
  C++ Note: riskl checked 60.0534 56.1054  
  C++ Note: df101 -447.464  
  C++ Note: df104 0.01  
  C++ Note: Starting Halves
  C++ Note: df501 -447.4645
  C++ Note: df504 0.01  
  C++ Note: values checked 0.01  
  C++ Note: sums checked 1016.5  
  C++ Note: risk checked 1016.5  
  C++ Note: risk1 checked 1673.67  
  C++ Note: risk2 checked 4753.83  
  C++ Note: riskr checked 3284.26 2905.4  
  C++ Note: riskl checked 60.0534 56.1054  
  C++ Note: df101 -447.464  
  C++ Note: df104 0.01  
  C++ Note: df100 14241 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:58 2024
  
  C++ Note: riskr checked 3284.26 2905.4  
  C++ Note: riskl checked 60.0534 56.1054  
  C++ Note: df101 -894.929  
  C++ Note: df104 0.01  
  C++ Note: ending guess 0
  C++ Note: df501 -447.4645
  C++ Note: df504 0.01  
  C++ Note: Refreshing matrices after all guesses
  C++ Note: Guess Results
  Guess number, parameter values, Log-Likelihood
  0, 0.01, -894.9289<-- Best Guess
  C++ Note: starting subterms 1 in best guess 0
  C++ Note: values checked 0.01  
  C++ Note: sums checked 1016.5  
  C++ Note: risk checked 1016.5  
  C++ Note: risk1 checked 1673.67  
  C++ Note: risk2 checked 4753.83  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 3284.26 2905.4  
  C++ Note: riskl checked 60.0534 56.1054  
  C++ Note: df101 -447.464  
  C++ Note: df104 0.01  
  C++ Note: Starting Halves
  C++ Note: df501 -447.4645
  C++ Note: df504 0.01  
  C++ Note: values checked 0.01  
  C++ Note: sums checked 1016.5  
  C++ Note: risk checked 1016.5  
  C++ Note: risk1 checked 1673.67  
  C++ Note: risk2 checked 4753.83  
  C++ Note: riskr checked 3284.26 2905.4  
  C++ Note: riskl checked 60.0534 56.1054  
  C++ Note: df101 -447.464  
  C++ Note: df104 0.01  
  C++ Note: df100 54550 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:58 2024
  
  C++ Note: riskr checked 3284.26 2905.4  
  C++ Note: riskl checked 60.0534 56.1054  
  C++ Note: df101 -447.464  
  C++ Note: df104 0.01  
  C++ Note: riskr checked 3284.26 2905.4  
  C++ Note: riskl checked 60.0534 56.1054  
  C++ Note: df101 -447.464  
  C++ Note: df104 0.01  
  C++ Note: Exiting Regression
  C++ Note: df501 -447.4645
  C++ Note: df504 0.01  
  Note: 2  strata used
  Note: 114 risk groups
  C++ Note: START_COX_GUESS
  C++ Note: Current Time, Fri Feb 23 05:58:58 2024
  
  C++ Note: Grouping Start
  C++ Note: df100 1425 0 0 -1,Prep_List
  C++ Note: Current Time, Fri Feb 23 05:58:58 2024
  
  C++ Note: riskr checked 3237  
  C++ Note: riskl checked 59  
  Note: 2  strata used
  Note: 114 risk groups
  C++ Note: START_COX_GUESS
  C++ Note: Current Time, Fri Feb 23 05:58:58 2024
  
  C++ Note: Term checked 0  
  C++ Note: df99,66,Starting
  C++ Note: Current Time, Fri Feb 23 05:58:58 2024
  
  C++ Note: Grouping Start
  C++ Note: df100 1548 0 0 -1,Prep_List
  C++ Note: Current Time, Fri Feb 23 05:58:58 2024
  
  C++ Note: starting subterms 1 in guess 0
  C++ Note: values checked 0.01  
  C++ Note: sums checked 1016.5  
  C++ Note: risk checked 1016.5  
  C++ Note: risk1 checked 1673.67  
  C++ Note: risk2 checked 4753.83  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 3284.26 2905.4  
  C++ Note: riskl checked 60.0534 56.1054  
  C++ Note: df101 -447.464  
  C++ Note: df102 -4.51629  
  C++ Note: df103 -38.8061  
  C++ Note: df104 0.01  
  C++ Note: df105 0.116381  
  C++ Note: df106 99.0778  
  C++ Note: Starting Halves
  C++ Note: df501 -447.4645
  C++ Note: df504 0.01  
  C++ Note: values checked -0.0772857  
  C++ Note: sums checked 886.858  
  C++ Note: risk checked 886.858  
  C++ Note: risk1 checked 1314.48  
  C++ Note: risk2 checked 3543.11  
  C++ Note: riskr checked 2906.58 2520.49  
  C++ Note: riskl checked 51.6944 47.43  
  C++ Note: df101 -447.218  
  C++ Note: df102 -1.11664  
  C++ Note: df103 -39.0819  
  C++ Note: df104 -0.0772857  
  C++ Note: df105 0.0285718  
  C++ Note: df106 400.504  
  C++ Note: df100 18501 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:58 2024
  
  C++ Note: riskr checked 2906.58 2520.49  
  C++ Note: riskl checked 51.6944 47.43  
  C++ Note: df101 -447.218  
  C++ Note: df102 -1.11664  
  C++ Note: df103 -39.0819  
  C++ Note: df104 -0.0772857  
  C++ Note: df105 0.0285718  
  C++ Note: df106 400.504  
  C++ Note: ending guess 0
  C++ Note: df501 -447.2185
  C++ Note: df504 -0.07728569  
  C++ Note: Refreshing matrices after all guesses
  C++ Note: Guess Results
  Guess number, parameter values, Log-Likelihood
  0, -0.07728569, -447.2185<-- Best Guess
  C++ Note: starting subterms 1 in best guess 0
  C++ Note: values checked -0.0772857  
  C++ Note: sums checked 886.858  
  C++ Note: risk checked 886.858  
  C++ Note: risk1 checked 1314.48  
  C++ Note: risk2 checked 3543.11  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 2906.58 2520.49  
  C++ Note: riskl checked 51.6944 47.43  
  C++ Note: df101 -894.437  
  C++ Note: df102 -2.23328  
  C++ Note: df103 -78.1638  
  C++ Note: df104 -0.0772857  
  C++ Note: df105 0.0285718  
  C++ Note: df106 400.504  
  C++ Note: Starting Halves
  C++ Note: df501 -447.2185
  C++ Note: df504 -0.07728569  
  C++ Note: values checked -0.0987146  
  C++ Note: sums checked 859.484  
  C++ Note: risk checked 859.484  
  C++ Note: risk1 checked 1241.17  
  C++ Note: risk2 checked 3301.92  
  C++ Note: riskr checked 2824.77 2437.74  
  C++ Note: riskl checked 49.9037 45.6007  
  C++ Note: df101 -447.204  
  C++ Note: df102 -0.27852  
  C++ Note: df103 -39.141  
  C++ Note: df104 -0.0987146  
  C++ Note: df105 0.00711582  
  C++ Note: df106 1605.64  
  C++ Note: df100 40919 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:58 2024
  
  C++ Note: riskr checked 2824.77 2437.74  
  C++ Note: riskl checked 49.9037 45.6007  
  C++ Note: df101 -447.204  
  C++ Note: df102 -0.27852  
  C++ Note: df103 -39.141  
  C++ Note: df104 -0.0987146  
  C++ Note: df105 0.00711582  
  C++ Note: df106 1605.64  
  C++ Note: riskr checked 2824.77 2437.74  
  C++ Note: riskl checked 49.9037 45.6007  
  C++ Note: df101 -447.204  
  C++ Note: df102 -0.27852  
  C++ Note: df103 -39.141  
  C++ Note: df104 -0.0987146  
  C++ Note: df105 0.00711582  
  C++ Note: df106 1605.64  
  C++ Note: Exiting Regression
  C++ Note: df501 -447.2035
  C++ Note: df504 -0.09871455  
  Note: 2  strata used
  Note: 114 risk groups
  C++ Note: START_COX_GUESS
  C++ Note: Current Time, Fri Feb 23 05:58:58 2024
  
  C++ Note: Grouping Start
  C++ Note: df100 1436 0 0 -1,Prep_List
  C++ Note: Current Time, Fri Feb 23 05:58:58 2024
  
  C++ Note: riskr checked 3237  
  C++ Note: riskl checked 59  
  Note: 2  strata used
  Note: 114 risk groups
  C++ Note: START_COX_GUESS
  C++ Note: Current Time, Fri Feb 23 05:58:58 2024
  
  C++ Note: Term checked 0  
  C++ Note: df99,59,Starting
  C++ Note: Current Time, Fri Feb 23 05:58:58 2024
  
  C++ Note: Grouping Start
  C++ Note: df100 1571 0 0 -1,Prep_List
  C++ Note: Current Time, Fri Feb 23 05:58:58 2024
  
  C++ Note: starting subterms 1 in guess 0
  C++ Note: values checked 0.01  
  C++ Note: sums checked 1016.5  
  C++ Note: dose checked 1000  
  C++ Note: non-dose checked 1016.5  
  C++ Note: LIN_non-dose checked 1000  
  C++ Note: PLIN_non-dose checked 1000  
  C++ Note: LOGLIN_non-dose checked 1016.5  
  C++ Note: risk checked 1016.5  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 3284.26 2905.4  
  C++ Note: riskl checked 60.0534 56.1054  
  C++ Note: df101 -447.464  
  C++ Note: df104 0.01  
  C++ Note: Starting Halves
  C++ Note: df501 -447.4645
  C++ Note: df504 0.01  
  C++ Note: values checked 0.01  
  C++ Note: sums checked 1016.5  
  C++ Note: dose checked 1000  
  C++ Note: non-dose checked 1016.5  
  C++ Note: LIN_non-dose checked 1000  
  C++ Note: PLIN_non-dose checked 1000  
  C++ Note: LOGLIN_non-dose checked 1016.5  
  C++ Note: risk checked 1016.5  
  C++ Note: riskr checked 3284.26 2905.4  
  C++ Note: riskl checked 60.0534 56.1054  
  C++ Note: df101 -447.464  
  C++ Note: df104 0.01  
  C++ Note: df100 18923 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:58 2024
  
  C++ Note: riskr checked 3284.26 2905.4  
  C++ Note: riskl checked 60.0534 56.1054  
  C++ Note: df101 -447.464  
  C++ Note: df104 0.01  
  C++ Note: ending guess 0
  C++ Note: df501 -447.4645
  C++ Note: df504 0.01  
  C++ Note: Refreshing matrices after all guesses
  C++ Note: Guess Results
  Guess number, parameter values, Log-Likelihood
  0, 0.01, -447.4645<-- Best Guess
  C++ Note: starting subterms 1 in best guess 0
  C++ Note: values checked 0.01  
  C++ Note: sums checked 1016.5  
  C++ Note: dose checked 1000  
  C++ Note: non-dose checked 1016.5  
  C++ Note: LIN_non-dose checked 1000  
  C++ Note: PLIN_non-dose checked 1000  
  C++ Note: LOGLIN_non-dose checked 1016.5  
  C++ Note: risk checked 1016.5  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 3284.26 2905.4  
  C++ Note: riskl checked 60.0534 56.1054  
  C++ Note: df101 -447.464  
  C++ Note: df104 0.01  
  C++ Note: Starting Halves
  C++ Note: df501 -447.4645
  C++ Note: df504 0.01  
  C++ Note: values checked 0.01  
  C++ Note: sums checked 1016.5  
  C++ Note: dose checked 1000  
  C++ Note: non-dose checked 1016.5  
  C++ Note: LIN_non-dose checked 1000  
  C++ Note: PLIN_non-dose checked 1000  
  C++ Note: LOGLIN_non-dose checked 1016.5  
  C++ Note: risk checked 1016.5  
  C++ Note: riskr checked 3284.26 2905.4  
  C++ Note: riskl checked 60.0534 56.1054  
  C++ Note: df101 -447.464  
  C++ Note: df104 0.01  
  C++ Note: df100 22957 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:58 2024
  
  C++ Note: riskr checked 3284.26 2905.4  
  C++ Note: riskl checked 60.0534 56.1054  
  C++ Note: df101 -447.464  
  C++ Note: df104 0.01  
  C++ Note: riskr checked 3284.26 2905.4  
  C++ Note: riskl checked 60.0534 56.1054  
  C++ Note: df101 -447.464  
  C++ Note: df104 0.01  
  C++ Note: Exiting Regression
  C++ Note: df501 -447.4645
  C++ Note: df504 0.01  
  Note: 2  strata used
  Note: 114 risk groups
  C++ Note: START_COX_GUESS
  C++ Note: Current Time, Fri Feb 23 05:58:58 2024
  
  C++ Note: Grouping Start
  C++ Note: df100 1405 0 0 -1,Prep_List
  C++ Note: Current Time, Fri Feb 23 05:58:58 2024
  
  C++ Note: riskr checked 3237  
  C++ Note: riskl checked 59  
  Note: 2  strata used
  Note: 114 risk groups
  C++ Note: START_COX_GUESS
  C++ Note: Current Time, Fri Feb 23 05:58:58 2024
  
  C++ Note: Term checked 0  
  C++ Note: df99,69,Starting
  C++ Note: Current Time, Fri Feb 23 05:58:58 2024
  
  C++ Note: Grouping Start
  C++ Note: df100 1635 0 0 -1,Prep_List
  C++ Note: Current Time, Fri Feb 23 05:58:58 2024
  
  C++ Note: starting subterms 1 in guess 0
  C++ Note: values checked 0.01  
  C++ Note: sums checked 1016.5  
  C++ Note: derivs checked 1673.67  
  C++ Note: second derivs checked 4753.83  
  C++ Note: dose checked 1000  
  C++ Note: non-dose checked 1016.5  
  C++ Note: LIN_non-dose checked 1000  
  C++ Note: PLIN_non-dose checked 1000  
  C++ Note: LOGLIN_non-dose checked 1016.5  
  C++ Note: risk checked 1016.5  
  C++ Note: risk1 checked 1673.67  
  C++ Note: risk2 checked 4753.83  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 3284.26 2905.4  
  C++ Note: riskl checked 60.0534 56.1054  
  C++ Note: df101 -447.464  
  C++ Note: df102 -4.51629  
  C++ Note: df103 -38.8061  
  C++ Note: df104 0.01  
  C++ Note: df105 0.116381  
  C++ Note: df106 99.0778  
  C++ Note: Starting Halves
  C++ Note: df501 -447.4645
  C++ Note: df504 0.01  
  C++ Note: values checked -0.0772857  
  C++ Note: sums checked 886.858  
  C++ Note: derivs checked 1314.48  
  C++ Note: second derivs checked 3543.11  
  C++ Note: dose checked 1000  
  C++ Note: non-dose checked 886.858  
  C++ Note: LIN_non-dose checked 1000  
  C++ Note: PLIN_non-dose checked 1000  
  C++ Note: LOGLIN_non-dose checked 886.858  
  C++ Note: risk checked 886.858  
  C++ Note: risk1 checked 1314.48  
  C++ Note: risk2 checked 3543.11  
  C++ Note: riskr checked 2906.58 2520.49  
  C++ Note: riskl checked 51.6944 47.43  
  C++ Note: df101 -447.218  
  C++ Note: df102 -1.11664  
  C++ Note: df103 -39.0819  
  C++ Note: df104 -0.0772857  
  C++ Note: df105 0.0285718  
  C++ Note: df106 400.504  
  C++ Note: df100 20182 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:58 2024
  
  C++ Note: riskr checked 2906.58 2520.49  
  C++ Note: riskl checked 51.6944 47.43  
  C++ Note: df101 -447.218  
  C++ Note: df102 -1.11664  
  C++ Note: df103 -39.0819  
  C++ Note: df104 -0.0772857  
  C++ Note: df105 0.0285718  
  C++ Note: df106 400.504  
  C++ Note: ending guess 0
  C++ Note: df501 -447.2185
  C++ Note: df504 -0.07728569  
  C++ Note: Refreshing matrices after all guesses
  C++ Note: Guess Results
  Guess number, parameter values, Log-Likelihood
  0, -0.07728569, -447.2185<-- Best Guess
  C++ Note: starting subterms 1 in best guess 0
  C++ Note: values checked -0.0772857  
  C++ Note: sums checked 886.858  
  C++ Note: derivs checked 1314.48  
  C++ Note: second derivs checked 3543.11  
  C++ Note: dose checked 1000  
  C++ Note: non-dose checked 886.858  
  C++ Note: LIN_non-dose checked 1000  
  C++ Note: PLIN_non-dose checked 1000  
  C++ Note: LOGLIN_non-dose checked 886.858  
  C++ Note: risk checked 886.858  
  C++ Note: risk1 checked 1314.48  
  C++ Note: risk2 checked 3543.11  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 2906.58 2520.49  
  C++ Note: riskl checked 51.6944 47.43  
  C++ Note: df101 -447.218  
  C++ Note: df102 -1.11664  
  C++ Note: df103 -39.0819  
  C++ Note: df104 -0.0772857  
  C++ Note: df105 0.0285718  
  C++ Note: df106 400.504  
  C++ Note: Starting Halves
  C++ Note: df501 -447.2185
  C++ Note: df504 -0.07728569  
  C++ Note: values checked -0.0987146  
  C++ Note: sums checked 859.484  
  C++ Note: derivs checked 1241.17  
  C++ Note: second derivs checked 3301.92  
  C++ Note: dose checked 1000  
  C++ Note: non-dose checked 859.484  
  C++ Note: LIN_non-dose checked 1000  
  C++ Note: PLIN_non-dose checked 1000  
  C++ Note: LOGLIN_non-dose checked 859.484  
  C++ Note: risk checked 859.484  
  C++ Note: risk1 checked 1241.17  
  C++ Note: risk2 checked 3301.92  
  C++ Note: riskr checked 2824.77 2437.74  
  C++ Note: riskl checked 49.9037 45.6007  
  C++ Note: df101 -447.204  
  C++ Note: df102 -0.27852  
  C++ Note: df103 -39.141  
  C++ Note: df104 -0.0987146  
  C++ Note: df105 0.00711582  
  C++ Note: df106 1605.64  
  C++ Note: df100 42909 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:58 2024
  
  C++ Note: riskr checked 2824.77 2437.74  
  C++ Note: riskl checked 49.9037 45.6007  
  C++ Note: df101 -447.204  
  C++ Note: df102 -0.27852  
  C++ Note: df103 -39.141  
  C++ Note: df104 -0.0987146  
  C++ Note: df105 0.00711582  
  C++ Note: df106 1605.64  
  C++ Note: riskr checked 2824.77 2437.74  
  C++ Note: riskl checked 49.9037 45.6007  
  C++ Note: df101 -447.204  
  C++ Note: df102 -0.27852  
  C++ Note: df103 -39.141  
  C++ Note: df104 -0.0987146  
  C++ Note: df105 0.00711582  
  C++ Note: df106 1605.64  
  C++ Note: Exiting Regression
  C++ Note: df501 -447.2035
  C++ Note: df504 -0.09871455  
  Note: 114 risk groups
  C++ Note: START_COX_GUESS
  C++ Note: Current Time, Fri Feb 23 05:58:59 2024
  
  C++ Note: Grouping Start
  C++ Note: df100 733 0 0 -1,Prep_List
  C++ Note: Current Time, Fri Feb 23 05:58:59 2024
  
  C++ Note: riskr checked 12119  
  C++ Note: riskl checked 114  
  Note: 114 risk groups
  C++ Note: START_COX_GUESS
  C++ Note: Current Time, Fri Feb 23 05:58:59 2024
  
  C++ Note: Term checked 0  
  C++ Note: df99,59,Starting
  C++ Note: Current Time, Fri Feb 23 05:58:59 2024
  
  C++ Note: Grouping Start
  C++ Note: df100 771 0 0 -1,Prep_List
  C++ Note: Current Time, Fri Feb 23 05:58:59 2024
  
  C++ Note: starting subterms 1 in guess 0
  C++ Note: values checked 0.01  
  C++ Note: sums checked 1016.5  
  C++ Note: risk checked 1016.5  
  C++ Note: risk1 checked 1673.67  
  C++ Note: risk2 checked 4753.83  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 12309.1  
  C++ Note: riskl checked 116.159  
  C++ Note: df101 -525.819  
  C++ Note: df104 0.01  
  C++ Note: Starting Halves
  C++ Note: df501 -525.8191
  C++ Note: df504 0.01  
  C++ Note: values checked 0.01  
  C++ Note: sums checked 1016.5  
  C++ Note: risk checked 1016.5  
  C++ Note: risk1 checked 1673.67  
  C++ Note: risk2 checked 4753.83  
  C++ Note: riskr checked 12309.1  
  C++ Note: riskl checked 116.159  
  C++ Note: df101 -525.819  
  C++ Note: df104 0.01  
  C++ Note: df100 2268 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:59 2024
  
  C++ Note: riskr checked 12309.1  
  C++ Note: riskl checked 116.159  
  C++ Note: df101 -525.819  
  C++ Note: df104 0.01  
  C++ Note: ending guess 0
  C++ Note: df501 -525.8191
  C++ Note: df504 0.01  
  C++ Note: Refreshing matrices after all guesses
  C++ Note: Guess Results
  Guess number, parameter values, Log-Likelihood
  0, 0.01, -525.8191<-- Best Guess
  C++ Note: starting subterms 1 in best guess 0
  C++ Note: values checked 0.01  
  C++ Note: sums checked 1016.5  
  C++ Note: risk checked 1016.5  
  C++ Note: risk1 checked 1673.67  
  C++ Note: risk2 checked 4753.83  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 12309.1  
  C++ Note: riskl checked 116.159  
  C++ Note: df101 -525.819  
  C++ Note: df104 0.01  
  C++ Note: Starting Halves
  C++ Note: df501 -525.8191
  C++ Note: df504 0.01  
  C++ Note: values checked 0.01  
  C++ Note: sums checked 1016.5  
  C++ Note: risk checked 1016.5  
  C++ Note: risk1 checked 1673.67  
  C++ Note: risk2 checked 4753.83  
  C++ Note: riskr checked 12309.1  
  C++ Note: riskl checked 116.159  
  C++ Note: df101 -525.819  
  C++ Note: df104 0.01  
  C++ Note: df100 4244 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:59 2024
  
  C++ Note: riskr checked 12309.1  
  C++ Note: riskl checked 116.159  
  C++ Note: df101 -525.819  
  C++ Note: df104 0.01  
  C++ Note: riskr checked 12309.1  
  C++ Note: riskl checked 116.159  
  C++ Note: df101 -525.819  
  C++ Note: df104 0.01  
  C++ Note: Exiting Regression
  C++ Note: df501 -525.8191
  C++ Note: df504 0.01  
  Note: 114 risk groups
  C++ Note: START_COX_GUESS
  C++ Note: Current Time, Fri Feb 23 05:58:59 2024
  
  C++ Note: Grouping Start
  C++ Note: df100 694 0 0 -1,Prep_List
  C++ Note: Current Time, Fri Feb 23 05:58:59 2024
  
  C++ Note: riskr checked 12119  
  C++ Note: riskl checked 114  
  Note: 114 risk groups
  C++ Note: START_COX_GUESS
  C++ Note: Current Time, Fri Feb 23 05:58:59 2024
  
  C++ Note: Term checked 0  
  C++ Note: df99,57,Starting
  C++ Note: Current Time, Fri Feb 23 05:58:59 2024
  
  C++ Note: Grouping Start
  C++ Note: df100 782 0 0 -1,Prep_List
  C++ Note: Current Time, Fri Feb 23 05:58:59 2024
  
  C++ Note: starting subterms 1 in guess 0
  C++ Note: values checked 0.01  
  C++ Note: sums checked 1016.5  
  C++ Note: risk checked 1016.5  
  C++ Note: risk1 checked 1673.67  
  C++ Note: risk2 checked 4753.83  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 12309.1  
  C++ Note: risk1r checked 19240.9  
  C++ Note: risk2r checked 46924.9  
  C++ Note: riskl checked 116.159  
  C++ Note: risk1l checked 218.829  
  C++ Note: risk2l checked 595.535  
  C++ Note: df101 -525.819  
  C++ Note: df102 -4.47019  
  C++ Note: df103 -39.2834  
  C++ Note: df104 0.01  
  C++ Note: df105 0.113793  
  C++ Note: df106 117.628  
  C++ Note: Starting Halves
  C++ Note: df501 -525.8191
  C++ Note: df504 0.01  
  C++ Note: values checked -0.0753449  
  C++ Note: sums checked 889.415  
  C++ Note: risk checked 889.415  
  C++ Note: risk1 checked 1321.38  
  C++ Note: risk2 checked 3565.92  
  C++ Note: riskr checked 10823.9  
  C++ Note: risk1r checked 15714.3  
  C++ Note: risk2r checked 36253.4  
  C++ Note: riskl checked 99.4622  
  C++ Note: risk1l checked 174.499  
  C++ Note: risk2l checked 450.907  
  C++ Note: df101 -525.581  
  C++ Note: df102 -1.10144  
  C++ Note: df103 -39.6548  
  C++ Note: df104 -0.0753449  
  C++ Note: df105 0.0277758  
  C++ Note: df106 477.175  
  C++ Note: df100 3790 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:59 2024
  
  C++ Note: riskr checked 10823.9  
  C++ Note: risk1r checked 15714.3  
  C++ Note: risk2r checked 36253.4  
  C++ Note: riskl checked 99.4622  
  C++ Note: risk1l checked 174.499  
  C++ Note: risk2l checked 450.907  
  C++ Note: df101 -525.581  
  C++ Note: df102 -1.10144  
  C++ Note: df103 -39.6548  
  C++ Note: df104 -0.0753449  
  C++ Note: df105 0.0277758  
  C++ Note: df106 477.175  
  C++ Note: ending guess 0
  C++ Note: df501 -525.5812
  C++ Note: df504 -0.07534494  
  C++ Note: Refreshing matrices after all guesses
  C++ Note: Guess Results
  Guess number, parameter values, Log-Likelihood
  0, -0.07534494, -525.5812<-- Best Guess
  C++ Note: starting subterms 1 in best guess 0
  C++ Note: values checked -0.0753449  
  C++ Note: sums checked 889.415  
  C++ Note: risk checked 889.415  
  C++ Note: risk1 checked 1321.38  
  C++ Note: risk2 checked 3565.92  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 10823.9  
  C++ Note: risk1r checked 15714.3  
  C++ Note: risk2r checked 36253.4  
  C++ Note: riskl checked 99.4622  
  C++ Note: risk1l checked 174.499  
  C++ Note: risk2l checked 450.907  
  C++ Note: df101 -525.581  
  C++ Note: df102 -1.10144  
  C++ Note: df103 -39.6548  
  C++ Note: df104 -0.0753449  
  C++ Note: df105 0.0277758  
  C++ Note: df106 477.175  
  C++ Note: Starting Halves
  C++ Note: df501 -525.5812
  C++ Note: df504 -0.07534494  
  C++ Note: values checked -0.0961768  
  C++ Note: sums checked 862.645  
  C++ Note: risk checked 862.645  
  C++ Note: risk1 checked 1249.59  
  C++ Note: risk2 checked 3329.49  
  C++ Note: riskr checked 10504.3  
  C++ Note: risk1r checked 14981.8  
  C++ Note: risk2r checked 34097.7  
  C++ Note: riskl checked 95.9227  
  C++ Note: risk1l checked 165.411  
  C++ Note: risk2l checked 421.981  
  C++ Note: df101 -1051.13  
  C++ Note: df102 -0.548941  
  C++ Note: df103 -79.4798  
  C++ Note: df104 -0.0961768  
  C++ Note: df105 0.00690668  
  C++ Note: df106 1914.84  
  C++ Note: df100 18925 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:59 2024
  
  C++ Note: Changing back to best
  C++ Note: values checked -0.0753449  
  C++ Note: sums checked 889.415  
  C++ Note: risk checked 889.415  
  C++ Note: risk1 checked 1321.38  
  C++ Note: risk2 checked 3565.92  
  C++ Note: riskr checked 10823.9  
  C++ Note: risk1r checked 15714.3  
  C++ Note: risk2r checked 36253.4  
  C++ Note: riskl checked 99.4622  
  C++ Note: risk1l checked 174.499  
  C++ Note: risk2l checked 450.907  
  C++ Note: df101 -525.581  
  C++ Note: df102 -1.10144  
  C++ Note: df103 -39.6548  
  C++ Note: df104 -0.0753449  
  C++ Note: df105 0.0277758  
  C++ Note: df106 477.175  
  C++ Note: riskr checked 10823.9  
  C++ Note: risk1r checked 15714.3  
  C++ Note: risk2r checked 36253.4  
  C++ Note: riskl checked 99.4622  
  C++ Note: risk1l checked 174.499  
  C++ Note: risk2l checked 450.907  
  C++ Note: df101 -525.581  
  C++ Note: df102 -1.10144  
  C++ Note: df103 -39.6548  
  C++ Note: df104 -0.0753449  
  C++ Note: df105 0.0277758  
  C++ Note: df106 477.175  
  C++ Note: Exiting Regression
  C++ Note: df501 -525.5812
  C++ Note: df504 -0.07534494  
  Note: 114 risk groups
  C++ Note: START_COX_GUESS
  C++ Note: Current Time, Fri Feb 23 05:58:59 2024
  
  C++ Note: Grouping Start
  C++ Note: df100 712 0 0 -1,Prep_List
  C++ Note: Current Time, Fri Feb 23 05:58:59 2024
  
  C++ Note: riskr checked 12119  
  C++ Note: riskl checked 114  
  Note: 114 risk groups
  C++ Note: START_COX_GUESS
  C++ Note: Current Time, Fri Feb 23 05:58:59 2024
  
  C++ Note: Term checked 0  
  C++ Note: df99,75,Starting
  C++ Note: Current Time, Fri Feb 23 05:58:59 2024
  
  C++ Note: Grouping Start
  C++ Note: df100 3102 0 0 -1,Prep_List
  C++ Note: Current Time, Fri Feb 23 05:58:59 2024
  
  C++ Note: starting subterms 1 in guess 0
  C++ Note: values checked 0.01  
  C++ Note: sums checked 1016.5  
  C++ Note: dose checked 1000  
  C++ Note: non-dose checked 1016.5  
  C++ Note: LIN_non-dose checked 1000  
  C++ Note: PLIN_non-dose checked 1000  
  C++ Note: LOGLIN_non-dose checked 1016.5  
  C++ Note: risk checked 1016.5  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 12309.1  
  C++ Note: riskl checked 116.159  
  C++ Note: df101 -1051.64  
  C++ Note: df104 0.01  
  C++ Note: Starting Halves
  C++ Note: df501 -1051.638
  C++ Note: df504 0.01  
  C++ Note: values checked 0.01  
  C++ Note: sums checked 1016.5  
  C++ Note: dose checked 1000  
  C++ Note: non-dose checked 1016.5  
  C++ Note: LIN_non-dose checked 1000  
  C++ Note: PLIN_non-dose checked 1000  
  C++ Note: LOGLIN_non-dose checked 1016.5  
  C++ Note: risk checked 1016.5  
  C++ Note: riskr checked 12309.1  
  C++ Note: riskl checked 116.159  
  C++ Note: df101 -1051.64  
  C++ Note: df104 0.01  
  C++ Note: df100 6195 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:59 2024
  
  C++ Note: riskr checked 12309.1  
  C++ Note: riskl checked 116.159  
  C++ Note: df101 -1051.64  
  C++ Note: df104 0.01  
  C++ Note: ending guess 0
  C++ Note: df501 -1051.638
  C++ Note: df504 0.01  
  C++ Note: Refreshing matrices after all guesses
  C++ Note: Guess Results
  Guess number, parameter values, Log-Likelihood
  0, 0.01, -1051.638<-- Best Guess
  C++ Note: starting subterms 1 in best guess 0
  C++ Note: values checked 0.01  
  C++ Note: sums checked 1016.5  
  C++ Note: dose checked 1000  
  C++ Note: non-dose checked 1016.5  
  C++ Note: LIN_non-dose checked 1000  
  C++ Note: PLIN_non-dose checked 1000  
  C++ Note: LOGLIN_non-dose checked 1016.5  
  C++ Note: risk checked 1016.5  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 12309.1  
  C++ Note: riskl checked 116.159  
  C++ Note: df101 -1051.64  
  C++ Note: df104 0.01  
  C++ Note: Starting Halves
  C++ Note: df501 -1051.638
  C++ Note: df504 0.01  
  C++ Note: values checked 0.01  
  C++ Note: sums checked 1016.5  
  C++ Note: dose checked 1000  
  C++ Note: non-dose checked 1016.5  
  C++ Note: LIN_non-dose checked 1000  
  C++ Note: PLIN_non-dose checked 1000  
  C++ Note: LOGLIN_non-dose checked 1016.5  
  C++ Note: risk checked 1016.5  
  C++ Note: riskr checked 12309.1  
  C++ Note: riskl checked 116.159  
  C++ Note: df101 -1051.64  
  C++ Note: df104 0.01  
  C++ Note: df100 10284 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:59 2024
  
  C++ Note: riskr checked 12309.1  
  C++ Note: riskl checked 116.159  
  C++ Note: df101 -1051.64  
  C++ Note: df104 0.01  
  C++ Note: riskr checked 12309.1  
  C++ Note: riskl checked 116.159  
  C++ Note: df101 -1051.64  
  C++ Note: df104 0.01  
  C++ Note: Exiting Regression
  C++ Note: df501 -1051.638
  C++ Note: df504 0.01  
  Note: 114 risk groups
  C++ Note: START_COX_GUESS
  C++ Note: Current Time, Fri Feb 23 05:58:59 2024
  
  C++ Note: Grouping Start
  C++ Note: df100 2317 0 0 -1,Prep_List
  C++ Note: Current Time, Fri Feb 23 05:58:59 2024
  
  C++ Note: riskr checked 12119  
  C++ Note: riskl checked 114  
  Note: 114 risk groups
  C++ Note: START_COX_GUESS
  C++ Note: Current Time, Fri Feb 23 05:58:59 2024
  
  C++ Note: Term checked 0  
  C++ Note: df99,62,Starting
  C++ Note: Current Time, Fri Feb 23 05:58:59 2024
  
  C++ Note: Grouping Start
  C++ Note: df100 3228 0 0 -1,Prep_List
  C++ Note: Current Time, Fri Feb 23 05:58:59 2024
  
  C++ Note: starting subterms 1 in guess 0
  C++ Note: values checked 0.01  
  C++ Note: sums checked 1016.5  
  C++ Note: derivs checked 1673.67  
  C++ Note: second derivs checked 4753.83  
  C++ Note: dose checked 1000  
  C++ Note: non-dose checked 1016.5  
  C++ Note: LIN_non-dose checked 1000  
  C++ Note: PLIN_non-dose checked 1000  
  C++ Note: LOGLIN_non-dose checked 1016.5  
  C++ Note: risk checked 1016.5  
  C++ Note: risk1 checked 1673.67  
  C++ Note: risk2 checked 4753.83  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 12309.1  
  C++ Note: risk1r checked 19240.9  
  C++ Note: risk2r checked 46924.9  
  C++ Note: riskl checked 116.159  
  C++ Note: risk1l checked 218.829  
  C++ Note: risk2l checked 595.535  
  C++ Note: df101 -1051.64  
  C++ Note: df102 -8.94037  
  C++ Note: df103 -78.5668  
  C++ Note: df104 0.01  
  C++ Note: df105 0.113793  
  C++ Note: df106 117.628  
  C++ Note: Starting Halves
  C++ Note: df501 -1051.638
  C++ Note: df504 0.01  
  C++ Note: values checked -0.0753449  
  C++ Note: sums checked 889.415  
  C++ Note: derivs checked 1321.38  
  C++ Note: second derivs checked 3565.92  
  C++ Note: dose checked 1000  
  C++ Note: non-dose checked 889.415  
  C++ Note: LIN_non-dose checked 1000  
  C++ Note: PLIN_non-dose checked 1000  
  C++ Note: LOGLIN_non-dose checked 889.415  
  C++ Note: risk checked 889.415  
  C++ Note: risk1 checked 1321.38  
  C++ Note: risk2 checked 3565.92  
  C++ Note: riskr checked 10823.9  
  C++ Note: risk1r checked 15714.3  
  C++ Note: risk2r checked 36253.4  
  C++ Note: riskl checked 99.4622  
  C++ Note: risk1l checked 174.499  
  C++ Note: risk2l checked 450.907  
  C++ Note: df101 -1051.16  
  C++ Note: df102 -2.20289  
  C++ Note: df103 -79.3096  
  C++ Note: df104 -0.0753449  
  C++ Note: df105 0.0277758  
  C++ Note: df106 477.175  
  C++ Note: df100 9738 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:59 2024
  
  C++ Note: riskr checked 10823.9  
  C++ Note: risk1r checked 15714.3  
  C++ Note: risk2r checked 36253.4  
  C++ Note: riskl checked 99.4622  
  C++ Note: risk1l checked 174.499  
  C++ Note: risk2l checked 450.907  
  C++ Note: df101 -1051.16  
  C++ Note: df102 -2.20289  
  C++ Note: df103 -79.3096  
  C++ Note: df104 -0.0753449  
  C++ Note: df105 0.0277758  
  C++ Note: df106 477.175  
  C++ Note: ending guess 0
  C++ Note: df501 -1051.162
  C++ Note: df504 -0.07534494  
  C++ Note: Refreshing matrices after all guesses
  C++ Note: Guess Results
  Guess number, parameter values, Log-Likelihood
  0, -0.07534494, -1051.162<-- Best Guess
  C++ Note: starting subterms 1 in best guess 0
  C++ Note: values checked -0.0753449  
  C++ Note: sums checked 889.415  
  C++ Note: derivs checked 1321.38  
  C++ Note: second derivs checked 3565.92  
  C++ Note: dose checked 1000  
  C++ Note: non-dose checked 889.415  
  C++ Note: LIN_non-dose checked 1000  
  C++ Note: PLIN_non-dose checked 1000  
  C++ Note: LOGLIN_non-dose checked 889.415  
  C++ Note: risk checked 889.415  
  C++ Note: risk1 checked 1321.38  
  C++ Note: risk2 checked 3565.92  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 10823.9  
  C++ Note: risk1r checked 15714.3  
  C++ Note: risk2r checked 36253.4  
  C++ Note: riskl checked 99.4622  
  C++ Note: risk1l checked 174.499  
  C++ Note: risk2l checked 450.907  
  C++ Note: df101 -1051.16  
  C++ Note: df102 -2.20289  
  C++ Note: df103 -79.3096  
  C++ Note: df104 -0.0753449  
  C++ Note: df105 0.0277758  
  C++ Note: df106 477.175  
  C++ Note: Starting Halves
  C++ Note: df501 -1051.162
  C++ Note: df504 -0.07534494  
  C++ Note: values checked -0.0961768  
  C++ Note: sums checked 862.645  
  C++ Note: derivs checked 1249.59  
  C++ Note: second derivs checked 3329.49  
  C++ Note: dose checked 1000  
  C++ Note: non-dose checked 862.645  
  C++ Note: LIN_non-dose checked 1000  
  C++ Note: PLIN_non-dose checked 1000  
  C++ Note: LOGLIN_non-dose checked 862.645  
  C++ Note: risk checked 862.645  
  C++ Note: risk1 checked 1249.59  
  C++ Note: risk2 checked 3329.49  
  C++ Note: riskr checked 10504.3  
  C++ Note: risk1r checked 14981.8  
  C++ Note: risk2r checked 34097.7  
  C++ Note: riskl checked 95.9227  
  C++ Note: risk1l checked 165.411  
  C++ Note: risk2l checked 421.981  
  C++ Note: df101 -1051.13  
  C++ Note: df102 -0.548941  
  C++ Note: df103 -79.4798  
  C++ Note: df104 -0.0961768  
  C++ Note: df105 0.00690668  
  C++ Note: df106 1914.84  
  C++ Note: df100 23639 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:58:59 2024
  
  C++ Note: riskr checked 10504.3  
  C++ Note: risk1r checked 14981.8  
  C++ Note: risk2r checked 34097.7  
  C++ Note: riskl checked 95.9227  
  C++ Note: risk1l checked 165.411  
  C++ Note: risk2l checked 421.981  
  C++ Note: df101 -1051.13  
  C++ Note: df102 -0.548941  
  C++ Note: df103 -79.4798  
  C++ Note: df104 -0.0961768  
  C++ Note: df105 0.00690668  
  C++ Note: df106 1914.84  
  C++ Note: riskr checked 10504.3  
  C++ Note: risk1r checked 14981.8  
  C++ Note: risk2r checked 34097.7  
  C++ Note: riskl checked 95.9227  
  C++ Note: risk1l checked 165.411  
  C++ Note: risk2l checked 421.981  
  C++ Note: df101 -1051.13  
  C++ Note: df102 -0.548941  
  C++ Note: df103 -79.4798  
  C++ Note: df104 -0.0961768  
  C++ Note: df105 0.00690668  
  C++ Note: df106 1914.84  
  C++ Note: Exiting Regression
  C++ Note: df501 -1051.134
  C++ Note: df504 -0.09617677  
  Note: 114 risk groups
  C++ Note: START_COX_GUESS
  C++ Note: Current Time, Fri Feb 23 05:58:59 2024
  
  C++ Note: Term checked 0  
  C++ Note: df99,73,Starting
  C++ Note: Current Time, Fri Feb 23 05:58:59 2024
  
  C++ Note: Grouping Start
  C++ Note: df100 1841 0 0 -1,Prep_List
  C++ Note: Current Time, Fri Feb 23 05:58:59 2024
  
