LaTeX errors when creating PDF version.
This typically indicates Rd problems.
LaTeX errors found:
! Argument of \href@split has an extra }.
<inserted text> 
                \par 
l.171 }
       
! Paragraph ended before \href@split was complete.
<to be read again> 
                   \par 
l.171 }
       
! Extra }, or forgotten \endgroup.
<recently read> }
                 
l.171 }
       
! Missing \endgroup inserted.
<inserted text> 
                \endgroup 
l.171 }
       
! Missing \endgroup inserted.
<inserted text> 
                \endgroup 
l.171 }
       
! Missing } inserted.
<inserted text> 
                }
l.171 }
       
! Extra alignment tab has been changed to \cr.
<recently read> \endtemplate 
                             
l.171 }
       
! Missing } inserted.
<inserted text> 
                }
l.171 }
       
! Missing } inserted.
<inserted text> 
                }
l.171 }
       
! Missing \cr inserted.
<inserted text> 
                \cr 
l.171 }
       
! Missing { inserted.
<inserted text> 
                {
l.171 }
       
! Missing } inserted.
<inserted text> 
                }
l.171 }
       
! Misplaced alignment tab character &.
<argument> ...tr=Investigational\%20Agent}{link} &
                                                   \href {https://www.isrctn...
l.171 }
       
! Misplaced alignment tab character &.
<argument> ...&searchType=advanced-search}{link} &
                                                   \\{} Definitions & \Rhref...
l.171 }
       
! Misplaced alignment tab character &.
<argument> ...d-search}{link} & \\{} Definitions &
                                                   \Rhref {https://eudract.e...
l.171 }
       
! Misplaced alignment tab character &.
<argument> ...t.ema.europa.eu/result.html}{link} &
                                                   \Rhref {https://prsinfo.c...
l.171 }
       
! Misplaced alignment tab character &.
<argument> ...ls.gov/prs-xml-schemas.html}{link} &
                                                   \Rhref {https://www.clini...
l.171 }
       
! Misplaced alignment tab character &.
<argument> ...tudies/study-data-structure}{link} &
                                                   \Rhref {https://www.isrct...
l.171 }
       
! Misplaced alignment tab character &.
<argument> ...isrctn.com/page/definitions}{link} &
                                                   \Rhref {https://www.ema.e...
l.171 }
       
! Misplaced \crcr.
\endlongtable ->\crcr 
                      \noalign {\let \LT@entry \LT@entry@chop \xdef \LT@save...
l.171 }
       
! Misplaced \noalign.
\endlongtable ->\crcr \noalign 
                               {\let \LT@entry \LT@entry@chop \xdef \LT@save...
l.171 }
       
! Misplaced \crcr.
\LT@echunk ->\crcr 
                   \LT@save@row \cr \egroup \global \setbox \@ne \lastbox \u...
l.171 }
       
! Misplaced alignment tab character &.
<argument> &
            
l.171 }
       
! Misplaced \omit.
\LT@entry ...->\ifhmode \@firstofone {&}\fi \omit 
                                                  \ifnum #1=\c@LT@chunks \el...
l.171 }
       
! Misplaced alignment tab character &.
<argument> &
            
l.171 }
       
! Misplaced \omit.
\LT@entry ...->\ifhmode \@firstofone {&}\fi \omit 
                                                  \ifnum #1=\c@LT@chunks \el...
l.171 }
       
! Misplaced alignment tab character &.
<argument> &
            
l.171 }
       
! Misplaced \omit.
\LT@entry ...->\ifhmode \@firstofone {&}\fi \omit 
                                                  \ifnum #1=\c@LT@chunks \el...
l.171 }
       
! Misplaced alignment tab character &.
<argument> &
            
l.171 }
       
! Misplaced \omit.
\LT@entry ...->\ifhmode \@firstofone {&}\fi \omit 
                                                  \ifnum #1=\c@LT@chunks \el...
l.171 }
       
! Misplaced alignment tab character &.
<argument> &
            
l.171 }
       
! Misplaced \omit.
\LT@entry ...->\ifhmode \@firstofone {&}\fi \omit 
                                                  \ifnum #1=\c@LT@chunks \el...
l.171 }
       
! Misplaced alignment tab character &.
<argument> &
            
l.171 }
       
! Misplaced \omit.
\LT@entry ...->\ifhmode \@firstofone {&}\fi \omit 
                                                  \ifnum #1=\c@LT@chunks \el...
l.171 }
       
! Misplaced \cr.
\LT@echunk ->\crcr \LT@save@row \cr 
                                    \egroup \global \setbox \@ne \lastbox \u...
l.171 }
       
! Extra }, or forgotten \endgroup.
\LT@echunk ->\crcr \LT@save@row \cr \egroup 
                                            \global \setbox \@ne \lastbox \u...
l.171 }
       
! Extra }, or forgotten \endgroup.
\LT@echunk ...etbox \@ne \lastbox \unskip \egroup 
                                                  
l.171 }
       
! Undefined control sequence.
<argument> \@currentHref 
                         
l.171 }
       
! LaTeX Error: \begin{list} on input line 140 ended by \end{longtable}.

See the LaTeX manual or LaTeX Companion for explanation.
Type  H <return>  for immediate help.
 ...                                              
! LaTeX Error: \begin{Rdsection} on input line 140 ended by \end{list}.

See the LaTeX manual or LaTeX Companion for explanation.
Type  H <return>  for immediate help.
 ...                                              
! LaTeX Error: \begin{Details} on input line 140 ended by \end{Rdsection}.

See the LaTeX manual or LaTeX Companion for explanation.
Type  H <return>  for immediate help.
 ...                                              
! LaTeX Error: \begin{document} ended by \end{Details}.

See the LaTeX manual or LaTeX Companion for explanation.
Type  H <return>  for immediate help.
 ...                                              
! Extra \endgroup.
<recently read> \endgroup 
                          
l.187 \end{Details}