Error(s) in re-building vignettes:
--- re-building ‘Exposure_Response_Example.Rmd’ using rmarkdown
Building exprespmodel ... done.
Warning: Using `size` aesthetic for lines was deprecated in ggplot2 3.4.0.
ℹ Please use `linewidth` instead.
Warning: The dot-dot notation (`..quantile..`) was deprecated in ggplot2 3.4.0.
ℹ Please use `after_stat(quantile)` instead.
Picking joint bandwidth of 0.015
Picking joint bandwidth of 0.015
Warning: Using the `size` aesthietic with geom_segment was deprecated in ggplot2 3.4.0.
ℹ Please use the `linewidth` aesthetic instead.
Picking joint bandwidth of 0.0648
Picking joint bandwidth of 0.0489
Picking joint bandwidth of 0.0491
Picking joint bandwidth of 0.0652
`summarise()` has grouped output by 'paramname', 'ID', 'WT', 'DOSE', 'SEV',
'covname'. You can override using the `.groups` argument.
Scale for x is already present.
Adding another scale for x, which will replace the existing scale.
--- finished re-building ‘Exposure_Response_Example.Rmd’

--- re-building ‘PKPD_Example.Rmd’ using rmarkdown
Building codepkpdmodelcov ... done.
Warning: Using `size` aesthetic for lines was deprecated in ggplot2 3.4.0.
ℹ Please use `linewidth` instead.
Scale for x is already present.
Adding another scale for x, which will replace the existing scale.
Warning: The dot-dot notation (`..quantile..`) was deprecated in ggplot2 3.4.0.
ℹ Please use `after_stat(quantile)` instead.
Picking joint bandwidth of 0.0276
Picking joint bandwidth of 0.0361
Picking joint bandwidth of 0.0328
Picking joint bandwidth of 0.0266
Picking joint bandwidth of 0.0372
Picking joint bandwidth of 0.0307
Picking joint bandwidth of 0.0266
Picking joint bandwidth of 0.0361
Picking joint bandwidth of 0.0299
Picking joint bandwidth of 0.027
Picking joint bandwidth of 0.0363
Picking joint bandwidth of 0.0299
Picking joint bandwidth of 0.0336
Picking joint bandwidth of 0.0404
Picking joint bandwidth of 0.0369
Picking joint bandwidth of 0.0266
Picking joint bandwidth of 0.036
Picking joint bandwidth of 0.0296
Warning: Using the `size` aesthietic with geom_segment was deprecated in ggplot2 3.4.0.
ℹ Please use the `linewidth` aesthetic instead.
`summarise()` has grouped output by 'paramname', 'covname'. You can override
using the `.groups` argument.
Scale for x is already present.
Adding another scale for x, which will replace the existing scale.
--- finished re-building ‘PKPD_Example.Rmd’

--- re-building ‘PK_Example.Rmd’ using rmarkdown
Building codepkmodelcov ... done.
Warning: Using `size` aesthetic for lines was deprecated in ggplot2 3.4.0.
ℹ Please use `linewidth` instead.
Warning: Transformation introduced infinite values in continuous y-axis
Warning: The dot-dot notation (`..quantile..`) was deprecated in ggplot2 3.4.0.
ℹ Please use `after_stat(quantile)` instead.
Picking joint bandwidth of 0.019
Picking joint bandwidth of 0.0398
Picking joint bandwidth of 0.0121
Warning: Using the `size` aesthietic with geom_segment was deprecated in ggplot2 3.4.0.
ℹ Please use the `linewidth` aesthetic instead.
Picking joint bandwidth of 0.019
Picking joint bandwidth of 0.0398
Picking joint bandwidth of 0.0121
Coordinate system already present. Adding new coordinate system, which will
replace the existing one.
Warning: Duplicated `override.aes` is ignored.
Scale for x is already present.
Adding another scale for x, which will replace the existing scale.
Picking joint bandwidth of 0.00995
Picking joint bandwidth of 0.0206
Picking joint bandwidth of 0.00648
Picking joint bandwidth of 0.00311
Picking joint bandwidth of 0.0071
Picking joint bandwidth of 0.0013
Picking joint bandwidth of 0.00705
Picking joint bandwidth of 0.0168
Picking joint bandwidth of 0.00293
Scale for x is already present.
Adding another scale for x, which will replace the existing scale.
Scale for x is already present.
Adding another scale for x, which will replace the existing scale.
Scale for x is already present.
Adding another scale for x, which will replace the existing scale.
Scale for x is already present.
Adding another scale for x, which will replace the existing scale.
Scale for x is already present.
Adding another scale for x, which will replace the existing scale.
Scale for x is already present.
Adding another scale for x, which will replace the existing scale.
Scale for colour is already present.
Adding another scale for colour, which will replace the existing scale.
--- finished re-building ‘PK_Example.Rmd’