  C++ Note: starting subterms 1 in guess 0
  C++ Note: values checked 0  
  C++ Note: sums checked 1000  
  C++ Note: derivs checked 1626.94  
  C++ Note: second derivs checked 4593.87  
  C++ Note: dose checked 1000  
  C++ Note: non-dose checked 1000  
  C++ Note: LIN_non-dose checked 1000  
  C++ Note: PLIN_non-dose checked 1000  
  C++ Note: LOGLIN_non-dose checked 1000  
  C++ Note: risk checked 1000  
  C++ Note: risk1 checked 1626.94  
  C++ Note: risk2 checked 4593.87  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 12119  
  C++ Note: risk1r checked 18778.8  
  C++ Note: risk2r checked 45501.3  
  C++ Note: riskl checked 114  
  C++ Note: risk1l checked 212.971  
  C++ Note: risk2l checked 576.121  
  C++ Note: df101 -1051.55  
  C++ Note: df102 -8.15425  
  C++ Note: df103 -78.6575  
  C++ Note: df104 0  
  C++ Note: df105 0.103668  
  C++ Note: df106 128.958  
  C++ Note: riskr checked 12119  
  C++ Note: risk1r checked 18778.8  
  C++ Note: risk2r checked 45501.3  
  C++ Note: riskl checked 114  
  C++ Note: risk1l checked 212.971  
  C++ Note: risk2l checked 576.121  
  C++ Note: df101 -1051.55  
  C++ Note: df102 -8.15425  
  C++ Note: df103 -78.6575  
  C++ Note: df104 0  
  C++ Note: df105 0.103668  
  C++ Note: df106 128.958  
  C++ Note: ending guess 0
  C++ Note: df501 -1051.553
  C++ Note: df504 0  
  C++ Note: Refreshing matrices after all guesses
  C++ Note: Guess Results
  Guess number, parameter values, Log-Likelihood
  0, 0, -1051.553<-- Best Guess
  C++ Note: starting subterms 1 in best guess 0
  C++ Note: values checked 0  
  C++ Note: sums checked 1000  
  C++ Note: derivs checked 1626.94  
  C++ Note: second derivs checked 4593.87  
  C++ Note: dose checked 1000  
  C++ Note: non-dose checked 1000  
  C++ Note: LIN_non-dose checked 1000  
  C++ Note: PLIN_non-dose checked 1000  
  C++ Note: LOGLIN_non-dose checked 1000  
  C++ Note: risk checked 1000  
  C++ Note: risk1 checked 1626.94  
  C++ Note: risk2 checked 4593.87  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 12119  
  C++ Note: risk1r checked 18778.8  
  C++ Note: risk2r checked 45501.3  
  C++ Note: riskl checked 114  
  C++ Note: risk1l checked 212.971  
  C++ Note: risk2l checked 576.121  
  C++ Note: df101 -1051.55  
  C++ Note: df102 -8.15425  
  C++ Note: df103 -78.6575  
  C++ Note: df104 0  
  C++ Note: df105 0.103668  
  C++ Note: df106 128.958  
  C++ Note: riskr checked 12119  
  C++ Note: risk1r checked 18778.8  
  C++ Note: risk2r checked 45501.3  
  C++ Note: riskl checked 114  
  C++ Note: risk1l checked 212.971  
  C++ Note: risk2l checked 576.121  
  C++ Note: df101 -1051.55  
  C++ Note: df102 -8.15425  
  C++ Note: df103 -78.6575  
  C++ Note: df104 0  
  C++ Note: df105 0.103668  
  C++ Note: df106 128.958  
  C++ Note: Exiting Regression
  C++ Note: df501 -1051.553
  C++ Note: df504 0  
  Note: 114 risk groups
  C++ Note: START_COX_GUESS
  C++ Note: Current Time, Fri Feb 23 05:58:59 2024
  
  C++ Note: Grouping Start
  C++ Note: df100 2431 0 0 -1,Prep_List
  C++ Note: Current Time, Fri Feb 23 05:58:59 2024
  
  C++ Note: riskr checked 12119  
  C++ Note: riskl checked 114  
  Note: 114 risk groups
  C++ Note: START_COX_GUESS
  C++ Note: Current Time, Fri Feb 23 05:58:59 2024
  
  C++ Note: Term checked 0  
  C++ Note: df99,77,Starting
  C++ Note: Current Time, Fri Feb 23 05:58:59 2024
  
  C++ Note: Grouping Start
  C++ Note: df100 2601 0 0 -1,Prep_List
  C++ Note: Current Time, Fri Feb 23 05:58:59 2024
  
  C++ Note: starting subterms 1 in guess 0
  C++ Note: values checked 0  
  C++ Note: sums checked 1000  
  C++ Note: risk checked 1000  
  C++ Note: risk1 checked 1626.94  
  C++ Note: risk2 checked 4593.87  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 12119  
  C++ Note: riskl checked 114  
  C++ Note: df101 -1051.55  
  C++ Note: df104 0  
  C++ Note: riskr checked 12119  
  C++ Note: riskl checked 114  
  C++ Note: df101 -1051.55  
  C++ Note: df104 0  
  C++ Note: ending guess 0
  C++ Note: df501 -1051.553
  C++ Note: df504 0  
  C++ Note: Refreshing matrices after all guesses
  C++ Note: Guess Results
  Guess number, parameter values, Log-Likelihood
  0, 0, -1051.553<-- Best Guess
  C++ Note: starting subterms 1 in best guess 0
  C++ Note: values checked 0  
  C++ Note: sums checked 1000  
  C++ Note: risk checked 1000  
  C++ Note: risk1 checked 1626.94  
  C++ Note: risk2 checked 4593.87  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 12119  
  C++ Note: riskl checked 114  
  C++ Note: df101 -1051.55  
  C++ Note: df104 0  
  C++ Note: riskr checked 12119  
  C++ Note: riskl checked 114  
  C++ Note: df101 -1051.55  
  C++ Note: df104 0  
  C++ Note: Exiting Regression
  C++ Note: df501 -1051.553
  C++ Note: df504 0  
  Note: 114 risk groups
  C++ Note: START_COX_GUESS
  C++ Note: Current Time, Fri Feb 23 05:58:59 2024
  
  C++ Note: Grouping Start
  C++ Note: df100 1977 0 0 -1,Prep_List
  C++ Note: Current Time, Fri Feb 23 05:58:59 2024
  
  C++ Note: riskr checked 12119  
  C++ Note: riskl checked 114  
  Note: 114 risk groups
  C++ Note: START_COX_GUESS
  C++ Note: Current Time, Fri Feb 23 05:58:59 2024
  
  C++ Note: Term checked 0  
  C++ Note: df99,67,Starting
  C++ Note: Current Time, Fri Feb 23 05:58:59 2024
  
  C++ Note: Grouping Start
  C++ Note: df100 946 0 0 -1,Prep_List
  C++ Note: Current Time, Fri Feb 23 05:58:59 2024
  
  C++ Note: starting subterms 1 in guess 0
  C++ Note: values checked 0  
  C++ Note: sums checked 1000  
  C++ Note: risk checked 1000  
  C++ Note: risk1 checked 1626.94  
  C++ Note: risk2 checked 4593.87  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 12119  
  C++ Note: risk1r checked 18778.8  
  C++ Note: risk2r checked 45501.3  
  C++ Note: riskl checked 114  
  C++ Note: risk1l checked 212.971  
  C++ Note: risk2l checked 576.121  
  C++ Note: df101 -525.776  
  C++ Note: df102 -4.07712  
  C++ Note: df103 -39.3287  
  C++ Note: df104 0  
  C++ Note: df105 0.103668  
  C++ Note: df106 128.958  
  C++ Note: riskr checked 12119  
  C++ Note: risk1r checked 18778.8  
  C++ Note: risk2r checked 45501.3  
  C++ Note: riskl checked 114  
  C++ Note: risk1l checked 212.971  
  C++ Note: risk2l checked 576.121  
  C++ Note: df101 -525.776  
  C++ Note: df102 -4.07712  
  C++ Note: df103 -39.3287  
  C++ Note: df104 0  
  C++ Note: df105 0.103668  
  C++ Note: df106 128.958  
  C++ Note: ending guess 0
  C++ Note: df501 -525.7764
  C++ Note: df504 0  
  C++ Note: Refreshing matrices after all guesses
  C++ Note: Guess Results
  Guess number, parameter values, Log-Likelihood
  0, 0, -525.7764<-- Best Guess
  C++ Note: starting subterms 1 in best guess 0
  C++ Note: values checked 0  
  C++ Note: sums checked 1000  
  C++ Note: risk checked 1000  
  C++ Note: risk1 checked 1626.94  
  C++ Note: risk2 checked 4593.87  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 12119  
  C++ Note: risk1r checked 18778.8  
  C++ Note: risk2r checked 45501.3  
  C++ Note: riskl checked 114  
  C++ Note: risk1l checked 212.971  
  C++ Note: risk2l checked 576.121  
  C++ Note: df101 -525.776  
  C++ Note: df102 -4.07712  
  C++ Note: df103 -39.3287  
  C++ Note: df104 0  
  C++ Note: df105 0.103668  
  C++ Note: df106 128.958  
  C++ Note: riskr checked 12119  
  C++ Note: risk1r checked 18778.8  
  C++ Note: risk2r checked 45501.3  
  C++ Note: riskl checked 114  
  C++ Note: risk1l checked 212.971  
  C++ Note: risk2l checked 576.121  
  C++ Note: df101 -525.776  
  C++ Note: df102 -4.07712  
  C++ Note: df103 -39.3287  
  C++ Note: df104 0  
  C++ Note: df105 0.103668  
  C++ Note: df106 128.958  
  C++ Note: Exiting Regression
  C++ Note: df501 -525.7764
  C++ Note: df504 0  
  Note: 114 risk groups
  C++ Note: START_COX_GUESS
  C++ Note: Current Time, Fri Feb 23 05:58:59 2024
  
  C++ Note: Grouping Start
  C++ Note: df100 743 0 0 -1,Prep_List
  C++ Note: Current Time, Fri Feb 23 05:58:59 2024
  
  C++ Note: riskr checked 12119  
  C++ Note: riskl checked 114  
  Note: 114 risk groups
  C++ Note: START_COX_GUESS
  C++ Note: Current Time, Fri Feb 23 05:58:59 2024
  
  C++ Note: Term checked 0  
  C++ Note: df99,78,Starting
  C++ Note: Current Time, Fri Feb 23 05:58:59 2024
  
  C++ Note: Grouping Start
  C++ Note: df100 840 0 0 -1,Prep_List
  C++ Note: Current Time, Fri Feb 23 05:58:59 2024
  
  C++ Note: starting subterms 1 in guess 0
  C++ Note: values checked 0  
  C++ Note: sums checked 1000  
  C++ Note: dose checked 1000  
  C++ Note: non-dose checked 1000  
  C++ Note: LIN_non-dose checked 1000  
  C++ Note: PLIN_non-dose checked 1000  
  C++ Note: LOGLIN_non-dose checked 1000  
  C++ Note: risk checked 1000  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 12119  
  C++ Note: riskl checked 114  
  C++ Note: df101 -525.776  
  C++ Note: df104 0  
  C++ Note: riskr checked 12119  
  C++ Note: riskl checked 114  
  C++ Note: df101 -525.776  
  C++ Note: df104 0  
  C++ Note: ending guess 0
  C++ Note: df501 -525.7764
  C++ Note: df504 0  
  C++ Note: Refreshing matrices after all guesses
  C++ Note: Guess Results
  Guess number, parameter values, Log-Likelihood
  0, 0, -525.7764<-- Best Guess
  C++ Note: starting subterms 1 in best guess 0
  C++ Note: values checked 0  
  C++ Note: sums checked 1000  
  C++ Note: dose checked 1000  
  C++ Note: non-dose checked 1000  
  C++ Note: LIN_non-dose checked 1000  
  C++ Note: PLIN_non-dose checked 1000  
  C++ Note: LOGLIN_non-dose checked 1000  
  C++ Note: risk checked 1000  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 12119  
  C++ Note: riskl checked 114  
  C++ Note: df101 -525.776  
  C++ Note: df104 0  
  C++ Note: riskr checked 12119  
  C++ Note: riskl checked 114  
  C++ Note: df101 -525.776  
  C++ Note: df104 0  
  C++ Note: Exiting Regression
  C++ Note: df501 -525.7764
  C++ Note: df504 0  
  Note: 114 risk groups
  C++ Note: START_COX_GUESS
  C++ Note: Current Time, Fri Feb 23 05:59:00 2024
  
  C++ Note: Grouping Start
  C++ Note: df100 678 0 0 -1,Prep_List
  C++ Note: Current Time, Fri Feb 23 05:59:00 2024
  
  C++ Note: riskr checked 12119  
  C++ Note: riskl checked 114  
  Note: 114 risk groups
  C++ Note: START_COX_GUESS
  C++ Note: Current Time, Fri Feb 23 05:59:00 2024
  
  C++ Note: Term checked 0  
  C++ Note: df99,59,Starting
  C++ Note: Current Time, Fri Feb 23 05:59:00 2024
  
  C++ Note: Grouping Start
  C++ Note: df100 3101 0 0 -1,Prep_List
  C++ Note: Current Time, Fri Feb 23 05:59:00 2024
  
  C++ Note: starting subterms 1 in guess 0
  C++ Note: values checked 0  
  C++ Note: sums checked 1000  
  C++ Note: derivs checked 1626.94  
  C++ Note: second derivs checked 4593.87  
  C++ Note: dose checked 1000  
  C++ Note: non-dose checked 1000  
  C++ Note: LIN_non-dose checked 1000  
  C++ Note: PLIN_non-dose checked 1000  
  C++ Note: LOGLIN_non-dose checked 1000  
  C++ Note: risk checked 1000  
  C++ Note: risk1 checked 1626.94  
  C++ Note: risk2 checked 4593.87  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 12119  
  C++ Note: risk1r checked 18778.8  
  C++ Note: risk2r checked 45501.3  
  C++ Note: riskl checked 114  
  C++ Note: risk1l checked 212.971  
  C++ Note: risk2l checked 576.121  
  C++ Note: df101 -525.776  
  C++ Note: df102 -4.07712  
  C++ Note: df103 -39.3287  
  C++ Note: df104 0  
  C++ Note: df105 0.103668  
  C++ Note: df106 128.958  
  C++ Note: riskr checked 12119  
  C++ Note: risk1r checked 18778.8  
  C++ Note: risk2r checked 45501.3  
  C++ Note: riskl checked 114  
  C++ Note: risk1l checked 212.971  
  C++ Note: risk2l checked 576.121  
  C++ Note: df101 -525.776  
  C++ Note: df102 -4.07712  
  C++ Note: df103 -39.3287  
  C++ Note: df104 0  
  C++ Note: df105 0.103668  
  C++ Note: df106 128.958  
  C++ Note: ending guess 0
  C++ Note: df501 -525.7764
  C++ Note: df504 0  
  C++ Note: Refreshing matrices after all guesses
  C++ Note: Guess Results
  Guess number, parameter values, Log-Likelihood
  0, 0, -525.7764<-- Best Guess
  C++ Note: starting subterms 1 in best guess 0
  C++ Note: values checked 0  
  C++ Note: sums checked 1000  
  C++ Note: derivs checked 1626.94  
  C++ Note: second derivs checked 4593.87  
  C++ Note: dose checked 1000  
  C++ Note: non-dose checked 1000  
  C++ Note: LIN_non-dose checked 1000  
  C++ Note: PLIN_non-dose checked 1000  
  C++ Note: LOGLIN_non-dose checked 1000  
  C++ Note: risk checked 1000  
  C++ Note: risk1 checked 1626.94  
  C++ Note: risk2 checked 4593.87  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 12119  
  C++ Note: risk1r checked 18778.8  
  C++ Note: risk2r checked 45501.3  
  C++ Note: riskl checked 114  
  C++ Note: risk1l checked 212.971  
  C++ Note: risk2l checked 576.121  
  C++ Note: df101 -525.776  
  C++ Note: df102 -4.07712  
  C++ Note: df103 -39.3287  
  C++ Note: df104 0  
  C++ Note: df105 0.103668  
  C++ Note: df106 128.958  
  C++ Note: riskr checked 12119  
  C++ Note: risk1r checked 18778.8  
  C++ Note: risk2r checked 45501.3  
  C++ Note: riskl checked 114  
  C++ Note: risk1l checked 212.971  
  C++ Note: risk2l checked 576.121  
  C++ Note: df101 -525.776  
  C++ Note: df102 -4.07712  
  C++ Note: df103 -39.3287  
  C++ Note: df104 0  
  C++ Note: df105 0.103668  
  C++ Note: df106 128.958  
  C++ Note: Exiting Regression
  C++ Note: df501 -525.7764
  C++ Note: df504 0  
  Note: 901 risk groups
  C++ Note: START_COX_GUESS
  C++ Note: Current Time, Fri Feb 23 05:59:00 2024
  
  C++ Note: Term checked 0 0  
  C++ Note: df99,75,Starting
  C++ Note: Current Time, Fri Feb 23 05:59:00 2024
  
  C++ Note: Grouping Start
  C++ Note: df100 4332 0 0 -1,Prep_List
  C++ Note: Current Time, Fri Feb 23 05:59:00 2024
  
  C++ Note: starting subterms 1 in guess 0
  C++ Note: values checked 0 0  
  C++ Note: sums checked 1000 1000  
  C++ Note: derivs checked 531  
  C++ Note: second derivs checked 531  
  C++ Note: dose checked 1000  
  C++ Note: non-dose checked 1000  
  C++ Note: LIN_non-dose checked 1000  
  C++ Note: PLIN_non-dose checked 1000  
  C++ Note: LOGLIN_non-dose checked 1000  
  C++ Note: risk checked 1000  
  C++ Note: risk1 checked 531  
  C++ Note: risk2 checked 531  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 94828  
  C++ Note: risk1r checked 50387  
  C++ Note: risk2r checked 50387  
  C++ Note: riskl checked 901  
  C++ Note: risk1l checked 479  
  C++ Note: risk2l checked 479  
  C++ Note: df101 -4115.03  
  C++ Note: df102 1.62  
  C++ Note: df103 -222.912  
  C++ Note: df104 0 0  
  C++ Note: df105 -0.00726744  
  C++ Note: df106 -2540.14  
  C++ Note: Starting Halves
  C++ Note: df501 -4115.028
  C++ Note: df504 0 0  
  C++ Note: values checked 0 0.00545058  
  C++ Note: sums checked 1000 1002.9  
  C++ Note: derivs checked 533.902  
  C++ Note: second derivs checked 533.902  
  C++ Note: dose checked 1000  
  C++ Note: non-dose checked 1002.9  
  C++ Note: LIN_non-dose checked 1000  
  C++ Note: PLIN_non-dose checked 1000  
  C++ Note: LOGLIN_non-dose checked 1002.9  
  C++ Note: risk checked 1002.9  
  C++ Note: risk1 checked 533.902  
  C++ Note: risk2 checked 533.902  
  C++ Note: riskr checked 95103.4  
  C++ Note: risk1r checked 50662.4  
  C++ Note: risk2r checked 50662.4  
  C++ Note: riskl checked 903.618  
  C++ Note: risk1l checked 481.618  
  C++ Note: risk2l checked 481.618  
  C++ Note: df101 -4115.02  
  C++ Note: df102 0.405212  
  C++ Note: df103 -222.834  
  C++ Note: df104 0 0.00545058  
  C++ Note: df105 -0.00181845  
  C++ Note: df106 -10155.2  
  C++ Note: df100 32870 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:00 2024
  
  C++ Note: riskr checked 95103.4  
  C++ Note: risk1r checked 50662.4  
  C++ Note: risk2r checked 50662.4  
  C++ Note: riskl checked 903.618  
  C++ Note: risk1l checked 481.618  
  C++ Note: risk2l checked 481.618  
  C++ Note: df101 -4115.02  
  C++ Note: df102 0.405212  
  C++ Note: df103 -222.834  
  C++ Note: df104 0 0.00545058  
  C++ Note: df105 -0.00181845  
  C++ Note: df106 -10155.2  
  C++ Note: ending guess 0
  C++ Note: df501 -4115.022
  C++ Note: df504 0 0.005450583  
  C++ Note: Refreshing matrices after all guesses
  C++ Note: Guess Results
  Guess number, parameter values, Log-Likelihood
  0, 0 0.005450583, -4115.022<-- Best Guess
  C++ Note: starting subterms 1 in best guess 0
  C++ Note: values checked 0 0.00545058  
  C++ Note: sums checked 1000 1002.9  
  C++ Note: derivs checked 533.902  
  C++ Note: second derivs checked 533.902  
  C++ Note: dose checked 1000  
  C++ Note: non-dose checked 1002.9  
  C++ Note: LIN_non-dose checked 1000  
  C++ Note: PLIN_non-dose checked 1000  
  C++ Note: LOGLIN_non-dose checked 1002.9  
  C++ Note: risk checked 1002.9  
  C++ Note: risk1 checked 533.902  
  C++ Note: risk2 checked 533.902  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 95103.4  
  C++ Note: risk1r checked 50662.4  
  C++ Note: risk2r checked 50662.4  
  C++ Note: riskl checked 903.618  
  C++ Note: risk1l checked 481.618  
  C++ Note: risk2l checked 481.618  
  C++ Note: df101 -4115.02  
  C++ Note: df102 0.405212  
  C++ Note: df103 -222.834  
  C++ Note: df104 0 0.00545058  
  C++ Note: df105 -0.00181845  
  C++ Note: df106 -10155.2  
  C++ Note: riskr checked 95103.4  
  C++ Note: risk1r checked 50662.4  
  C++ Note: risk2r checked 50662.4  
  C++ Note: riskl checked 903.618  
  C++ Note: risk1l checked 481.618  
  C++ Note: risk2l checked 481.618  
  C++ Note: df101 -4115.02  
  C++ Note: df102 0.405212  
  C++ Note: df103 -222.834  
  C++ Note: df104 0 0.00545058  
  C++ Note: df105 -0.00181845  
  C++ Note: df106 -10155.2  
  C++ Note: Exiting Regression
  C++ Note: df501 -4115.022
  C++ Note: df504 0 0.005450583  
  C++ Note: START_PLOT
  C++ Note: Current Time, Fri Feb 23 05:59:00 2024
  
  C++ Note: Term checked 0 0  
  C++ Note: df99,82,Starting
  C++ Note: Current Time, Fri Feb 23 05:59:00 2024
  
  C++ Note: values checked 0 0  
  C++ Note: sums checked 1000 1000  
  C++ Note: derivs checked 531  
  C++ Note: second derivs checked 531  
  C++ Note: dose checked 1000  
  C++ Note: non-dose checked 1000  
  C++ Note: LIN_non-dose checked 1000  
  C++ Note: PLIN_non-dose checked 1000  
  C++ Note: LOGLIN_non-dose checked 1000  
  C++ Note: risk checked 1000  
  C++ Note: risk1 checked 531  
  C++ Note: risk2 checked 531  
  C++ Note: Grouping Start
  C++ Note: df100 18435 0 0 -1,Prep_List
  C++ Note: Current Time, Fri Feb 23 05:59:00 2024
  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 94828  
  C++ Note: risk1r checked 50387  
  C++ Note: risk2r checked 50387  
  C++ Note: riskl checked 901  
  C++ Note: risk1l checked 479  
  C++ Note: risk2l checked 479  
  C++ Note: df101 -4115.03  
  C++ Note: df102 1.62  
  C++ Note: df103 -222.912  
  C++ Note: df104 0 0  
  C++ Note: df105 -0.00726744  
  C++ Note: df106 -2540.14  
  Saving 7 x 7 in image
  Note: 5  strata used
  Note: 26 risk groups
  C++ Note: START_COX_GUESS
  C++ Note: Current Time, Fri Feb 23 05:59:01 2024
  
  C++ Note: Term checked 0 0  
  C++ Note: df99,82,Starting
  C++ Note: Current Time, Fri Feb 23 05:59:01 2024
  
  C++ Note: Grouping Start
  C++ Note: df100 801 0 0 -1,Prep_List
  C++ Note: Current Time, Fri Feb 23 05:59:01 2024
  
  C++ Note: starting subterms 1 in guess 0
  C++ Note: values checked -0.1 -0.1  
  C++ Note: sums checked 851.028 949.469  
  C++ Note: risk checked 807.883  
  C++ Note: risk1 checked 1229.85 410.233  
  C++ Note: risk2 checked 3319.14 410.233  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 109.969 102.565 75.071 118.205 66.864  
  C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621  
  C++ Note: df101 -82.5546 -82.5546  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: Starting Halves
  C++ Note: df501 -82.55461
  C++ Note: df504 -0.1 -0.1  
  C++ Note: values checked -0.1 -0.1  
  C++ Note: sums checked 851.028 949.469  
  C++ Note: risk checked 807.883  
  C++ Note: risk1 checked 1229.85 410.233  
  C++ Note: risk2 checked 3319.14 410.233  
  C++ Note: riskr checked 109.969 102.565 75.071 118.205 66.864  
  C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621  
  C++ Note: df101 -82.5546 -82.5546  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: df100 3299 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:01 2024
  
  C++ Note: values checked -0.1 -0.1  
  C++ Note: sums checked 851.028 949.469  
  C++ Note: risk checked 807.883  
  C++ Note: risk1 checked 1229.85 410.233  
  C++ Note: risk2 checked 3319.14 410.233  
  C++ Note: riskr checked 109.969 102.565 75.071 118.205 66.864  
  C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621  
  C++ Note: df101 -82.5546 -82.5546  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: df100 20208 2 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:01 2024
  
  C++ Note: riskr checked 109.969 102.565 75.071 118.205 66.864  
  C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621  
  C++ Note: df101 -82.5546 -82.5546  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: ending guess 0
  C++ Note: df501 -82.55461
  C++ Note: df504 -0.1 -0.1  
  C++ Note: Refreshing matrices after all guesses
  C++ Note: Guess Results
  Guess number, parameter values, Log-Likelihood
  0, -0.1 -0.1, -82.55461<-- Best Guess
  C++ Note: starting subterms 1 in best guess 0
  C++ Note: values checked -0.1 -0.1  
  C++ Note: sums checked 851.028 949.469  
  C++ Note: risk checked 807.883  
  C++ Note: risk1 checked 1229.85 410.233  
  C++ Note: risk2 checked 3319.14 410.233  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 109.969 102.565 75.071 118.205 66.864  
  C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621  
  C++ Note: df101 -82.5546 -82.5546  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: Starting Halves
  C++ Note: df501 -82.55461
  C++ Note: df504 -0.1 -0.1  
  C++ Note: values checked -0.1 -0.1  
  C++ Note: sums checked 851.028 949.469  
  C++ Note: risk checked 807.883  
  C++ Note: risk1 checked 1229.85 410.233  
  C++ Note: risk2 checked 3319.14 410.233  
  C++ Note: riskr checked 109.969 102.565 75.071 118.205 66.864  
  C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621  
  C++ Note: df101 -82.5546 -82.5546  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: df100 23487 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:02 2024
  
  C++ Note: values checked -0.1 -0.1  
  C++ Note: sums checked 851.028 949.469  
  C++ Note: risk checked 807.883  
  C++ Note: risk1 checked 1229.85 410.233  
  C++ Note: risk2 checked 3319.14 410.233  
  C++ Note: riskr checked 109.969 102.565 75.071 118.205 66.864  
  C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621  
  C++ Note: df101 -82.5546 -82.5546  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: df100 24617 2 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:02 2024
  
  C++ Note: riskr checked 109.969 102.565 75.071 118.205 66.864  
  C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621  
  C++ Note: df101 -82.5546 -82.5546  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: riskr checked 109.969 102.565 75.071 118.205 66.864  
  C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621  
  C++ Note: df101 -82.5546 -82.5546  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: Exiting Regression
  C++ Note: df501 -82.55461
  C++ Note: df504 -0.1 -0.1  
  Note: 5  strata used
  Note: 26 risk groups
  C++ Note: START_COX_GUESS
  C++ Note: Current Time, Fri Feb 23 05:59:02 2024
  
  C++ Note: Term checked 0 0  
  C++ Note: df99,74,Starting
  C++ Note: Current Time, Fri Feb 23 05:59:02 2024
  
  C++ Note: Grouping Start
  C++ Note: df100 14415 0 0 -1,Prep_List
  C++ Note: Current Time, Fri Feb 23 05:59:02 2024
  
  C++ Note: starting subterms 1 in guess 0
  C++ Note: values checked -0.1 -0.1  
  C++ Note: sums checked 851.028 949.469  
  C++ Note: risk checked 807.883  
  C++ Note: risk1 checked 1229.85 410.233  
  C++ Note: risk2 checked 3319.14 410.233  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 109.969 102.565 75.071 118.205 66.864  
  C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621  
  C++ Note: df101 -82.5546 -82.5546  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: Starting Halves
  C++ Note: df501 -82.55461
  C++ Note: df504 -0.1 -0.1  
  C++ Note: values checked -0.1 -0.1  
  C++ Note: sums checked 851.028 949.469  
  C++ Note: risk checked 807.883  
  C++ Note: risk1 checked 1229.85 410.233  
  C++ Note: risk2 checked 3319.14 410.233  
  C++ Note: riskr checked 109.969 102.565 75.071 118.205 66.864  
  C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621  
  C++ Note: df101 -82.5546 -82.5546  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: df100 24569 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:02 2024
  
  C++ Note: values checked -0.1 -0.1  
  C++ Note: sums checked 851.028 949.469  
  C++ Note: risk checked 807.883  
  C++ Note: risk1 checked 1229.85 410.233  
  C++ Note: risk2 checked 3319.14 410.233  
  C++ Note: riskr checked 109.969 102.565 75.071 118.205 66.864  
  C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621  
  C++ Note: df101 -82.5546 -82.5546  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: df100 25723 2 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:02 2024
  
  C++ Note: riskr checked 109.969 102.565 75.071 118.205 66.864  
  C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621  
  C++ Note: df101 -82.5546 -82.5546  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: ending guess 0
  C++ Note: df501 -82.55461
  C++ Note: df504 -0.1 -0.1  
  C++ Note: Refreshing matrices after all guesses
  C++ Note: Guess Results
  Guess number, parameter values, Log-Likelihood
  0, -0.1 -0.1, -82.55461<-- Best Guess
  C++ Note: starting subterms 1 in best guess 0
  C++ Note: values checked -0.1 -0.1  
  C++ Note: sums checked 851.028 949.469  
  C++ Note: risk checked 807.883  
  C++ Note: risk1 checked 1229.85 410.233  
  C++ Note: risk2 checked 3319.14 410.233  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 109.969 102.565 75.071 118.205 66.864  
  C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621  
  C++ Note: df101 -82.5546 -82.5546  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: Starting Halves
  C++ Note: df501 -82.55461
  C++ Note: df504 -0.1 -0.1  
  C++ Note: values checked -0.1 -0.1  
  C++ Note: sums checked 851.028 949.469  
  C++ Note: risk checked 807.883  
  C++ Note: risk1 checked 1229.85 410.233  
  C++ Note: risk2 checked 3319.14 410.233  
  C++ Note: riskr checked 109.969 102.565 75.071 118.205 66.864  
  C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621  
  C++ Note: df101 -82.5546 -82.5546  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: df100 29033 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:02 2024
  
  C++ Note: values checked -0.1 -0.1  
  C++ Note: sums checked 851.028 949.469  
  C++ Note: risk checked 807.883  
  C++ Note: risk1 checked 1229.85 410.233  
  C++ Note: risk2 checked 3319.14 410.233  
  C++ Note: riskr checked 109.969 102.565 75.071 118.205 66.864  
  C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621  
  C++ Note: df101 -82.5546 -82.5546  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: df100 30186 2 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:02 2024
  
  C++ Note: riskr checked 109.969 102.565 75.071 118.205 66.864  
  C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621  
  C++ Note: df101 -82.5546 -82.5546  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: riskr checked 109.969 102.565 75.071 118.205 66.864  
  C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621  
  C++ Note: df101 -82.5546 -82.5546  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: Exiting Regression
  C++ Note: df501 -82.55461
  C++ Note: df504 -0.1 -0.1  
  Note: 5  strata used
  Note: 26 risk groups
  C++ Note: START_COX_GUESS
  C++ Note: Current Time, Fri Feb 23 05:59:02 2024
  
  C++ Note: Term checked 0 0  
  C++ Note: df99,65,Starting
  C++ Note: Current Time, Fri Feb 23 05:59:02 2024
  
  C++ Note: Grouping Start
  C++ Note: df100 627 0 0 -1,Prep_List
  C++ Note: Current Time, Fri Feb 23 05:59:02 2024
  
  C++ Note: starting subterms 1 in guess 0
  C++ Note: values checked -0.1 -0.1  
  C++ Note: sums checked 851.028 949.469  
  C++ Note: risk checked 807.883  
  C++ Note: risk1 checked 1229.85 410.233  
  C++ Note: risk2 checked 3319.14 410.233  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 98.3613 91.6176 87.587 110.11 71.113  
  C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621  
  C++ Note: df101 -79.5885 -79.5885  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: Starting Halves
  C++ Note: df501 -79.58847
  C++ Note: df504 -0.1 -0.1  
  C++ Note: values checked -0.1 -0.1  
  C++ Note: sums checked 851.028 949.469  
  C++ Note: risk checked 807.883  
  C++ Note: risk1 checked 1229.85 410.233  
  C++ Note: risk2 checked 3319.14 410.233  
  C++ Note: riskr checked 98.3613 91.6176 87.587 110.11 71.113  
  C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621  
  C++ Note: df101 -79.5885 -79.5885  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: df100 2754 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:02 2024
  
  C++ Note: values checked -0.1 -0.1  
  C++ Note: sums checked 851.028 949.469  
  C++ Note: risk checked 807.883  
  C++ Note: risk1 checked 1229.85 410.233  
  C++ Note: risk2 checked 3319.14 410.233  
  C++ Note: riskr checked 98.3613 91.6176 87.587 110.11 71.113  
  C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621  
  C++ Note: df101 -79.5885 -79.5885  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: df100 19841 2 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:02 2024
  
  C++ Note: riskr checked 98.3613 91.6176 87.587 110.11 71.113  
  C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621  
  C++ Note: df101 -79.5885 -79.5885  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: ending guess 0
  C++ Note: df501 -79.58847
  C++ Note: df504 -0.1 -0.1  
  C++ Note: Refreshing matrices after all guesses
  C++ Note: Guess Results
  Guess number, parameter values, Log-Likelihood
  0, -0.1 -0.1, -79.58847<-- Best Guess
  C++ Note: starting subterms 1 in best guess 0
  C++ Note: values checked -0.1 -0.1  
  C++ Note: sums checked 851.028 949.469  
  C++ Note: risk checked 807.883  
  C++ Note: risk1 checked 1229.85 410.233  
  C++ Note: risk2 checked 3319.14 410.233  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 98.3613 91.6176 87.587 110.11 71.113  
  C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621  
  C++ Note: df101 -79.5885 -79.5885  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: Starting Halves
  C++ Note: df501 -79.58847
  C++ Note: df504 -0.1 -0.1  
  C++ Note: values checked -0.1 -0.1  
  C++ Note: sums checked 851.028 949.469  
  C++ Note: risk checked 807.883  
  C++ Note: risk1 checked 1229.85 410.233  
  C++ Note: risk2 checked 3319.14 410.233  
  C++ Note: riskr checked 98.3613 91.6176 87.587 110.11 71.113  
  C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621  
  C++ Note: df101 -79.5885 -79.5885  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: df100 22836 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:02 2024
  
  C++ Note: values checked -0.1 -0.1  
  C++ Note: sums checked 851.028 949.469  
  C++ Note: risk checked 807.883  
  C++ Note: risk1 checked 1229.85 410.233  
  C++ Note: risk2 checked 3319.14 410.233  
  C++ Note: riskr checked 98.3613 91.6176 87.587 110.11 71.113  
  C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621  
  C++ Note: df101 -79.5885 -79.5885  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: df100 23838 2 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:02 2024
  
  C++ Note: riskr checked 98.3613 91.6176 87.587 110.11 71.113  
  C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621  
  C++ Note: df101 -79.5885 -79.5885  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: riskr checked 98.3613 91.6176 87.587 110.11 71.113  
  C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621  
  C++ Note: df101 -79.5885 -79.5885  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: Exiting Regression
  C++ Note: df501 -79.58847
  C++ Note: df504 -0.1 -0.1  
  Note: 5  strata used
  Note: 26 risk groups
  C++ Note: START_COX_GUESS
  C++ Note: Current Time, Fri Feb 23 05:59:02 2024
  
  C++ Note: Term checked 0 0  
  C++ Note: df99,81,Starting
  C++ Note: Current Time, Fri Feb 23 05:59:02 2024
  
  C++ Note: Grouping Start
  C++ Note: df100 629 0 0 -1,Prep_List
  C++ Note: Current Time, Fri Feb 23 05:59:02 2024
  
  C++ Note: starting subterms 1 in guess 0
  C++ Note: values checked -0.1 -0.1  
  C++ Note: sums checked 851.028 949.469  
  C++ Note: risk checked 807.883  
  C++ Note: risk1 checked 1229.85 410.233  
  C++ Note: risk2 checked 3319.14 410.233  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 98.3613 91.6176 87.587 110.11 71.113  
  C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621  
  C++ Note: df101 -79.5885 -79.5885  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: Starting Halves
  C++ Note: df501 -79.58847
  C++ Note: df504 -0.1 -0.1  
  C++ Note: values checked -0.1 -0.1  
  C++ Note: sums checked 851.028 949.469  
  C++ Note: risk checked 807.883  
  C++ Note: risk1 checked 1229.85 410.233  
  C++ Note: risk2 checked 3319.14 410.233  
  C++ Note: riskr checked 98.3613 91.6176 87.587 110.11 71.113  
  C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621  
  C++ Note: df101 -79.5885 -79.5885  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: df100 2827 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:02 2024
  
  C++ Note: values checked -0.1 -0.1  
  C++ Note: sums checked 851.028 949.469  
  C++ Note: risk checked 807.883  
  C++ Note: risk1 checked 1229.85 410.233  
  C++ Note: risk2 checked 3319.14 410.233  
  C++ Note: riskr checked 98.3613 91.6176 87.587 110.11 71.113  
  C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621  
  C++ Note: df101 -79.5885 -79.5885  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: df100 3864 2 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:02 2024
  
  C++ Note: riskr checked 98.3613 91.6176 87.587 110.11 71.113  
  C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621  
  C++ Note: df101 -79.5885 -79.5885  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: ending guess 0
  C++ Note: df501 -79.58847
  C++ Note: df504 -0.1 -0.1  
  C++ Note: Refreshing matrices after all guesses
  C++ Note: Guess Results
  Guess number, parameter values, Log-Likelihood
  0, -0.1 -0.1, -79.58847<-- Best Guess
  C++ Note: starting subterms 1 in best guess 0
  C++ Note: values checked -0.1 -0.1  
  C++ Note: sums checked 851.028 949.469  
  C++ Note: risk checked 807.883  
  C++ Note: risk1 checked 1229.85 410.233  
  C++ Note: risk2 checked 3319.14 410.233  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 98.3613 91.6176 87.587 110.11 71.113  
  C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621  
  C++ Note: df101 -79.5885 -79.5885  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: Starting Halves
  C++ Note: df501 -79.58847
  C++ Note: df504 -0.1 -0.1  
  C++ Note: values checked -0.1 -0.1  
  C++ Note: sums checked 851.028 949.469  
  C++ Note: risk checked 807.883  
  C++ Note: risk1 checked 1229.85 410.233  
  C++ Note: risk2 checked 3319.14 410.233  
  C++ Note: riskr checked 98.3613 91.6176 87.587 110.11 71.113  
  C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621  
  C++ Note: df101 -79.5885 -79.5885  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: df100 22579 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:02 2024
  
  C++ Note: values checked -0.1 -0.1  
  C++ Note: sums checked 851.028 949.469  
  C++ Note: risk checked 807.883  
  C++ Note: risk1 checked 1229.85 410.233  
  C++ Note: risk2 checked 3319.14 410.233  
  C++ Note: riskr checked 98.3613 91.6176 87.587 110.11 71.113  
  C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621  
  C++ Note: df101 -79.5885 -79.5885  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: df100 23570 2 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:02 2024
  
  C++ Note: riskr checked 98.3613 91.6176 87.587 110.11 71.113  
  C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621  
  C++ Note: df101 -79.5885 -79.5885  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: riskr checked 98.3613 91.6176 87.587 110.11 71.113  
  C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621  
  C++ Note: df101 -79.5885 -79.5885  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: Exiting Regression
  C++ Note: df501 -79.58847
  C++ Note: df504 -0.1 -0.1  
  Note: 5  strata used
  Note: 26 risk groups
  C++ Note: START_COX_GUESS
  C++ Note: Current Time, Fri Feb 23 05:59:02 2024
  
  C++ Note: Term checked 0 0  
  C++ Note: df99,77,Starting
  C++ Note: Current Time, Fri Feb 23 05:59:02 2024
  
  C++ Note: Grouping Start
  C++ Note: df100 694 0 0 -1,Prep_List
  C++ Note: Current Time, Fri Feb 23 05:59:02 2024
  
  C++ Note: starting subterms 1 in guess 0
  C++ Note: values checked -0.1 -0.1  
  C++ Note: sums checked 851.028 949.469  
  C++ Note: risk checked 807.883  
  C++ Note: risk1 checked 1229.85 410.233  
  C++ Note: risk2 checked 3319.14 410.233  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 109.969 102.565 75.071 118.205 66.864  
  C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621  
  C++ Note: df101 -82.5546 -82.5546  
  C++ Note: df102 19.8692 3.2049  
  C++ Note: df103 -19.1334 -6.17679  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: df105 -1.03846 -0.518862  
  C++ Note: df106 -4.1549 -25.7589  
  C++ Note: Starting Halves
  C++ Note: df501 -82.55461
  C++ Note: df504 -0.1 -0.1  
  C++ Note: values checked 0.702609 0.405935  
  C++ Note: sums checked 5765.37 1265.87  
  C++ Note: risk checked 7235.91  
  C++ Note: risk1 checked 23875.5 4407.46  
  C++ Note: risk2 checked 95114.7 4407.46  
  C++ Note: riskr checked 1029.36 657.301 440.368 779.123 340.451  
  C++ Note: riskl checked 83.3734 40.9432 39.5706 39.8431 33.7665  
  C++ Note: df101 -71.2819 -71.2819  
  C++ Note: df102 6.53346 0.663705  
  C++ Note: df103 -13.6957 -6.04035  
  C++ Note: df104 0.702609 0.405935  
  C++ Note: df105 -0.477045 -0.109879  
  C++ Note: df106 -10.9103 -107.4  
  C++ Note: df100 21452 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:02 2024
  
  C++ Note: riskr checked 1029.36 657.301 440.368 779.123 340.451  
  C++ Note: riskl checked 83.3734 40.9432 39.5706 39.8431 33.7665  
  C++ Note: df101 -71.2819 -71.2819  
  C++ Note: df102 6.53346 0.663705  
  C++ Note: df103 -13.6957 -6.04035  
  C++ Note: df104 0.702609 0.405935  
  C++ Note: df105 -0.477045 -0.109879  
  C++ Note: df106 -10.9103 -107.4  
  C++ Note: ending guess 0
  C++ Note: df501 -71.28193
  C++ Note: df504 0.7026092 0.4059355  
  C++ Note: Refreshing matrices after all guesses
  C++ Note: Guess Results
  Guess number, parameter values, Log-Likelihood
  0, 0.7026092 0.4059355, -71.28193<-- Best Guess
  C++ Note: starting subterms 1 in best guess 0
  C++ Note: values checked 0.702609 0.405935  
  C++ Note: sums checked 5765.37 1265.87  
  C++ Note: risk checked 7235.91  
  C++ Note: risk1 checked 23875.5 4407.46  
  C++ Note: risk2 checked 95114.7 4407.46  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 1029.36 657.301 440.368 779.123 340.451  
  C++ Note: riskl checked 83.3734 40.9432 39.5706 39.8431 33.7665  
  C++ Note: df101 -71.2819 -71.2819  
  C++ Note: df102 6.53346 0.663705  
  C++ Note: df103 -13.6957 -6.04035  
  C++ Note: df104 0.702609 0.405935  
  C++ Note: df105 -0.477045 -0.109879  
  C++ Note: df106 -10.9103 -107.4  
  C++ Note: Starting Halves
  C++ Note: df501 -71.28193
  C++ Note: df504 0.7026092 0.4059355  
  C++ Note: values checked 1.06614 0.527334  
  C++ Note: sums checked 22078.7 1368.73  
  C++ Note: risk checked 29733.3  
  C++ Note: risk1 checked 119904 18677.8  
  C++ Note: risk2 checked 536010 18677.8  
  C++ Note: riskr checked 4013.84 1761.95 1075.19 2341.29 1010.29  
  C++ Note: riskl checked 390.452 140.821 119.569 110.838 125.172  
  C++ Note: df101 -69.6786 -69.6786  
  C++ Note: df102 2.18197 0.178373  
  C++ Note: df103 -10.8366 -5.93902  
  C++ Note: df104 1.06614 0.527334  
  C++ Note: df105 -0.201352 -0.0300341  
  C++ Note: df106 -31.9338 -390.634  
  C++ Note: df100 27769 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:02 2024
  
  C++ Note: riskr checked 4013.84 1761.95 1075.19 2341.29 1010.29  
  C++ Note: riskl checked 390.452 140.821 119.569 110.838 125.172  
  C++ Note: df101 -69.6786 -69.6786  
  C++ Note: df102 2.18197 0.178373  
  C++ Note: df103 -10.8366 -5.93902  
  C++ Note: df104 1.06614 0.527334  
  C++ Note: df105 -0.201352 -0.0300341  
  C++ Note: df106 -31.9338 -390.634  
  C++ Note: riskr checked 4013.84 1761.95 1075.19 2341.29 1010.29  
  C++ Note: riskl checked 390.452 140.821 119.569 110.838 125.172  
  C++ Note: df101 -69.6786 -69.6786  
  C++ Note: df102 2.18197 0.178373  
  C++ Note: df103 -10.8366 -5.93902  
  C++ Note: df104 1.06614 0.527334  
  C++ Note: df105 -0.201352 -0.0300341  
  C++ Note: df106 -31.9338 -390.634  
  C++ Note: Exiting Regression
  C++ Note: df501 -69.67859
  C++ Note: df504 1.066135 0.5273336  
  Note: 5  strata used
  Note: 26 risk groups
  C++ Note: START_COX_GUESS
  C++ Note: Current Time, Fri Feb 23 05:59:02 2024
  
  C++ Note: Term checked 0 0  
  C++ Note: df99,69,Starting
  C++ Note: Current Time, Fri Feb 23 05:59:02 2024
  
  C++ Note: Grouping Start
  C++ Note: df100 638 0 0 -1,Prep_List
  C++ Note: Current Time, Fri Feb 23 05:59:02 2024
  
  C++ Note: starting subterms 1 in guess 0
  C++ Note: values checked -0.1 -0.1  
  C++ Note: sums checked 851.028 949.469  
  C++ Note: risk checked 807.883  
  C++ Note: risk1 checked 1229.85 410.233  
  C++ Note: risk2 checked 3319.14 410.233  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 109.969 102.565 75.071 118.205 66.864  
  C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621  
  C++ Note: df101 -82.5546 -82.5546  
  C++ Note: df102 19.8692 3.2049  
  C++ Note: df103 -19.1334 -6.17679  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: df105 -1.03846 -0.518862  
  C++ Note: df106 -4.1549 -25.7589  
  C++ Note: Starting Halves
  C++ Note: df501 -82.55461
  C++ Note: df504 -0.1 -0.1  
  C++ Note: values checked 0.678843 0.289146  
  C++ Note: sums checked 5332.15 1178.04  
  C++ Note: risk checked 6244.38  
  C++ Note: risk1 checked 20292.1 3632.95  
  C++ Note: risk2 checked 80174.7 3632.95  
  C++ Note: riskr checked 899.189 581.433 385.076 688.511 299.436  
  C++ Note: riskl checked 70.4668 36.2982 33.2589 35.4616 28.5259  
  C++ Note: df101 -143.116 -143.116  
  C++ Note: df102 13.571 2.71894  
  C++ Note: df103 -27.8461 -12.2687  
  C++ Note: df104 0.678843 0.289146  
  C++ Note: df105 -0.487357 -0.221615  
  C++ Note: df106 -10.5458 -52.6369  
  C++ Note: df100 40554 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:02 2024
  
  C++ Note: values checked 0.289421 0.0945731  
  C++ Note: sums checked 1791.23 1052.67  
  C++ Note: risk checked 1884.29  
  C++ Note: risk1 checked 4400.12 1031.3  
  C++ Note: risk2 checked 14680.4 1031.3  
  C++ Note: riskr checked 262.551 226.442 160.324 257.064 126.085  
  C++ Note: riskl checked 15.1599 10.7534 10.4668 12.232 8.24392  
  C++ Note: df101 -75.6796 -75.6796  
  C++ Note: df102 12.7837 2.30284  
  C++ Note: df103 -17.4756 -6.19166  
  C++ Note: df104 0.289421 0.0945731  
  C++ Note: df105 -0.731516 -0.371925  
  C++ Note: df106 -5.92 -32.8637  
  C++ Note: df100 42778 2 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:02 2024
  
  C++ Note: riskr checked 262.551 226.442 160.324 257.064 126.085  
  C++ Note: riskl checked 15.1599 10.7534 10.4668 12.232 8.24392  
  C++ Note: df101 -75.6796 -75.6796  
  C++ Note: df102 12.7837 2.30284  
  C++ Note: df103 -17.4756 -6.19166  
  C++ Note: df104 0.289421 0.0945731  
  C++ Note: df105 -0.731516 -0.371925  
  C++ Note: df106 -5.92 -32.8637  
  C++ Note: ending guess 0
  C++ Note: df501 -75.67958
  C++ Note: df504 0.2894214 0.09457311  
  C++ Note: Refreshing matrices after all guesses
  C++ Note: Guess Results
  Guess number, parameter values, Log-Likelihood
  0, 0.2894214 0.09457311, -75.67958<-- Best Guess
  C++ Note: starting subterms 1 in best guess 0
  C++ Note: values checked 0.289421 0.0945731  
  C++ Note: sums checked 1791.23 1052.67  
  C++ Note: risk checked 1884.29  
  C++ Note: risk1 checked 4400.12 1031.3  
  C++ Note: risk2 checked 14680.4 1031.3  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 262.551 226.442 160.324 257.064 126.085  
  C++ Note: riskl checked 15.1599 10.7534 10.4668 12.232 8.24392  
  C++ Note: df101 -75.6796 -75.6796  
  C++ Note: df102 12.7837 2.30284  
  C++ Note: df103 -17.4756 -6.19166  
  C++ Note: df104 0.289421 0.0945731  
  C++ Note: df105 -0.731516 -0.371925  
  C++ Note: df106 -5.92 -32.8637  
  C++ Note: Starting Halves
  C++ Note: df501 -75.67958
  C++ Note: df504 0.2894214 0.09457311  
  C++ Note: values checked 0.838059 0.373517  
  C++ Note: sums checked 9215.05 1240.46  
  C++ Note: risk checked 11322  
  C++ Note: risk1 checked 40711.1 6759.64  
  C++ Note: risk2 checked 170080 6759.64  
  C++ Note: riskr checked 1614.5 894.988 572.892 1100.76 468.244  
  C++ Note: riskl checked 139.475 62.2898 55.0689 55.9737 50.733  
  C++ Note: df101 -141.093 -141.093  
  C++ Note: df102 9.47351 1.89862  
  C++ Note: df103 -25.0749 -12.1626  
  C++ Note: df104 0.838059 0.373517  
  C++ Note: df105 -0.377808 -0.156103  
  C++ Note: df106 -14.8934 -74.3136  
  C++ Note: df100 80554 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:02 2024
  
  C++ Note: values checked 0.56374 0.234045  
  C++ Note: sums checked 3720.42 1140.03  
  C++ Note: risk checked 4225.1  
  C++ Note: risk1 checked 12606.8 2418.53  
  C++ Note: risk2 checked 47612.8 2418.53  
  C++ Note: riskr checked 605.798 433.663 293.944 503.495 225.281  
  C++ Note: riskl checked 43.8614 24.9535 23.4332 25.7254 19.3074  
  C++ Note: df101 -72.5139 -72.5139  
  C++ Note: df102 8.41343 1.62295  
  C++ Note: df103 -14.9958 -6.15888  
  C++ Note: df104 0.56374 0.234045  
  C++ Note: df105 -0.561053 -0.263513  
  C++ Note: df106 -8.61883 -44.6804  
  C++ Note: df100 82794 2 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:02 2024
  
  C++ Note: riskr checked 605.798 433.663 293.944 503.495 225.281  
  C++ Note: riskl checked 43.8614 24.9535 23.4332 25.7254 19.3074  
  C++ Note: df101 -72.5139 -72.5139  
  C++ Note: df102 8.41343 1.62295  
  C++ Note: df103 -14.9958 -6.15888  
  C++ Note: df104 0.56374 0.234045  
  C++ Note: df105 -0.561053 -0.263513  
  C++ Note: df106 -8.61883 -44.6804  
  C++ Note: riskr checked 605.798 433.663 293.944 503.495 225.281  
  C++ Note: riskl checked 43.8614 24.9535 23.4332 25.7254 19.3074  
  C++ Note: df101 -72.5139 -72.5139  
  C++ Note: df102 8.41343 1.62295  
  C++ Note: df103 -14.9958 -6.15888  
  C++ Note: df104 0.56374 0.234045  
  C++ Note: df105 -0.561053 -0.263513  
  C++ Note: df106 -8.61883 -44.6804  
  C++ Note: Exiting Regression
  C++ Note: df501 -72.51393
  C++ Note: df504 0.5637399 0.2340451  
  Note: 5  strata used
  Note: 26 risk groups
  C++ Note: START_COX_GUESS
  C++ Note: Current Time, Fri Feb 23 05:59:02 2024
  
  C++ Note: Term checked 0 0  
  C++ Note: df99,67,Starting
  C++ Note: Current Time, Fri Feb 23 05:59:02 2024
  
  C++ Note: Grouping Start
  C++ Note: df100 570 0 0 -1,Prep_List
  C++ Note: Current Time, Fri Feb 23 05:59:02 2024
  
  C++ Note: starting subterms 1 in guess 0
  C++ Note: values checked -0.1 -0.1  
  C++ Note: sums checked 851.028 949.469  
  C++ Note: risk checked 807.883  
  C++ Note: risk1 checked 1229.85 410.233  
  C++ Note: risk2 checked 3319.14 410.233  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 98.3613 91.6176 87.587 110.11 71.113  
  C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621  
  C++ Note: df101 -159.177 -159.177  
  C++ Note: df102 10.8541 4.28403  
  C++ Note: df103 -14.2337 -12.4254  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: df105 -0.762564 -0.34478  
  C++ Note: df106 -14.6652 -37.1559  
  C++ Note: Starting Halves
  C++ Note: df501 -159.1769
  C++ Note: df504 -0.1 -0.1  
  C++ Note: values checked 0.550424 0.30353  
  C++ Note: sums checked 3575.85 1188.31  
  C++ Note: risk checked 4228.8  
  C++ Note: risk1 checked 12473.9 2494.15  
  C++ Note: risk2 checked 46827.4 2494.15  
  C++ Note: riskr checked 616.483 485.721 374.917 603.993 261.606  
  C++ Note: riskl checked 43.76 24.6658 24.1668 25.7075 19.5703  
  C++ Note: df101 -76.8654 -76.8654  
  C++ Note: df102 1.27777 0.508497  
  C++ Note: df103 -7.18963 -6.04474  
  C++ Note: df104 0.550424 0.30353  
  C++ Note: df105 -0.177724 -0.0841223  
  C++ Note: df106 -60.1559 -151.162  
  C++ Note: df100 28326 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:02 2024
  
  C++ Note: riskr checked 616.483 485.721 374.917 603.993 261.606  
  C++ Note: riskl checked 43.76 24.6658 24.1668 25.7075 19.5703  
  C++ Note: df101 -76.8654 -76.8654  
  C++ Note: df102 1.27777 0.508497  
  C++ Note: df103 -7.18963 -6.04474  
  C++ Note: df104 0.550424 0.30353  
  C++ Note: df105 -0.177724 -0.0841223  
  C++ Note: df106 -60.1559 -151.162  
  C++ Note: ending guess 0
  C++ Note: df501 -76.86543
  C++ Note: df504 0.5504238 0.3035295  
  C++ Note: Refreshing matrices after all guesses
  C++ Note: Guess Results
  Guess number, parameter values, Log-Likelihood
  0, 0.5504238 0.3035295, -76.86543<-- Best Guess
  C++ Note: starting subterms 1 in best guess 0
  C++ Note: values checked 0.550424 0.30353  
  C++ Note: sums checked 3575.85 1188.31  
  C++ Note: risk checked 4228.8  
  C++ Note: risk1 checked 12473.9 2494.15  
  C++ Note: risk2 checked 46827.4 2494.15  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 616.483 485.721 374.917 603.993 261.606  
  C++ Note: riskl checked 43.76 24.6658 24.1668 25.7075 19.5703  
  C++ Note: df101 -76.8654 -76.8654  
  C++ Note: df102 1.27777 0.508497  
  C++ Note: df103 -7.18963 -6.04474  
  C++ Note: df104 0.550424 0.30353  
  C++ Note: df105 -0.177724 -0.0841223  
  C++ Note: df106 -60.1559 -151.162  
  C++ Note: Starting Halves
  C++ Note: df501 -76.86543
  C++ Note: df504 0.5504238 0.3035295  
  C++ Note: values checked 0.699516 0.396693  
  C++ Note: sums checked 5706.63 1258.54  
  C++ Note: risk checked 7122.36  
  C++ Note: risk1 checked 23453.2 4323.35  
  C++ Note: risk2 checked 93329.8 4323.35  
  C++ Note: riskr checked 1103.97 748.255 549.423 973.678 397.318  
  C++ Note: riskl checked 81.8797 40.3981 38.9034 39.35 33.1873  
  C++ Note: df101 -76.7167 -76.7167  
  C++ Note: df102 0.321463 0.127669  
  C++ Note: df103 -7.13078 -5.96512  
  C++ Note: df104 0.699516 0.396693  
  C++ Note: df105 -0.045081 -0.0214027  
  C++ Note: df106 -238.649 -600.901  
  C++ Note: df100 50538 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:02 2024
  
  C++ Note: riskr checked 1103.97 748.255 549.423 973.678 397.318  
  C++ Note: riskl checked 81.8797 40.3981 38.9034 39.35 33.1873  
  C++ Note: df101 -76.7167 -76.7167  
  C++ Note: df102 0.321463 0.127669  
  C++ Note: df103 -7.13078 -5.96512  
  C++ Note: df104 0.699516 0.396693  
  C++ Note: df105 -0.045081 -0.0214027  
  C++ Note: df106 -238.649 -600.901  
  C++ Note: riskr checked 1103.97 748.255 549.423 973.678 397.318  
  C++ Note: riskl checked 81.8797 40.3981 38.9034 39.35 33.1873  
  C++ Note: df101 -76.7167 -76.7167  
  C++ Note: df102 0.321463 0.127669  
  C++ Note: df103 -7.13078 -5.96512  
  C++ Note: df104 0.699516 0.396693  
  C++ Note: df105 -0.045081 -0.0214027  
  C++ Note: df106 -238.649 -600.901  
  C++ Note: Exiting Regression
  C++ Note: df501 -76.71665
  C++ Note: df504 0.6995155 0.3966929  
  Note: 5  strata used
  Note: 26 risk groups
  C++ Note: START_COX_GUESS
  C++ Note: Current Time, Fri Feb 23 05:59:02 2024
  
  C++ Note: Term checked 0 0  
  C++ Note: df99,67,Starting
  C++ Note: Current Time, Fri Feb 23 05:59:02 2024
  
  C++ Note: Grouping Start
  C++ Note: df100 15058 0 0 -1,Prep_List
  C++ Note: Current Time, Fri Feb 23 05:59:02 2024
  
  C++ Note: starting subterms 1 in guess 0
  C++ Note: values checked -0.1 -0.1  
  C++ Note: sums checked 851.028 949.469  
  C++ Note: risk checked 807.883  
  C++ Note: risk1 checked 1229.85 410.233  
  C++ Note: risk2 checked 3319.14 410.233  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 98.3613 91.6176 87.587 110.11 71.113  
  C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621  
  C++ Note: df101 -79.5885 -79.5885  
  C++ Note: df102 5.42704 2.14202  
  C++ Note: df103 -7.11684 -6.21271  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: df105 -0.762564 -0.34478  
  C++ Note: df106 -14.6652 -37.1559  
  C++ Note: Starting Halves
  C++ Note: df501 -79.58847
  C++ Note: df504 -0.1 -0.1  
  C++ Note: values checked 0.471923 0.158585  
  C++ Note: sums checked 2855.18 1091.25  
  C++ Note: risk checked 3109.21  
  C++ Note: risk1 checked 8604.8 1732.23  
  C++ Note: risk2 checked 31265.5 1732.23  
  C++ Note: riskr checked 437.598 369.44 288.407 451.269 203.987  
  C++ Note: riskl checked 29.7555 18.4415 17.3204 19.7081 14.0257  
  C++ Note: df101 -77.1115 -77.1115  
  C++ Note: df102 1.6628 1.2965  
  C++ Note: df103 -7.18852 -6.1617  
  C++ Note: df104 0.471923 0.158585  
  C++ Note: df105 -0.231313 -0.210412  
  C++ Note: df106 -46.3745 -59.4767  
  C++ Note: df100 26947 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:02 2024
  
  C++ Note: riskr checked 437.598 369.44 288.407 451.269 203.987  
  C++ Note: riskl checked 29.7555 18.4415 17.3204 19.7081 14.0257  
  C++ Note: df101 -77.1115 -77.1115  
  C++ Note: df102 1.6628 1.2965  
  C++ Note: df103 -7.18852 -6.1617  
  C++ Note: df104 0.471923 0.158585  
  C++ Note: df105 -0.231313 -0.210412  
  C++ Note: df106 -46.3745 -59.4767  
  C++ Note: ending guess 0
  C++ Note: df501 -77.11153
  C++ Note: df504 0.4719227 0.1585847  
  C++ Note: Refreshing matrices after all guesses
  C++ Note: Guess Results
  Guess number, parameter values, Log-Likelihood
  0, 0.4719227 0.1585847, -77.11153<-- Best Guess
  C++ Note: starting subterms 1 in best guess 0
  C++ Note: values checked 0.471923 0.158585  
  C++ Note: sums checked 2855.18 1091.25  
  C++ Note: risk checked 3109.21  
  C++ Note: risk1 checked 8604.8 1732.23  
  C++ Note: risk2 checked 31265.5 1732.23  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 437.598 369.44 288.407 451.269 203.987  
  C++ Note: riskl checked 29.7555 18.4415 17.3204 19.7081 14.0257  
  C++ Note: df101 -77.1115 -77.1115  
  C++ Note: df102 1.6628 1.2965  
  C++ Note: df103 -7.18852 -6.1617  
  C++ Note: df104 0.471923 0.158585  
  C++ Note: df105 -0.231313 -0.210412  
  C++ Note: df106 -46.3745 -59.4767  
  C++ Note: Starting Halves
  C++ Note: df501 -77.11153
  C++ Note: df504 0.4719227 0.1585847  
  C++ Note: values checked 0.645408 0.316394  
  C++ Note: sums checked 4787.64 1197.62  
  C++ Note: risk checked 5698.95  
  C++ Note: risk1 checked 18076.9 3359.94  
  C++ Note: risk2 checked 70503.7 3359.94  
  C++ Note: riskr checked 866.381 621.431 461.192 794.093 330.167  
  C++ Note: riskl checked 63.0668 33.0727 31.2711 32.9428 26.3017  
  C++ Note: df101 -153.538 -153.538  
  C++ Note: df102 1.22455 1.09128  
  C++ Note: df103 -14.2968 -12.0928  
  C++ Note: df104 0.645408 0.316394  
  C++ Note: df105 -0.0856523 -0.0902421  
  C++ Note: df106 -125.383 -140.695  
  C++ Note: df100 67256 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:02 2024
  
  C++ Note: values checked 0.558665 0.237489  
  C++ Note: sums checked 3664.46 1142.34  
  C++ Note: risk checked 4169.96  
  C++ Note: risk1 checked 12391.6 2391.23  
  C++ Note: risk2 checked 46700.8 2391.23  
  C++ Note: riskr checked 610.982 477.554 363.467 595.201 257.016  
  C++ Note: riskl checked 43.1389 24.6092 23.2052 25.4369 19.0707  
  C++ Note: df101 -76.9026 -76.9026  
  C++ Note: df102 1.13776 0.91999  
  C++ Note: df103 -7.1743 -6.10978  
  C++ Note: df104 0.558665 0.237489  
  C++ Note: df105 -0.158589 -0.150577  
  C++ Note: df106 -67.5911 -83.5907  
  C++ Note: df100 69265 2 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:02 2024
  
  C++ Note: riskr checked 610.982 477.554 363.467 595.201 257.016  
  C++ Note: riskl checked 43.1389 24.6092 23.2052 25.4369 19.0707  
  C++ Note: df101 -76.9026 -76.9026  
  C++ Note: df102 1.13776 0.91999  
  C++ Note: df103 -7.1743 -6.10978  
  C++ Note: df104 0.558665 0.237489  
  C++ Note: df105 -0.158589 -0.150577  
  C++ Note: df106 -67.5911 -83.5907  
  C++ Note: riskr checked 610.982 477.554 363.467 595.201 257.016  
  C++ Note: riskl checked 43.1389 24.6092 23.2052 25.4369 19.0707  
  C++ Note: df101 -76.9026 -76.9026  
  C++ Note: df102 1.13776 0.91999  
  C++ Note: df103 -7.1743 -6.10978  
  C++ Note: df104 0.558665 0.237489  
  C++ Note: df105 -0.158589 -0.150577  
  C++ Note: df106 -67.5911 -83.5907  
  C++ Note: Exiting Regression
  C++ Note: df501 -76.90262
  C++ Note: df504 0.5586651 0.2374893  
  Note: 5  strata used
  Note: 26 risk groups
  C++ Note: START_COX_GUESS
  C++ Note: Current Time, Fri Feb 23 05:59:02 2024
  
  C++ Note: Term checked 0 0  
  C++ Note: df99,68,Starting
  C++ Note: Current Time, Fri Feb 23 05:59:02 2024
  
  C++ Note: Grouping Start
  C++ Note: df100 15602 0 0 -1,Prep_List
  C++ Note: Current Time, Fri Feb 23 05:59:02 2024
  
  C++ Note: starting subterms 1 in guess 0
  C++ Note: values checked -0.1 -0.1  
  C++ Note: sums checked 807.883 807.883  
  C++ Note: dose checked 1000  
  C++ Note: non-dose checked 807.883  
  C++ Note: LIN_non-dose checked 1000  
  C++ Note: PLIN_non-dose checked 1000  
  C++ Note: LOGLIN_non-dose checked 807.883  
  C++ Note: risk checked 807.883  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 109.969 102.565 75.071 118.205 66.864  
  C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621  
  C++ Note: df101 -82.5546 -82.5546  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: Starting Halves
  C++ Note: df501 -82.55461
  C++ Note: df504 -0.1 -0.1  
  C++ Note: values checked -0.1 -0.1  
  C++ Note: sums checked 807.883 807.883  
  C++ Note: dose checked 1000  
  C++ Note: non-dose checked 807.883  
  C++ Note: LIN_non-dose checked 1000  
  C++ Note: PLIN_non-dose checked 1000  
  C++ Note: LOGLIN_non-dose checked 807.883  
  C++ Note: risk checked 807.883  
  C++ Note: riskr checked 109.969 102.565 75.071 118.205 66.864  
  C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621  
  C++ Note: df101 -82.5546 -82.5546  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: df100 17854 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:02 2024
  
  C++ Note: values checked -0.1 -0.1  
  C++ Note: sums checked 807.883 807.883  
  C++ Note: dose checked 1000  
  C++ Note: non-dose checked 807.883  
  C++ Note: LIN_non-dose checked 1000  
  C++ Note: PLIN_non-dose checked 1000  
  C++ Note: LOGLIN_non-dose checked 807.883  
  C++ Note: risk checked 807.883  
  C++ Note: riskr checked 109.969 102.565 75.071 118.205 66.864  
  C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621  
  C++ Note: df101 -82.5546 -82.5546  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: df100 18901 2 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:02 2024
  
  C++ Note: riskr checked 109.969 102.565 75.071 118.205 66.864  
  C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621  
  C++ Note: df101 -82.5546 -82.5546  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: ending guess 0
  C++ Note: df501 -82.55461
  C++ Note: df504 -0.1 -0.1  
  C++ Note: Refreshing matrices after all guesses
  C++ Note: Guess Results
  Guess number, parameter values, Log-Likelihood
  0, -0.1 -0.1, -82.55461<-- Best Guess
  C++ Note: starting subterms 1 in best guess 0
  C++ Note: values checked -0.1 -0.1  
  C++ Note: sums checked 807.883 807.883  
  C++ Note: dose checked 1000  
  C++ Note: non-dose checked 807.883  
  C++ Note: LIN_non-dose checked 1000  
  C++ Note: PLIN_non-dose checked 1000  
  C++ Note: LOGLIN_non-dose checked 807.883  
  C++ Note: risk checked 807.883  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 109.969 102.565 75.071 118.205 66.864  
  C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621  
  C++ Note: df101 -82.5546 -82.5546  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: Starting Halves
  C++ Note: df501 -82.55461
  C++ Note: df504 -0.1 -0.1  
  C++ Note: values checked -0.1 -0.1  
  C++ Note: sums checked 807.883 807.883  
  C++ Note: dose checked 1000  
  C++ Note: non-dose checked 807.883  
  C++ Note: LIN_non-dose checked 1000  
  C++ Note: PLIN_non-dose checked 1000  
  C++ Note: LOGLIN_non-dose checked 807.883  
  C++ Note: risk checked 807.883  
  C++ Note: riskr checked 109.969 102.565 75.071 118.205 66.864  
  C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621  
  C++ Note: df101 -82.5546 -82.5546  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: df100 21985 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:02 2024
  
  C++ Note: values checked -0.1 -0.1  
  C++ Note: sums checked 807.883 807.883  
  C++ Note: dose checked 1000  
  C++ Note: non-dose checked 807.883  
  C++ Note: LIN_non-dose checked 1000  
  C++ Note: PLIN_non-dose checked 1000  
  C++ Note: LOGLIN_non-dose checked 807.883  
  C++ Note: risk checked 807.883  
  C++ Note: riskr checked 109.969 102.565 75.071 118.205 66.864  
  C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621  
  C++ Note: df101 -82.5546 -82.5546  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: df100 23132 2 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:02 2024
  
  C++ Note: riskr checked 109.969 102.565 75.071 118.205 66.864  
  C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621  
  C++ Note: df101 -82.5546 -82.5546  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: riskr checked 109.969 102.565 75.071 118.205 66.864  
  C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621  
  C++ Note: df101 -82.5546 -82.5546  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: Exiting Regression
  C++ Note: df501 -82.55461
  C++ Note: df504 -0.1 -0.1  
  Note: 5  strata used
  Note: 26 risk groups
  C++ Note: START_COX_GUESS
  C++ Note: Current Time, Fri Feb 23 05:59:02 2024
  
  C++ Note: Term checked 0 0  
  C++ Note: df99,88,Starting
  C++ Note: Current Time, Fri Feb 23 05:59:02 2024
  
  C++ Note: Grouping Start
  C++ Note: df100 676 0 0 -1,Prep_List
  C++ Note: Current Time, Fri Feb 23 05:59:02 2024
  
  C++ Note: starting subterms 1 in guess 0
  C++ Note: values checked -0.1 -0.1  
  C++ Note: sums checked 807.883 807.883  
  C++ Note: dose checked 1000  
  C++ Note: non-dose checked 807.883  
  C++ Note: LIN_non-dose checked 1000  
  C++ Note: PLIN_non-dose checked 1000  
  C++ Note: LOGLIN_non-dose checked 807.883  
  C++ Note: risk checked 807.883  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 109.969 102.565 75.071 118.205 66.864  
  C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621  
  C++ Note: df101 -82.5546 -82.5546  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: Starting Halves
  C++ Note: df501 -82.55461
  C++ Note: df504 -0.1 -0.1  
  C++ Note: values checked -0.1 -0.1  
  C++ Note: sums checked 807.883 807.883  
  C++ Note: dose checked 1000  
  C++ Note: non-dose checked 807.883  
  C++ Note: LIN_non-dose checked 1000  
  C++ Note: PLIN_non-dose checked 1000  
  C++ Note: LOGLIN_non-dose checked 807.883  
  C++ Note: risk checked 807.883  
  C++ Note: riskr checked 109.969 102.565 75.071 118.205 66.864  
  C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621  
  C++ Note: df101 -82.5546 -82.5546  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: df100 3030 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:02 2024
  
  C++ Note: values checked -0.1 -0.1  
  C++ Note: sums checked 807.883 807.883  
  C++ Note: dose checked 1000  
  C++ Note: non-dose checked 807.883  
  C++ Note: LIN_non-dose checked 1000  
  C++ Note: PLIN_non-dose checked 1000  
  C++ Note: LOGLIN_non-dose checked 807.883  
  C++ Note: risk checked 807.883  
  C++ Note: riskr checked 109.969 102.565 75.071 118.205 66.864  
  C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621  
  C++ Note: df101 -82.5546 -82.5546  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: df100 19851 2 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:02 2024
  
  C++ Note: riskr checked 109.969 102.565 75.071 118.205 66.864  
  C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621  
  C++ Note: df101 -82.5546 -82.5546  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: ending guess 0
  C++ Note: df501 -82.55461
  C++ Note: df504 -0.1 -0.1  
  C++ Note: Refreshing matrices after all guesses
  C++ Note: Guess Results
  Guess number, parameter values, Log-Likelihood
  0, -0.1 -0.1, -82.55461<-- Best Guess
  C++ Note: starting subterms 1 in best guess 0
  C++ Note: values checked -0.1 -0.1  
  C++ Note: sums checked 807.883 807.883  
  C++ Note: dose checked 1000  
  C++ Note: non-dose checked 807.883  
  C++ Note: LIN_non-dose checked 1000  
  C++ Note: PLIN_non-dose checked 1000  
  C++ Note: LOGLIN_non-dose checked 807.883  
  C++ Note: risk checked 807.883  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 109.969 102.565 75.071 118.205 66.864  
  C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621  
  C++ Note: df101 -82.5546 -82.5546  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: Starting Halves
  C++ Note: df501 -82.55461
  C++ Note: df504 -0.1 -0.1  
  C++ Note: values checked -0.1 -0.1  
  C++ Note: sums checked 807.883 807.883  
  C++ Note: dose checked 1000  
  C++ Note: non-dose checked 807.883  
  C++ Note: LIN_non-dose checked 1000  
  C++ Note: PLIN_non-dose checked 1000  
  C++ Note: LOGLIN_non-dose checked 807.883  
  C++ Note: risk checked 807.883  
  C++ Note: riskr checked 109.969 102.565 75.071 118.205 66.864  
  C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621  
  C++ Note: df101 -82.5546 -82.5546  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: df100 23017 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:02 2024
  
  C++ Note: values checked -0.1 -0.1  
  C++ Note: sums checked 807.883 807.883  
  C++ Note: dose checked 1000  
  C++ Note: non-dose checked 807.883  
  C++ Note: LIN_non-dose checked 1000  
  C++ Note: PLIN_non-dose checked 1000  
  C++ Note: LOGLIN_non-dose checked 807.883  
  C++ Note: risk checked 807.883  
  C++ Note: riskr checked 109.969 102.565 75.071 118.205 66.864  
  C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621  
  C++ Note: df101 -82.5546 -82.5546  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: df100 24102 2 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:02 2024
  
  C++ Note: riskr checked 109.969 102.565 75.071 118.205 66.864  
  C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621  
  C++ Note: df101 -82.5546 -82.5546  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: riskr checked 109.969 102.565 75.071 118.205 66.864  
  C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621  
  C++ Note: df101 -82.5546 -82.5546  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: Exiting Regression
  C++ Note: df501 -82.55461
  C++ Note: df504 -0.1 -0.1  
  Note: 5  strata used
  Note: 26 risk groups
  C++ Note: START_COX_GUESS
  C++ Note: Current Time, Fri Feb 23 05:59:02 2024
  
  C++ Note: Term checked 0 0  
  C++ Note: df99,73,Starting
  C++ Note: Current Time, Fri Feb 23 05:59:02 2024
  
  C++ Note: Grouping Start
  C++ Note: df100 654 0 0 -1,Prep_List
  C++ Note: Current Time, Fri Feb 23 05:59:02 2024
  
  C++ Note: starting subterms 1 in guess 0
  C++ Note: values checked -0.1 -0.1  
  C++ Note: sums checked 807.883 807.883  
  C++ Note: dose checked 1000  
  C++ Note: non-dose checked 807.883  
  C++ Note: LIN_non-dose checked 1000  
  C++ Note: PLIN_non-dose checked 1000  
  C++ Note: LOGLIN_non-dose checked 807.883  
  C++ Note: risk checked 807.883  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 98.3613 91.6176 87.587 110.11 71.113  
  C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621  
  C++ Note: df101 -79.5885 -79.5885  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: Starting Halves
  C++ Note: df501 -79.58847
  C++ Note: df504 -0.1 -0.1  
  C++ Note: values checked -0.1 -0.1  
  C++ Note: sums checked 807.883 807.883  
  C++ Note: dose checked 1000  
  C++ Note: non-dose checked 807.883  
  C++ Note: LIN_non-dose checked 1000  
  C++ Note: PLIN_non-dose checked 1000  
  C++ Note: LOGLIN_non-dose checked 807.883  
  C++ Note: risk checked 807.883  
  C++ Note: riskr checked 98.3613 91.6176 87.587 110.11 71.113  
  C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621  
  C++ Note: df101 -79.5885 -79.5885  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: df100 18501 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:02 2024
  
  C++ Note: values checked -0.1 -0.1  
  C++ Note: sums checked 807.883 807.883  
  C++ Note: dose checked 1000  
  C++ Note: non-dose checked 807.883  
  C++ Note: LIN_non-dose checked 1000  
  C++ Note: PLIN_non-dose checked 1000  
  C++ Note: LOGLIN_non-dose checked 807.883  
  C++ Note: risk checked 807.883  
  C++ Note: riskr checked 98.3613 91.6176 87.587 110.11 71.113  
  C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621  
  C++ Note: df101 -79.5885 -79.5885  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: df100 19601 2 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:02 2024
  
  C++ Note: riskr checked 98.3613 91.6176 87.587 110.11 71.113  
  C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621  
  C++ Note: df101 -79.5885 -79.5885  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: ending guess 0
  C++ Note: df501 -79.58847
  C++ Note: df504 -0.1 -0.1  
  C++ Note: Refreshing matrices after all guesses
  C++ Note: Guess Results
  Guess number, parameter values, Log-Likelihood
  0, -0.1 -0.1, -79.58847<-- Best Guess
  C++ Note: starting subterms 1 in best guess 0
  C++ Note: values checked -0.1 -0.1  
  C++ Note: sums checked 807.883 807.883  
  C++ Note: dose checked 1000  
  C++ Note: non-dose checked 807.883  
  C++ Note: LIN_non-dose checked 1000  
  C++ Note: PLIN_non-dose checked 1000  
  C++ Note: LOGLIN_non-dose checked 807.883  
  C++ Note: risk checked 807.883  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 98.3613 91.6176 87.587 110.11 71.113  
  C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621  
  C++ Note: df101 -79.5885 -79.5885  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: Starting Halves
  C++ Note: df501 -79.58847
  C++ Note: df504 -0.1 -0.1  
  C++ Note: values checked -0.1 -0.1  
  C++ Note: sums checked 807.883 807.883  
  C++ Note: dose checked 1000  
  C++ Note: non-dose checked 807.883  
  C++ Note: LIN_non-dose checked 1000  
  C++ Note: PLIN_non-dose checked 1000  
  C++ Note: LOGLIN_non-dose checked 807.883  
  C++ Note: risk checked 807.883  
  C++ Note: riskr checked 98.3613 91.6176 87.587 110.11 71.113  
  C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621  
  C++ Note: df101 -79.5885 -79.5885  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: df100 22611 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:02 2024
  
  C++ Note: values checked -0.1 -0.1  
  C++ Note: sums checked 807.883 807.883  
  C++ Note: dose checked 1000  
  C++ Note: non-dose checked 807.883  
  C++ Note: LIN_non-dose checked 1000  
  C++ Note: PLIN_non-dose checked 1000  
  C++ Note: LOGLIN_non-dose checked 807.883  
  C++ Note: risk checked 807.883  
  C++ Note: riskr checked 98.3613 91.6176 87.587 110.11 71.113  
  C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621  
  C++ Note: df101 -79.5885 -79.5885  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: df100 23588 2 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:02 2024
  
  C++ Note: riskr checked 98.3613 91.6176 87.587 110.11 71.113  
  C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621  
  C++ Note: df101 -79.5885 -79.5885  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: riskr checked 98.3613 91.6176 87.587 110.11 71.113  
  C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621  
  C++ Note: df101 -79.5885 -79.5885  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: Exiting Regression
  C++ Note: df501 -79.58847
  C++ Note: df504 -0.1 -0.1  
  Note: 5  strata used
  Note: 26 risk groups
  C++ Note: START_COX_GUESS
  C++ Note: Current Time, Fri Feb 23 05:59:02 2024
  
  C++ Note: Term checked 0 0  
  C++ Note: df99,73,Starting
  C++ Note: Current Time, Fri Feb 23 05:59:02 2024
  
  C++ Note: Grouping Start
  C++ Note: df100 619 0 0 -1,Prep_List
  C++ Note: Current Time, Fri Feb 23 05:59:02 2024
  
  C++ Note: starting subterms 1 in guess 0
  C++ Note: values checked -0.1 -0.1  
  C++ Note: sums checked 807.883 807.883  
  C++ Note: dose checked 1000  
  C++ Note: non-dose checked 807.883  
  C++ Note: LIN_non-dose checked 1000  
  C++ Note: PLIN_non-dose checked 1000  
  C++ Note: LOGLIN_non-dose checked 807.883  
  C++ Note: risk checked 807.883  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 98.3613 91.6176 87.587 110.11 71.113  
  C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621  
  C++ Note: df101 -79.5885 -79.5885  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: Starting Halves
  C++ Note: df501 -79.58847
  C++ Note: df504 -0.1 -0.1  
  C++ Note: values checked -0.1 -0.1  
  C++ Note: sums checked 807.883 807.883  
  C++ Note: dose checked 1000  
  C++ Note: non-dose checked 807.883  
  C++ Note: LIN_non-dose checked 1000  
  C++ Note: PLIN_non-dose checked 1000  
  C++ Note: LOGLIN_non-dose checked 807.883  
  C++ Note: risk checked 807.883  
  C++ Note: riskr checked 98.3613 91.6176 87.587 110.11 71.113  
  C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621  
  C++ Note: df101 -79.5885 -79.5885  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: df100 18841 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:03 2024
  
  C++ Note: values checked -0.1 -0.1  
  C++ Note: sums checked 807.883 807.883  
  C++ Note: dose checked 1000  
  C++ Note: non-dose checked 807.883  
  C++ Note: LIN_non-dose checked 1000  
  C++ Note: PLIN_non-dose checked 1000  
  C++ Note: LOGLIN_non-dose checked 807.883  
  C++ Note: risk checked 807.883  
  C++ Note: riskr checked 98.3613 91.6176 87.587 110.11 71.113  
  C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621  
  C++ Note: df101 -79.5885 -79.5885  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: df100 19884 2 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:03 2024
  
  C++ Note: riskr checked 98.3613 91.6176 87.587 110.11 71.113  
  C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621  
  C++ Note: df101 -79.5885 -79.5885  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: ending guess 0
  C++ Note: df501 -79.58847
  C++ Note: df504 -0.1 -0.1  
  C++ Note: Refreshing matrices after all guesses
  C++ Note: Guess Results
  Guess number, parameter values, Log-Likelihood
  0, -0.1 -0.1, -79.58847<-- Best Guess
  C++ Note: starting subterms 1 in best guess 0
  C++ Note: values checked -0.1 -0.1  
  C++ Note: sums checked 807.883 807.883  
  C++ Note: dose checked 1000  
  C++ Note: non-dose checked 807.883  
  C++ Note: LIN_non-dose checked 1000  
  C++ Note: PLIN_non-dose checked 1000  
  C++ Note: LOGLIN_non-dose checked 807.883  
  C++ Note: risk checked 807.883  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 98.3613 91.6176 87.587 110.11 71.113  
  C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621  
  C++ Note: df101 -79.5885 -79.5885  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: Starting Halves
  C++ Note: df501 -79.58847
  C++ Note: df504 -0.1 -0.1  
  C++ Note: values checked -0.1 -0.1  
  C++ Note: sums checked 807.883 807.883  
  C++ Note: dose checked 1000  
  C++ Note: non-dose checked 807.883  
  C++ Note: LIN_non-dose checked 1000  
  C++ Note: PLIN_non-dose checked 1000  
  C++ Note: LOGLIN_non-dose checked 807.883  
  C++ Note: risk checked 807.883  
  C++ Note: riskr checked 98.3613 91.6176 87.587 110.11 71.113  
  C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621  
  C++ Note: df101 -79.5885 -79.5885  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: df100 22648 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:03 2024
  
  C++ Note: values checked -0.1 -0.1  
  C++ Note: sums checked 807.883 807.883  
  C++ Note: dose checked 1000  
  C++ Note: non-dose checked 807.883  
  C++ Note: LIN_non-dose checked 1000  
  C++ Note: PLIN_non-dose checked 1000  
  C++ Note: LOGLIN_non-dose checked 807.883  
  C++ Note: risk checked 807.883  
  C++ Note: riskr checked 98.3613 91.6176 87.587 110.11 71.113  
  C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621  
  C++ Note: df101 -159.177 -159.177  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: df100 38207 2 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:03 2024
  
  C++ Note: riskr checked 98.3613 91.6176 87.587 110.11 71.113  
  C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621  
  C++ Note: df101 -79.5885 -79.5885  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: riskr checked 98.3613 91.6176 87.587 110.11 71.113  
  C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621  
  C++ Note: df101 -79.5885 -79.5885  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: Exiting Regression
  C++ Note: df501 -79.58847
  C++ Note: df504 -0.1 -0.1  
  Note: 5  strata used
  Note: 26 risk groups
  C++ Note: START_COX_GUESS
  C++ Note: Current Time, Fri Feb 23 05:59:03 2024
  
  C++ Note: Term checked 0 0  
  C++ Note: df99,71,Starting
  C++ Note: Current Time, Fri Feb 23 05:59:03 2024
  
  C++ Note: Grouping Start
  C++ Note: df100 14483 0 0 -1,Prep_List
  C++ Note: Current Time, Fri Feb 23 05:59:03 2024
  
  C++ Note: starting subterms 1 in guess 0
  C++ Note: values checked -0.1 -0.1  
  C++ Note: sums checked 807.883 807.883  
  C++ Note: derivs checked 1229.85 410.233  
  C++ Note: second derivs checked 3319.14 410.233  
  C++ Note: dose checked 1000  
  C++ Note: non-dose checked 807.883  
  C++ Note: LIN_non-dose checked 1000  
  C++ Note: PLIN_non-dose checked 1000  
  C++ Note: LOGLIN_non-dose checked 807.883  
  C++ Note: risk checked 807.883  
  C++ Note: risk1 checked 1229.85 410.233  
  C++ Note: risk2 checked 3319.14 410.233  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 109.969 102.565 75.071 118.205 66.864  
  C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621  
  C++ Note: df101 -165.109 -165.109  
  C++ Note: df102 39.7385 6.4098  
  C++ Note: df103 -38.2668 -12.3536  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: df105 -1.03846 -0.518862  
  C++ Note: df106 -4.1549 -25.7589  
  C++ Note: Starting Halves
  C++ Note: df501 -165.1092
  C++ Note: df504 -0.1 -0.1  
  C++ Note: values checked 0.702609 0.405935  
  C++ Note: sums checked 7235.91 7235.91  
  C++ Note: derivs checked 23875.5 4407.46  
  C++ Note: second derivs checked 95114.7 4407.46  
  C++ Note: dose checked 1000  
  C++ Note: non-dose checked 7235.91  
  C++ Note: LIN_non-dose checked 1000  
  C++ Note: PLIN_non-dose checked 1000  
  C++ Note: LOGLIN_non-dose checked 7235.91  
  C++ Note: risk checked 7235.91  
  C++ Note: risk1 checked 23875.5 4407.46  
  C++ Note: risk2 checked 95114.7 4407.46  
  C++ Note: riskr checked 1029.36 657.301 440.368 779.123 340.451  
  C++ Note: riskl checked 83.3734 40.9432 39.5706 39.8431 33.7665  
  C++ Note: df101 -71.2819 -71.2819  
  C++ Note: df102 6.53346 0.663705  
  C++ Note: df103 -13.6957 -6.04035  
  C++ Note: df104 0.702609 0.405935  
  C++ Note: df105 -0.477045 -0.109879  
  C++ Note: df106 -10.9103 -107.4  
  C++ Note: df100 37304 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:03 2024
  
  C++ Note: riskr checked 1029.36 657.301 440.368 779.123 340.451  
  C++ Note: riskl checked 83.3734 40.9432 39.5706 39.8431 33.7665  
  C++ Note: df101 -71.2819 -71.2819  
  C++ Note: df102 6.53346 0.663705  
  C++ Note: df103 -13.6957 -6.04035  
  C++ Note: df104 0.702609 0.405935  
  C++ Note: df105 -0.477045 -0.109879  
  C++ Note: df106 -10.9103 -107.4  
  C++ Note: ending guess 0
  C++ Note: df501 -71.28193
  C++ Note: df504 0.7026092 0.4059355  
  C++ Note: Refreshing matrices after all guesses
  C++ Note: Guess Results
  Guess number, parameter values, Log-Likelihood
  0, 0.7026092 0.4059355, -71.28193<-- Best Guess
  C++ Note: starting subterms 1 in best guess 0
  C++ Note: values checked 0.702609 0.405935  
  C++ Note: sums checked 7235.91 7235.91  
  C++ Note: derivs checked 23875.5 4407.46  
  C++ Note: second derivs checked 95114.7 4407.46  
  C++ Note: dose checked 1000  
  C++ Note: non-dose checked 7235.91  
  C++ Note: LIN_non-dose checked 1000  
  C++ Note: PLIN_non-dose checked 1000  
  C++ Note: LOGLIN_non-dose checked 7235.91  
  C++ Note: risk checked 7235.91  
  C++ Note: risk1 checked 23875.5 4407.46  
  C++ Note: risk2 checked 95114.7 4407.46  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 1029.36 657.301 440.368 779.123 340.451  
  C++ Note: riskl checked 83.3734 40.9432 39.5706 39.8431 33.7665  
  C++ Note: df101 -71.2819 -71.2819  
  C++ Note: df102 6.53346 0.663705  
  C++ Note: df103 -13.6957 -6.04035  
  C++ Note: df104 0.702609 0.405935  
  C++ Note: df105 -0.477045 -0.109879  
  C++ Note: df106 -10.9103 -107.4  
  C++ Note: Starting Halves
  C++ Note: df501 -71.28193
  C++ Note: df504 0.7026092 0.4059355  
  C++ Note: values checked 1.06614 0.527334  
  C++ Note: sums checked 29733.3 29733.3  
  C++ Note: derivs checked 119904 18677.8  
  C++ Note: second derivs checked 536010 18677.8  
  C++ Note: dose checked 1000  
  C++ Note: non-dose checked 29733.3  
  C++ Note: LIN_non-dose checked 1000  
  C++ Note: PLIN_non-dose checked 1000  
  C++ Note: LOGLIN_non-dose checked 29733.3  
  C++ Note: risk checked 29733.3  
  C++ Note: risk1 checked 119904 18677.8  
  C++ Note: risk2 checked 536010 18677.8  
  C++ Note: riskr checked 4013.84 1761.95 1075.19 2341.29 1010.29  
  C++ Note: riskl checked 390.452 140.821 119.569 110.838 125.172  
  C++ Note: df101 -69.6786 -69.6786  
  C++ Note: df102 2.18197 0.178373  
  C++ Note: df103 -10.8366 -5.93902  
  C++ Note: df104 1.06614 0.527334  
  C++ Note: df105 -0.201352 -0.0300341  
  C++ Note: df106 -31.9338 -390.634  
  C++ Note: df100 44779 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:03 2024
  
  C++ Note: riskr checked 4013.84 1761.95 1075.19 2341.29 1010.29  
  C++ Note: riskl checked 390.452 140.821 119.569 110.838 125.172  
  C++ Note: df101 -69.6786 -69.6786  
  C++ Note: df102 2.18197 0.178373  
  C++ Note: df103 -10.8366 -5.93902  
  C++ Note: df104 1.06614 0.527334  
  C++ Note: df105 -0.201352 -0.0300341  
  C++ Note: df106 -31.9338 -390.634  
  C++ Note: riskr checked 4013.84 1761.95 1075.19 2341.29 1010.29  
  C++ Note: riskl checked 390.452 140.821 119.569 110.838 125.172  
  C++ Note: df101 -69.6786 -69.6786  
  C++ Note: df102 2.18197 0.178373  
  C++ Note: df103 -10.8366 -5.93902  
  C++ Note: df104 1.06614 0.527334  
  C++ Note: df105 -0.201352 -0.0300341  
  C++ Note: df106 -31.9338 -390.634  
  C++ Note: Exiting Regression
  C++ Note: df501 -69.67859
  C++ Note: df504 1.066135 0.5273336  
  Note: 5  strata used
  Note: 26 risk groups
  C++ Note: START_COX_GUESS
  C++ Note: Current Time, Fri Feb 23 05:59:03 2024
  
  C++ Note: Term checked 0 0  
  C++ Note: df99,78,Starting
  C++ Note: Current Time, Fri Feb 23 05:59:03 2024
  
  C++ Note: Grouping Start
  C++ Note: df100 720 0 0 -1,Prep_List
  C++ Note: Current Time, Fri Feb 23 05:59:03 2024
  
  C++ Note: starting subterms 1 in guess 0
  C++ Note: values checked -0.1 -0.1  
  C++ Note: sums checked 807.883 807.883  
  C++ Note: derivs checked 1229.85 410.233  
  C++ Note: second derivs checked 3319.14 410.233  
  C++ Note: dose checked 1000  
  C++ Note: non-dose checked 807.883  
  C++ Note: LIN_non-dose checked 1000  
  C++ Note: PLIN_non-dose checked 1000  
  C++ Note: LOGLIN_non-dose checked 807.883  
  C++ Note: risk checked 807.883  
  C++ Note: risk1 checked 1229.85 410.233  
  C++ Note: risk2 checked 3319.14 410.233  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 109.969 102.565 75.071 118.205 66.864  
  C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621  
  C++ Note: df101 -165.109 -165.109  
  C++ Note: df102 39.7385 6.4098  
  C++ Note: df103 -38.2668 -12.3536  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: df105 -1.03846 -0.518862  
  C++ Note: df106 -4.1549 -25.7589  
  C++ Note: Starting Halves
  C++ Note: df501 -165.1092
  C++ Note: df504 -0.1 -0.1  
  C++ Note: values checked 0.678843 0.289146  
  C++ Note: sums checked 6244.38 6244.38  
  C++ Note: derivs checked 20292.1 3632.95  
  C++ Note: second derivs checked 80174.7 3632.95  
  C++ Note: dose checked 1000  
  C++ Note: non-dose checked 6244.38  
  C++ Note: LIN_non-dose checked 1000  
  C++ Note: PLIN_non-dose checked 1000  
  C++ Note: LOGLIN_non-dose checked 6244.38  
  C++ Note: risk checked 6244.38  
  C++ Note: risk1 checked 20292.1 3632.95  
  C++ Note: risk2 checked 80174.7 3632.95  
  C++ Note: riskr checked 899.189 581.433 385.076 688.511 299.436  
  C++ Note: riskl checked 70.4668 36.2982 33.2589 35.4616 28.5259  
  C++ Note: df101 -71.5582 -71.5582  
  C++ Note: df102 6.7855 1.35947  
  C++ Note: df103 -13.923 -6.13436  
  C++ Note: df104 0.678843 0.289146  
  C++ Note: df105 -0.487357 -0.221615  
  C++ Note: df106 -10.5458 -52.6369  
  C++ Note: df100 29643 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:03 2024
  
  C++ Note: riskr checked 899.189 581.433 385.076 688.511 299.436  
  C++ Note: riskl checked 70.4668 36.2982 33.2589 35.4616 28.5259  
  C++ Note: df101 -71.5582 -71.5582  
  C++ Note: df102 6.7855 1.35947  
  C++ Note: df103 -13.923 -6.13436  
  C++ Note: df104 0.678843 0.289146  
  C++ Note: df105 -0.487357 -0.221615  
  C++ Note: df106 -10.5458 -52.6369  
  C++ Note: ending guess 0
  C++ Note: df501 -71.55823
  C++ Note: df504 0.6788427 0.2891462  
  C++ Note: Refreshing matrices after all guesses
  C++ Note: Guess Results
  Guess number, parameter values, Log-Likelihood
  0, 0.6788427 0.2891462, -71.55823<-- Best Guess
  C++ Note: starting subterms 1 in best guess 0
  C++ Note: values checked 0.678843 0.289146  
  C++ Note: sums checked 6244.38 6244.38  
  C++ Note: derivs checked 20292.1 3632.95  
  C++ Note: second derivs checked 80174.7 3632.95  
  C++ Note: dose checked 1000  
  C++ Note: non-dose checked 6244.38  
  C++ Note: LIN_non-dose checked 1000  
  C++ Note: PLIN_non-dose checked 1000  
  C++ Note: LOGLIN_non-dose checked 6244.38  
  C++ Note: risk checked 6244.38  
  C++ Note: risk1 checked 20292.1 3632.95  
  C++ Note: risk2 checked 80174.7 3632.95  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 899.189 581.433 385.076 688.511 299.436  
  C++ Note: riskl checked 70.4668 36.2982 33.2589 35.4616 28.5259  
  C++ Note: df101 -71.5582 -71.5582  
  C++ Note: df102 6.7855 1.35947  
  C++ Note: df103 -13.923 -6.13436  
  C++ Note: df104 0.678843 0.289146  
  C++ Note: df105 -0.487357 -0.221615  
  C++ Note: df106 -10.5458 -52.6369  
  C++ Note: Starting Halves
  C++ Note: df501 -71.55823
  C++ Note: df504 0.6788427 0.2891462  
  C++ Note: values checked 1.04436 0.455358  
  C++ Note: sums checked 26056 26056  
  C++ Note: derivs checked 104097 15935.8  
  C++ Note: second derivs checked 462614 15935.8  
  C++ Note: dose checked 1000  
  C++ Note: non-dose checked 26056  
  C++ Note: LIN_non-dose checked 1000  
  C++ Note: PLIN_non-dose checked 1000  
  C++ Note: LOGLIN_non-dose checked 26056  
  C++ Note: risk checked 26056  
  C++ Note: risk1 checked 104097 15935.8  
  C++ Note: risk2 checked 462614 15935.8  
  C++ Note: riskr checked 3566.45 1594.5 968.276 2102.11 897.328  
  C++ Note: riskl checked 341.759 127.646 104.884 101.194 108.836  
  C++ Note: df101 -139.512 -139.512  
  C++ Note: df102 4.74055 1.18748  
  C++ Note: df103 -21.979 -12.031  
  C++ Note: df104 1.04436 0.455358  
  C++ Note: df105 -0.215686 -0.0987019  
  C++ Note: df106 -29.4295 -117.486  
  C++ Note: df100 74991 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:03 2024
  
  C++ Note: values checked 0.861602 0.372252  
  C++ Note: sums checked 12320 12320  
  C++ Note: derivs checked 44902.4 7343.29  
  C++ Note: second derivs checked 189035 7343.29  
  C++ Note: dose checked 1000  
  C++ Note: non-dose checked 12320  
  C++ Note: LIN_non-dose checked 1000  
  C++ Note: PLIN_non-dose checked 1000  
  C++ Note: LOGLIN_non-dose checked 12320  
  C++ Note: risk checked 12320  
  C++ Note: risk1 checked 44902.4 7343.29  
  C++ Note: risk2 checked 189035 7343.29  
  C++ Note: riskr checked 1754.01 948.413 602.532 1174.8 498.324  
  C++ Note: riskl checked 153.273 67.2451 58.6128 59.5609 54.7389  
  C++ Note: df101 -140.879 -140.879  
  C++ Note: df102 8.88597 1.94549  
  C++ Note: df103 -24.6948 -12.1676  
  C++ Note: df104 0.861602 0.372252  
  C++ Note: df105 -0.359832 -0.159892  
  C++ Note: df106 -15.8541 -72.4132  
  C++ Note: df100 88763 2 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:03 2024
  
  C++ Note: Changing back to best
  C++ Note: values checked 0.678843 0.289146  
  C++ Note: sums checked 6244.38 6244.38  
  C++ Note: derivs checked 20292.1 3632.95  
  C++ Note: second derivs checked 80174.7 3632.95  
  C++ Note: dose checked 1000  
  C++ Note: non-dose checked 6244.38  
  C++ Note: LIN_non-dose checked 1000  
  C++ Note: PLIN_non-dose checked 1000  
  C++ Note: LOGLIN_non-dose checked 6244.38  
  C++ Note: risk checked 6244.38  
  C++ Note: risk1 checked 20292.1 3632.95  
  C++ Note: risk2 checked 80174.7 3632.95  
  C++ Note: riskr checked 899.189 581.433 385.076 688.511 299.436  
  C++ Note: riskl checked 70.4668 36.2982 33.2589 35.4616 28.5259  
  C++ Note: df101 -71.5582 -71.5582  
  C++ Note: df102 6.7855 1.35947  
  C++ Note: df103 -13.923 -6.13436  
  C++ Note: df104 0.678843 0.289146  
  C++ Note: df105 -0.487357 -0.221615  
  C++ Note: df106 -10.5458 -52.6369  
  C++ Note: riskr checked 899.189 581.433 385.076 688.511 299.436  
  C++ Note: riskl checked 70.4668 36.2982 33.2589 35.4616 28.5259  
  C++ Note: df101 -71.5582 -71.5582  
  C++ Note: df102 6.7855 1.35947  
  C++ Note: df103 -13.923 -6.13436  
  C++ Note: df104 0.678843 0.289146  
  C++ Note: df105 -0.487357 -0.221615  
  C++ Note: df106 -10.5458 -52.6369  
  C++ Note: Exiting Regression
  C++ Note: df501 -71.55823
  C++ Note: df504 0.6788427 0.2891462  
  Note: 5  strata used
  Note: 26 risk groups
  C++ Note: START_COX_GUESS
  C++ Note: Current Time, Fri Feb 23 05:59:03 2024
  
  C++ Note: Term checked 0 0  
  C++ Note: df99,94,Starting
  C++ Note: Current Time, Fri Feb 23 05:59:03 2024
  
  C++ Note: Grouping Start
  C++ Note: df100 708 0 0 -1,Prep_List
  C++ Note: Current Time, Fri Feb 23 05:59:03 2024
  
  C++ Note: starting subterms 1 in guess 0
  C++ Note: values checked -0.1 -0.1  
  C++ Note: sums checked 807.883 807.883  
  C++ Note: derivs checked 1229.85 410.233  
  C++ Note: second derivs checked 3319.14 410.233  
  C++ Note: dose checked 1000  
  C++ Note: non-dose checked 807.883  
  C++ Note: LIN_non-dose checked 1000  
  C++ Note: PLIN_non-dose checked 1000  
  C++ Note: LOGLIN_non-dose checked 807.883  
  C++ Note: risk checked 807.883  
  C++ Note: risk1 checked 1229.85 410.233  
  C++ Note: risk2 checked 3319.14 410.233  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 98.3613 91.6176 87.587 110.11 71.113  
  C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621  
  C++ Note: df101 -79.5885 -79.5885  
  C++ Note: df102 5.42704 2.14202  
  C++ Note: df103 -7.11684 -6.21271  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: df105 -0.762564 -0.34478  
  C++ Note: df106 -14.6652 -37.1559  
  C++ Note: Starting Halves
  C++ Note: df501 -79.58847
  C++ Note: df504 -0.1 -0.1  
  C++ Note: values checked 0.550424 0.30353  
  C++ Note: sums checked 4228.8 4228.8  
  C++ Note: derivs checked 12473.9 2494.15  
  C++ Note: second derivs checked 46827.4 2494.15  
  C++ Note: dose checked 1000  
  C++ Note: non-dose checked 4228.8  
  C++ Note: LIN_non-dose checked 1000  
  C++ Note: PLIN_non-dose checked 1000  
  C++ Note: LOGLIN_non-dose checked 4228.8  
  C++ Note: risk checked 4228.8  
  C++ Note: risk1 checked 12473.9 2494.15  
  C++ Note: risk2 checked 46827.4 2494.15  
  C++ Note: riskr checked 616.483 485.721 374.917 603.993 261.606  
  C++ Note: riskl checked 43.76 24.6658 24.1668 25.7075 19.5703  
  C++ Note: df101 -76.8654 -76.8654  
  C++ Note: df102 1.27777 0.508497  
  C++ Note: df103 -7.18963 -6.04474  
  C++ Note: df104 0.550424 0.30353  
  C++ Note: df105 -0.177724 -0.0841223  
  C++ Note: df106 -60.1559 -151.162  
  C++ Note: df100 5323 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:03 2024
  
  C++ Note: riskr checked 616.483 485.721 374.917 603.993 261.606  
  C++ Note: riskl checked 43.76 24.6658 24.1668 25.7075 19.5703  
  C++ Note: df101 -76.8654 -76.8654  
  C++ Note: df102 1.27777 0.508497  
  C++ Note: df103 -7.18963 -6.04474  
  C++ Note: df104 0.550424 0.30353  
  C++ Note: df105 -0.177724 -0.0841223  
  C++ Note: df106 -60.1559 -151.162  
  C++ Note: ending guess 0
  C++ Note: df501 -76.86543
  C++ Note: df504 0.5504238 0.3035295  
  C++ Note: Refreshing matrices after all guesses
  C++ Note: Guess Results
  Guess number, parameter values, Log-Likelihood
  0, 0.5504238 0.3035295, -76.86543<-- Best Guess
  C++ Note: starting subterms 1 in best guess 0
  C++ Note: values checked 0.550424 0.30353  
  C++ Note: sums checked 4228.8 4228.8  
  C++ Note: derivs checked 12473.9 2494.15  
  C++ Note: second derivs checked 46827.4 2494.15  
  C++ Note: dose checked 1000  
  C++ Note: non-dose checked 4228.8  
  C++ Note: LIN_non-dose checked 1000  
  C++ Note: PLIN_non-dose checked 1000  
  C++ Note: LOGLIN_non-dose checked 4228.8  
  C++ Note: risk checked 4228.8  
  C++ Note: risk1 checked 12473.9 2494.15  
  C++ Note: risk2 checked 46827.4 2494.15  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 616.483 485.721 374.917 603.993 261.606  
  C++ Note: riskl checked 43.76 24.6658 24.1668 25.7075 19.5703  
  C++ Note: df101 -76.8654 -76.8654  
  C++ Note: df102 1.27777 0.508497  
  C++ Note: df103 -7.18963 -6.04474  
  C++ Note: df104 0.550424 0.30353  
  C++ Note: df105 -0.177724 -0.0841223  
  C++ Note: df106 -60.1559 -151.162  
  C++ Note: Starting Halves
  C++ Note: df501 -76.86543
  C++ Note: df504 0.5504238 0.3035295  
  C++ Note: values checked 0.699516 0.396693  
  C++ Note: sums checked 7122.36 7122.36  
  C++ Note: derivs checked 23453.2 4323.35  
  C++ Note: second derivs checked 93329.8 4323.35  
  C++ Note: dose checked 1000  
  C++ Note: non-dose checked 7122.36  
  C++ Note: LIN_non-dose checked 1000  
  C++ Note: PLIN_non-dose checked 1000  
  C++ Note: LOGLIN_non-dose checked 7122.36  
  C++ Note: risk checked 7122.36  
  C++ Note: risk1 checked 23453.2 4323.35  
  C++ Note: risk2 checked 93329.8 4323.35  
  C++ Note: riskr checked 1103.97 748.255 549.423 973.678 397.318  
  C++ Note: riskl checked 81.8797 40.3981 38.9034 39.35 33.1873  
  C++ Note: df101 -76.7167 -76.7167  
  C++ Note: df102 0.321463 0.127669  
  C++ Note: df103 -7.13078 -5.96512  
  C++ Note: df104 0.699516 0.396693  
  C++ Note: df105 -0.045081 -0.0214027  
  C++ Note: df106 -238.649 -600.901  
  C++ Note: df100 11558 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:03 2024
  
  C++ Note: riskr checked 1103.97 748.255 549.423 973.678 397.318  
  C++ Note: riskl checked 81.8797 40.3981 38.9034 39.35 33.1873  
  C++ Note: df101 -76.7167 -76.7167  
  C++ Note: df102 0.321463 0.127669  
  C++ Note: df103 -7.13078 -5.96512  
  C++ Note: df104 0.699516 0.396693  
  C++ Note: df105 -0.045081 -0.0214027  
  C++ Note: df106 -238.649 -600.901  
  C++ Note: riskr checked 1103.97 748.255 549.423 973.678 397.318  
  C++ Note: riskl checked 81.8797 40.3981 38.9034 39.35 33.1873  
  C++ Note: df101 -76.7167 -76.7167  
  C++ Note: df102 0.321463 0.127669  
  C++ Note: df103 -7.13078 -5.96512  
  C++ Note: df104 0.699516 0.396693  
  C++ Note: df105 -0.045081 -0.0214027  
  C++ Note: df106 -238.649 -600.901  
  C++ Note: Exiting Regression
  C++ Note: df501 -76.71665
  C++ Note: df504 0.6995155 0.3966929  
  Note: 5  strata used
  Note: 26 risk groups
  C++ Note: START_COX_GUESS
  C++ Note: Current Time, Fri Feb 23 05:59:03 2024
  
  C++ Note: Term checked 0 0  
  C++ Note: df99,65,Starting
  C++ Note: Current Time, Fri Feb 23 05:59:03 2024
  
  C++ Note: Grouping Start
  C++ Note: df100 626 0 0 -1,Prep_List
  C++ Note: Current Time, Fri Feb 23 05:59:03 2024
  
  C++ Note: starting subterms 1 in guess 0
  C++ Note: values checked -0.1 -0.1  
  C++ Note: sums checked 807.883 807.883  
  C++ Note: derivs checked 1229.85 410.233  
  C++ Note: second derivs checked 3319.14 410.233  
  C++ Note: dose checked 1000  
  C++ Note: non-dose checked 807.883  
  C++ Note: LIN_non-dose checked 1000  
  C++ Note: PLIN_non-dose checked 1000  
  C++ Note: LOGLIN_non-dose checked 807.883  
  C++ Note: risk checked 807.883  
  C++ Note: risk1 checked 1229.85 410.233  
  C++ Note: risk2 checked 3319.14 410.233  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 98.3613 91.6176 87.587 110.11 71.113  
  C++ Note: riskl checked 4.29942 3.84392 3.7452 4.59508 3.12621  
  C++ Note: df101 -79.5885 -79.5885  
  C++ Note: df102 5.42704 2.14202  
  C++ Note: df103 -7.11684 -6.21271  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: df105 -0.762564 -0.34478  
  C++ Note: df106 -14.6652 -37.1559  
  C++ Note: Starting Halves
  C++ Note: df501 -79.58847
  C++ Note: df504 -0.1 -0.1  
  C++ Note: values checked 0.471923 0.158585  
  C++ Note: sums checked 3109.21 3109.21  
  C++ Note: derivs checked 8604.8 1732.23  
  C++ Note: second derivs checked 31265.5 1732.23  
  C++ Note: dose checked 1000  
  C++ Note: non-dose checked 3109.21  
  C++ Note: LIN_non-dose checked 1000  
  C++ Note: PLIN_non-dose checked 1000  
  C++ Note: LOGLIN_non-dose checked 3109.21  
  C++ Note: risk checked 3109.21  
  C++ Note: risk1 checked 8604.8 1732.23  
  C++ Note: risk2 checked 31265.5 1732.23  
  C++ Note: riskr checked 437.598 369.44 288.407 451.269 203.987  
  C++ Note: riskl checked 29.7555 18.4415 17.3204 19.7081 14.0257  
  C++ Note: df101 -77.1115 -77.1115  
  C++ Note: df102 1.6628 1.2965  
  C++ Note: df103 -7.18852 -6.1617  
  C++ Note: df104 0.471923 0.158585  
  C++ Note: df105 -0.231313 -0.210412  
  C++ Note: df106 -46.3745 -59.4767  
  C++ Note: df100 9355 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:03 2024
  
  C++ Note: riskr checked 437.598 369.44 288.407 451.269 203.987  
  C++ Note: riskl checked 29.7555 18.4415 17.3204 19.7081 14.0257  
  C++ Note: df101 -77.1115 -77.1115  
  C++ Note: df102 1.6628 1.2965  
  C++ Note: df103 -7.18852 -6.1617  
  C++ Note: df104 0.471923 0.158585  
  C++ Note: df105 -0.231313 -0.210412  
  C++ Note: df106 -46.3745 -59.4767  
  C++ Note: ending guess 0
  C++ Note: df501 -77.11153
  C++ Note: df504 0.4719227 0.1585847  
  C++ Note: Refreshing matrices after all guesses
  C++ Note: Guess Results
  Guess number, parameter values, Log-Likelihood
  0, 0.4719227 0.1585847, -77.11153<-- Best Guess
  C++ Note: starting subterms 1 in best guess 0
  C++ Note: values checked 0.471923 0.158585  
  C++ Note: sums checked 3109.21 3109.21  
  C++ Note: derivs checked 8604.8 1732.23  
  C++ Note: second derivs checked 31265.5 1732.23  
  C++ Note: dose checked 1000  
  C++ Note: non-dose checked 3109.21  
  C++ Note: LIN_non-dose checked 1000  
  C++ Note: PLIN_non-dose checked 1000  
  C++ Note: LOGLIN_non-dose checked 3109.21  
  C++ Note: risk checked 3109.21  
  C++ Note: risk1 checked 8604.8 1732.23  
  C++ Note: risk2 checked 31265.5 1732.23  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 437.598 369.44 288.407 451.269 203.987  
  C++ Note: riskl checked 29.7555 18.4415 17.3204 19.7081 14.0257  
  C++ Note: df101 -77.1115 -77.1115  
  C++ Note: df102 1.6628 1.2965  
  C++ Note: df103 -7.18852 -6.1617  
  C++ Note: df104 0.471923 0.158585  
  C++ Note: df105 -0.231313 -0.210412  
  C++ Note: df106 -46.3745 -59.4767  
  C++ Note: Starting Halves
  C++ Note: df501 -77.11153
  C++ Note: df504 0.4719227 0.1585847  
  C++ Note: values checked 0.645408 0.316394  
  C++ Note: sums checked 5698.95 5698.95  
  C++ Note: derivs checked 18076.9 3359.94  
  C++ Note: second derivs checked 70503.7 3359.94  
  C++ Note: dose checked 1000  
  C++ Note: non-dose checked 5698.95  
  C++ Note: LIN_non-dose checked 1000  
  C++ Note: PLIN_non-dose checked 1000  
  C++ Note: LOGLIN_non-dose checked 5698.95  
  C++ Note: risk checked 5698.95  
  C++ Note: risk1 checked 18076.9 3359.94  
  C++ Note: risk2 checked 70503.7 3359.94  
  C++ Note: riskr checked 866.381 621.431 461.192 794.093 330.167  
  C++ Note: riskl checked 63.0668 33.0727 31.2711 32.9428 26.3017  
  C++ Note: df101 -76.7689 -76.7689  
  C++ Note: df102 0.612277 0.54564  
  C++ Note: df103 -7.1484 -6.0464  
  C++ Note: df104 0.645408 0.316394  
  C++ Note: df105 -0.0856523 -0.0902421  
  C++ Note: df106 -125.383 -140.695  
  C++ Note: df100 15782 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:03 2024
  
  C++ Note: riskr checked 866.381 621.431 461.192 794.093 330.167  
  C++ Note: riskl checked 63.0668 33.0727 31.2711 32.9428 26.3017  
  C++ Note: df101 -76.7689 -76.7689  
  C++ Note: df102 0.612277 0.54564  
  C++ Note: df103 -7.1484 -6.0464  
  C++ Note: df104 0.645408 0.316394  
  C++ Note: df105 -0.0856523 -0.0902421  
  C++ Note: df106 -125.383 -140.695  
  C++ Note: riskr checked 866.381 621.431 461.192 794.093 330.167  
  C++ Note: riskl checked 63.0668 33.0727 31.2711 32.9428 26.3017  
  C++ Note: df101 -76.7689 -76.7689  
  C++ Note: df102 0.612277 0.54564  
  C++ Note: df103 -7.1484 -6.0464  
  C++ Note: df104 0.645408 0.316394  
  C++ Note: df105 -0.0856523 -0.0902421  
  C++ Note: df106 -125.383 -140.695  
  C++ Note: Exiting Regression
  C++ Note: df501 -76.76892
  C++ Note: df504 0.6454076 0.316394  
  Note: 26 risk groups
  C++ Note: START_COX_GUESS
  C++ Note: Current Time, Fri Feb 23 05:59:03 2024
  
  C++ Note: Term checked 0 0  
  C++ Note: df99,67,Starting
  C++ Note: Current Time, Fri Feb 23 05:59:03 2024
  
  C++ Note: Grouping Start
  C++ Note: df100 14960 0 0 -1,Prep_List
  C++ Note: Current Time, Fri Feb 23 05:59:03 2024
  
  C++ Note: starting subterms 1 in guess 0
  C++ Note: values checked -0.1 -0.1  
  C++ Note: sums checked 851.028 949.469  
  C++ Note: risk checked 807.883  
  C++ Note: risk1 checked 1229.85 410.233  
  C++ Note: risk2 checked 3319.14 410.233  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 2197.44  
  C++ Note: riskl checked 19.6098  
  C++ Note: df101 -122.891 -122.891  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: Starting Halves
  C++ Note: df501 -122.8909
  C++ Note: df504 -0.1 -0.1  
  C++ Note: values checked -0.1 -0.1  
  C++ Note: sums checked 851.028 949.469  
  C++ Note: risk checked 807.883  
  C++ Note: risk1 checked 1229.85 410.233  
  C++ Note: risk2 checked 3319.14 410.233  
  C++ Note: riskr checked 2197.44  
  C++ Note: riskl checked 19.6098  
  C++ Note: df101 -122.891 -122.891  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: df100 16420 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:03 2024
  
  C++ Note: values checked -0.1 -0.1  
  C++ Note: sums checked 851.028 949.469  
  C++ Note: risk checked 807.883  
  C++ Note: risk1 checked 1229.85 410.233  
  C++ Note: risk2 checked 3319.14 410.233  
  C++ Note: riskr checked 2197.44  
  C++ Note: riskl checked 19.6098  
  C++ Note: df101 -122.891 -122.891  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: df100 17065 2 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:03 2024
  
  C++ Note: riskr checked 2197.44  
  C++ Note: riskl checked 19.6098  
  C++ Note: df101 -122.891 -122.891  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: ending guess 0
  C++ Note: df501 -122.8909
  C++ Note: df504 -0.1 -0.1  
  C++ Note: Refreshing matrices after all guesses
  C++ Note: Guess Results
  Guess number, parameter values, Log-Likelihood
  0, -0.1 -0.1, -122.8909<-- Best Guess
  C++ Note: starting subterms 1 in best guess 0
  C++ Note: values checked -0.1 -0.1  
  C++ Note: sums checked 851.028 949.469  
  C++ Note: risk checked 807.883  
  C++ Note: risk1 checked 1229.85 410.233  
  C++ Note: risk2 checked 3319.14 410.233  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 2197.44  
  C++ Note: riskl checked 19.6098  
  C++ Note: df101 -122.891 -122.891  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: Starting Halves
  C++ Note: df501 -122.8909
  C++ Note: df504 -0.1 -0.1  
  C++ Note: values checked -0.1 -0.1  
  C++ Note: sums checked 851.028 949.469  
  C++ Note: risk checked 807.883  
  C++ Note: risk1 checked 1229.85 410.233  
  C++ Note: risk2 checked 3319.14 410.233  
  C++ Note: riskr checked 2197.44  
  C++ Note: riskl checked 19.6098  
  C++ Note: df101 -122.891 -122.891  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: df100 18853 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:03 2024
  
  C++ Note: values checked -0.1 -0.1  
  C++ Note: sums checked 851.028 949.469  
  C++ Note: risk checked 807.883  
  C++ Note: risk1 checked 1229.85 410.233  
  C++ Note: risk2 checked 3319.14 410.233  
  C++ Note: riskr checked 2197.44  
  C++ Note: riskl checked 19.6098  
  C++ Note: df101 -122.891 -122.891  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: df100 19510 2 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:03 2024
  
  C++ Note: riskr checked 2197.44  
  C++ Note: riskl checked 19.6098  
  C++ Note: df101 -122.891 -122.891  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: riskr checked 2197.44  
  C++ Note: riskl checked 19.6098  
  C++ Note: df101 -122.891 -122.891  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: Exiting Regression
  C++ Note: df501 -122.8909
  C++ Note: df504 -0.1 -0.1  
  Note: 26 risk groups
  C++ Note: START_COX_GUESS
  C++ Note: Current Time, Fri Feb 23 05:59:03 2024
  
  C++ Note: Term checked 0 0  
  C++ Note: df99,76,Starting
  C++ Note: Current Time, Fri Feb 23 05:59:03 2024
  
  C++ Note: Grouping Start
  C++ Note: df100 574 0 0 -1,Prep_List
  C++ Note: Current Time, Fri Feb 23 05:59:03 2024
  
  C++ Note: starting subterms 1 in guess 0
  C++ Note: values checked -0.1 -0.1  
  C++ Note: sums checked 851.028 949.469  
  C++ Note: risk checked 807.883  
  C++ Note: risk1 checked 1229.85 410.233  
  C++ Note: risk2 checked 3319.14 410.233  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 2197.44  
  C++ Note: riskl checked 19.6098  
  C++ Note: df101 -122.891 -122.891  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: Starting Halves
  C++ Note: df501 -122.8909
  C++ Note: df504 -0.1 -0.1  
  C++ Note: values checked -0.1 -0.1  
  C++ Note: sums checked 851.028 949.469  
  C++ Note: risk checked 807.883  
  C++ Note: risk1 checked 1229.85 410.233  
  C++ Note: risk2 checked 3319.14 410.233  
  C++ Note: riskr checked 2197.44  
  C++ Note: riskl checked 19.6098  
  C++ Note: df101 -122.891 -122.891  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: df100 1962 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:03 2024
  
  C++ Note: values checked -0.1 -0.1  
  C++ Note: sums checked 851.028 949.469  
  C++ Note: risk checked 807.883  
  C++ Note: risk1 checked 1229.85 410.233  
  C++ Note: risk2 checked 3319.14 410.233  
  C++ Note: riskr checked 2197.44  
  C++ Note: riskl checked 19.6098  
  C++ Note: df101 -122.891 -122.891  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: df100 2652 2 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:03 2024
  
  C++ Note: riskr checked 2197.44  
  C++ Note: riskl checked 19.6098  
  C++ Note: df101 -122.891 -122.891  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: ending guess 0
  C++ Note: df501 -122.8909
  C++ Note: df504 -0.1 -0.1  
  C++ Note: Refreshing matrices after all guesses
  C++ Note: Guess Results
  Guess number, parameter values, Log-Likelihood
  0, -0.1 -0.1, -122.8909<-- Best Guess
  C++ Note: starting subterms 1 in best guess 0
  C++ Note: values checked -0.1 -0.1  
  C++ Note: sums checked 851.028 949.469  
  C++ Note: risk checked 807.883  
  C++ Note: risk1 checked 1229.85 410.233  
  C++ Note: risk2 checked 3319.14 410.233  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 2197.44  
  C++ Note: riskl checked 19.6098  
  C++ Note: df101 -122.891 -122.891  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: Starting Halves
  C++ Note: df501 -122.8909
  C++ Note: df504 -0.1 -0.1  
  C++ Note: values checked -0.1 -0.1  
  C++ Note: sums checked 851.028 949.469  
  C++ Note: risk checked 807.883  
  C++ Note: risk1 checked 1229.85 410.233  
  C++ Note: risk2 checked 3319.14 410.233  
  C++ Note: riskr checked 2197.44  
  C++ Note: riskl checked 19.6098  
  C++ Note: df101 -122.891 -122.891  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: df100 4558 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:03 2024
  
  C++ Note: values checked -0.1 -0.1  
  C++ Note: sums checked 851.028 949.469  
  C++ Note: risk checked 807.883  
  C++ Note: risk1 checked 1229.85 410.233  
  C++ Note: risk2 checked 3319.14 410.233  
  C++ Note: riskr checked 2197.44  
  C++ Note: riskl checked 19.6098  
  C++ Note: df101 -122.891 -122.891  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: df100 5216 2 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:03 2024
  
  C++ Note: riskr checked 2197.44  
  C++ Note: riskl checked 19.6098  
  C++ Note: df101 -122.891 -122.891  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: riskr checked 2197.44  
  C++ Note: riskl checked 19.6098  
  C++ Note: df101 -122.891 -122.891  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: Exiting Regression
  C++ Note: df501 -122.8909
  C++ Note: df504 -0.1 -0.1  
  Note: 26 risk groups
  C++ Note: START_COX_GUESS
  C++ Note: Current Time, Fri Feb 23 05:59:03 2024
  
  C++ Note: Term checked 0 0  
  C++ Note: df99,86,Starting
  C++ Note: Current Time, Fri Feb 23 05:59:03 2024
  
  C++ Note: Grouping Start
  C++ Note: df100 353 0 0 -1,Prep_List
  C++ Note: Current Time, Fri Feb 23 05:59:03 2024
  
  C++ Note: starting subterms 1 in guess 0
  C++ Note: values checked -0.1 -0.1  
  C++ Note: sums checked 851.028 949.469  
  C++ Note: risk checked 807.883  
  C++ Note: risk1 checked 1229.85 410.233  
  C++ Note: risk2 checked 3319.14 410.233  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 2125.36  
  C++ Note: riskl checked 19.6098  
  C++ Note: df101 -119.981 -119.981  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: Starting Halves
  C++ Note: df501 -119.9814
  C++ Note: df504 -0.1 -0.1  
  C++ Note: values checked -0.1 -0.1  
  C++ Note: sums checked 851.028 949.469  
  C++ Note: risk checked 807.883  
  C++ Note: risk1 checked 1229.85 410.233  
  C++ Note: risk2 checked 3319.14 410.233  
  C++ Note: riskr checked 2125.36  
  C++ Note: riskl checked 19.6098  
  C++ Note: df101 -119.981 -119.981  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: df100 1376 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:03 2024
  
  C++ Note: values checked -0.1 -0.1  
  C++ Note: sums checked 851.028 949.469  
  C++ Note: risk checked 807.883  
  C++ Note: risk1 checked 1229.85 410.233  
  C++ Note: risk2 checked 3319.14 410.233  
  C++ Note: riskr checked 2125.36  
  C++ Note: riskl checked 19.6098  
  C++ Note: df101 -119.981 -119.981  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: df100 1851 2 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:03 2024
  
  C++ Note: riskr checked 2125.36  
  C++ Note: riskl checked 19.6098  
  C++ Note: df101 -119.981 -119.981  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: ending guess 0
  C++ Note: df501 -119.9814
  C++ Note: df504 -0.1 -0.1  
  C++ Note: Refreshing matrices after all guesses
  C++ Note: Guess Results
  Guess number, parameter values, Log-Likelihood
  0, -0.1 -0.1, -119.9814<-- Best Guess
  C++ Note: starting subterms 1 in best guess 0
  C++ Note: values checked -0.1 -0.1  
  C++ Note: sums checked 851.028 949.469  
  C++ Note: risk checked 807.883  
  C++ Note: risk1 checked 1229.85 410.233  
  C++ Note: risk2 checked 3319.14 410.233  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 2125.36  
  C++ Note: riskl checked 19.6098  
  C++ Note: df101 -119.981 -119.981  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: Starting Halves
  C++ Note: df501 -119.9814
  C++ Note: df504 -0.1 -0.1  
  C++ Note: values checked -0.1 -0.1  
  C++ Note: sums checked 851.028 949.469  
  C++ Note: risk checked 807.883  
  C++ Note: risk1 checked 1229.85 410.233  
  C++ Note: risk2 checked 3319.14 410.233  
  C++ Note: riskr checked 2125.36  
  C++ Note: riskl checked 19.6098  
  C++ Note: df101 -119.981 -119.981  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: df100 3190 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:03 2024
  
  C++ Note: values checked -0.1 -0.1  
  C++ Note: sums checked 851.028 949.469  
  C++ Note: risk checked 807.883  
  C++ Note: risk1 checked 1229.85 410.233  
  C++ Note: risk2 checked 3319.14 410.233  
  C++ Note: riskr checked 2125.36  
  C++ Note: riskl checked 19.6098  
  C++ Note: df101 -119.981 -119.981  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: df100 3665 2 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:03 2024
  
  C++ Note: riskr checked 2125.36  
  C++ Note: riskl checked 19.6098  
  C++ Note: df101 -119.981 -119.981  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: riskr checked 2125.36  
  C++ Note: riskl checked 19.6098  
  C++ Note: df101 -119.981 -119.981  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: Exiting Regression
  C++ Note: df501 -119.9814
  C++ Note: df504 -0.1 -0.1  
  Note: 26 risk groups
  C++ Note: START_COX_GUESS
  C++ Note: Current Time, Fri Feb 23 05:59:03 2024
  
  C++ Note: Term checked 0 0  
  C++ Note: df99,69,Starting
  C++ Note: Current Time, Fri Feb 23 05:59:03 2024
  
  C++ Note: Grouping Start
  C++ Note: df100 332 0 0 -1,Prep_List
  C++ Note: Current Time, Fri Feb 23 05:59:03 2024
  
  C++ Note: starting subterms 1 in guess 0
  C++ Note: values checked -0.1 -0.1  
  C++ Note: sums checked 851.028 949.469  
  C++ Note: risk checked 807.883  
  C++ Note: risk1 checked 1229.85 410.233  
  C++ Note: risk2 checked 3319.14 410.233  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 2125.36  
  C++ Note: riskl checked 19.6098  
  C++ Note: df101 -119.981 -119.981  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: Starting Halves
  C++ Note: df501 -119.9814
  C++ Note: df504 -0.1 -0.1  
  C++ Note: values checked -0.1 -0.1  
  C++ Note: sums checked 851.028 949.469  
  C++ Note: risk checked 807.883  
  C++ Note: risk1 checked 1229.85 410.233  
  C++ Note: risk2 checked 3319.14 410.233  
  C++ Note: riskr checked 2125.36  
  C++ Note: riskl checked 19.6098  
  C++ Note: df101 -119.981 -119.981  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: df100 1341 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:03 2024
  
  C++ Note: values checked -0.1 -0.1  
  C++ Note: sums checked 851.028 949.469  
  C++ Note: risk checked 807.883  
  C++ Note: risk1 checked 1229.85 410.233  
  C++ Note: risk2 checked 3319.14 410.233  
  C++ Note: riskr checked 2125.36  
  C++ Note: riskl checked 19.6098  
  C++ Note: df101 -119.981 -119.981  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: df100 1820 2 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:03 2024
  
  C++ Note: riskr checked 2125.36  
  C++ Note: riskl checked 19.6098  
  C++ Note: df101 -119.981 -119.981  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: ending guess 0
  C++ Note: df501 -119.9814
  C++ Note: df504 -0.1 -0.1  
  C++ Note: Refreshing matrices after all guesses
  C++ Note: Guess Results
  Guess number, parameter values, Log-Likelihood
  0, -0.1 -0.1, -119.9814<-- Best Guess
  C++ Note: starting subterms 1 in best guess 0
  C++ Note: values checked -0.1 -0.1  
  C++ Note: sums checked 851.028 949.469  
  C++ Note: risk checked 807.883  
  C++ Note: risk1 checked 1229.85 410.233  
  C++ Note: risk2 checked 3319.14 410.233  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 2125.36  
  C++ Note: riskl checked 19.6098  
  C++ Note: df101 -119.981 -119.981  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: Starting Halves
  C++ Note: df501 -119.9814
  C++ Note: df504 -0.1 -0.1  
  C++ Note: values checked -0.1 -0.1  
  C++ Note: sums checked 851.028 949.469  
  C++ Note: risk checked 807.883  
  C++ Note: risk1 checked 1229.85 410.233  
  C++ Note: risk2 checked 3319.14 410.233  
  C++ Note: riskr checked 2125.36  
  C++ Note: riskl checked 19.6098  
  C++ Note: df101 -119.981 -119.981  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: df100 3084 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:03 2024
  
  C++ Note: values checked -0.1 -0.1  
  C++ Note: sums checked 851.028 949.469  
  C++ Note: risk checked 807.883  
  C++ Note: risk1 checked 1229.85 410.233  
  C++ Note: risk2 checked 3319.14 410.233  
  C++ Note: riskr checked 2125.36  
  C++ Note: riskl checked 19.6098  
  C++ Note: df101 -119.981 -119.981  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: df100 3547 2 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:03 2024
  
  C++ Note: riskr checked 2125.36  
  C++ Note: riskl checked 19.6098  
  C++ Note: df101 -119.981 -119.981  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: riskr checked 2125.36  
  C++ Note: riskl checked 19.6098  
  C++ Note: df101 -119.981 -119.981  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: Exiting Regression
  C++ Note: df501 -119.9814
  C++ Note: df504 -0.1 -0.1  
  Note: 26 risk groups
  C++ Note: START_COX_GUESS
  C++ Note: Current Time, Fri Feb 23 05:59:03 2024
  
  C++ Note: Term checked 0 0  
  C++ Note: df99,68,Starting
  C++ Note: Current Time, Fri Feb 23 05:59:03 2024
  
  C++ Note: Grouping Start
  C++ Note: df100 442 0 0 -1,Prep_List
  C++ Note: Current Time, Fri Feb 23 05:59:03 2024
  
  C++ Note: starting subterms 1 in guess 0
  C++ Note: values checked -0.1 -0.1  
  C++ Note: sums checked 851.028 949.469  
  C++ Note: risk checked 807.883  
  C++ Note: risk1 checked 1229.85 410.233  
  C++ Note: risk2 checked 3319.14 410.233  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 2197.44  
  C++ Note: risk1r checked 3174.27 1089.12  
  C++ Note: risk2r checked 7204.63 1089.12  
  C++ Note: riskl checked 19.6098  
  C++ Note: risk1l checked 42.0717 11.5472  
  C++ Note: risk2l checked 118.124 11.5472  
  C++ Note: df101 -122.891 -122.891  
  C++ Note: df102 21.2331 3.11507  
  C++ Note: df103 -19.7104 -6.49727  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: df105 -1.07726 -0.479443  
  C++ Note: df106 -5.78769 -39.4505  
  C++ Note: Starting Halves
  C++ Note: df501 -122.8909
  C++ Note: df504 -0.1 -0.1  
  C++ Note: values checked 0.732916 0.388699  
  C++ Note: sums checked 6380.99 1252.26  
  C++ Note: risk checked 7921.99  
  C++ Note: risk1 checked 26681.9 4784.79  
  C++ Note: risk2 checked 107491 4784.79  
  C++ Note: riskr checked 15672.9  
  C++ Note: risk1r checked 42701.5 9198.27  
  C++ Note: risk2r checked 144140 9198.27  
  C++ Note: riskl checked 259.026  
  C++ Note: risk1l checked 843.134 168.735  
  C++ Note: risk2l checked 3047.41 168.735  
  C++ Note: df101 -110.801 -110.801  
  C++ Note: df102 6.10212 0.649377  
  C++ Note: df103 -15.9738 -6.28124  
  C++ Note: df104 0.732916 0.388699  
  C++ Note: df105 -0.382009 -0.103384  
  C++ Note: df106 -18.1578 -170.627  
  C++ Note: df100 4513 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:03 2024
  
  C++ Note: riskr checked 15672.9  
  C++ Note: risk1r checked 42701.5 9198.27  
  C++ Note: risk2r checked 144140 9198.27  
  C++ Note: riskl checked 259.026  
  C++ Note: risk1l checked 843.134 168.735  
  C++ Note: risk2l checked 3047.41 168.735  
  C++ Note: df101 -110.801 -110.801  
  C++ Note: df102 6.10212 0.649377  
  C++ Note: df103 -15.9738 -6.28124  
  C++ Note: df104 0.732916 0.388699  
  C++ Note: df105 -0.382009 -0.103384  
  C++ Note: df106 -18.1578 -170.627  
  C++ Note: ending guess 0
  C++ Note: df501 -110.8014
  C++ Note: df504 0.732916 0.3886995  
  C++ Note: Refreshing matrices after all guesses
  C++ Note: Guess Results
  Guess number, parameter values, Log-Likelihood
  0, 0.732916 0.3886995, -110.8014<-- Best Guess
  C++ Note: starting subterms 1 in best guess 0
  C++ Note: values checked 0.732916 0.388699  
  C++ Note: sums checked 6380.99 1252.26  
  C++ Note: risk checked 7921.99  
  C++ Note: risk1 checked 26681.9 4784.79  
  C++ Note: risk2 checked 107491 4784.79  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 15672.9  
  C++ Note: risk1r checked 42701.5 9198.27  
  C++ Note: risk2r checked 144140 9198.27  
  C++ Note: riskl checked 259.026  
  C++ Note: risk1l checked 843.134 168.735  
  C++ Note: risk2l checked 3047.41 168.735  
  C++ Note: df101 -110.801 -110.801  
  C++ Note: df102 6.10212 0.649377  
  C++ Note: df103 -15.9738 -6.28124  
  C++ Note: df104 0.732916 0.388699  
  C++ Note: df105 -0.382009 -0.103384  
  C++ Note: df106 -18.1578 -170.627  
  C++ Note: Starting Halves
  C++ Note: df501 -110.8014
  C++ Note: df504 0.732916 0.3886995  
  C++ Note: values checked 1.02333 0.493704  
  C++ Note: sums checked 18600.8 1338.98  
  C++ Note: risk checked 24538.9  
  C++ Note: risk1 checked 97084.4 15240.1  
  C++ Note: risk2 checked 428953 15240.1  
  C++ Note: riskr checked 39636.5  
  C++ Note: risk1r checked 128036 24066.7  
  C++ Note: risk2r checked 480878 24066.7  
  C++ Note: riskl checked 745.302  
  C++ Note: risk1l checked 2645.43 469.387  
  C++ Note: risk2l checked 10112.8 469.387  
  C++ Note: df101 -109.621 -109.621  
  C++ Note: df102 1.83938 0.14137  
  C++ Note: df103 -13.8104 -6.17729  
  C++ Note: df104 1.02333 0.493704  
  C++ Note: df105 -0.133188 -0.0228854  
  C++ Note: df106 -59.5969 -775.422  
  C++ Note: df100 22453 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:03 2024
  
  C++ Note: riskr checked 39636.5  
  C++ Note: risk1r checked 128036 24066.7  
  C++ Note: risk2r checked 480878 24066.7  
  C++ Note: riskl checked 745.302  
  C++ Note: risk1l checked 2645.43 469.387  
  C++ Note: risk2l checked 10112.8 469.387  
  C++ Note: df101 -109.621 -109.621  
  C++ Note: df102 1.83938 0.14137  
  C++ Note: df103 -13.8104 -6.17729  
  C++ Note: df104 1.02333 0.493704  
  C++ Note: df105 -0.133188 -0.0228854  
  C++ Note: df106 -59.5969 -775.422  
  C++ Note: riskr checked 39636.5  
  C++ Note: risk1r checked 128036 24066.7  
  C++ Note: risk2r checked 480878 24066.7  
  C++ Note: riskl checked 745.302  
  C++ Note: risk1l checked 2645.43 469.387  
  C++ Note: risk2l checked 10112.8 469.387  
  C++ Note: df101 -109.621 -109.621  
  C++ Note: df102 1.83938 0.14137  
  C++ Note: df103 -13.8104 -6.17729  
  C++ Note: df104 1.02333 0.493704  
  C++ Note: df105 -0.133188 -0.0228854  
  C++ Note: df106 -59.5969 -775.422  
  C++ Note: Exiting Regression
  C++ Note: df501 -109.6211
  C++ Note: df504 1.023328 0.4937042  
  Note: 26 risk groups
  C++ Note: START_COX_GUESS
  C++ Note: Current Time, Fri Feb 23 05:59:03 2024
  
  C++ Note: Term checked 0 0  
  C++ Note: df99,69,Starting
  C++ Note: Current Time, Fri Feb 23 05:59:03 2024
  
  C++ Note: Grouping Start
  C++ Note: df100 447 0 0 -1,Prep_List
  C++ Note: Current Time, Fri Feb 23 05:59:03 2024
  
  C++ Note: starting subterms 1 in guess 0
  C++ Note: values checked -0.1 -0.1  
  C++ Note: sums checked 851.028 949.469  
  C++ Note: risk checked 807.883  
  C++ Note: risk1 checked 1229.85 410.233  
  C++ Note: risk2 checked 3319.14 410.233  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 2197.44  
  C++ Note: risk1r checked 3174.27 1089.12  
  C++ Note: risk2r checked 7204.63 1089.12  
  C++ Note: riskl checked 19.6098  
  C++ Note: risk1l checked 42.0717 11.5472  
  C++ Note: risk2l checked 118.124 11.5472  
  C++ Note: df101 -122.891 -122.891  
  C++ Note: df102 21.2331 3.11507  
  C++ Note: df103 -19.7104 -6.49727  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: df105 -1.07726 -0.479443  
  C++ Note: df106 -5.78769 -39.4505  
  C++ Note: Starting Halves
  C++ Note: df501 -122.8909
  C++ Note: df504 -0.1 -0.1  
  C++ Note: values checked 0.707943 0.259582  
  C++ Note: sums checked 5868.37 1157.38  
  C++ Note: risk checked 6754.07  
  C++ Note: risk1 checked 22400.3 3873.99  
  C++ Note: risk2 checked 89482.9 3873.99  
  C++ Note: riskr checked 13607.5  
  C++ Note: risk1r checked 36518.1 7564.8  
  C++ Note: risk2r checked 122057 7564.8  
  C++ Note: riskl checked 219.94  
  C++ Note: risk1l checked 713.45 137.505  
  C++ Note: risk2l checked 2579.26 137.505  
  C++ Note: df101 -111.093 -111.093  
  C++ Note: df102 6.4244 1.45354  
  C++ Note: df103 -16.1091 -6.40177  
  C++ Note: df104 0.707943 0.259582  
  C++ Note: df105 -0.398805 -0.227053  
  C++ Note: df106 -17.2924 -76.4296  
  C++ Note: df100 4588 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:03 2024
  
  C++ Note: riskr checked 13607.5  
  C++ Note: risk1r checked 36518.1 7564.8  
  C++ Note: risk2r checked 122057 7564.8  
  C++ Note: riskl checked 219.94  
  C++ Note: risk1l checked 713.45 137.505  
  C++ Note: risk2l checked 2579.26 137.505  
  C++ Note: df101 -111.093 -111.093  
  C++ Note: df102 6.4244 1.45354  
  C++ Note: df103 -16.1091 -6.40177  
  C++ Note: df104 0.707943 0.259582  
  C++ Note: df105 -0.398805 -0.227053  
  C++ Note: df106 -17.2924 -76.4296  
  C++ Note: ending guess 0
  C++ Note: df501 -111.0934
  C++ Note: df504 0.7079435 0.259582  
  C++ Note: Refreshing matrices after all guesses
  C++ Note: Guess Results
  Guess number, parameter values, Log-Likelihood
  0, 0.7079435 0.259582, -111.0934<-- Best Guess
  C++ Note: starting subterms 1 in best guess 0
  C++ Note: values checked 0.707943 0.259582  
  C++ Note: sums checked 5868.37 1157.38  
  C++ Note: risk checked 6754.07  
  C++ Note: risk1 checked 22400.3 3873.99  
  C++ Note: risk2 checked 89482.9 3873.99  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 13607.5  
  C++ Note: risk1r checked 36518.1 7564.8  
  C++ Note: risk2r checked 122057 7564.8  
  C++ Note: riskl checked 219.94  
  C++ Note: risk1l checked 713.45 137.505  
  C++ Note: risk2l checked 2579.26 137.505  
  C++ Note: df101 -111.093 -111.093  
  C++ Note: df102 6.4244 1.45354  
  C++ Note: df103 -16.1091 -6.40177  
  C++ Note: df104 0.707943 0.259582  
  C++ Note: df105 -0.398805 -0.227053  
  C++ Note: df106 -17.2924 -76.4296  
  C++ Note: Starting Halves
  C++ Note: df501 -111.0934
  C++ Note: df504 0.7079435 0.259582  
  C++ Note: values checked 1.00705 0.429872  
  C++ Note: sums checked 17441.8 1285.18  
  C++ Note: risk checked 22129.4  
  C++ Note: risk1 checked 86917.6 13416  
  C++ Note: risk2 checked 382294 13416  
  C++ Note: riskr checked 36201.7  
  C++ Note: risk1r checked 115958 21431.5  
  C++ Note: risk2r checked 433026 21431.5  
  C++ Note: riskl checked 676.025  
  C++ Note: risk1l checked 2396.11 417.501  
  C++ Note: risk2l checked 9159.18 417.501  
  C++ Note: df101 -109.674 -109.674  
  C++ Note: df102 2.03825 0.531514  
  C++ Note: df103 -13.8822 -6.25712  
  C++ Note: df104 1.00705 0.429872  
  C++ Note: df105 -0.146825 -0.0849455  
  C++ Note: df106 -53.8081 -206.343  
  C++ Note: df100 18023 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:03 2024
  
  C++ Note: riskr checked 36201.7  
  C++ Note: risk1r checked 115958 21431.5  
  C++ Note: risk2r checked 433026 21431.5  
  C++ Note: riskl checked 676.025  
  C++ Note: risk1l checked 2396.11 417.501  
  C++ Note: risk2l checked 9159.18 417.501  
  C++ Note: df101 -109.674 -109.674  
  C++ Note: df102 2.03825 0.531514  
  C++ Note: df103 -13.8822 -6.25712  
  C++ Note: df104 1.00705 0.429872  
  C++ Note: df105 -0.146825 -0.0849455  
  C++ Note: df106 -53.8081 -206.343  
  C++ Note: riskr checked 36201.7  
  C++ Note: risk1r checked 115958 21431.5  
  C++ Note: risk2r checked 433026 21431.5  
  C++ Note: riskl checked 676.025  
  C++ Note: risk1l checked 2396.11 417.501  
  C++ Note: risk2l checked 9159.18 417.501  
  C++ Note: df101 -109.674 -109.674  
  C++ Note: df102 2.03825 0.531514  
  C++ Note: df103 -13.8822 -6.25712  
  C++ Note: df104 1.00705 0.429872  
  C++ Note: df105 -0.146825 -0.0849455  
  C++ Note: df106 -53.8081 -206.343  
  C++ Note: Exiting Regression
  C++ Note: df501 -109.6742
  C++ Note: df504 1.007047 0.4298716  
  Note: 26 risk groups
  C++ Note: START_COX_GUESS
  C++ Note: Current Time, Fri Feb 23 05:59:03 2024
  
  C++ Note: Term checked 0 0  
  C++ Note: df99,68,Starting
  C++ Note: Current Time, Fri Feb 23 05:59:03 2024
  
  C++ Note: Grouping Start
  C++ Note: df100 310 0 0 -1,Prep_List
  C++ Note: Current Time, Fri Feb 23 05:59:03 2024
  
  C++ Note: starting subterms 1 in guess 0
  C++ Note: values checked -0.1 -0.1  
  C++ Note: sums checked 851.028 949.469  
  C++ Note: risk checked 807.883  
  C++ Note: risk1 checked 1229.85 410.233  
  C++ Note: risk2 checked 3319.14 410.233  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 2125.36  
  C++ Note: risk1r checked 3418.73 1095.31  
  C++ Note: risk2r checked 8667.81 1095.31  
  C++ Note: riskl checked 19.6098  
  C++ Note: risk1l checked 42.0717 11.5472  
  C++ Note: risk2l checked 118.124 11.5472  
  C++ Note: df101 -119.981 -119.981  
  C++ Note: df102 6.06579 2.41134  
  C++ Note: df103 -8.60689 -6.47374  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: df105 -0.70476 -0.37248  
  C++ Note: df106 -19.78 -49.7572  
  C++ Note: Starting Halves
  C++ Note: df501 -119.9814
  C++ Note: df504 -0.1 -0.1  
  C++ Note: values checked 0.497478 0.312164  
  C++ Note: sums checked 3067.26 1194.55  
  C++ Note: risk checked 3648.05  
  C++ Note: risk1 checked 10299.6 2165.99  
  C++ Note: risk2 checked 37798.4 2165.99  
  C++ Note: riskr checked 9367.5  
  C++ Note: risk1r checked 24562.6 5580.77  
  C++ Note: risk2r checked 81557.6 5580.77  
  C++ Note: riskl checked 118.249  
  C++ Note: risk1l checked 351.472 78.443  
  C++ Note: risk2l checked 1199.14 78.443  
  C++ Note: df101 -117.142 -117.142  
  C++ Note: df102 1.31609 0.547704  
  C++ Note: df103 -9.05233 -6.2666  
  C++ Note: df104 0.497478 0.312164  
  C++ Note: df105 -0.145387 -0.0874005  
  C++ Note: df106 -89.0079 -213.879  
  C++ Note: df100 2500 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:03 2024
  
  C++ Note: riskr checked 9367.5  
  C++ Note: risk1r checked 24562.6 5580.77  
  C++ Note: risk2r checked 81557.6 5580.77  
  C++ Note: riskl checked 118.249  
  C++ Note: risk1l checked 351.472 78.443  
  C++ Note: risk2l checked 1199.14 78.443  
  C++ Note: df101 -117.142 -117.142  
  C++ Note: df102 1.31609 0.547704  
  C++ Note: df103 -9.05233 -6.2666  
  C++ Note: df104 0.497478 0.312164  
  C++ Note: df105 -0.145387 -0.0874005  
  C++ Note: df106 -89.0079 -213.879  
  C++ Note: ending guess 0
  C++ Note: df501 -117.1424
  C++ Note: df504 0.4974778 0.3121644  
  C++ Note: Refreshing matrices after all guesses
  C++ Note: Guess Results
  Guess number, parameter values, Log-Likelihood
  0, 0.4974778 0.3121644, -117.1424<-- Best Guess
  C++ Note: starting subterms 1 in best guess 0
  C++ Note: values checked 0.497478 0.312164  
  C++ Note: sums checked 3067.26 1194.55  
  C++ Note: risk checked 3648.05  
  C++ Note: risk1 checked 10299.6 2165.99  
  C++ Note: risk2 checked 37798.4 2165.99  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 9367.5  
  C++ Note: risk1r checked 24562.6 5580.77  
  C++ Note: risk2r checked 81557.6 5580.77  
  C++ Note: riskl checked 118.249  
  C++ Note: risk1l checked 351.472 78.443  
  C++ Note: risk2l checked 1199.14 78.443  
  C++ Note: df101 -117.142 -117.142  
  C++ Note: df102 1.31609 0.547704  
  C++ Note: df103 -9.05233 -6.2666  
  C++ Note: df104 0.497478 0.312164  
  C++ Note: df105 -0.145387 -0.0874005  
  C++ Note: df106 -89.0079 -213.879  
  C++ Note: Starting Halves
  C++ Note: df501 -117.1424
  C++ Note: df504 0.4974778 0.3121644  
  C++ Note: values checked 0.617144 0.398893  
  C++ Note: sums checked 4379.75 1260.28  
  C++ Note: risk checked 5479.95  
  C++ Note: risk1 checked 17006.9 3344.7  
  C++ Note: risk2 checked 65563.9 3344.7  
  C++ Note: riskr checked 13683.9  
  C++ Note: risk1r checked 38812.2 8366.11  
  C++ Note: risk2r checked 134810 8366.11  
  C++ Note: riskl checked 180.348  
  C++ Note: risk1l checked 561.69 120.669  
  C++ Note: risk2l checked 1971.73 120.669  
  C++ Note: df101 -117.015 -117.015  
  C++ Note: df102 0.320802 0.13496  
  C++ Note: df103 -9.12088 -6.18217  
  C++ Note: df104 0.617144 0.398893  
  C++ Note: df105 -0.0351723 -0.0218306  
  C++ Note: df106 -364.756 -867.031  
  C++ Note: df100 5495 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:03 2024
  
  C++ Note: riskr checked 13683.9  
  C++ Note: risk1r checked 38812.2 8366.11  
  C++ Note: risk2r checked 134810 8366.11  
  C++ Note: riskl checked 180.348  
  C++ Note: risk1l checked 561.69 120.669  
  C++ Note: risk2l checked 1971.73 120.669  
  C++ Note: df101 -117.015 -117.015  
  C++ Note: df102 0.320802 0.13496  
  C++ Note: df103 -9.12088 -6.18217  
  C++ Note: df104 0.617144 0.398893  
  C++ Note: df105 -0.0351723 -0.0218306  
  C++ Note: df106 -364.756 -867.031  
  C++ Note: riskr checked 13683.9  
  C++ Note: risk1r checked 38812.2 8366.11  
  C++ Note: risk2r checked 134810 8366.11  
  C++ Note: riskl checked 180.348  
  C++ Note: risk1l checked 561.69 120.669  
  C++ Note: risk2l checked 1971.73 120.669  
  C++ Note: df101 -117.015 -117.015  
  C++ Note: df102 0.320802 0.13496  
  C++ Note: df103 -9.12088 -6.18217  
  C++ Note: df104 0.617144 0.398893  
  C++ Note: df105 -0.0351723 -0.0218306  
  C++ Note: df106 -364.756 -867.031  
  C++ Note: Exiting Regression
  C++ Note: df501 -117.0147
  C++ Note: df504 0.6171437 0.3988932  
  Note: 26 risk groups
  C++ Note: START_COX_GUESS
  C++ Note: Current Time, Fri Feb 23 05:59:03 2024
  
  C++ Note: Term checked 0 0  
  C++ Note: df99,68,Starting
  C++ Note: Current Time, Fri Feb 23 05:59:03 2024
  
  C++ Note: Grouping Start
  C++ Note: df100 343 0 0 -1,Prep_List
  C++ Note: Current Time, Fri Feb 23 05:59:03 2024
  
  C++ Note: starting subterms 1 in guess 0
  C++ Note: values checked -0.1 -0.1  
  C++ Note: sums checked 851.028 949.469  
  C++ Note: risk checked 807.883  
  C++ Note: risk1 checked 1229.85 410.233  
  C++ Note: risk2 checked 3319.14 410.233  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 2125.36  
  C++ Note: risk1r checked 3418.73 1095.31  
  C++ Note: risk2r checked 8667.81 1095.31  
  C++ Note: riskl checked 19.6098  
  C++ Note: risk1l checked 42.0717 11.5472  
  C++ Note: risk2l checked 118.124 11.5472  
  C++ Note: df101 -119.981 -119.981  
  C++ Note: df102 6.06579 2.41134  
  C++ Note: df103 -8.60689 -6.47374  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: df105 -0.70476 -0.37248  
  C++ Note: df106 -19.78 -49.7572  
  C++ Note: Starting Halves
  C++ Note: df501 -119.9814
  C++ Note: df504 -0.1 -0.1  
  C++ Note: values checked 0.42857 0.17936  
  C++ Note: sums checked 2537.47 1104.32  
  C++ Note: risk checked 2796.31  
  C++ Note: risk1 checked 7446.21 1576.41  
  C++ Note: risk2 checked 26529.4 1576.41  
  C++ Note: riskr checked 7268.45  
  C++ Note: risk1r checked 18181.7 4116.59  
  C++ Note: risk2r checked 58803.1 4116.59  
  C++ Note: riskl checked 88.5975  
  C++ Note: risk1l checked 256.339 56.699  
  C++ Note: risk2l checked 862.409 56.699  
  C++ Note: df101 -117.373 -117.373  
  C++ Note: df102 1.78502 1.30975  
  C++ Note: df103 -8.96103 -6.38772  
  C++ Note: df104 0.42857 0.17936  
  C++ Note: df105 -0.199199 -0.205041  
  C++ Note: df106 -65.7541 -89.6148  
  C++ Note: df100 2503 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:03 2024
  
  C++ Note: riskr checked 7268.45  
  C++ Note: risk1r checked 18181.7 4116.59  
  C++ Note: risk2r checked 58803.1 4116.59  
  C++ Note: riskl checked 88.5975  
  C++ Note: risk1l checked 256.339 56.699  
  C++ Note: risk2l checked 862.409 56.699  
  C++ Note: df101 -117.373 -117.373  
  C++ Note: df102 1.78502 1.30975  
  C++ Note: df103 -8.96103 -6.38772  
  C++ Note: df104 0.42857 0.17936  
  C++ Note: df105 -0.199199 -0.205041  
  C++ Note: df106 -65.7541 -89.6148  
  C++ Note: ending guess 0
  C++ Note: df501 -117.3726
  C++ Note: df504 0.4285697 0.17936  
  C++ Note: Refreshing matrices after all guesses
  C++ Note: Guess Results
  Guess number, parameter values, Log-Likelihood
  0, 0.4285697 0.17936, -117.3726<-- Best Guess
  C++ Note: starting subterms 1 in best guess 0
  C++ Note: values checked 0.42857 0.17936  
  C++ Note: sums checked 2537.47 1104.32  
  C++ Note: risk checked 2796.31  
  C++ Note: risk1 checked 7446.21 1576.41  
  C++ Note: risk2 checked 26529.4 1576.41  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 7268.45  
  C++ Note: risk1r checked 18181.7 4116.59  
  C++ Note: risk2r checked 58803.1 4116.59  
  C++ Note: riskl checked 88.5975  
  C++ Note: risk1l checked 256.339 56.699  
  C++ Note: risk2l checked 862.409 56.699  
  C++ Note: df101 -117.373 -117.373  
  C++ Note: df102 1.78502 1.30975  
  C++ Note: df103 -8.96103 -6.38772  
  C++ Note: df104 0.42857 0.17936  
  C++ Note: df105 -0.199199 -0.205041  
  C++ Note: df106 -65.7541 -89.6148  
  C++ Note: Starting Halves
  C++ Note: df501 -117.3726
  C++ Note: df504 0.4285697 0.17936  
  C++ Note: values checked 0.577969 0.333141  
  C++ Note: sums checked 3883.17 1209.93  
  C++ Note: risk checked 4672.1  
  C++ Note: risk1 checked 14081.1 2784.48  
  C++ Note: risk2 checked 53455.8 2784.48  
  C++ Note: riskr checked 11783.5  
  C++ Note: risk1r checked 32618.6 7038.87  
  C++ Note: risk2r checked 111717 7038.87  
  C++ Note: riskl checked 152.934  
  C++ Note: risk1l checked 470.041 100.807  
  C++ Note: risk2l checked 1638.11 100.807  
  C++ Note: df101 -117.054 -117.054  
  C++ Note: df102 0.609162 0.503449  
  C++ Note: df103 -9.07577 -6.25818  
  C++ Note: df104 0.577969 0.333141  
  C++ Note: df105 -0.0671196 -0.0804466  
  C++ Note: df106 -192.156 -232.504  
  C++ Note: df100 5585 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:03 2024
  
  C++ Note: riskr checked 11783.5  
  C++ Note: risk1r checked 32618.6 7038.87  
  C++ Note: risk2r checked 111717 7038.87  
  C++ Note: riskl checked 152.934  
  C++ Note: risk1l checked 470.041 100.807  
  C++ Note: risk2l checked 1638.11 100.807  
  C++ Note: df101 -117.054 -117.054  
  C++ Note: df102 0.609162 0.503449  
  C++ Note: df103 -9.07577 -6.25818  
  C++ Note: df104 0.577969 0.333141  
  C++ Note: df105 -0.0671196 -0.0804466  
  C++ Note: df106 -192.156 -232.504  
  C++ Note: riskr checked 11783.5  
  C++ Note: risk1r checked 32618.6 7038.87  
  C++ Note: risk2r checked 111717 7038.87  
  C++ Note: riskl checked 152.934  
  C++ Note: risk1l checked 470.041 100.807  
  C++ Note: risk2l checked 1638.11 100.807  
  C++ Note: df101 -117.054 -117.054  
  C++ Note: df102 0.609162 0.503449  
  C++ Note: df103 -9.07577 -6.25818  
  C++ Note: df104 0.577969 0.333141  
  C++ Note: df105 -0.0671196 -0.0804466  
  C++ Note: df106 -192.156 -232.504  
  C++ Note: Exiting Regression
  C++ Note: df501 -117.0539
  C++ Note: df504 0.5779686 0.3331409  
  Note: 26 risk groups
  C++ Note: START_COX_GUESS
  C++ Note: Current Time, Fri Feb 23 05:59:03 2024
  
  C++ Note: Term checked 0 0  
  C++ Note: df99,83,Starting
  C++ Note: Current Time, Fri Feb 23 05:59:03 2024
  
  C++ Note: Grouping Start
  C++ Note: df100 484 0 0 -1,Prep_List
  C++ Note: Current Time, Fri Feb 23 05:59:03 2024
  
  C++ Note: starting subterms 1 in guess 0
  C++ Note: values checked -0.1 -0.1  
  C++ Note: sums checked 807.883 807.883  
  C++ Note: dose checked 1000  
  C++ Note: non-dose checked 807.883  
  C++ Note: LIN_non-dose checked 1000  
  C++ Note: PLIN_non-dose checked 1000  
  C++ Note: LOGLIN_non-dose checked 807.883  
  C++ Note: risk checked 807.883  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 2197.44  
  C++ Note: riskl checked 19.6098  
  C++ Note: df101 -122.891 0  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: Starting Halves
  C++ Note: df501 -122.8909
  C++ Note: df504 -0.1 -0.1  
  C++ Note: values checked -0.1 -0.1  
  C++ Note: sums checked 807.883 807.883  
  C++ Note: dose checked 1000  
  C++ Note: non-dose checked 807.883  
  C++ Note: LIN_non-dose checked 1000  
  C++ Note: PLIN_non-dose checked 1000  
  C++ Note: LOGLIN_non-dose checked 807.883  
  C++ Note: risk checked 807.883  
  C++ Note: riskr checked 2197.44  
  C++ Note: riskl checked 19.6098  
  C++ Note: df101 -122.891 0  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: df100 1986 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:03 2024
  
  C++ Note: values checked -0.1 -0.1  
  C++ Note: sums checked 807.883 807.883  
  C++ Note: dose checked 1000  
  C++ Note: non-dose checked 807.883  
  C++ Note: LIN_non-dose checked 1000  
  C++ Note: PLIN_non-dose checked 1000  
  C++ Note: LOGLIN_non-dose checked 807.883  
  C++ Note: risk checked 807.883  
  C++ Note: riskr checked 2197.44  
  C++ Note: riskl checked 19.6098  
  C++ Note: df101 -122.891 0  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: df100 2677 2 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:03 2024
  
  C++ Note: riskr checked 2197.44  
  C++ Note: riskl checked 19.6098  
  C++ Note: df101 -122.891 0  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: ending guess 0
  C++ Note: df501 -122.8909
  C++ Note: df504 -0.1 -0.1  
  C++ Note: Refreshing matrices after all guesses
  C++ Note: Guess Results
  Guess number, parameter values, Log-Likelihood
  0, -0.1 -0.1, -122.8909<-- Best Guess
  C++ Note: starting subterms 1 in best guess 0
  C++ Note: values checked -0.1 -0.1  
  C++ Note: sums checked 807.883 807.883  
  C++ Note: dose checked 1000  
  C++ Note: non-dose checked 807.883  
  C++ Note: LIN_non-dose checked 1000  
  C++ Note: PLIN_non-dose checked 1000  
  C++ Note: LOGLIN_non-dose checked 807.883  
  C++ Note: risk checked 807.883  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 2197.44  
  C++ Note: riskl checked 19.6098  
  C++ Note: df101 -122.891 0  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: Starting Halves
  C++ Note: df501 -122.8909
  C++ Note: df504 -0.1 -0.1  
  C++ Note: values checked -0.1 -0.1  
  C++ Note: sums checked 807.883 807.883  
  C++ Note: dose checked 1000  
  C++ Note: non-dose checked 807.883  
  C++ Note: LIN_non-dose checked 1000  
  C++ Note: PLIN_non-dose checked 1000  
  C++ Note: LOGLIN_non-dose checked 807.883  
  C++ Note: risk checked 807.883  
  C++ Note: riskr checked 2197.44  
  C++ Note: riskl checked 19.6098  
  C++ Note: df101 -122.891 0  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: df100 4588 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:03 2024
  
  C++ Note: values checked -0.1 -0.1  
  C++ Note: sums checked 807.883 807.883  
  C++ Note: dose checked 1000  
  C++ Note: non-dose checked 807.883  
  C++ Note: LIN_non-dose checked 1000  
  C++ Note: PLIN_non-dose checked 1000  
  C++ Note: LOGLIN_non-dose checked 807.883  
  C++ Note: risk checked 807.883  
  C++ Note: riskr checked 2197.44  
  C++ Note: riskl checked 19.6098  
  C++ Note: df101 -122.891 0  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: df100 5288 2 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:03 2024
  
  C++ Note: riskr checked 2197.44  
  C++ Note: riskl checked 19.6098  
  C++ Note: df101 -122.891 0  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: riskr checked 2197.44  
  C++ Note: riskl checked 19.6098  
  C++ Note: df101 -122.891 0  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: Exiting Regression
  C++ Note: df501 -122.8909
  C++ Note: df504 -0.1 -0.1  
  Note: 26 risk groups
  C++ Note: START_COX_GUESS
  C++ Note: Current Time, Fri Feb 23 05:59:04 2024
  
  C++ Note: Term checked 0 0  
  C++ Note: df99,71,Starting
  C++ Note: Current Time, Fri Feb 23 05:59:04 2024
  
  C++ Note: Grouping Start
  C++ Note: df100 428 0 0 -1,Prep_List
  C++ Note: Current Time, Fri Feb 23 05:59:04 2024
  
  C++ Note: starting subterms 1 in guess 0
  C++ Note: values checked -0.1 -0.1  
  C++ Note: sums checked 807.883 807.883  
  C++ Note: dose checked 1000  
  C++ Note: non-dose checked 807.883  
  C++ Note: LIN_non-dose checked 1000  
  C++ Note: PLIN_non-dose checked 1000  
  C++ Note: LOGLIN_non-dose checked 807.883  
  C++ Note: risk checked 807.883  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 2197.44  
  C++ Note: riskl checked 19.6098  
  C++ Note: df101 -122.891 0  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: Starting Halves
  C++ Note: df501 -122.8909
  C++ Note: df504 -0.1 -0.1  
  C++ Note: values checked -0.1 -0.1  
  C++ Note: sums checked 807.883 807.883  
  C++ Note: dose checked 1000  
  C++ Note: non-dose checked 807.883  
  C++ Note: LIN_non-dose checked 1000  
  C++ Note: PLIN_non-dose checked 1000  
  C++ Note: LOGLIN_non-dose checked 807.883  
  C++ Note: risk checked 807.883  
  C++ Note: riskr checked 2197.44  
  C++ Note: riskl checked 19.6098  
  C++ Note: df101 -122.891 0  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: df100 1942 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:04 2024
  
  C++ Note: values checked -0.1 -0.1  
  C++ Note: sums checked 807.883 807.883  
  C++ Note: dose checked 1000  
  C++ Note: non-dose checked 807.883  
  C++ Note: LIN_non-dose checked 1000  
  C++ Note: PLIN_non-dose checked 1000  
  C++ Note: LOGLIN_non-dose checked 807.883  
  C++ Note: risk checked 807.883  
  C++ Note: riskr checked 2197.44  
  C++ Note: riskl checked 19.6098  
  C++ Note: df101 -122.891 0  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: df100 2610 2 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:04 2024
  
  C++ Note: riskr checked 2197.44  
  C++ Note: riskl checked 19.6098  
  C++ Note: df101 -122.891 0  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: ending guess 0
  C++ Note: df501 -122.8909
  C++ Note: df504 -0.1 -0.1  
  C++ Note: Refreshing matrices after all guesses
  C++ Note: Guess Results
  Guess number, parameter values, Log-Likelihood
  0, -0.1 -0.1, -122.8909<-- Best Guess
  C++ Note: starting subterms 1 in best guess 0
  C++ Note: values checked -0.1 -0.1  
  C++ Note: sums checked 807.883 807.883  
  C++ Note: dose checked 1000  
  C++ Note: non-dose checked 807.883  
  C++ Note: LIN_non-dose checked 1000  
  C++ Note: PLIN_non-dose checked 1000  
  C++ Note: LOGLIN_non-dose checked 807.883  
  C++ Note: risk checked 807.883  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 2197.44  
  C++ Note: riskl checked 19.6098  
  C++ Note: df101 -122.891 0  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: Starting Halves
  C++ Note: df501 -122.8909
  C++ Note: df504 -0.1 -0.1  
  C++ Note: values checked -0.1 -0.1  
  C++ Note: sums checked 807.883 807.883  
  C++ Note: dose checked 1000  
  C++ Note: non-dose checked 807.883  
  C++ Note: LIN_non-dose checked 1000  
  C++ Note: PLIN_non-dose checked 1000  
  C++ Note: LOGLIN_non-dose checked 807.883  
  C++ Note: risk checked 807.883  
  C++ Note: riskr checked 2197.44  
  C++ Note: riskl checked 19.6098  
  C++ Note: df101 -122.891 0  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: df100 4483 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:04 2024
  
  C++ Note: values checked -0.1 -0.1  
  C++ Note: sums checked 807.883 807.883  
  C++ Note: dose checked 1000  
  C++ Note: non-dose checked 807.883  
  C++ Note: LIN_non-dose checked 1000  
  C++ Note: PLIN_non-dose checked 1000  
  C++ Note: LOGLIN_non-dose checked 807.883  
  C++ Note: risk checked 807.883  
  C++ Note: riskr checked 2197.44  
  C++ Note: riskl checked 19.6098  
  C++ Note: df101 -122.891 0  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: df100 5173 2 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:04 2024
  
  C++ Note: riskr checked 2197.44  
  C++ Note: riskl checked 19.6098  
  C++ Note: df101 -122.891 0  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: riskr checked 2197.44  
  C++ Note: riskl checked 19.6098  
  C++ Note: df101 -122.891 0  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: Exiting Regression
  C++ Note: df501 -122.8909
  C++ Note: df504 -0.1 -0.1  
  Note: 26 risk groups
  C++ Note: START_COX_GUESS
  C++ Note: Current Time, Fri Feb 23 05:59:04 2024
  
  C++ Note: Term checked 0 0  
  C++ Note: df99,65,Starting
  C++ Note: Current Time, Fri Feb 23 05:59:04 2024
  
  C++ Note: Grouping Start
  C++ Note: df100 308 0 0 -1,Prep_List
  C++ Note: Current Time, Fri Feb 23 05:59:04 2024
  
  C++ Note: starting subterms 1 in guess 0
  C++ Note: values checked -0.1 -0.1  
  C++ Note: sums checked 807.883 807.883  
  C++ Note: dose checked 1000  
  C++ Note: non-dose checked 807.883  
  C++ Note: LIN_non-dose checked 1000  
  C++ Note: PLIN_non-dose checked 1000  
  C++ Note: LOGLIN_non-dose checked 807.883  
  C++ Note: risk checked 807.883  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 2125.36  
  C++ Note: riskl checked 19.6098  
  C++ Note: df101 -119.981 0  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: Starting Halves
  C++ Note: df501 -119.9814
  C++ Note: df504 -0.1 -0.1  
  C++ Note: values checked -0.1 -0.1  
  C++ Note: sums checked 807.883 807.883  
  C++ Note: dose checked 1000  
  C++ Note: non-dose checked 807.883  
  C++ Note: LIN_non-dose checked 1000  
  C++ Note: PLIN_non-dose checked 1000  
  C++ Note: LOGLIN_non-dose checked 807.883  
  C++ Note: risk checked 807.883  
  C++ Note: riskr checked 2125.36  
  C++ Note: riskl checked 19.6098  
  C++ Note: df101 -119.981 0  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: df100 1439 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:04 2024
  
  C++ Note: values checked -0.1 -0.1  
  C++ Note: sums checked 807.883 807.883  
  C++ Note: dose checked 1000  
  C++ Note: non-dose checked 807.883  
  C++ Note: LIN_non-dose checked 1000  
  C++ Note: PLIN_non-dose checked 1000  
  C++ Note: LOGLIN_non-dose checked 807.883  
  C++ Note: risk checked 807.883  
  C++ Note: riskr checked 2125.36  
  C++ Note: riskl checked 19.6098  
  C++ Note: df101 -119.981 0  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: df100 1989 2 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:04 2024
  
  C++ Note: riskr checked 2125.36  
  C++ Note: riskl checked 19.6098  
  C++ Note: df101 -119.981 0  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: ending guess 0
  C++ Note: df501 -119.9814
  C++ Note: df504 -0.1 -0.1  
  C++ Note: Refreshing matrices after all guesses
  C++ Note: Guess Results
  Guess number, parameter values, Log-Likelihood
  0, -0.1 -0.1, -119.9814<-- Best Guess
  C++ Note: starting subterms 1 in best guess 0
  C++ Note: values checked -0.1 -0.1  
  C++ Note: sums checked 807.883 807.883  
  C++ Note: dose checked 1000  
  C++ Note: non-dose checked 807.883  
  C++ Note: LIN_non-dose checked 1000  
  C++ Note: PLIN_non-dose checked 1000  
  C++ Note: LOGLIN_non-dose checked 807.883  
  C++ Note: risk checked 807.883  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 2125.36  
  C++ Note: riskl checked 19.6098  
  C++ Note: df101 -119.981 0  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: Starting Halves
  C++ Note: df501 -119.9814
  C++ Note: df504 -0.1 -0.1  
  C++ Note: values checked -0.1 -0.1  
  C++ Note: sums checked 807.883 807.883  
  C++ Note: dose checked 1000  
  C++ Note: non-dose checked 807.883  
  C++ Note: LIN_non-dose checked 1000  
  C++ Note: PLIN_non-dose checked 1000  
  C++ Note: LOGLIN_non-dose checked 807.883  
  C++ Note: risk checked 807.883  
  C++ Note: riskr checked 2125.36  
  C++ Note: riskl checked 19.6098  
  C++ Note: df101 -119.981 0  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: df100 3439 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:04 2024
  
  C++ Note: values checked -0.1 -0.1  
  C++ Note: sums checked 807.883 807.883  
  C++ Note: dose checked 1000  
  C++ Note: non-dose checked 807.883  
  C++ Note: LIN_non-dose checked 1000  
  C++ Note: PLIN_non-dose checked 1000  
  C++ Note: LOGLIN_non-dose checked 807.883  
  C++ Note: risk checked 807.883  
  C++ Note: riskr checked 2125.36  
  C++ Note: riskl checked 19.6098  
  C++ Note: df101 -119.981 0  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: df100 3954 2 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:04 2024
  
  C++ Note: riskr checked 2125.36  
  C++ Note: riskl checked 19.6098  
  C++ Note: df101 -119.981 0  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: riskr checked 2125.36  
  C++ Note: riskl checked 19.6098  
  C++ Note: df101 -119.981 0  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: Exiting Regression
  C++ Note: df501 -119.9814
  C++ Note: df504 -0.1 -0.1  
  Note: 26 risk groups
  C++ Note: START_COX_GUESS
  C++ Note: Current Time, Fri Feb 23 05:59:04 2024
  
  C++ Note: Term checked 0 0  
  C++ Note: df99,64,Starting
  C++ Note: Current Time, Fri Feb 23 05:59:04 2024
  
  C++ Note: Grouping Start
  C++ Note: df100 311 0 0 -1,Prep_List
  C++ Note: Current Time, Fri Feb 23 05:59:04 2024
  
  C++ Note: starting subterms 1 in guess 0
  C++ Note: values checked -0.1 -0.1  
  C++ Note: sums checked 807.883 807.883  
  C++ Note: dose checked 1000  
  C++ Note: non-dose checked 807.883  
  C++ Note: LIN_non-dose checked 1000  
  C++ Note: PLIN_non-dose checked 1000  
  C++ Note: LOGLIN_non-dose checked 807.883  
  C++ Note: risk checked 807.883  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 2125.36  
  C++ Note: riskl checked 19.6098  
  C++ Note: df101 -119.981 0  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: Starting Halves
  C++ Note: df501 -119.9814
  C++ Note: df504 -0.1 -0.1  
  C++ Note: values checked -0.1 -0.1  
  C++ Note: sums checked 807.883 807.883  
  C++ Note: dose checked 1000  
  C++ Note: non-dose checked 807.883  
  C++ Note: LIN_non-dose checked 1000  
  C++ Note: PLIN_non-dose checked 1000  
  C++ Note: LOGLIN_non-dose checked 807.883  
  C++ Note: risk checked 807.883  
  C++ Note: riskr checked 2125.36  
  C++ Note: riskl checked 19.6098  
  C++ Note: df101 -119.981 0  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: df100 1464 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:04 2024
  
  C++ Note: values checked -0.1 -0.1  
  C++ Note: sums checked 807.883 807.883  
  C++ Note: dose checked 1000  
  C++ Note: non-dose checked 807.883  
  C++ Note: LIN_non-dose checked 1000  
  C++ Note: PLIN_non-dose checked 1000  
  C++ Note: LOGLIN_non-dose checked 807.883  
  C++ Note: risk checked 807.883  
  C++ Note: riskr checked 2125.36  
  C++ Note: riskl checked 19.6098  
  C++ Note: df101 -119.981 0  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: df100 1985 2 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:04 2024
  
  C++ Note: riskr checked 2125.36  
  C++ Note: riskl checked 19.6098  
  C++ Note: df101 -119.981 0  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: ending guess 0
  C++ Note: df501 -119.9814
  C++ Note: df504 -0.1 -0.1  
  C++ Note: Refreshing matrices after all guesses
  C++ Note: Guess Results
  Guess number, parameter values, Log-Likelihood
  0, -0.1 -0.1, -119.9814<-- Best Guess
  C++ Note: starting subterms 1 in best guess 0
  C++ Note: values checked -0.1 -0.1  
  C++ Note: sums checked 807.883 807.883  
  C++ Note: dose checked 1000  
  C++ Note: non-dose checked 807.883  
  C++ Note: LIN_non-dose checked 1000  
  C++ Note: PLIN_non-dose checked 1000  
  C++ Note: LOGLIN_non-dose checked 807.883  
  C++ Note: risk checked 807.883  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 2125.36  
  C++ Note: riskl checked 19.6098  
  C++ Note: df101 -119.981 0  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: Starting Halves
  C++ Note: df501 -119.9814
  C++ Note: df504 -0.1 -0.1  
  C++ Note: values checked -0.1 -0.1  
  C++ Note: sums checked 807.883 807.883  
  C++ Note: dose checked 1000  
  C++ Note: non-dose checked 807.883  
  C++ Note: LIN_non-dose checked 1000  
  C++ Note: PLIN_non-dose checked 1000  
  C++ Note: LOGLIN_non-dose checked 807.883  
  C++ Note: risk checked 807.883  
  C++ Note: riskr checked 2125.36  
  C++ Note: riskl checked 19.6098  
  C++ Note: df101 -119.981 0  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: df100 3400 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:04 2024
  
  C++ Note: values checked -0.1 -0.1  
  C++ Note: sums checked 807.883 807.883  
  C++ Note: dose checked 1000  
  C++ Note: non-dose checked 807.883  
  C++ Note: LIN_non-dose checked 1000  
  C++ Note: PLIN_non-dose checked 1000  
  C++ Note: LOGLIN_non-dose checked 807.883  
  C++ Note: risk checked 807.883  
  C++ Note: riskr checked 2125.36  
  C++ Note: riskl checked 19.6098  
  C++ Note: df101 -119.981 0  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: df100 3925 2 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:04 2024
  
  C++ Note: riskr checked 2125.36  
  C++ Note: riskl checked 19.6098  
  C++ Note: df101 -119.981 0  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: riskr checked 2125.36  
  C++ Note: riskl checked 19.6098  
  C++ Note: df101 -119.981 0  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: Exiting Regression
  C++ Note: df501 -119.9814
  C++ Note: df504 -0.1 -0.1  
  Note: 26 risk groups
  C++ Note: START_COX_GUESS
  C++ Note: Current Time, Fri Feb 23 05:59:04 2024
  
  C++ Note: Term checked 0 0  
  C++ Note: df99,58,Starting
  C++ Note: Current Time, Fri Feb 23 05:59:04 2024
  
  C++ Note: Grouping Start
  C++ Note: df100 429 0 0 -1,Prep_List
  C++ Note: Current Time, Fri Feb 23 05:59:04 2024
  
  C++ Note: starting subterms 1 in guess 0
  C++ Note: values checked -0.1 -0.1  
  C++ Note: sums checked 807.883 807.883  
  C++ Note: derivs checked 1229.85 410.233  
  C++ Note: second derivs checked 3319.14 410.233  
  C++ Note: dose checked 1000  
  C++ Note: non-dose checked 807.883  
  C++ Note: LIN_non-dose checked 1000  
  C++ Note: PLIN_non-dose checked 1000  
  C++ Note: LOGLIN_non-dose checked 807.883  
  C++ Note: risk checked 807.883  
  C++ Note: risk1 checked 1229.85 410.233  
  C++ Note: risk2 checked 3319.14 410.233  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 2197.44  
  C++ Note: risk1r checked 3174.27 1089.12  
  C++ Note: risk2r checked 7204.63 1089.12  
  C++ Note: riskl checked 19.6098  
  C++ Note: risk1l checked 42.0717 11.5472  
  C++ Note: risk2l checked 118.124 11.5472  
  C++ Note: df101 -122.891 -122.891  
  C++ Note: df102 21.2331 3.11507  
  C++ Note: df103 -19.7104 -6.49727  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: df105 -1.07726 -0.479443  
  C++ Note: df106 -5.78769 -39.4505  
  C++ Note: Starting Halves
  C++ Note: df501 -122.8909
  C++ Note: df504 -0.1 -0.1  
  C++ Note: values checked 0.732916 0.388699  
  C++ Note: sums checked 7921.99 7921.99  
  C++ Note: derivs checked 26681.9 4784.79  
  C++ Note: second derivs checked 107491 4784.79  
  C++ Note: dose checked 1000  
  C++ Note: non-dose checked 7921.99  
  C++ Note: LIN_non-dose checked 1000  
  C++ Note: PLIN_non-dose checked 1000  
  C++ Note: LOGLIN_non-dose checked 7921.99  
  C++ Note: risk checked 7921.99  
  C++ Note: risk1 checked 26681.9 4784.79  
  C++ Note: risk2 checked 107491 4784.79  
  C++ Note: riskr checked 15672.9  
  C++ Note: risk1r checked 42701.5 9198.27  
  C++ Note: risk2r checked 144140 9198.27  
  C++ Note: riskl checked 259.026  
  C++ Note: risk1l checked 843.134 168.735  
  C++ Note: risk2l checked 3047.41 168.735  
  C++ Note: df101 -110.801 -110.801  
  C++ Note: df102 6.10212 0.649377  
  C++ Note: df103 -15.9738 -6.28124  
  C++ Note: df104 0.732916 0.388699  
  C++ Note: df105 -0.382009 -0.103384  
  C++ Note: df106 -18.1578 -170.627  
  C++ Note: df100 4867 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:04 2024
  
  C++ Note: riskr checked 15672.9  
  C++ Note: risk1r checked 42701.5 9198.27  
  C++ Note: risk2r checked 144140 9198.27  
  C++ Note: riskl checked 259.026  
  C++ Note: risk1l checked 843.134 168.735  
  C++ Note: risk2l checked 3047.41 168.735  
  C++ Note: df101 -110.801 -110.801  
  C++ Note: df102 6.10212 0.649377  
  C++ Note: df103 -15.9738 -6.28124  
  C++ Note: df104 0.732916 0.388699  
  C++ Note: df105 -0.382009 -0.103384  
  C++ Note: df106 -18.1578 -170.627  
  C++ Note: ending guess 0
  C++ Note: df501 -110.8014
  C++ Note: df504 0.732916 0.3886995  
  C++ Note: Refreshing matrices after all guesses
  C++ Note: Guess Results
  Guess number, parameter values, Log-Likelihood
  0, 0.732916 0.3886995, -110.8014<-- Best Guess
  C++ Note: starting subterms 1 in best guess 0
  C++ Note: values checked 0.732916 0.388699  
  C++ Note: sums checked 7921.99 7921.99  
  C++ Note: derivs checked 26681.9 4784.79  
  C++ Note: second derivs checked 107491 4784.79  
  C++ Note: dose checked 1000  
  C++ Note: non-dose checked 7921.99  
  C++ Note: LIN_non-dose checked 1000  
  C++ Note: PLIN_non-dose checked 1000  
  C++ Note: LOGLIN_non-dose checked 7921.99  
  C++ Note: risk checked 7921.99  
  C++ Note: risk1 checked 26681.9 4784.79  
  C++ Note: risk2 checked 107491 4784.79  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 15672.9  
  C++ Note: risk1r checked 42701.5 9198.27  
  C++ Note: risk2r checked 144140 9198.27  
  C++ Note: riskl checked 259.026  
  C++ Note: risk1l checked 843.134 168.735  
  C++ Note: risk2l checked 3047.41 168.735  
  C++ Note: df101 -110.801 -110.801  
  C++ Note: df102 6.10212 0.649377  
  C++ Note: df103 -15.9738 -6.28124  
  C++ Note: df104 0.732916 0.388699  
  C++ Note: df105 -0.382009 -0.103384  
  C++ Note: df106 -18.1578 -170.627  
  C++ Note: Starting Halves
  C++ Note: df501 -110.8014
  C++ Note: df504 0.732916 0.3886995  
  C++ Note: values checked 1.02333 0.493704  
  C++ Note: sums checked 24538.9 24538.9  
  C++ Note: derivs checked 97084.4 15240.1  
  C++ Note: second derivs checked 428953 15240.1  
  C++ Note: dose checked 1000  
  C++ Note: non-dose checked 24538.9  
  C++ Note: LIN_non-dose checked 1000  
  C++ Note: PLIN_non-dose checked 1000  
  C++ Note: LOGLIN_non-dose checked 24538.9  
  C++ Note: risk checked 24538.9  
  C++ Note: risk1 checked 97084.4 15240.1  
  C++ Note: risk2 checked 428953 15240.1  
  C++ Note: riskr checked 39636.5  
  C++ Note: risk1r checked 128036 24066.7  
  C++ Note: risk2r checked 480878 24066.7  
  C++ Note: riskl checked 745.302  
  C++ Note: risk1l checked 2645.43 469.387  
  C++ Note: risk2l checked 10112.8 469.387  
  C++ Note: df101 -109.621 -109.621  
  C++ Note: df102 1.83938 0.14137  
  C++ Note: df103 -13.8104 -6.17729  
  C++ Note: df104 1.02333 0.493704  
  C++ Note: df105 -0.133188 -0.0228854  
  C++ Note: df106 -59.5969 -775.422  
  C++ Note: df100 22097 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:04 2024
  
  C++ Note: riskr checked 39636.5  
  C++ Note: risk1r checked 128036 24066.7  
  C++ Note: risk2r checked 480878 24066.7  
  C++ Note: riskl checked 745.302  
  C++ Note: risk1l checked 2645.43 469.387  
  C++ Note: risk2l checked 10112.8 469.387  
  C++ Note: df101 -109.621 -109.621  
  C++ Note: df102 1.83938 0.14137  
  C++ Note: df103 -13.8104 -6.17729  
  C++ Note: df104 1.02333 0.493704  
  C++ Note: df105 -0.133188 -0.0228854  
  C++ Note: df106 -59.5969 -775.422  
  C++ Note: riskr checked 39636.5  
  C++ Note: risk1r checked 128036 24066.7  
  C++ Note: risk2r checked 480878 24066.7  
  C++ Note: riskl checked 745.302  
  C++ Note: risk1l checked 2645.43 469.387  
  C++ Note: risk2l checked 10112.8 469.387  
  C++ Note: df101 -109.621 -109.621  
  C++ Note: df102 1.83938 0.14137  
  C++ Note: df103 -13.8104 -6.17729  
  C++ Note: df104 1.02333 0.493704  
  C++ Note: df105 -0.133188 -0.0228854  
  C++ Note: df106 -59.5969 -775.422  
  C++ Note: Exiting Regression
  C++ Note: df501 -109.6211
  C++ Note: df504 1.023328 0.4937042  
  Note: 26 risk groups
  C++ Note: START_COX_GUESS
  C++ Note: Current Time, Fri Feb 23 05:59:04 2024
  
  C++ Note: Term checked 0 0  
  C++ Note: df99,72,Starting
  C++ Note: Current Time, Fri Feb 23 05:59:04 2024
  
  C++ Note: Grouping Start
  C++ Note: df100 433 0 0 -1,Prep_List
  C++ Note: Current Time, Fri Feb 23 05:59:04 2024
  
  C++ Note: starting subterms 1 in guess 0
  C++ Note: values checked -0.1 -0.1  
  C++ Note: sums checked 807.883 807.883  
  C++ Note: derivs checked 1229.85 410.233  
  C++ Note: second derivs checked 3319.14 410.233  
  C++ Note: dose checked 1000  
  C++ Note: non-dose checked 807.883  
  C++ Note: LIN_non-dose checked 1000  
  C++ Note: PLIN_non-dose checked 1000  
  C++ Note: LOGLIN_non-dose checked 807.883  
  C++ Note: risk checked 807.883  
  C++ Note: risk1 checked 1229.85 410.233  
  C++ Note: risk2 checked 3319.14 410.233  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 2197.44  
  C++ Note: risk1r checked 3174.27 1089.12  
  C++ Note: risk2r checked 7204.63 1089.12  
  C++ Note: riskl checked 19.6098  
  C++ Note: risk1l checked 42.0717 11.5472  
  C++ Note: risk2l checked 118.124 11.5472  
  C++ Note: df101 -122.891 -122.891  
  C++ Note: df102 21.2331 3.11507  
  C++ Note: df103 -19.7104 -6.49727  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: df105 -1.07726 -0.479443  
  C++ Note: df106 -5.78769 -39.4505  
  C++ Note: Starting Halves
  C++ Note: df501 -122.8909
  C++ Note: df504 -0.1 -0.1  
  C++ Note: values checked 0.707943 0.259582  
  C++ Note: sums checked 6754.07 6754.07  
  C++ Note: derivs checked 22400.3 3873.99  
  C++ Note: second derivs checked 89482.9 3873.99  
  C++ Note: dose checked 1000  
  C++ Note: non-dose checked 6754.07  
  C++ Note: LIN_non-dose checked 1000  
  C++ Note: PLIN_non-dose checked 1000  
  C++ Note: LOGLIN_non-dose checked 6754.07  
  C++ Note: risk checked 6754.07  
  C++ Note: risk1 checked 22400.3 3873.99  
  C++ Note: risk2 checked 89482.9 3873.99  
  C++ Note: riskr checked 13607.5  
  C++ Note: risk1r checked 36518.1 7564.8  
  C++ Note: risk2r checked 122057 7564.8  
  C++ Note: riskl checked 219.94  
  C++ Note: risk1l checked 713.45 137.505  
  C++ Note: risk2l checked 2579.26 137.505  
  C++ Note: df101 -111.093 -111.093  
  C++ Note: df102 6.4244 1.45354  
  C++ Note: df103 -16.1091 -6.40177  
  C++ Note: df104 0.707943 0.259582  
  C++ Note: df105 -0.398805 -0.227053  
  C++ Note: df106 -17.2924 -76.4296  
  C++ Note: df100 14511 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:04 2024
  
  C++ Note: riskr checked 13607.5  
  C++ Note: risk1r checked 36518.1 7564.8  
  C++ Note: risk2r checked 122057 7564.8  
  C++ Note: riskl checked 219.94  
  C++ Note: risk1l checked 713.45 137.505  
  C++ Note: risk2l checked 2579.26 137.505  
  C++ Note: df101 -111.093 -111.093  
  C++ Note: df102 6.4244 1.45354  
  C++ Note: df103 -16.1091 -6.40177  
  C++ Note: df104 0.707943 0.259582  
  C++ Note: df105 -0.398805 -0.227053  
  C++ Note: df106 -17.2924 -76.4296  
  C++ Note: ending guess 0
  C++ Note: df501 -111.0934
  C++ Note: df504 0.7079435 0.259582  
  C++ Note: Refreshing matrices after all guesses
  C++ Note: Guess Results
  Guess number, parameter values, Log-Likelihood
  0, 0.7079435 0.259582, -111.0934<-- Best Guess
  C++ Note: starting subterms 1 in best guess 0
  C++ Note: values checked 0.707943 0.259582  
  C++ Note: sums checked 6754.07 6754.07  
  C++ Note: derivs checked 22400.3 3873.99  
  C++ Note: second derivs checked 89482.9 3873.99  
  C++ Note: dose checked 1000  
  C++ Note: non-dose checked 6754.07  
  C++ Note: LIN_non-dose checked 1000  
  C++ Note: PLIN_non-dose checked 1000  
  C++ Note: LOGLIN_non-dose checked 6754.07  
  C++ Note: risk checked 6754.07  
  C++ Note: risk1 checked 22400.3 3873.99  
  C++ Note: risk2 checked 89482.9 3873.99  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 13607.5  
  C++ Note: risk1r checked 36518.1 7564.8  
  C++ Note: risk2r checked 122057 7564.8  
  C++ Note: riskl checked 219.94  
  C++ Note: risk1l checked 713.45 137.505  
  C++ Note: risk2l checked 2579.26 137.505  
  C++ Note: df101 -111.093 -111.093  
  C++ Note: df102 6.4244 1.45354  
  C++ Note: df103 -16.1091 -6.40177  
  C++ Note: df104 0.707943 0.259582  
  C++ Note: df105 -0.398805 -0.227053  
  C++ Note: df106 -17.2924 -76.4296  
  C++ Note: Starting Halves
  C++ Note: df501 -111.0934
  C++ Note: df504 0.7079435 0.259582  
  C++ Note: values checked 1.00705 0.429872  
  C++ Note: sums checked 22129.4 22129.4  
  C++ Note: derivs checked 86917.6 13416  
  C++ Note: second derivs checked 382294 13416  
  C++ Note: dose checked 1000  
  C++ Note: non-dose checked 22129.4  
  C++ Note: LIN_non-dose checked 1000  
  C++ Note: PLIN_non-dose checked 1000  
  C++ Note: LOGLIN_non-dose checked 22129.4  
  C++ Note: risk checked 22129.4  
  C++ Note: risk1 checked 86917.6 13416  
  C++ Note: risk2 checked 382294 13416  
  C++ Note: riskr checked 36201.7  
  C++ Note: risk1r checked 115958 21431.5  
  C++ Note: risk2r checked 433026 21431.5  
  C++ Note: riskl checked 676.025  
  C++ Note: risk1l checked 2396.11 417.501  
  C++ Note: risk2l checked 9159.18 417.501  
  C++ Note: df101 -109.674 -109.674  
  C++ Note: df102 2.03825 0.531514  
  C++ Note: df103 -13.8822 -6.25712  
  C++ Note: df104 1.00705 0.429872  
  C++ Note: df105 -0.146825 -0.0849455  
  C++ Note: df106 -53.8081 -206.343  
  C++ Note: df100 20971 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:04 2024
  
  C++ Note: riskr checked 36201.7  
  C++ Note: risk1r checked 115958 21431.5  
  C++ Note: risk2r checked 433026 21431.5  
  C++ Note: riskl checked 676.025  
  C++ Note: risk1l checked 2396.11 417.501  
  C++ Note: risk2l checked 9159.18 417.501  
  C++ Note: df101 -109.674 -109.674  
  C++ Note: df102 2.03825 0.531514  
  C++ Note: df103 -13.8822 -6.25712  
  C++ Note: df104 1.00705 0.429872  
  C++ Note: df105 -0.146825 -0.0849455  
  C++ Note: df106 -53.8081 -206.343  
  C++ Note: riskr checked 36201.7  
  C++ Note: risk1r checked 115958 21431.5  
  C++ Note: risk2r checked 433026 21431.5  
  C++ Note: riskl checked 676.025  
  C++ Note: risk1l checked 2396.11 417.501  
  C++ Note: risk2l checked 9159.18 417.501  
  C++ Note: df101 -109.674 -109.674  
  C++ Note: df102 2.03825 0.531514  
  C++ Note: df103 -13.8822 -6.25712  
  C++ Note: df104 1.00705 0.429872  
  C++ Note: df105 -0.146825 -0.0849455  
  C++ Note: df106 -53.8081 -206.343  
  C++ Note: Exiting Regression
  C++ Note: df501 -109.6742
  C++ Note: df504 1.007047 0.4298716  
  Note: 26 risk groups
  C++ Note: START_COX_GUESS
  C++ Note: Current Time, Fri Feb 23 05:59:04 2024
  
  C++ Note: Term checked 0 0  
  C++ Note: df99,75,Starting
  C++ Note: Current Time, Fri Feb 23 05:59:04 2024
  
  C++ Note: Grouping Start
  C++ Note: df100 386 0 0 -1,Prep_List
  C++ Note: Current Time, Fri Feb 23 05:59:04 2024
  
  C++ Note: starting subterms 1 in guess 0
  C++ Note: values checked -0.1 -0.1  
  C++ Note: sums checked 807.883 807.883  
  C++ Note: derivs checked 1229.85 410.233  
  C++ Note: second derivs checked 3319.14 410.233  
  C++ Note: dose checked 1000  
  C++ Note: non-dose checked 807.883  
  C++ Note: LIN_non-dose checked 1000  
  C++ Note: PLIN_non-dose checked 1000  
  C++ Note: LOGLIN_non-dose checked 807.883  
  C++ Note: risk checked 807.883  
  C++ Note: risk1 checked 1229.85 410.233  
  C++ Note: risk2 checked 3319.14 410.233  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 2125.36  
  C++ Note: risk1r checked 3418.73 1095.31  
  C++ Note: risk2r checked 8667.81 1095.31  
  C++ Note: riskl checked 19.6098  
  C++ Note: risk1l checked 42.0717 11.5472  
  C++ Note: risk2l checked 118.124 11.5472  
  C++ Note: df101 -119.981 -119.981  
  C++ Note: df102 6.06579 2.41134  
  C++ Note: df103 -8.60689 -6.47374  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: df105 -0.70476 -0.37248  
  C++ Note: df106 -19.78 -49.7572  
  C++ Note: Starting Halves
  C++ Note: df501 -119.9814
  C++ Note: df504 -0.1 -0.1  
  C++ Note: values checked 0.497478 0.312164  
  C++ Note: sums checked 3648.05 3648.05  
  C++ Note: derivs checked 10299.6 2165.99  
  C++ Note: second derivs checked 37798.4 2165.99  
  C++ Note: dose checked 1000  
  C++ Note: non-dose checked 3648.05  
  C++ Note: LIN_non-dose checked 1000  
  C++ Note: PLIN_non-dose checked 1000  
  C++ Note: LOGLIN_non-dose checked 3648.05  
  C++ Note: risk checked 3648.05  
  C++ Note: risk1 checked 10299.6 2165.99  
  C++ Note: risk2 checked 37798.4 2165.99  
  C++ Note: riskr checked 9367.5  
  C++ Note: risk1r checked 24562.6 5580.77  
  C++ Note: risk2r checked 81557.6 5580.77  
  C++ Note: riskl checked 118.249  
  C++ Note: risk1l checked 351.472 78.443  
  C++ Note: risk2l checked 1199.14 78.443  
  C++ Note: df101 -117.142 -117.142  
  C++ Note: df102 1.31609 0.547704  
  C++ Note: df103 -9.05233 -6.2666  
  C++ Note: df104 0.497478 0.312164  
  C++ Note: df105 -0.145387 -0.0874005  
  C++ Note: df106 -89.0079 -213.879  
  C++ Note: df100 3325 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:04 2024
  
  C++ Note: riskr checked 9367.5  
  C++ Note: risk1r checked 24562.6 5580.77  
  C++ Note: risk2r checked 81557.6 5580.77  
  C++ Note: riskl checked 118.249  
  C++ Note: risk1l checked 351.472 78.443  
  C++ Note: risk2l checked 1199.14 78.443  
  C++ Note: df101 -117.142 -117.142  
  C++ Note: df102 1.31609 0.547704  
  C++ Note: df103 -9.05233 -6.2666  
  C++ Note: df104 0.497478 0.312164  
  C++ Note: df105 -0.145387 -0.0874005  
  C++ Note: df106 -89.0079 -213.879  
  C++ Note: ending guess 0
  C++ Note: df501 -117.1424
  C++ Note: df504 0.4974778 0.3121644  
  C++ Note: Refreshing matrices after all guesses
  C++ Note: Guess Results
  Guess number, parameter values, Log-Likelihood
  0, 0.4974778 0.3121644, -117.1424<-- Best Guess
  C++ Note: starting subterms 1 in best guess 0
  C++ Note: values checked 0.497478 0.312164  
  C++ Note: sums checked 3648.05 3648.05  
  C++ Note: derivs checked 10299.6 2165.99  
  C++ Note: second derivs checked 37798.4 2165.99  
  C++ Note: dose checked 1000  
  C++ Note: non-dose checked 3648.05  
  C++ Note: LIN_non-dose checked 1000  
  C++ Note: PLIN_non-dose checked 1000  
  C++ Note: LOGLIN_non-dose checked 3648.05  
  C++ Note: risk checked 3648.05  
  C++ Note: risk1 checked 10299.6 2165.99  
  C++ Note: risk2 checked 37798.4 2165.99  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 9367.5  
  C++ Note: risk1r checked 24562.6 5580.77  
  C++ Note: risk2r checked 81557.6 5580.77  
  C++ Note: riskl checked 118.249  
  C++ Note: risk1l checked 351.472 78.443  
  C++ Note: risk2l checked 1199.14 78.443  
  C++ Note: df101 -117.142 -117.142  
  C++ Note: df102 1.31609 0.547704  
  C++ Note: df103 -9.05233 -6.2666  
  C++ Note: df104 0.497478 0.312164  
  C++ Note: df105 -0.145387 -0.0874005  
  C++ Note: df106 -89.0079 -213.879  
  C++ Note: Starting Halves
  C++ Note: df501 -117.1424
  C++ Note: df504 0.4974778 0.3121644  
  C++ Note: values checked 0.617144 0.398893  
  C++ Note: sums checked 5479.95 5479.95  
  C++ Note: derivs checked 17006.9 3344.7  
  C++ Note: second derivs checked 65563.9 3344.7  
  C++ Note: dose checked 1000  
  C++ Note: non-dose checked 5479.95  
  C++ Note: LIN_non-dose checked 1000  
  C++ Note: PLIN_non-dose checked 1000  
  C++ Note: LOGLIN_non-dose checked 5479.95  
  C++ Note: risk checked 5479.95  
  C++ Note: risk1 checked 17006.9 3344.7  
  C++ Note: risk2 checked 65563.9 3344.7  
  C++ Note: riskr checked 13683.9  
  C++ Note: risk1r checked 38812.2 8366.11  
  C++ Note: risk2r checked 134810 8366.11  
  C++ Note: riskl checked 180.348  
  C++ Note: risk1l checked 561.69 120.669  
  C++ Note: risk2l checked 1971.73 120.669  
  C++ Note: df101 -117.015 -117.015  
  C++ Note: df102 0.320802 0.13496  
  C++ Note: df103 -9.12088 -6.18217  
  C++ Note: df104 0.617144 0.398893  
  C++ Note: df105 -0.0351723 -0.0218306  
  C++ Note: df106 -364.756 -867.031  
  C++ Note: df100 6994 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:04 2024
  
  C++ Note: riskr checked 13683.9  
  C++ Note: risk1r checked 38812.2 8366.11  
  C++ Note: risk2r checked 134810 8366.11  
  C++ Note: riskl checked 180.348  
  C++ Note: risk1l checked 561.69 120.669  
  C++ Note: risk2l checked 1971.73 120.669  
  C++ Note: df101 -117.015 -117.015  
  C++ Note: df102 0.320802 0.13496  
  C++ Note: df103 -9.12088 -6.18217  
  C++ Note: df104 0.617144 0.398893  
  C++ Note: df105 -0.0351723 -0.0218306  
  C++ Note: df106 -364.756 -867.031  
  C++ Note: riskr checked 13683.9  
  C++ Note: risk1r checked 38812.2 8366.11  
  C++ Note: risk2r checked 134810 8366.11  
  C++ Note: riskl checked 180.348  
  C++ Note: risk1l checked 561.69 120.669  
  C++ Note: risk2l checked 1971.73 120.669  
  C++ Note: df101 -117.015 -117.015  
  C++ Note: df102 0.320802 0.13496  
  C++ Note: df103 -9.12088 -6.18217  
  C++ Note: df104 0.617144 0.398893  
  C++ Note: df105 -0.0351723 -0.0218306  
  C++ Note: df106 -364.756 -867.031  
  C++ Note: Exiting Regression
  C++ Note: df501 -117.0147
  C++ Note: df504 0.6171437 0.3988932  
  Note: 26 risk groups
  C++ Note: START_COX_GUESS
  C++ Note: Current Time, Fri Feb 23 05:59:04 2024
  
  C++ Note: Term checked 0 0  
  C++ Note: df99,77,Starting
  C++ Note: Current Time, Fri Feb 23 05:59:04 2024
  
  C++ Note: Grouping Start
  C++ Note: df100 366 0 0 -1,Prep_List
  C++ Note: Current Time, Fri Feb 23 05:59:04 2024
  
  C++ Note: starting subterms 1 in guess 0
  C++ Note: values checked -0.1 -0.1  
  C++ Note: sums checked 807.883 807.883  
  C++ Note: derivs checked 1229.85 410.233  
  C++ Note: second derivs checked 3319.14 410.233  
  C++ Note: dose checked 1000  
  C++ Note: non-dose checked 807.883  
  C++ Note: LIN_non-dose checked 1000  
  C++ Note: PLIN_non-dose checked 1000  
  C++ Note: LOGLIN_non-dose checked 807.883  
  C++ Note: risk checked 807.883  
  C++ Note: risk1 checked 1229.85 410.233  
  C++ Note: risk2 checked 3319.14 410.233  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 2125.36  
  C++ Note: risk1r checked 3418.73 1095.31  
  C++ Note: risk2r checked 8667.81 1095.31  
  C++ Note: riskl checked 19.6098  
  C++ Note: risk1l checked 42.0717 11.5472  
  C++ Note: risk2l checked 118.124 11.5472  
  C++ Note: df101 -119.981 -119.981  
  C++ Note: df102 6.06579 2.41134  
  C++ Note: df103 -8.60689 -6.47374  
  C++ Note: df104 -0.1 -0.1  
  C++ Note: df105 -0.70476 -0.37248  
  C++ Note: df106 -19.78 -49.7572  
  C++ Note: Starting Halves
  C++ Note: df501 -119.9814
  C++ Note: df504 -0.1 -0.1  
  C++ Note: values checked 0.42857 0.17936  
  C++ Note: sums checked 2796.31 2796.31  
  C++ Note: derivs checked 7446.21 1576.41  
  C++ Note: second derivs checked 26529.4 1576.41  
  C++ Note: dose checked 1000  
  C++ Note: non-dose checked 2796.31  
  C++ Note: LIN_non-dose checked 1000  
  C++ Note: PLIN_non-dose checked 1000  
  C++ Note: LOGLIN_non-dose checked 2796.31  
  C++ Note: risk checked 2796.31  
  C++ Note: risk1 checked 7446.21 1576.41  
  C++ Note: risk2 checked 26529.4 1576.41  
  C++ Note: riskr checked 7268.45  
  C++ Note: risk1r checked 18181.7 4116.59  
  C++ Note: risk2r checked 58803.1 4116.59  
  C++ Note: riskl checked 88.5975  
  C++ Note: risk1l checked 256.339 56.699  
  C++ Note: risk2l checked 862.409 56.699  
  C++ Note: df101 -117.373 -117.373  
  C++ Note: df102 1.78502 1.30975  
  C++ Note: df103 -8.96103 -6.38772  
  C++ Note: df104 0.42857 0.17936  
  C++ Note: df105 -0.199199 -0.205041  
  C++ Note: df106 -65.7541 -89.6148  
  C++ Note: df100 3350 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:04 2024
  
  C++ Note: riskr checked 7268.45  
  C++ Note: risk1r checked 18181.7 4116.59  
  C++ Note: risk2r checked 58803.1 4116.59  
  C++ Note: riskl checked 88.5975  
  C++ Note: risk1l checked 256.339 56.699  
  C++ Note: risk2l checked 862.409 56.699  
  C++ Note: df101 -117.373 -117.373  
  C++ Note: df102 1.78502 1.30975  
  C++ Note: df103 -8.96103 -6.38772  
  C++ Note: df104 0.42857 0.17936  
  C++ Note: df105 -0.199199 -0.205041  
  C++ Note: df106 -65.7541 -89.6148  
  C++ Note: ending guess 0
  C++ Note: df501 -117.3726
  C++ Note: df504 0.4285697 0.17936  
  C++ Note: Refreshing matrices after all guesses
  C++ Note: Guess Results
  Guess number, parameter values, Log-Likelihood
  0, 0.4285697 0.17936, -117.3726<-- Best Guess
  C++ Note: starting subterms 1 in best guess 0
  C++ Note: values checked 0.42857 0.17936  
  C++ Note: sums checked 2796.31 2796.31  
  C++ Note: derivs checked 7446.21 1576.41  
  C++ Note: second derivs checked 26529.4 1576.41  
  C++ Note: dose checked 1000  
  C++ Note: non-dose checked 2796.31  
  C++ Note: LIN_non-dose checked 1000  
  C++ Note: PLIN_non-dose checked 1000  
  C++ Note: LOGLIN_non-dose checked 2796.31  
  C++ Note: risk checked 2796.31  
  C++ Note: risk1 checked 7446.21 1576.41  
  C++ Note: risk2 checked 26529.4 1576.41  
  C++ Note: Made Risk Side Lists
  C++ Note: riskr checked 7268.45  
  C++ Note: risk1r checked 18181.7 4116.59  
  C++ Note: risk2r checked 58803.1 4116.59  
  C++ Note: riskl checked 88.5975  
  C++ Note: risk1l checked 256.339 56.699  
  C++ Note: risk2l checked 862.409 56.699  
  C++ Note: df101 -117.373 -117.373  
  C++ Note: df102 1.78502 1.30975  
  C++ Note: df103 -8.96103 -6.38772  
  C++ Note: df104 0.42857 0.17936  
  C++ Note: df105 -0.199199 -0.205041  
  C++ Note: df106 -65.7541 -89.6148  
  C++ Note: Starting Halves
  C++ Note: df501 -117.3726
  C++ Note: df504 0.4285697 0.17936  
  C++ Note: values checked 0.577969 0.333141  
  C++ Note: sums checked 4672.1 4672.1  
  C++ Note: derivs checked 14081.1 2784.48  
  C++ Note: second derivs checked 53455.8 2784.48  
  C++ Note: dose checked 1000  
  C++ Note: non-dose checked 4672.1  
  C++ Note: LIN_non-dose checked 1000  
  C++ Note: PLIN_non-dose checked 1000  
  C++ Note: LOGLIN_non-dose checked 4672.1  
  C++ Note: risk checked 4672.1  
  C++ Note: risk1 checked 14081.1 2784.48  
  C++ Note: risk2 checked 53455.8 2784.48  
  C++ Note: riskr checked 11783.5  
  C++ Note: risk1r checked 32618.6 7038.87  
  C++ Note: risk2r checked 111717 7038.87  
  C++ Note: riskl checked 152.934  
  C++ Note: risk1l checked 470.041 100.807  
  C++ Note: risk2l checked 1638.11 100.807  
  C++ Note: df101 -117.054 -117.054  
  C++ Note: df102 0.609162 0.503449  
  C++ Note: df103 -9.07577 -6.25818  
  C++ Note: df104 0.577969 0.333141  
  C++ Note: df105 -0.0671196 -0.0804466  
  C++ Note: df106 -192.156 -232.504  
  C++ Note: df100 6939 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:04 2024
  
  C++ Note: riskr checked 11783.5  
  C++ Note: risk1r checked 32618.6 7038.87  
  C++ Note: risk2r checked 111717 7038.87  
  C++ Note: riskl checked 152.934  
  C++ Note: risk1l checked 470.041 100.807  
  C++ Note: risk2l checked 1638.11 100.807  
  C++ Note: df101 -117.054 -117.054  
  C++ Note: df102 0.609162 0.503449  
  C++ Note: df103 -9.07577 -6.25818  
  C++ Note: df104 0.577969 0.333141  
  C++ Note: df105 -0.0671196 -0.0804466  
  C++ Note: df106 -192.156 -232.504  
  C++ Note: riskr checked 11783.5  
  C++ Note: risk1r checked 32618.6 7038.87  
  C++ Note: risk2r checked 111717 7038.87  
  C++ Note: riskl checked 152.934  
  C++ Note: risk1l checked 470.041 100.807  
  C++ Note: risk2l checked 1638.11 100.807  
  C++ Note: df101 -117.054 -117.054  
  C++ Note: df102 0.609162 0.503449  
  C++ Note: df103 -9.07577 -6.25818  
  C++ Note: df104 0.577969 0.333141  
  C++ Note: df105 -0.0671196 -0.0804466  
  C++ Note: df106 -192.156 -232.504  
  C++ Note: Exiting Regression
  C++ Note: df501 -117.0539
  C++ Note: df504 0.5779686 0.3331409  
  Warning: model covariate order changed
  C++ Note: START_POIS_GUESS
  C++ Note: Current Time, Fri Feb 23 05:59:04 2024
  
  C++ Note: Term checked 0 1 2  
  C++ Note: df99,113,Starting
  C++ Note: Current Time, Fri Feb 23 05:59:04 2024
  
  C++ Note: starting subterms 3 in guess 0
  C++ Note: values checked 0.1 0.1 0.01  
  C++ Note: sums checked 1229.91 1229.91 1016.5  
  C++ Note: dose checked 1000 1000 1000  
  C++ Note: non-dose checked 1229.91 1229.91 1016.5  
  C++ Note: LIN_non-dose checked 1000 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000 1000  
  C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5  
  C++ Note: risk checked 135.17  
  C++ Note: df101 -467.661 -467.661 -467.661  
  C++ Note: df104 0.1 0.1 0.01  
  C++ Note: Checking Deviance 707.321
  C++ Note: Starting Halves
  C++ Note: df501 -467.6607
  C++ Note: df504 0.1 0.1 0.01  
  C++ Note: values checked 0.1 0.1 0.01  
  C++ Note: sums checked 1229.91 1229.91 1016.5  
  C++ Note: dose checked 1000 1000 1000  
  C++ Note: non-dose checked 1229.91 1229.91 1016.5  
  C++ Note: LIN_non-dose checked 1000 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000 1000  
  C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5  
  C++ Note: risk checked 135.17  
  C++ Note: df101 -467.661 -467.661 -467.661  
  C++ Note: df104 0.1 0.1 0.01  
  C++ Note: Checking Deviance 707.321
  C++ Note: df100 7951 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:04 2024
  
  C++ Note: values checked 0.1 0.1 0.01  
  C++ Note: sums checked 1229.91 1229.91 1016.5  
  C++ Note: dose checked 1000 1000 1000  
  C++ Note: non-dose checked 1229.91 1229.91 1016.5  
  C++ Note: LIN_non-dose checked 1000 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000 1000  
  C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5  
  C++ Note: risk checked 135.17  
  C++ Note: df101 -467.661 -467.661 -467.661  
  C++ Note: df104 0.1 0.1 0.01  
  C++ Note: Checking Deviance 707.321
  C++ Note: df100 8734 2 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:04 2024
  
  C++ Note: values checked 0.1 0.1 0.01  
  C++ Note: sums checked 1229.91 1229.91 1016.5  
  C++ Note: dose checked 1000 1000 1000  
  C++ Note: non-dose checked 1229.91 1229.91 1016.5  
  C++ Note: LIN_non-dose checked 1000 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000 1000  
  C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5  
  C++ Note: risk checked 135.17  
  C++ Note: df101 -467.661 -467.661 -467.661  
  C++ Note: df104 0.1 0.1 0.01  
  C++ Note: Checking Deviance 707.321
  C++ Note: df100 9462 3 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:04 2024
  
  C++ Note: values checked 0.1 0.1 0.01  
  C++ Note: sums checked 1229.91 1229.91 1016.5  
  C++ Note: dose checked 1000 1000 1000  
  C++ Note: non-dose checked 1229.91 1229.91 1016.5  
  C++ Note: LIN_non-dose checked 1000 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000 1000  
  C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5  
  C++ Note: risk checked 135.17  
  C++ Note: df101 -467.661 -467.661 -467.661  
  C++ Note: df104 0.1 0.1 0.01  
  C++ Note: Checking Deviance 707.321
  C++ Note: df100 10192 4 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:04 2024
  
  C++ Note: values checked 0.1 0.1 0.01  
  C++ Note: sums checked 1229.91 1229.91 1016.5  
  C++ Note: dose checked 1000 1000 1000  
  C++ Note: non-dose checked 1229.91 1229.91 1016.5  
  C++ Note: LIN_non-dose checked 1000 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000 1000  
  C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5  
  C++ Note: risk checked 135.17  
  C++ Note: df101 -467.661 -467.661 -467.661  
  C++ Note: df104 0.1 0.1 0.01  
  C++ Note: Checking Deviance 707.321
  C++ Note: df100 10914 5 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:04 2024
  
  C++ Note: df100 10989 0 0 0,Update_Calc
  C++ Note: Current Time, Fri Feb 23 05:59:04 2024
  
  C++ Note: df101 -467.6607 -467.6607 -467.6607  
  C++ Note: df104 0.1 0.1 0.01  
  C++ Note: df101 -467.661 -467.661 -467.661  
  C++ Note: df104 0.1 0.1 0.01  
  C++ Note: Checking Deviance 707.321
  C++ Note: ending guess 0
  C++ Note: df501 -467.6607
  C++ Note: df504 0.1 0.1 0.01  
  C++ Note: Refreshing matrices after all guesses
  C++ Note: Guess Results
  Guess number, parameter values, Log-Likelihood
  0, 0.1 0.1 0.01, -467.6607<-- Best Guess
  C++ Note: starting subterms 3 in best guess 0
  C++ Note: values checked 0.1 0.1 0.01  
  C++ Note: sums checked 1229.91 1229.91 1016.5  
  C++ Note: dose checked 1000 1000 1000  
  C++ Note: non-dose checked 1229.91 1229.91 1016.5  
  C++ Note: LIN_non-dose checked 1000 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000 1000  
  C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5  
  C++ Note: risk checked 135.17  
  C++ Note: Made Risk Side Lists
  C++ Note: df101 -467.661 -467.661 -467.661  
  C++ Note: df104 0.1 0.1 0.01  
  C++ Note: Checking Deviance 707.321
  C++ Note: Starting Halves
  C++ Note: df501 -467.6607
  C++ Note: df504 0.1 0.1 0.01  
  C++ Note: values checked 0.1 0.1 0.01  
  C++ Note: sums checked 1229.91 1229.91 1016.5  
  C++ Note: dose checked 1000 1000 1000  
  C++ Note: non-dose checked 1229.91 1229.91 1016.5  
  C++ Note: LIN_non-dose checked 1000 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000 1000  
  C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5  
  C++ Note: risk checked 135.17  
  C++ Note: df101 -467.661 -467.661 -467.661  
  C++ Note: df104 0.1 0.1 0.01  
  C++ Note: Checking Deviance 707.321
  C++ Note: df100 12959 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:04 2024
  
  C++ Note: values checked 0.1 0.1 0.01  
  C++ Note: sums checked 1229.91 1229.91 1016.5  
  C++ Note: dose checked 1000 1000 1000  
  C++ Note: non-dose checked 1229.91 1229.91 1016.5  
  C++ Note: LIN_non-dose checked 1000 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000 1000  
  C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5  
  C++ Note: risk checked 135.17  
  C++ Note: df101 -467.661 -467.661 -467.661  
  C++ Note: df104 0.1 0.1 0.01  
  C++ Note: Checking Deviance 707.321
  C++ Note: df100 13698 2 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:04 2024
  
  C++ Note: values checked 0.1 0.1 0.01  
  C++ Note: sums checked 1229.91 1229.91 1016.5  
  C++ Note: dose checked 1000 1000 1000  
  C++ Note: non-dose checked 1229.91 1229.91 1016.5  
  C++ Note: LIN_non-dose checked 1000 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000 1000  
  C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5  
  C++ Note: risk checked 135.17  
  C++ Note: df101 -467.661 -467.661 -467.661  
  C++ Note: df104 0.1 0.1 0.01  
  C++ Note: Checking Deviance 707.321
  C++ Note: df100 14400 3 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:04 2024
  
  C++ Note: values checked 0.1 0.1 0.01  
  C++ Note: sums checked 1229.91 1229.91 1016.5  
  C++ Note: dose checked 1000 1000 1000  
  C++ Note: non-dose checked 1229.91 1229.91 1016.5  
  C++ Note: LIN_non-dose checked 1000 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000 1000  
  C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5  
  C++ Note: risk checked 135.17  
  C++ Note: df101 -467.661 -467.661 -467.661  
  C++ Note: df104 0.1 0.1 0.01  
  C++ Note: Checking Deviance 707.321
  C++ Note: df100 15030 4 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:04 2024
  
  C++ Note: values checked 0.1 0.1 0.01  
  C++ Note: sums checked 1229.91 1229.91 1016.5  
  C++ Note: dose checked 1000 1000 1000  
  C++ Note: non-dose checked 1229.91 1229.91 1016.5  
  C++ Note: LIN_non-dose checked 1000 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000 1000  
  C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5  
  C++ Note: risk checked 135.17  
  C++ Note: df101 -467.661 -467.661 -467.661  
  C++ Note: df104 0.1 0.1 0.01  
  C++ Note: Checking Deviance 707.321
  C++ Note: df100 15699 5 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:04 2024
  
  C++ Note: df100 15766 0 0 0,Update_Calc
  C++ Note: Current Time, Fri Feb 23 05:59:04 2024
  
  C++ Note: df101 -467.6607 -467.6607 -467.6607  
  C++ Note: df104 0.1 0.1 0.01  
  C++ Note: df101 -467.661 -467.661 -467.661  
  C++ Note: df104 0.1 0.1 0.01  
  C++ Note: Checking Deviance 707.321
  C++ Note: df501 -467.6607
  C++ Note: df504 0.1 0.1 0.01  
  Warning: model covariate order changed
  C++ Note: START_POIS_GUESS
  C++ Note: Current Time, Fri Feb 23 05:59:04 2024
  
  C++ Note: Term checked 0 1 2  
  C++ Note: df99,110,Starting
  C++ Note: Current Time, Fri Feb 23 05:59:04 2024
  
  C++ Note: starting subterms 3 in guess 0
  C++ Note: values checked 0.1 0.1 0.01  
  C++ Note: sums checked 1229.91 1229.91 1016.5  
  C++ Note: dose checked 1000 1000 1000  
  C++ Note: non-dose checked 1229.91 1229.91 1016.5  
  C++ Note: LIN_non-dose checked 1000 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000 1000  
  C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5  
  C++ Note: risk checked 116.849  
  C++ Note: df101 -463.51 -463.51 -463.51  
  C++ Note: df104 0.1 0.1 0.01  
  C++ Note: Checking Deviance 699.02
  C++ Note: Starting Halves
  C++ Note: df501 -463.5098
  C++ Note: df504 0.1 0.1 0.01  
  C++ Note: values checked 0.1 0.1 0.01  
  C++ Note: sums checked 1229.91 1229.91 1016.5  
  C++ Note: dose checked 1000 1000 1000  
  C++ Note: non-dose checked 1229.91 1229.91 1016.5  
  C++ Note: LIN_non-dose checked 1000 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000 1000  
  C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5  
  C++ Note: risk checked 116.849  
  C++ Note: df101 -463.51 -463.51 -463.51  
  C++ Note: df104 0.1 0.1 0.01  
  C++ Note: Checking Deviance 699.02
  C++ Note: df100 1831 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:04 2024
  
  C++ Note: values checked 0.1 0.1 0.01  
  C++ Note: sums checked 1229.91 1229.91 1016.5  
  C++ Note: dose checked 1000 1000 1000  
  C++ Note: non-dose checked 1229.91 1229.91 1016.5  
  C++ Note: LIN_non-dose checked 1000 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000 1000  
  C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5  
  C++ Note: risk checked 116.849  
  C++ Note: df101 -463.51 -463.51 -463.51  
  C++ Note: df104 0.1 0.1 0.01  
  C++ Note: Checking Deviance 699.02
  C++ Note: df100 2559 2 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:04 2024
  
  C++ Note: values checked 0.1 0.1 0.01  
  C++ Note: sums checked 1229.91 1229.91 1016.5  
  C++ Note: dose checked 1000 1000 1000  
  C++ Note: non-dose checked 1229.91 1229.91 1016.5  
  C++ Note: LIN_non-dose checked 1000 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000 1000  
  C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5  
  C++ Note: risk checked 116.849  
  C++ Note: df101 -463.51 -463.51 -463.51  
  C++ Note: df104 0.1 0.1 0.01  
  C++ Note: Checking Deviance 699.02
  C++ Note: df100 11858 3 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:04 2024
  
  C++ Note: values checked 0.1 0.1 0.01  
  C++ Note: sums checked 1229.91 1229.91 1016.5  
  C++ Note: dose checked 1000 1000 1000  
  C++ Note: non-dose checked 1229.91 1229.91 1016.5  
  C++ Note: LIN_non-dose checked 1000 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000 1000  
  C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5  
  C++ Note: risk checked 116.849  
  C++ Note: df101 -463.51 -463.51 -463.51  
  C++ Note: df104 0.1 0.1 0.01  
  C++ Note: Checking Deviance 699.02
  C++ Note: df100 12626 4 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:04 2024
  
  C++ Note: values checked 0.1 0.1 0.01  
  C++ Note: sums checked 1229.91 1229.91 1016.5  
  C++ Note: dose checked 1000 1000 1000  
  C++ Note: non-dose checked 1229.91 1229.91 1016.5  
  C++ Note: LIN_non-dose checked 1000 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000 1000  
  C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5  
  C++ Note: risk checked 116.849  
  C++ Note: df101 -463.51 -463.51 -463.51  
  C++ Note: df104 0.1 0.1 0.01  
  C++ Note: Checking Deviance 699.02
  C++ Note: df100 13344 5 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:04 2024
  
  C++ Note: df100 13417 0 0 0,Update_Calc
  C++ Note: Current Time, Fri Feb 23 05:59:04 2024
  
  C++ Note: df101 -463.5098 -463.5098 -463.5098  
  C++ Note: df104 0.1 0.1 0.01  
  C++ Note: df101 -463.51 -463.51 -463.51  
  C++ Note: df104 0.1 0.1 0.01  
  C++ Note: Checking Deviance 699.02
  C++ Note: ending guess 0
  C++ Note: df501 -463.5098
  C++ Note: df504 0.1 0.1 0.01  
  C++ Note: Refreshing matrices after all guesses
  C++ Note: Guess Results
  Guess number, parameter values, Log-Likelihood
  0, 0.1 0.1 0.01, -463.5098<-- Best Guess
  C++ Note: starting subterms 3 in best guess 0
  C++ Note: values checked 0.1 0.1 0.01  
  C++ Note: sums checked 1229.91 1229.91 1016.5  
  C++ Note: dose checked 1000 1000 1000  
  C++ Note: non-dose checked 1229.91 1229.91 1016.5  
  C++ Note: LIN_non-dose checked 1000 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000 1000  
  C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5  
  C++ Note: risk checked 116.849  
  C++ Note: Made Risk Side Lists
  C++ Note: df101 -463.51 -463.51 -463.51  
  C++ Note: df104 0.1 0.1 0.01  
  C++ Note: Checking Deviance 699.02
  C++ Note: Starting Halves
  C++ Note: df501 -463.5098
  C++ Note: df504 0.1 0.1 0.01  
  C++ Note: values checked 0.1 0.1 0.01  
  C++ Note: sums checked 1229.91 1229.91 1016.5  
  C++ Note: dose checked 1000 1000 1000  
  C++ Note: non-dose checked 1229.91 1229.91 1016.5  
  C++ Note: LIN_non-dose checked 1000 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000 1000  
  C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5  
  C++ Note: risk checked 116.849  
  C++ Note: df101 -463.51 -463.51 -463.51  
  C++ Note: df104 0.1 0.1 0.01  
  C++ Note: Checking Deviance 699.02
  C++ Note: df100 31903 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:04 2024
  
  C++ Note: values checked 0.1 0.1 0.01  
  C++ Note: sums checked 1229.91 1229.91 1016.5  
  C++ Note: dose checked 1000 1000 1000  
  C++ Note: non-dose checked 1229.91 1229.91 1016.5  
  C++ Note: LIN_non-dose checked 1000 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000 1000  
  C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5  
  C++ Note: risk checked 116.849  
  C++ Note: df101 -463.51 -463.51 -463.51  
  C++ Note: df104 0.1 0.1 0.01  
  C++ Note: Checking Deviance 699.02
  C++ Note: df100 32710 2 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:04 2024
  
  C++ Note: values checked 0.1 0.1 0.01  
  C++ Note: sums checked 1229.91 1229.91 1016.5  
  C++ Note: dose checked 1000 1000 1000  
  C++ Note: non-dose checked 1229.91 1229.91 1016.5  
  C++ Note: LIN_non-dose checked 1000 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000 1000  
  C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5  
  C++ Note: risk checked 116.849  
  C++ Note: df101 -463.51 -463.51 -463.51  
  C++ Note: df104 0.1 0.1 0.01  
  C++ Note: Checking Deviance 699.02
  C++ Note: df100 33455 3 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:04 2024
  
  C++ Note: values checked 0.1 0.1 0.01  
  C++ Note: sums checked 1229.91 1229.91 1016.5  
  C++ Note: dose checked 1000 1000 1000  
  C++ Note: non-dose checked 1229.91 1229.91 1016.5  
  C++ Note: LIN_non-dose checked 1000 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000 1000  
  C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5  
  C++ Note: risk checked 116.849  
  C++ Note: df101 -463.51 -463.51 -463.51  
  C++ Note: df104 0.1 0.1 0.01  
  C++ Note: Checking Deviance 699.02
  C++ Note: df100 34198 4 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:04 2024
  
  C++ Note: values checked 0.1 0.1 0.01  
  C++ Note: sums checked 1229.91 1229.91 1016.5  
  C++ Note: dose checked 1000 1000 1000  
  C++ Note: non-dose checked 1229.91 1229.91 1016.5  
  C++ Note: LIN_non-dose checked 1000 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000 1000  
  C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5  
  C++ Note: risk checked 116.849  
  C++ Note: df101 -463.51 -463.51 -463.51  
  C++ Note: df104 0.1 0.1 0.01  
  C++ Note: Checking Deviance 699.02
  C++ Note: df100 34955 5 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:04 2024
  
  C++ Note: df100 35034 0 0 0,Update_Calc
  C++ Note: Current Time, Fri Feb 23 05:59:04 2024
  
  C++ Note: df101 -463.5098 -463.5098 -463.5098  
  C++ Note: df104 0.1 0.1 0.01  
  C++ Note: df101 -463.51 -463.51 -463.51  
  C++ Note: df104 0.1 0.1 0.01  
  C++ Note: Checking Deviance 699.02
  C++ Note: df501 -463.5098
  C++ Note: df504 0.1 0.1 0.01  
  Warning: model covariate order changed
  C++ Note: START_POIS_GUESS
  C++ Note: Current Time, Fri Feb 23 05:59:04 2024
  
  C++ Note: Term checked 0 1 2  
  C++ Note: df99,81,Starting
  C++ Note: Current Time, Fri Feb 23 05:59:04 2024
  
  C++ Note: starting subterms 3 in guess 0
  C++ Note: values checked 0.1 0.1 0.01  
  C++ Note: sums checked 1229.91 1229.91 1016.5  
  C++ Note: derivs checked 2662.16 2662.16 1673.67  
  C++ Note: second derivs checked 8088.51 8088.51 4753.83  
  C++ Note: dose checked 1000 1000 1000  
  C++ Note: non-dose checked 1229.91 1229.91 1016.5  
  C++ Note: LIN_non-dose checked 1000 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000 1000  
  C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5  
  C++ Note: risk checked 135.17  
  C++ Note: risk1 checked 302.14 121.78 68.7623  
  C++ Note: risk2 checked 928.77 380.955 194.839  
  C++ Note: df101 -467.661 -467.661 -467.661  
  C++ Note: df102 -94.3101 -39.4194 -9.93487  
  C++ Note: df103 -1040.45 -259.573 -93.8514  
  C++ Note: df104 0.1 0.1 0.01  
  C++ Note: Checking Deviance 707.321
  C++ Note: df105 0.0906437 0.151862 0.105857  
  C++ Note: df106 4.95875 11.8637 47.0727  
  C++ Note: Starting Halves
  C++ Note: df501 -467.6607
  C++ Note: df504 0.1 0.1 0.01  
  C++ Note: values checked 0.0320172 -0.0138968 -0.0693931  
  C++ Note: sums checked 1066.29 973.12 897.344  
  C++ Note: derivs checked 2170.09 1895.1 1342.81  
  C++ Note: second derivs checked 6452.98 5549.74 3636.92  
  C++ Note: dose checked 1000 1000 1000  
  C++ Note: non-dose checked 1066.29 973.12 897.344  
  C++ Note: LIN_non-dose checked 1000 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000 1000  
  C++ Note: LOGLIN_non-dose checked 1066.29 973.12 897.344  
  C++ Note: risk checked 102.86  
  C++ Note: risk1 checked 208.566 69.9862 48.0225  
  C++ Note: risk2 checked 619.655 207.132 129.963  
  C++ Note: df101 -463.451 -463.451 -463.451  
  C++ Note: df102 10.3802 4.17009 9.3252  
  C++ Note: df103 -694.198 -76.4056 -27.9422  
  C++ Note: df104 0.0320172 -0.0138968 -0.0693931  
  C++ Note: Checking Deviance 698.903
  C++ Note: df105 -0.0149527 -0.0545783 -0.333732  
  C++ Note: df106 -44.6478 -111.137 -49.6988  
  C++ Note: df100 3152 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:04 2024
  
  C++ Note: df100 3237 0 0 0,Update_Calc
  C++ Note: Current Time, Fri Feb 23 05:59:04 2024
  
  C++ Note: df101 -463.4514 -463.4514 -463.4514  
  C++ Note: df102 10.38017 4.170085 9.325204  
  C++ Note: df103 -694.1983 -76.40556 -27.94216  
  C++ Note: df104 0.03201725 -0.01389683 -0.06939307  
  C++ Note: Checking Deviance 698.9028
  C++ Note: df105 -0.01495275 -0.05457829 -0.3337324  
  C++ Note: df106 -44.64776 -111.1372 -49.69879  
  C++ Note: df101 -463.451 -463.451 -463.451  
  C++ Note: df102 10.3802 4.17009 9.3252  
  C++ Note: df103 -694.198 -76.4056 -27.9422  
  C++ Note: df104 0.0320172 -0.0138968 -0.0693931  
  C++ Note: Checking Deviance 698.903
  C++ Note: df105 -0.0149527 -0.0545783 -0.333732  
  C++ Note: df106 -44.6478 -111.137 -49.6988  
  C++ Note: ending guess 0
  C++ Note: df501 -463.4514
  C++ Note: df504 0.03201725 -0.01389683 -0.06939307  
  C++ Note: Refreshing matrices after all guesses
  C++ Note: Guess Results
  Guess number, parameter values, Log-Likelihood
  0, 0.03201725 -0.01389683 -0.06939307, -463.4514<-- Best Guess
  C++ Note: starting subterms 3 in best guess 0
  C++ Note: values checked 0.0320172 -0.0138968 -0.0693931  
  C++ Note: sums checked 1066.29 973.12 897.344  
  C++ Note: derivs checked 2170.09 1895.1 1342.81  
  C++ Note: second derivs checked 6452.98 5549.74 3636.92  
  C++ Note: dose checked 1000 1000 1000  
  C++ Note: non-dose checked 1066.29 973.12 897.344  
  C++ Note: LIN_non-dose checked 1000 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000 1000  
  C++ Note: LOGLIN_non-dose checked 1066.29 973.12 897.344  
  C++ Note: risk checked 102.86  
  C++ Note: risk1 checked 208.566 69.9862 48.0225  
  C++ Note: risk2 checked 619.655 207.132 129.963  
  C++ Note: Made Risk Side Lists
  C++ Note: df101 -463.451 -463.451 -463.451  
  C++ Note: df102 10.3802 4.17009 9.3252  
  C++ Note: df103 -694.198 -76.4056 -27.9422  
  C++ Note: df104 0.0320172 -0.0138968 -0.0693931  
  C++ Note: Checking Deviance 698.903
  C++ Note: df105 -0.0149527 -0.0545783 -0.333732  
  C++ Note: df106 -44.6478 -111.137 -49.6988  
  C++ Note: Starting Halves
  C++ Note: df501 -463.4514
  C++ Note: df504 0.03201725 -0.01389683 -0.06939307  
  C++ Note: values checked 0.0432318 0.0270369 0.180906  
  C++ Note: sums checked 1091.03 1055.56 1388.12  
  C++ Note: derivs checked 2243.81 2138.21 2787.22  
  C++ Note: second derivs checked 6696.56 6347.84 8719.98  
  C++ Note: dose checked 1000 1000 1000  
  C++ Note: non-dose checked 1091.03 1055.56 1388.12  
  C++ Note: LIN_non-dose checked 1000 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000 1000  
  C++ Note: LOGLIN_non-dose checked 1091.03 1055.56 1388.12  
  C++ Note: risk checked 126.33  
  C++ Note: risk1 checked 260.899 81.7736 101.847  
  C++ Note: risk2 checked 778.474 246.131 318.199  
  C++ Note: df101 -464.18 -464.18 -464.18  
  C++ Note: df102 -47.7167 -15.934 -19.8545  
  C++ Note: df103 -870.336 -126.985 -214.851  
  C++ Note: df104 0.0432318 0.0270369 0.180906  
  C++ Note: Checking Deviance 700.36
  C++ Note: df105 0.0548256 0.125479 0.0924107  
  C++ Note: df106 9.72783 29.1314 23.379  
  C++ Note: df100 6738 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:04 2024
  
  C++ Note: values checked 0.0376245 0.00657003 0.0557566  
  C++ Note: sums checked 1078.56 1013.1 1098.33  
  C++ Note: derivs checked 2206.61 2012.57 1909.31  
  C++ Note: second derivs checked 6573.57 5934.53 5569.82  
  C++ Note: dose checked 1000 1000 1000  
  C++ Note: non-dose checked 1078.56 1013.1 1098.33  
  C++ Note: LIN_non-dose checked 1000 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000 1000  
  C++ Note: LOGLIN_non-dose checked 1078.56 1013.1 1098.33  
  C++ Note: risk checked 112.808  
  C++ Note: risk1 checked 231.02 75.6258 69.025  
  C++ Note: risk2 checked 688.083 225.739 201.15  
  C++ Note: df101 -462.759 -462.759 -462.759  
  C++ Note: df102 -14.5654 -5.21187 0.637868  
  C++ Note: df103 -770.184 -99.8931 -90.8891  
  C++ Note: df104 0.0376245 0.00657003 0.0557566  
  C++ Note: Checking Deviance 697.518
  C++ Note: df105 0.0189115 0.0521745 -0.00701809  
  C++ Note: df106 31.7712 88.7894 -725.478  
  C++ Note: df100 8103 2 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:04 2024
  
  C++ Note: df100 8192 0 0 0,Update_Calc
  C++ Note: Current Time, Fri Feb 23 05:59:04 2024
  
  C++ Note: df101 -462.7591 -462.7591 -462.7591  
  C++ Note: df102 -14.56536 -5.211874 0.6378678  
  C++ Note: df103 -770.1842 -99.89313 -90.88914  
  C++ Note: df104 0.03762453 0.006570034 0.05575656  
  C++ Note: Checking Deviance 697.5182
  C++ Note: df105 0.01891153 0.0521745 -0.007018085  
  C++ Note: df106 31.7712 88.78939 -725.4781  
  C++ Note: df101 -462.759 -462.759 -462.759  
  C++ Note: df102 -14.5654 -5.21187 0.637868  
  C++ Note: df103 -770.184 -99.8931 -90.8891  
  C++ Note: df104 0.0376245 0.00657003 0.0557566  
  C++ Note: Checking Deviance 697.518
  C++ Note: df105 0.0189115 0.0521745 -0.00701809  
  C++ Note: df106 31.7712 88.7894 -725.478  
  C++ Note: df501 -462.7591
  C++ Note: df504 0.03762453 0.006570034 0.05575656  
  Warning: model covariate order changed
  C++ Note: START_POIS_GUESS
  C++ Note: Current Time, Fri Feb 23 05:59:04 2024
  
  C++ Note: Term checked 0 1 2  
  C++ Note: df99,16143,Starting
  C++ Note: Current Time, Fri Feb 23 05:59:04 2024
  
  C++ Note: starting subterms 3 in guess 0
  C++ Note: values checked 0.1 0.1 0.01  
  C++ Note: sums checked 1229.91 1229.91 1016.5  
  C++ Note: derivs checked 2662.16 2662.16 1673.67  
  C++ Note: second derivs checked 8088.51 8088.51 4753.83  
  C++ Note: dose checked 1000 1000 1000  
  C++ Note: non-dose checked 1229.91 1229.91 1016.5  
  C++ Note: LIN_non-dose checked 1000 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000 1000  
  C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5  
  C++ Note: risk checked 58.4243  
  C++ Note: risk1 checked 44.7331 44.7331 28.109  
  C++ Note: risk2 checked 135.895 135.895 79.8278  
  C++ Note: df101 -476.566 -476.566 -476.566  
  C++ Note: df102 38.0843 38.0843 31.1135  
  C++ Note: df103 8.9011 8.9011 29.7803  
  C++ Note: df104 0.1 0.1 0.01  
  C++ Note: Checking Deviance 725.133
  C++ Note: df105 4.27861 4.27861 1.04477  
  C++ Note: df106 -12.5134 -12.5134 -15.317  
  C++ Note: Starting Halves
  C++ Note: df501 -476.5664
  C++ Note: df504 0.1 0.1 0.01  
  C++ Note: values checked -0.9 -0.9 -0.773576  
  C++ Note: sums checked 332.131 332.131 440.781  
  C++ Note: derivs checked 214.877 214.877 288.504  
  C++ Note: second derivs checked 428.076 428.076 498.731  
  C++ Note: dose checked 1000 1000 1000  
  C++ Note: non-dose checked 332.131 332.131 440.781  
  C++ Note: LIN_non-dose checked 1000 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000 1000  
  C++ Note: LOGLIN_non-dose checked 332.131 332.131 440.781  
  C++ Note: risk checked 18.5778  
  C++ Note: risk1 checked 3.6124 3.6124 4.84827  
  C++ Note: risk2 checked 7.19479 7.19479 8.37644  
  C++ Note: df101 -622.059 -622.059 -622.059  
  C++ Note: df102 46.447 46.447 70.436  
  C++ Note: df103 87.3905 87.3905 79.6545  
  C++ Note: df104 -0.9 -0.9 -0.773576  
  C++ Note: Checking Deviance 1016.12
  C++ Note: df105 0.531488 0.531488 0.884269  
  C++ Note: df106 -13.3929 -13.3929 -8.83155  
  C++ Note: df100 22660 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:04 2024
  
  C++ Note: values checked -0.4 -0.4 -0.381788  
  C++ Note: sums checked 526.466 526.466 608.26  
  C++ Note: derivs checked 661.348 661.348 622.665  
  C++ Note: second derivs checked 1665.05 1665.05 1383.89  
  C++ Note: dose checked 1000 1000 1000  
  C++ Note: non-dose checked 526.466 526.466 608.26  
  C++ Note: LIN_non-dose checked 1000 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000 1000  
  C++ Note: LOGLIN_non-dose checked 526.466 526.466 608.26  
  C++ Note: risk checked 27.9248  
  C++ Note: risk1 checked 11.1154 11.1154 10.4601  
  C++ Note: risk2 checked 27.9794 27.9794 23.2394  
  C++ Note: df101 -545.945 -545.945 -545.945  
  C++ Note: df102 55.7221 55.7221 54.8164  
  C++ Note: df103 101.637 101.637 78.7808  
  C++ Note: df104 -0.4 -0.4 -0.381788  
  C++ Note: Checking Deviance 863.889
  C++ Note: df105 0.548245 0.548245 0.69581  
  C++ Note: df106 -9.79764 -9.79764 -9.9595  
  C++ Note: df100 23957 2 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:04 2024
  
  C++ Note: values checked -0.15 -0.15 -0.185894  
  C++ Note: sums checked 759.794 759.794 762.724  
  C++ Note: derivs checked 1284.16 1284.16 990.331  
  C++ Note: second derivs checked 3581.38 3581.38 2495.47  
  C++ Note: dose checked 1000 1000 1000  
  C++ Note: non-dose checked 759.794 759.794 762.724  
  C++ Note: LIN_non-dose checked 1000 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000 1000  
  C++ Note: LOGLIN_non-dose checked 759.794 759.794 762.724  
  C++ Note: risk checked 38.3621  
  C++ Note: risk1 checked 21.5805 21.5805 16.6341  
  C++ Note: risk2 checked 60.1758 60.1758 41.9048  
  C++ Note: df101 -508.21 -508.21 -508.21  
  C++ Note: df102 54.5798 54.5798 44.7273  
  C++ Note: df103 82.9709 82.9709 66.0113  
  C++ Note: df104 -0.15 -0.15 -0.185894  
  C++ Note: Checking Deviance 788.42
  C++ Note: df105 0.657819 0.657819 0.67757  
  C++ Note: df106 -9.31131 -9.31131 -11.3624  
  C++ Note: df100 25253 3 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:04 2024
  
  C++ Note: values checked -0.025 -0.025 -0.087947  
  C++ Note: sums checked 952.416 952.416 873.043  
  C++ Note: derivs checked 1834.58 1834.58 1277.36  
  C++ Note: second derivs checked 5352.21 5352.21 3420.71  
  C++ Note: dose checked 1000 1000 1000  
  C++ Note: non-dose checked 952.416 952.416 873.043  
  C++ Note: LIN_non-dose checked 1000 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000 1000  
  C++ Note: LOGLIN_non-dose checked 952.416 952.416 873.043  
  C++ Note: risk checked 46.6889  
  C++ Note: risk1 checked 30.8287 30.8287 21.454  
  C++ Note: risk2 checked 89.926 89.926 57.4416  
  C++ Note: df101 -491.052 -491.052 -491.052  
  C++ Note: df102 49.2027 49.2027 38.6036  
  C++ Note: df103 55.9231 55.9231 52.1823  
  C++ Note: df104 -0.025 -0.025 -0.087947  
  C++ Note: Checking Deviance 754.104
  C++ Note: df105 0.879828 0.879828 0.739785  
  C++ Note: df106 -9.98019 -9.98019 -12.7204  
  C++ Note: df100 26516 4 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:04 2024
  
  C++ Note: values checked 0.0375 0.0375 -0.0389735  
  C++ Note: sums checked 1078.28 1078.28 939.932  
  C++ Note: derivs checked 2205.79 2205.79 1459.24  
  C++ Note: second derivs checked 6570.87 6570.87 4025.66  
  C++ Note: dose checked 1000 1000 1000  
  C++ Note: non-dose checked 1078.28 1078.28 939.932  
  C++ Note: LIN_non-dose checked 1000 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000 1000  
  C++ Note: LOGLIN_non-dose checked 1078.28 1078.28 939.932  
  C++ Note: risk checked 52.0424  
  C++ Note: risk1 checked 37.0656 37.0656 24.5083  
  C++ Note: risk2 checked 110.399 110.399 67.6001  
  C++ Note: df101 -483.372 -483.372 -483.372  
  C++ Note: df102 44.5211 44.5211 35.0775  
  C++ Note: df103 35.4395 35.4395 42.2881  
  C++ Note: df104 0.0375 0.0375 -0.0389735  
  C++ Note: Checking Deviance 738.745
  C++ Note: df105 1.25625 1.25625 0.829489  
  C++ Note: df106 -10.8572 -10.8572 -13.7801  
  C++ Note: df100 49269 5 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:04 2024
  
  C++ Note: Changing back to best
  C++ Note: values checked 0.1 0.1 0.01  
  C++ Note: sums checked 1229.91 1229.91 1016.5  
  C++ Note: derivs checked 2662.16 2662.16 1673.67  
  C++ Note: second derivs checked 8088.51 8088.51 4753.83  
  C++ Note: dose checked 1000 1000 1000  
  C++ Note: non-dose checked 1229.91 1229.91 1016.5  
  C++ Note: LIN_non-dose checked 1000 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000 1000  
  C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5  
  C++ Note: risk checked 58.4243  
  C++ Note: risk1 checked 44.7331 44.7331 28.109  
  C++ Note: risk2 checked 135.895 135.895 79.8278  
  C++ Note: df101 -476.566 -476.566 -476.566  
  C++ Note: df102 38.0843 38.0843 31.1135  
  C++ Note: df103 8.9011 8.9011 29.7803  
  C++ Note: df104 0.1 0.1 0.01  
  C++ Note: Checking Deviance 725.133
  C++ Note: df105 4.27861 4.27861 1.04477  
  C++ Note: df106 -12.5134 -12.5134 -15.317  
  C++ Note: df100 50550 0 0 0,Update_Calc
  C++ Note: Current Time, Fri Feb 23 05:59:04 2024
  
  C++ Note: df101 -476.5664 -476.5664 -476.5664  
  C++ Note: df102 38.08434 38.08434 31.11351  
  C++ Note: df103 8.901104 8.901104 29.78032  
  C++ Note: df104 0.1 0.1 0.01  
  C++ Note: Checking Deviance 725.1328
  C++ Note: df105 4.278608 4.278608 1.044768  
  C++ Note: df106 -12.51345 -12.51345 -15.31702  
  C++ Note: df101 -476.566 -476.566 -476.566  
  C++ Note: df102 38.0843 38.0843 31.1135  
  C++ Note: df103 8.9011 8.9011 29.7803  
  C++ Note: df104 0.1 0.1 0.01  
  C++ Note: Checking Deviance 725.133
  C++ Note: df105 4.27861 4.27861 1.04477  
  C++ Note: df106 -12.5134 -12.5134 -15.317  
  C++ Note: ending guess 0
  C++ Note: df501 -476.5664
  C++ Note: df504 0.1 0.1 0.01  
  C++ Note: Refreshing matrices after all guesses
  C++ Note: Guess Results
  Guess number, parameter values, Log-Likelihood
  0, 0.1 0.1 0.01, -476.5664<-- Best Guess
  C++ Note: starting subterms 3 in best guess 0
  C++ Note: values checked 0.1 0.1 0.01  
  C++ Note: sums checked 1229.91 1229.91 1016.5  
  C++ Note: derivs checked 2662.16 2662.16 1673.67  
  C++ Note: second derivs checked 8088.51 8088.51 4753.83  
  C++ Note: dose checked 1000 1000 1000  
  C++ Note: non-dose checked 1229.91 1229.91 1016.5  
  C++ Note: LIN_non-dose checked 1000 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000 1000  
  C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5  
  C++ Note: risk checked 58.4243  
  C++ Note: risk1 checked 44.7331 44.7331 28.109  
  C++ Note: risk2 checked 135.895 135.895 79.8278  
  C++ Note: Made Risk Side Lists
  C++ Note: df101 -476.566 -476.566 -476.566  
  C++ Note: df102 38.0843 38.0843 31.1135  
  C++ Note: df103 8.9011 8.9011 29.7803  
  C++ Note: df104 0.1 0.1 0.01  
  C++ Note: Checking Deviance 725.133
  C++ Note: df105 4.27861 4.27861 1.04477  
  C++ Note: df106 -12.5134 -12.5134 -15.317  
  C++ Note: Starting Halves
  C++ Note: df501 -476.5664
  C++ Note: df504 0.1 0.1 0.01  
  C++ Note: values checked -0.9 -0.9 -0.773576  
  C++ Note: sums checked 332.131 332.131 440.781  
  C++ Note: derivs checked 214.877 214.877 288.504  
  C++ Note: second derivs checked 428.076 428.076 498.731  
  C++ Note: dose checked 1000 1000 1000  
  C++ Note: non-dose checked 332.131 332.131 440.781  
  C++ Note: LIN_non-dose checked 1000 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000 1000  
  C++ Note: LOGLIN_non-dose checked 332.131 332.131 440.781  
  C++ Note: risk checked 18.5778  
  C++ Note: risk1 checked 3.6124 3.6124 4.84827  
  C++ Note: risk2 checked 7.19479 7.19479 8.37644  
  C++ Note: df101 -622.059 -622.059 -622.059  
  C++ Note: df102 46.447 46.447 70.436  
  C++ Note: df103 87.3905 87.3905 79.6545  
  C++ Note: df104 -0.9 -0.9 -0.773576  
  C++ Note: Checking Deviance 1016.12
  C++ Note: df105 0.531488 0.531488 0.884269  
  C++ Note: df106 -13.3929 -13.3929 -8.83155  
  C++ Note: df100 53717 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:04 2024
  
  C++ Note: values checked -0.4 -0.4 -0.381788  
  C++ Note: sums checked 526.466 526.466 608.26  
  C++ Note: derivs checked 661.348 661.348 622.665  
  C++ Note: second derivs checked 1665.05 1665.05 1383.89  
  C++ Note: dose checked 1000 1000 1000  
  C++ Note: non-dose checked 526.466 526.466 608.26  
  C++ Note: LIN_non-dose checked 1000 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000 1000  
  C++ Note: LOGLIN_non-dose checked 526.466 526.466 608.26  
  C++ Note: risk checked 27.9248  
  C++ Note: risk1 checked 11.1154 11.1154 10.4601  
  C++ Note: risk2 checked 27.9794 27.9794 23.2394  
  C++ Note: df101 -545.945 -545.945 -545.945  
  C++ Note: df102 55.7221 55.7221 54.8164  
  C++ Note: df103 101.637 101.637 78.7808  
  C++ Note: df104 -0.4 -0.4 -0.381788  
  C++ Note: Checking Deviance 863.889
  C++ Note: df105 0.548245 0.548245 0.69581  
  C++ Note: df106 -9.79764 -9.79764 -9.9595  
  C++ Note: df100 54899 2 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:04 2024
  
  C++ Note: values checked -0.15 -0.15 -0.185894  
  C++ Note: sums checked 759.794 759.794 762.724  
  C++ Note: derivs checked 1284.16 1284.16 990.331  
  C++ Note: second derivs checked 3581.38 3581.38 2495.47  
  C++ Note: dose checked 1000 1000 1000  
  C++ Note: non-dose checked 759.794 759.794 762.724  
  C++ Note: LIN_non-dose checked 1000 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000 1000  
  C++ Note: LOGLIN_non-dose checked 759.794 759.794 762.724  
  C++ Note: risk checked 38.3621  
  C++ Note: risk1 checked 21.5805 21.5805 16.6341  
  C++ Note: risk2 checked 60.1758 60.1758 41.9048  
  C++ Note: df101 -508.21 -508.21 -508.21  
  C++ Note: df102 54.5798 54.5798 44.7273  
  C++ Note: df103 82.9709 82.9709 66.0113  
  C++ Note: df104 -0.15 -0.15 -0.185894  
  C++ Note: Checking Deviance 788.42
  C++ Note: df105 0.657819 0.657819 0.67757  
  C++ Note: df106 -9.31131 -9.31131 -11.3624  
  C++ Note: df100 56125 3 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:04 2024
  
  C++ Note: values checked -0.025 -0.025 -0.087947  
  C++ Note: sums checked 952.416 952.416 873.043  
  C++ Note: derivs checked 1834.58 1834.58 1277.36  
  C++ Note: second derivs checked 5352.21 5352.21 3420.71  
  C++ Note: dose checked 1000 1000 1000  
  C++ Note: non-dose checked 952.416 952.416 873.043  
  C++ Note: LIN_non-dose checked 1000 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000 1000  
  C++ Note: LOGLIN_non-dose checked 952.416 952.416 873.043  
  C++ Note: risk checked 46.6889  
  C++ Note: risk1 checked 30.8287 30.8287 21.454  
  C++ Note: risk2 checked 89.926 89.926 57.4416  
  C++ Note: df101 -491.052 -491.052 -491.052  
  C++ Note: df102 49.2027 49.2027 38.6036  
  C++ Note: df103 55.9231 55.9231 52.1823  
  C++ Note: df104 -0.025 -0.025 -0.087947  
  C++ Note: Checking Deviance 754.104
  C++ Note: df105 0.879828 0.879828 0.739785  
  C++ Note: df106 -9.98019 -9.98019 -12.7204  
  C++ Note: df100 57409 4 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:04 2024
  
  C++ Note: values checked 0.0375 0.0375 -0.0389735  
  C++ Note: sums checked 1078.28 1078.28 939.932  
  C++ Note: derivs checked 2205.79 2205.79 1459.24  
  C++ Note: second derivs checked 6570.87 6570.87 4025.66  
  C++ Note: dose checked 1000 1000 1000  
  C++ Note: non-dose checked 1078.28 1078.28 939.932  
  C++ Note: LIN_non-dose checked 1000 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000 1000  
  C++ Note: LOGLIN_non-dose checked 1078.28 1078.28 939.932  
  C++ Note: risk checked 52.0424  
  C++ Note: risk1 checked 37.0656 37.0656 24.5083  
  C++ Note: risk2 checked 110.399 110.399 67.6001  
  C++ Note: df101 -483.372 -483.372 -483.372  
  C++ Note: df102 44.5211 44.5211 35.0775  
  C++ Note: df103 35.4395 35.4395 42.2881  
  C++ Note: df104 0.0375 0.0375 -0.0389735  
  C++ Note: Checking Deviance 738.745
  C++ Note: df105 1.25625 1.25625 0.829489  
  C++ Note: df106 -10.8572 -10.8572 -13.7801  
  C++ Note: df100 58627 5 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:04 2024
  
  C++ Note: Changing back to best
  C++ Note: values checked 0.1 0.1 0.01  
  C++ Note: sums checked 1229.91 1229.91 1016.5  
  C++ Note: derivs checked 2662.16 2662.16 1673.67  
  C++ Note: second derivs checked 8088.51 8088.51 4753.83  
  C++ Note: dose checked 1000 1000 1000  
  C++ Note: non-dose checked 1229.91 1229.91 1016.5  
  C++ Note: LIN_non-dose checked 1000 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000 1000  
  C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5  
  C++ Note: risk checked 58.4243  
  C++ Note: risk1 checked 44.7331 44.7331 28.109  
  C++ Note: risk2 checked 135.895 135.895 79.8278  
  C++ Note: df101 -476.566 -476.566 -476.566  
  C++ Note: df102 38.0843 38.0843 31.1135  
  C++ Note: df103 8.9011 8.9011 29.7803  
  C++ Note: df104 0.1 0.1 0.01  
  C++ Note: Checking Deviance 725.133
  C++ Note: df105 4.27861 4.27861 1.04477  
  C++ Note: df106 -12.5134 -12.5134 -15.317  
  C++ Note: df100 59846 0 0 0,Update_Calc
  C++ Note: Current Time, Fri Feb 23 05:59:04 2024
  
  C++ Note: df101 -476.5664 -476.5664 -476.5664  
  C++ Note: df102 38.08434 38.08434 31.11351  
  C++ Note: df103 8.901104 8.901104 29.78032  
  C++ Note: df104 0.1 0.1 0.01  
  C++ Note: Checking Deviance 725.1328
  C++ Note: df105 4.278608 4.278608 1.044768  
  C++ Note: df106 -12.51345 -12.51345 -15.31702  
  C++ Note: df101 -476.566 -476.566 -476.566  
  C++ Note: df102 38.0843 38.0843 31.1135  
  C++ Note: df103 8.9011 8.9011 29.7803  
  C++ Note: df104 0.1 0.1 0.01  
  C++ Note: Checking Deviance 725.133
  C++ Note: df105 4.27861 4.27861 1.04477  
  C++ Note: df106 -12.5134 -12.5134 -15.317  
  C++ Note: df501 -476.5664
  C++ Note: df504 0.1 0.1 0.01  
  Warning: model covariate order changed
  C++ Note: START_POIS_GUESS
  C++ Note: Current Time, Fri Feb 23 05:59:04 2024
  
  C++ Note: Term checked 0 1 2  
  C++ Note: df99,73,Starting
  C++ Note: Current Time, Fri Feb 23 05:59:04 2024
  
  C++ Note: starting subterms 3 in guess 0
  C++ Note: values checked 0.1 0.1 0.01  
  C++ Note: sums checked 1229.91 1229.91 1016.5  
  C++ Note: dose checked 1000 1000 1000  
  C++ Note: non-dose checked 1229.91 1229.91 1016.5  
  C++ Note: LIN_non-dose checked 1000 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000 1000  
  C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5  
  C++ Note: risk checked 4021.52  
  C++ Note: df101 -4464.36 -4464.36 -4464.36  
  C++ Note: df104 0.1 0.1 0.01  
  C++ Note: Checking Deviance 8700.72
  C++ Note: Starting Halves
  C++ Note: df501 -4464.359
  C++ Note: df504 0.1 0.1 0.01  
  C++ Note: values checked 0.1 0.1 0.01  
  C++ Note: sums checked 1229.91 1229.91 1016.5  
  C++ Note: dose checked 1000 1000 1000  
  C++ Note: non-dose checked 1229.91 1229.91 1016.5  
  C++ Note: LIN_non-dose checked 1000 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000 1000  
  C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5  
  C++ Note: risk checked 4021.52  
  C++ Note: df101 -4464.36 -4464.36 -4464.36  
  C++ Note: df104 0.1 0.1 0.01  
  C++ Note: Checking Deviance 8700.72
  C++ Note: df100 11726 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:04 2024
  
  C++ Note: values checked 0.1 0.1 0.01  
  C++ Note: sums checked 1229.91 1229.91 1016.5  
  C++ Note: dose checked 1000 1000 1000  
  C++ Note: non-dose checked 1229.91 1229.91 1016.5  
  C++ Note: LIN_non-dose checked 1000 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000 1000  
  C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5  
  C++ Note: risk checked 4021.52  
  C++ Note: df101 -4464.36 -4464.36 -4464.36  
  C++ Note: df104 0.1 0.1 0.01  
  C++ Note: Checking Deviance 8700.72
  C++ Note: df100 12435 2 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:04 2024
  
  C++ Note: values checked 0.1 0.1 0.01  
  C++ Note: sums checked 1229.91 1229.91 1016.5  
  C++ Note: dose checked 1000 1000 1000  
  C++ Note: non-dose checked 1229.91 1229.91 1016.5  
  C++ Note: LIN_non-dose checked 1000 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000 1000  
  C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5  
  C++ Note: risk checked 4021.52  
  C++ Note: df101 -4464.36 -4464.36 -4464.36  
  C++ Note: df104 0.1 0.1 0.01  
  C++ Note: Checking Deviance 8700.72
  C++ Note: df100 13098 3 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:04 2024
  
  C++ Note: values checked 0.1 0.1 0.01  
  C++ Note: sums checked 1229.91 1229.91 1016.5  
  C++ Note: dose checked 1000 1000 1000  
  C++ Note: non-dose checked 1229.91 1229.91 1016.5  
  C++ Note: LIN_non-dose checked 1000 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000 1000  
  C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5  
  C++ Note: risk checked 4021.52  
  C++ Note: df101 -4464.36 -4464.36 -4464.36  
  C++ Note: df104 0.1 0.1 0.01  
  C++ Note: Checking Deviance 8700.72
  C++ Note: df100 13726 4 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:04 2024
  
  C++ Note: values checked 0.1 0.1 0.01  
  C++ Note: sums checked 1229.91 1229.91 1016.5  
  C++ Note: dose checked 1000 1000 1000  
  C++ Note: non-dose checked 1229.91 1229.91 1016.5  
  C++ Note: LIN_non-dose checked 1000 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000 1000  
  C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5  
  C++ Note: risk checked 4021.52  
  C++ Note: df101 -4464.36 -4464.36 -4464.36  
  C++ Note: df104 0.1 0.1 0.01  
  C++ Note: Checking Deviance 8700.72
  C++ Note: df100 14323 5 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:04 2024
  
  C++ Note: df100 14383 0 0 0,Update_Calc
  C++ Note: Current Time, Fri Feb 23 05:59:04 2024
  
  C++ Note: df101 -4464.359 -4464.359 -4464.359  
  C++ Note: df104 0.1 0.1 0.01  
  C++ Note: df101 -4464.36 -4464.36 -4464.36  
  C++ Note: df104 0.1 0.1 0.01  
  C++ Note: Checking Deviance 8700.72
  C++ Note: ending guess 0
  C++ Note: df501 -4464.359
  C++ Note: df504 0.1 0.1 0.01  
  C++ Note: Refreshing matrices after all guesses
  C++ Note: Guess Results
  Guess number, parameter values, Log-Likelihood
  0, 0.1 0.1 0.01, -4464.359<-- Best Guess
  C++ Note: starting subterms 3 in best guess 0
  C++ Note: values checked 0.1 0.1 0.01  
  C++ Note: sums checked 1229.91 1229.91 1016.5  
  C++ Note: dose checked 1000 1000 1000  
  C++ Note: non-dose checked 1229.91 1229.91 1016.5  
  C++ Note: LIN_non-dose checked 1000 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000 1000  
  C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5  
  C++ Note: risk checked 4021.52  
  C++ Note: Made Risk Side Lists
  C++ Note: df101 -4464.36 -4464.36 -4464.36  
  C++ Note: df104 0.1 0.1 0.01  
  C++ Note: Checking Deviance 8700.72
  C++ Note: Starting Halves
  C++ Note: df501 -4464.359
  C++ Note: df504 0.1 0.1 0.01  
  C++ Note: values checked 0.1 0.1 0.01  
  C++ Note: sums checked 1229.91 1229.91 1016.5  
  C++ Note: dose checked 1000 1000 1000  
  C++ Note: non-dose checked 1229.91 1229.91 1016.5  
  C++ Note: LIN_non-dose checked 1000 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000 1000  
  C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5  
  C++ Note: risk checked 4021.52  
  C++ Note: df101 -4464.36 -4464.36 -4464.36  
  C++ Note: df104 0.1 0.1 0.01  
  C++ Note: Checking Deviance 8700.72
  C++ Note: df100 15977 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:04 2024
  
  C++ Note: values checked 0.1 0.1 0.01  
  C++ Note: sums checked 1229.91 1229.91 1016.5  
  C++ Note: dose checked 1000 1000 1000  
  C++ Note: non-dose checked 1229.91 1229.91 1016.5  
  C++ Note: LIN_non-dose checked 1000 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000 1000  
  C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5  
  C++ Note: risk checked 4021.52  
  C++ Note: df101 -4464.36 -4464.36 -4464.36  
  C++ Note: df104 0.1 0.1 0.01  
  C++ Note: Checking Deviance 8700.72
  C++ Note: df100 16603 2 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:04 2024
  
  C++ Note: values checked 0.1 0.1 0.01  
  C++ Note: sums checked 1229.91 1229.91 1016.5  
  C++ Note: dose checked 1000 1000 1000  
  C++ Note: non-dose checked 1229.91 1229.91 1016.5  
  C++ Note: LIN_non-dose checked 1000 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000 1000  
  C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5  
  C++ Note: risk checked 4021.52  
  C++ Note: df101 -4464.36 -4464.36 -4464.36  
  C++ Note: df104 0.1 0.1 0.01  
  C++ Note: Checking Deviance 8700.72
  C++ Note: df100 17214 3 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:04 2024
  
  C++ Note: values checked 0.1 0.1 0.01  
  C++ Note: sums checked 1229.91 1229.91 1016.5  
  C++ Note: dose checked 1000 1000 1000  
  C++ Note: non-dose checked 1229.91 1229.91 1016.5  
  C++ Note: LIN_non-dose checked 1000 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000 1000  
  C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5  
  C++ Note: risk checked 4021.52  
  C++ Note: df101 -4464.36 -4464.36 -4464.36  
  C++ Note: df104 0.1 0.1 0.01  
  C++ Note: Checking Deviance 8700.72
  C++ Note: df100 17912 4 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:04 2024
  
  C++ Note: values checked 0.1 0.1 0.01  
  C++ Note: sums checked 1229.91 1229.91 1016.5  
  C++ Note: dose checked 1000 1000 1000  
  C++ Note: non-dose checked 1229.91 1229.91 1016.5  
  C++ Note: LIN_non-dose checked 1000 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000 1000  
  C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5  
  C++ Note: risk checked 4021.52  
  C++ Note: df101 -4464.36 -4464.36 -4464.36  
  C++ Note: df104 0.1 0.1 0.01  
  C++ Note: Checking Deviance 8700.72
  C++ Note: df100 18612 5 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:04 2024
  
  C++ Note: df100 18687 0 0 0,Update_Calc
  C++ Note: Current Time, Fri Feb 23 05:59:04 2024
  
  C++ Note: df101 -4464.359 -4464.359 -4464.359  
  C++ Note: df104 0.1 0.1 0.01  
  C++ Note: df101 -4464.36 -4464.36 -4464.36  
  C++ Note: df104 0.1 0.1 0.01  
  C++ Note: Checking Deviance 8700.72
  C++ Note: df501 -4464.359
  C++ Note: df504 0.1 0.1 0.01  
  Warning: model covariate order changed
  C++ Note: START_POIS_GUESS
  C++ Note: Current Time, Fri Feb 23 05:59:04 2024
  
  C++ Note: Term checked 0 1 2  
  C++ Note: df99,73,Starting
  C++ Note: Current Time, Fri Feb 23 05:59:04 2024
  
  C++ Note: starting subterms 3 in guess 0
  C++ Note: values checked 0.1 0.1 0.01  
  C++ Note: sums checked 1229.91 1229.91 1016.5  
  C++ Note: dose checked 1000 1000 1000  
  C++ Note: non-dose checked 1229.91 1229.91 1016.5  
  C++ Note: LIN_non-dose checked 1000 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000 1000  
  C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5  
  C++ Note: risk checked 3476.32  
  C++ Note: df101 -3870.25 -3870.25 -3870.25  
  C++ Note: df104 0.1 0.1 0.01  
  C++ Note: Checking Deviance 7512.5
  C++ Note: Starting Halves
  C++ Note: df501 -3870.252
  C++ Note: df504 0.1 0.1 0.01  
  C++ Note: values checked 0.1 0.1 0.01  
  C++ Note: sums checked 1229.91 1229.91 1016.5  
  C++ Note: dose checked 1000 1000 1000  
  C++ Note: non-dose checked 1229.91 1229.91 1016.5  
  C++ Note: LIN_non-dose checked 1000 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000 1000  
  C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5  
  C++ Note: risk checked 3476.32  
  C++ Note: df101 -3870.25 -3870.25 -3870.25  
  C++ Note: df104 0.1 0.1 0.01  
  C++ Note: Checking Deviance 7512.5
  C++ Note: df100 1494 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:04 2024
  
  C++ Note: values checked 0.1 0.1 0.01  
  C++ Note: sums checked 1229.91 1229.91 1016.5  
  C++ Note: dose checked 1000 1000 1000  
  C++ Note: non-dose checked 1229.91 1229.91 1016.5  
  C++ Note: LIN_non-dose checked 1000 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000 1000  
  C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5  
  C++ Note: risk checked 3476.32  
  C++ Note: df101 -3870.25 -3870.25 -3870.25  
  C++ Note: df104 0.1 0.1 0.01  
  C++ Note: Checking Deviance 7512.5
  C++ Note: df100 2130 2 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:04 2024
  
  C++ Note: values checked 0.1 0.1 0.01  
  C++ Note: sums checked 1229.91 1229.91 1016.5  
  C++ Note: dose checked 1000 1000 1000  
  C++ Note: non-dose checked 1229.91 1229.91 1016.5  
  C++ Note: LIN_non-dose checked 1000 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000 1000  
  C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5  
  C++ Note: risk checked 3476.32  
  C++ Note: df101 -3870.25 -3870.25 -3870.25  
  C++ Note: df104 0.1 0.1 0.01  
  C++ Note: Checking Deviance 7512.5
  C++ Note: df100 14828 3 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:04 2024
  
  C++ Note: values checked 0.1 0.1 0.01  
  C++ Note: sums checked 1229.91 1229.91 1016.5  
  C++ Note: dose checked 1000 1000 1000  
  C++ Note: non-dose checked 1229.91 1229.91 1016.5  
  C++ Note: LIN_non-dose checked 1000 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000 1000  
  C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5  
  C++ Note: risk checked 3476.32  
  C++ Note: df101 -3870.25 -3870.25 -3870.25  
  C++ Note: df104 0.1 0.1 0.01  
  C++ Note: Checking Deviance 7512.5
  C++ Note: df100 15484 4 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:04 2024
  
  C++ Note: values checked 0.1 0.1 0.01  
  C++ Note: sums checked 1229.91 1229.91 1016.5  
  C++ Note: dose checked 1000 1000 1000  
  C++ Note: non-dose checked 1229.91 1229.91 1016.5  
  C++ Note: LIN_non-dose checked 1000 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000 1000  
  C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5  
  C++ Note: risk checked 3476.32  
  C++ Note: df101 -3870.25 -3870.25 -3870.25  
  C++ Note: df104 0.1 0.1 0.01  
  C++ Note: Checking Deviance 7512.5
  C++ Note: df100 16110 5 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:04 2024
  
  C++ Note: df100 16175 0 0 0,Update_Calc
  C++ Note: Current Time, Fri Feb 23 05:59:04 2024
  
  C++ Note: df101 -3870.252 -3870.252 -3870.252  
  C++ Note: df104 0.1 0.1 0.01  
  C++ Note: df101 -3870.25 -3870.25 -3870.25  
  C++ Note: df104 0.1 0.1 0.01  
  C++ Note: Checking Deviance 7512.5
  C++ Note: ending guess 0
  C++ Note: df501 -3870.252
  C++ Note: df504 0.1 0.1 0.01  
  C++ Note: Refreshing matrices after all guesses
  C++ Note: Guess Results
  Guess number, parameter values, Log-Likelihood
  0, 0.1 0.1 0.01, -3870.252<-- Best Guess
  C++ Note: starting subterms 3 in best guess 0
  C++ Note: values checked 0.1 0.1 0.01  
  C++ Note: sums checked 1229.91 1229.91 1016.5  
  C++ Note: dose checked 1000 1000 1000  
  C++ Note: non-dose checked 1229.91 1229.91 1016.5  
  C++ Note: LIN_non-dose checked 1000 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000 1000  
  C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5  
  C++ Note: risk checked 3476.32  
  C++ Note: Made Risk Side Lists
  C++ Note: df101 -3870.25 -3870.25 -3870.25  
  C++ Note: df104 0.1 0.1 0.01  
  C++ Note: Checking Deviance 7512.5
  C++ Note: Starting Halves
  C++ Note: df501 -3870.252
  C++ Note: df504 0.1 0.1 0.01  
  C++ Note: values checked 0.1 0.1 0.01  
  C++ Note: sums checked 1229.91 1229.91 1016.5  
  C++ Note: dose checked 1000 1000 1000  
  C++ Note: non-dose checked 1229.91 1229.91 1016.5  
  C++ Note: LIN_non-dose checked 1000 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000 1000  
  C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5  
  C++ Note: risk checked 3476.32  
  C++ Note: df101 -3870.25 -3870.25 -3870.25  
  C++ Note: df104 0.1 0.1 0.01  
  C++ Note: Checking Deviance 7512.5
  C++ Note: df100 17805 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:04 2024
  
  C++ Note: values checked 0.1 0.1 0.01  
  C++ Note: sums checked 1229.91 1229.91 1016.5  
  C++ Note: dose checked 1000 1000 1000  
  C++ Note: non-dose checked 1229.91 1229.91 1016.5  
  C++ Note: LIN_non-dose checked 1000 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000 1000  
  C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5  
  C++ Note: risk checked 3476.32  
  C++ Note: df101 -3870.25 -3870.25 -3870.25  
  C++ Note: df104 0.1 0.1 0.01  
  C++ Note: Checking Deviance 7512.5
  C++ Note: df100 18459 2 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:04 2024
  
  C++ Note: values checked 0.1 0.1 0.01  
  C++ Note: sums checked 1229.91 1229.91 1016.5  
  C++ Note: dose checked 1000 1000 1000  
  C++ Note: non-dose checked 1229.91 1229.91 1016.5  
  C++ Note: LIN_non-dose checked 1000 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000 1000  
  C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5  
  C++ Note: risk checked 3476.32  
  C++ Note: df101 -3870.25 -3870.25 -3870.25  
  C++ Note: df104 0.1 0.1 0.01  
  C++ Note: Checking Deviance 7512.5
  C++ Note: df100 19181 3 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:04 2024
  
  C++ Note: values checked 0.1 0.1 0.01  
  C++ Note: sums checked 1229.91 1229.91 1016.5  
  C++ Note: dose checked 1000 1000 1000  
  C++ Note: non-dose checked 1229.91 1229.91 1016.5  
  C++ Note: LIN_non-dose checked 1000 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000 1000  
  C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5  
  C++ Note: risk checked 3476.32  
  C++ Note: df101 -3870.25 -3870.25 -3870.25  
  C++ Note: df104 0.1 0.1 0.01  
  C++ Note: Checking Deviance 7512.5
  C++ Note: df100 19920 4 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:04 2024
  
  C++ Note: values checked 0.1 0.1 0.01  
  C++ Note: sums checked 1229.91 1229.91 1016.5  
  C++ Note: dose checked 1000 1000 1000  
  C++ Note: non-dose checked 1229.91 1229.91 1016.5  
  C++ Note: LIN_non-dose checked 1000 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000 1000  
  C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5  
  C++ Note: risk checked 3476.32  
  C++ Note: df101 -3870.25 -3870.25 -3870.25  
  C++ Note: df104 0.1 0.1 0.01  
  C++ Note: Checking Deviance 7512.5
  C++ Note: df100 20625 5 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:04 2024
  
  C++ Note: df100 20703 0 0 0,Update_Calc
  C++ Note: Current Time, Fri Feb 23 05:59:04 2024
  
  C++ Note: df101 -3870.252 -3870.252 -3870.252  
  C++ Note: df104 0.1 0.1 0.01  
  C++ Note: df101 -3870.25 -3870.25 -3870.25  
  C++ Note: df104 0.1 0.1 0.01  
  C++ Note: Checking Deviance 7512.5
  C++ Note: df501 -3870.252
  C++ Note: df504 0.1 0.1 0.01  
  Warning: model covariate order changed
  C++ Note: START_POIS_GUESS
  C++ Note: Current Time, Fri Feb 23 05:59:05 2024
  
  C++ Note: Term checked 0 1 2  
  C++ Note: df99,79,Starting
  C++ Note: Current Time, Fri Feb 23 05:59:05 2024
  
  C++ Note: starting subterms 3 in guess 0
  C++ Note: values checked 0.1 0.1 0.01  
  C++ Note: sums checked 1229.91 1229.91 1016.5  
  C++ Note: derivs checked 2662.16 2662.16 1673.67  
  C++ Note: second derivs checked 8088.51 8088.51 4753.83  
  C++ Note: dose checked 1000 1000 1000  
  C++ Note: non-dose checked 1229.91 1229.91 1016.5  
  C++ Note: LIN_non-dose checked 1000 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000 1000  
  C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5  
  C++ Note: risk checked 4021.52  
  C++ Note: risk1 checked 8990.66 3623.84 2047.21  
  C++ Note: risk2 checked 27640.9 11337.7 5801.4  
  C++ Note: df101 -4464.36 -4464.36 -4464.36  
  C++ Note: df102 -9823.7 -3961.6 -2223.36  
  C++ Note: df103 -30965.7 -12538.3 -6371.77  
  C++ Note: df104 0.1 0.1 0.01  
  C++ Note: Checking Deviance 8700.72
  C++ Note: df105 0.317244 0.315959 0.34894  
  C++ Note: df106 0.454448 1.12691 2.00793  
  C++ Note: Starting Halves
  C++ Note: df501 -4464.359
  C++ Note: df504 0.1 0.1 0.01  
  C++ Note: values checked -0.137933 -0.136969 -0.251705  
  C++ Note: sums checked 775.553 776.836 702.601  
  C++ Note: derivs checked 1328.21 1331.8 841.86  
  C++ Note: second derivs checked 3721.09 3732.5 2034.61  
  C++ Note: dose checked 1000 1000 1000  
  C++ Note: non-dose checked 775.553 776.836 702.601  
  C++ Note: LIN_non-dose checked 1000 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000 1000  
  C++ Note: LOGLIN_non-dose checked 775.553 776.836 702.601  
  C++ Note: risk checked 1943.25  
  C++ Note: risk1 checked 3180.78 914.006 655.882  
  C++ Note: risk2 checked 8802.59 2426.63 1587.74  
  C++ Note: df101 -2228.98 -2228.98 -2228.98  
  C++ Note: df102 -3323.52 -952.67 -688.275  
  C++ Note: df103 -9864.88 -2573.61 -1698.13  
  C++ Note: df104 -0.137933 -0.136969 -0.251705  
  C++ Note: Checking Deviance 4229.97
  C++ Note: df105 0.336904 0.370169 0.405314  
  C++ Note: df106 0.67067 2.33972 3.23851  
  C++ Note: df100 11621 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:05 2024
  
  C++ Note: df100 11695 0 0 0,Update_Calc
  C++ Note: Current Time, Fri Feb 23 05:59:05 2024
  
  C++ Note: df101 -2228.983 -2228.983 -2228.983  
  C++ Note: df102 -3323.517 -952.6701 -688.2751  
  C++ Note: df103 -9864.881 -2573.61 -1698.127  
  C++ Note: df104 -0.1379333 -0.1369691 -0.2517047  
  C++ Note: Checking Deviance 4229.966
  C++ Note: df105 0.336904 0.3701688 0.4053143  
  C++ Note: df106 0.6706698 2.339722 3.238506  
  C++ Note: df101 -2228.98 -2228.98 -2228.98  
  C++ Note: df102 -3323.52 -952.67 -688.275  
  C++ Note: df103 -9864.88 -2573.61 -1698.13  
  C++ Note: df104 -0.137933 -0.136969 -0.251705  
  C++ Note: Checking Deviance 4229.97
  C++ Note: df105 0.336904 0.370169 0.405314  
  C++ Note: df106 0.67067 2.33972 3.23851  
  C++ Note: ending guess 0
  C++ Note: df501 -2228.983
  C++ Note: df504 -0.1379333 -0.1369691 -0.2517047  
  C++ Note: Refreshing matrices after all guesses
  C++ Note: Guess Results
  Guess number, parameter values, Log-Likelihood
  0, -0.1379333 -0.1369691 -0.2517047, -2228.983<-- Best Guess
  C++ Note: starting subterms 3 in best guess 0
  C++ Note: values checked -0.137933 -0.136969 -0.251705  
  C++ Note: sums checked 775.553 776.836 702.601  
  C++ Note: derivs checked 1328.21 1331.8 841.86  
  C++ Note: second derivs checked 3721.09 3732.5 2034.61  
  C++ Note: dose checked 1000 1000 1000  
  C++ Note: non-dose checked 775.553 776.836 702.601  
  C++ Note: LIN_non-dose checked 1000 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000 1000  
  C++ Note: LOGLIN_non-dose checked 775.553 776.836 702.601  
  C++ Note: risk checked 1943.25  
  C++ Note: risk1 checked 3180.78 914.006 655.882  
  C++ Note: risk2 checked 8802.59 2426.63 1587.74  
  C++ Note: Made Risk Side Lists
  C++ Note: df101 -2228.98 -2228.98 -2228.98  
  C++ Note: df102 -3323.52 -952.67 -688.275  
  C++ Note: df103 -9864.88 -2573.61 -1698.13  
  C++ Note: df104 -0.137933 -0.136969 -0.251705  
  C++ Note: Checking Deviance 4229.97
  C++ Note: df105 0.336904 0.370169 0.405314  
  C++ Note: df106 0.67067 2.33972 3.23851  
  C++ Note: Starting Halves
  C++ Note: df501 -2228.983
  C++ Note: df504 -0.1379333 -0.1369691 -0.2517047  
  C++ Note: values checked -0.390611 -0.414596 -0.55569  
  C++ Note: sums checked 532.749 516.988 517.87  
  C++ Note: derivs checked 677.199 637.561 432.04  
  C++ Note: second derivs checked 1711.97 1594.9 857.807  
  C++ Note: dose checked 1000 1000 1000  
  C++ Note: non-dose checked 532.749 516.988 517.87  
  C++ Note: LIN_non-dose checked 1000 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000 1000  
  C++ Note: LOGLIN_non-dose checked 532.749 516.988 517.87  
  C++ Note: risk checked 1160.77  
  C++ Note: risk1 checked 1287.6 260.671 231.783  
  C++ Note: risk2 checked 3158.62 543.41 460.892  
  C++ Note: df101 -1440.04 -1440.04 -1440.04  
  C++ Note: df102 -1204.6 -248.036 -228.728  
  C++ Note: df103 -3543.56 -513.003 -465.909  
  C++ Note: df104 -0.390611 -0.414596 -0.55569  
  C++ Note: Checking Deviance 2652.09
  C++ Note: df105 0.339942 0.483498 0.49093  
  C++ Note: df106 1.19545 5.80578 6.29587  
  C++ Note: df100 14345 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:05 2024
  
  C++ Note: df100 14412 0 0 0,Update_Calc
  C++ Note: Current Time, Fri Feb 23 05:59:05 2024
  
  C++ Note: df101 -1440.044 -1440.044 -1440.044  
  C++ Note: df102 -1204.604 -248.0364 -228.7284  
  C++ Note: df103 -3543.556 -513.0035 -465.9085  
  C++ Note: df104 -0.3906113 -0.4145957 -0.5556904  
  C++ Note: Checking Deviance 2652.088
  C++ Note: df105 0.3399422 0.4834984 0.4909299  
  C++ Note: df106 1.19545 5.805777 6.295868  
  C++ Note: df101 -1440.04 -1440.04 -1440.04  
  C++ Note: df102 -1204.6 -248.036 -228.728  
  C++ Note: df103 -3543.56 -513.003 -465.909  
  C++ Note: df104 -0.390611 -0.414596 -0.55569  
  C++ Note: Checking Deviance 2652.09
  C++ Note: df105 0.339942 0.483498 0.49093  
  C++ Note: df106 1.19545 5.80578 6.29587  
  C++ Note: df501 -1440.044
  C++ Note: df504 -0.3906113 -0.4145957 -0.5556904  
  Warning: model covariate order changed
  C++ Note: START_POIS_GUESS
  C++ Note: Current Time, Fri Feb 23 05:59:05 2024
  
  C++ Note: Term checked 0 1 2  
  C++ Note: df99,81,Starting
  C++ Note: Current Time, Fri Feb 23 05:59:05 2024
  
  C++ Note: starting subterms 3 in guess 0
  C++ Note: values checked 0.1 0.1 0.01  
  C++ Note: sums checked 1229.91 1229.91 1016.5  
  C++ Note: derivs checked 2662.16 2662.16 1673.67  
  C++ Note: second derivs checked 8088.51 8088.51 4753.83  
  C++ Note: dose checked 1000 1000 1000  
  C++ Note: non-dose checked 1229.91 1229.91 1016.5  
  C++ Note: LIN_non-dose checked 1000 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000 1000  
  C++ Note: LOGLIN_non-dose checked 1229.91 1229.91 1016.5  
  C++ Note: risk checked 3476.32  
  C++ Note: risk1 checked 2662.16 2662.16 1673.67  
  C++ Note: risk2 checked 8088.51 8088.51 4753.83  
  C++ Note: df101 -3870.25 -3870.25 -3870.25  
  C++ Note: df102 -2892.89 -2892.89 -1814.56  
  C++ Note: df103 -8899.28 -8899.28 -5219.6  
  C++ Note: df104 0.1 0.1 0.01  
  C++ Note: Checking Deviance 7512.5
  C++ Note: df105 0.32507 0.32507 0.347644  
  C++ Note: df106 1.33785 1.33785 2.13288  
  C++ Note: Starting Halves
  C++ Note: df501 -3870.252
  C++ Note: df504 0.1 0.1 0.01  
  C++ Note: values checked -0.143803 -0.143803 -0.250733  
  C++ Note: sums checked 767.821 767.821 703.42  
  C++ Note: derivs checked 1306.57 1306.57 843.84  
  C++ Note: second derivs checked 3652.41 3652.41 2040.66  
  C++ Note: dose checked 1000 1000 1000  
  C++ Note: non-dose checked 767.821 767.821 703.42  
  C++ Note: LIN_non-dose checked 1000 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000 1000  
  C++ Note: LOGLIN_non-dose checked 767.821 767.821 703.42  
  C++ Note: risk checked 2239.06  
  C++ Note: risk1 checked 1306.57 1306.57 843.84  
  C++ Note: risk2 checked 3652.41 3652.41 2040.66  
  C++ Note: df101 -2541.39 -2541.39 -2541.39  
  C++ Note: df102 -1381.02 -1381.02 -889.259  
  C++ Note: df103 -3933.71 -3933.71 -2190.79  
  C++ Note: df104 -0.143803 -0.143803 -0.250733  
  C++ Note: Checking Deviance 4854.78
  C++ Note: df105 0.351073 0.351073 0.405908  
  C++ Note: df106 1.84023 1.84023 2.85787  
  C++ Note: df100 2670 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:05 2024
  
  C++ Note: df100 2750 0 0 0,Update_Calc
  C++ Note: Current Time, Fri Feb 23 05:59:05 2024
  
  C++ Note: df101 -2541.39 -2541.39 -2541.39  
  C++ Note: df102 -1381.017 -1381.017 -889.2586  
  C++ Note: df103 -3933.706 -3933.706 -2190.791  
  C++ Note: df104 -0.1438028 -0.1438028 -0.2507329  
  C++ Note: Checking Deviance 4854.78
  C++ Note: df105 0.3510728 0.3510728 0.4059076  
  C++ Note: df106 1.84023 1.84023 2.857875  
  C++ Note: df101 -2541.39 -2541.39 -2541.39  
  C++ Note: df102 -1381.02 -1381.02 -889.259  
  C++ Note: df103 -3933.71 -3933.71 -2190.79  
  C++ Note: df104 -0.143803 -0.143803 -0.250733  
  C++ Note: Checking Deviance 4854.78
  C++ Note: df105 0.351073 0.351073 0.405908  
  C++ Note: df106 1.84023 1.84023 2.85787  
  C++ Note: ending guess 0
  C++ Note: df501 -2541.39
  C++ Note: df504 -0.1438028 -0.1438028 -0.2507329  
  C++ Note: Refreshing matrices after all guesses
  C++ Note: Guess Results
  Guess number, parameter values, Log-Likelihood
  0, -0.1438028 -0.1438028 -0.2507329, -2541.39<-- Best Guess
  C++ Note: starting subterms 3 in best guess 0
  C++ Note: values checked -0.143803 -0.143803 -0.250733  
  C++ Note: sums checked 767.821 767.821 703.42  
  C++ Note: derivs checked 1306.57 1306.57 843.84  
  C++ Note: second derivs checked 3652.41 3652.41 2040.66  
  C++ Note: dose checked 1000 1000 1000  
  C++ Note: non-dose checked 767.821 767.821 703.42  
  C++ Note: LIN_non-dose checked 1000 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000 1000  
  C++ Note: LOGLIN_non-dose checked 767.821 767.821 703.42  
  C++ Note: risk checked 2239.06  
  C++ Note: risk1 checked 1306.57 1306.57 843.84  
  C++ Note: risk2 checked 3652.41 3652.41 2040.66  
  C++ Note: Made Risk Side Lists
  C++ Note: df101 -2541.39 -2541.39 -2541.39  
  C++ Note: df102 -1381.02 -1381.02 -889.259  
  C++ Note: df103 -3933.71 -3933.71 -2190.79  
  C++ Note: df104 -0.143803 -0.143803 -0.250733  
  C++ Note: Checking Deviance 4854.78
  C++ Note: df105 0.351073 0.351073 0.405908  
  C++ Note: df106 1.84023 1.84023 2.85787  
  C++ Note: Starting Halves
  C++ Note: df501 -2541.39
  C++ Note: df504 -0.1438028 -0.1438028 -0.2507329  
  C++ Note: values checked -0.407107 -0.407107 -0.555164  
  C++ Note: sums checked 521.807 521.807 518.098  
  C++ Note: derivs checked 649.637 649.637 432.492  
  C++ Note: second derivs checked 1630.48 1630.48 858.997  
  C++ Note: dose checked 1000 1000 1000  
  C++ Note: non-dose checked 521.807 521.807 518.098  
  C++ Note: LIN_non-dose checked 1000 1000 1000  
  C++ Note: PLIN_non-dose checked 1000 1000 1000  
  C++ Note: LOGLIN_non-dose checked 521.807 521.807 518.098  
  C++ Note: risk checked 1561.71  
  C++ Note: risk1 checked 649.637 649.637 432.492  
  C++ Note: risk2 checked 1630.48 1630.48 858.997  
  C++ Note: df101 -1840.51 -1840.51 -1840.51  
  C++ Note: df102 -652.83 -652.83 -432.167  
  C++ Note: df103 -1682.85 -1682.85 -882.861  
  C++ Note: df104 -0.407107 -0.407107 -0.555164  
  C++ Note: Checking Deviance 3453.02
  C++ Note: df105 0.387933 0.387933 0.489507  
  C++ Note: df106 2.81927 2.81927 4.25879  
  C++ Note: df100 14306 1 1 0,Update_calc
  C++ Note: Current Time, Fri Feb 23 05:59:05 2024
  
  C++ Note: df100 14375 0 0 0,Update_Calc
  C++ Note: Current Time, Fri Feb 23 05:59:05 2024
  
  C++ Note: df101 -1840.508 -1840.508 -1840.508  
  C++ Note: df102 -652.8304 -652.8304 -432.1668  
  C++ Note: df103 -1682.845 -1682.845 -882.8612  
  C++ Note: df104 -0.4071074 -0.4071074 -0.5551637  
  C++ Note: Checking Deviance 3453.016
  C++ Note: df105 0.3879325 0.3879325 0.4895071  
  C++ Note: df106 2.819274 2.819274 4.258791  
  C++ Note: df101 -1840.51 -1840.51 -1840.51  
  C++ Note: df102 -652.83 -652.83 -432.167  
  C++ Note: df103 -1682.85 -1682.85 -882.861  
  C++ Note: df104 -0.407107 -0.407107 -0.555164  
  C++ Note: Checking Deviance 3453.02
  C++ Note: df105 0.387933 0.387933 0.489507  
  C++ Note: df106 2.81927 2.81927 4.25879  
  C++ Note: df501 -1840.508
  C++ Note: df504 -0.4071074 -0.4071074 -0.5551637  
  [ FAIL 6 | WARN 0 | SKIP 0 | PASS 1089 ]
  
  ══ Failed tests ════════════════════════════════════════════════════════════════
  ── Failure ('test-Poisson_Regression_CPP_ALT.R:39:5'): Pois loglin_M Strata ────
  e$beta_0 (`actual`) not equal to c(0.05476188) (`expected`).
  
    `actual`: 0.3
  `expected`: 0.1
  ── Failure ('test-omnibus.R:60:17'): Coxph basic_single_null match ─────────────
  e0$LogLik (`actual`) not equal to e1$LogLik (`expected`).
  
    `actual`: -1052
  `expected`:  -526
  ── Failure ('test-omnibus.R:60:17'): Coxph basic_single_null match ─────────────
  e0$LogLik (`actual`) not equal to e1$LogLik (`expected`).
  
    `actual`: -1052
  `expected`:  -526
  ── Failure ('test-omnibus.R:60:17'): Coxph basic_single_null match ─────────────
  e0$LogLik (`actual`) not equal to e1$LogLik (`expected`).
  
    `actual`: -1052
  `expected`:  -526
  ── Failure ('test-omnibus.R:60:17'): Coxph basic_single_null match ─────────────
  e0$LogLik (`actual`) not equal to e1$LogLik (`expected`).
  
    `actual`: -1052
  `expected`:  -526
  ── Failure ('test-omnibus.R:60:17'): Coxph basic_single_null match ─────────────
  e0$LogLik (`actual`) not equal to e1$LogLik (`expected`).
  
    `actual`: -1052
  `expected`:  -526
  
  [ FAIL 6 | WARN 0 | SKIP 0 | PASS 1089 ]
  Error: Test failures
  Execution halted