--- re-building ‘PK_Example_full.Rmd’ using rmarkdown
Building codepkmodelcov ... done.
Warning: Using `size` aesthetic for lines was deprecated in ggplot2 3.4.0.
ℹ Please use `linewidth` instead.
Warning: Transformation introduced infinite values in continuous y-axis
Warning: The dot-dot notation (`..quantile..`) was deprecated in ggplot2 3.4.0.
ℹ Please use `after_stat(quantile)` instead.
Picking joint bandwidth of 0.019
Picking joint bandwidth of 0.0395
Picking joint bandwidth of 0.0122
Warning: Using the `size` aesthietic with geom_segment was deprecated in ggplot2 3.4.0.
ℹ Please use the `linewidth` aesthetic instead.
Picking joint bandwidth of 0.019
Picking joint bandwidth of 0.0395
Picking joint bandwidth of 0.0122
`stat_bin()` using `bins = 30`. Pick better value with `binwidth`.
`stat_bin()` using `bins = 30`. Pick better value with `binwidth`.
Warning in table1::eqcut(ALB, 2, f) :
  Because of duplicate values, it's not possible to form 2 equal-sized groups. Largest group size: 111622; smallest group size: 84378
Warning in table1::eqcut(ALB, 2, f) :
  Because of duplicate values, it's not possible to form 2 equal-sized groups. Largest group size: 111622; smallest group size: 84378
Warning in table1::eqcut(ALB, 2, f) :
  Because of duplicate values, it's not possible to form 2 equal-sized groups. Largest group size: 111622; smallest group size: 84378
Warning in table1::eqcut(WT, 2) :
  Because of duplicate values, it's not possible to form 2 equal-sized groups. Largest group size: 98098; smallest group size: 97902
Warning in table1::eqcut(WT, 2) :
  Because of duplicate values, it's not possible to form 2 equal-sized groups. Largest group size: 98098; smallest group size: 97902
Warning in table1::eqcut(WT, 2) :
  Because of duplicate values, it's not possible to form 2 equal-sized groups. Largest group size: 98098; smallest group size: 97902
Warning in table1::eqcut(ALB, 2, f) :
  Because of duplicate values, it's not possible to form 2 equal-sized groups. Largest group size: 111622; smallest group size: 84378
Warning in table1::eqcut(WT, 2) :
  Because of duplicate values, it's not possible to form 2 equal-sized groups. Largest group size: 98098; smallest group size: 97902
Warning in table1::eqcut(ALB, 2, f) :
  Because of duplicate values, it's not possible to form 2 equal-sized groups. Largest group size: 111622; smallest group size: 84378
Warning in table1::eqcut(WT, 2) :
  Because of duplicate values, it's not possible to form 2 equal-sized groups. Largest group size: 98098; smallest group size: 97902
Warning in table1::eqcut(WT, 2) :
  Because of duplicate values, it's not possible to form 2 equal-sized groups. Largest group size: 98098; smallest group size: 97902
Warning in table1::eqcut(ALB, 2, f) :
  Because of duplicate values, it's not possible to form 2 equal-sized groups. Largest group size: 111622; smallest group size: 84378
Warning in table1::eqcut(WT, 2) :
  Because of duplicate values, it's not possible to form 2 equal-sized groups. Largest group size: 98098; smallest group size: 97902
Warning in table1::eqcut(ALB, 2, f) :
  Because of duplicate values, it's not possible to form 2 equal-sized groups. Largest group size: 111622; smallest group size: 84378
Warning in table1::eqcut(WT, 2) :
  Because of duplicate values, it's not possible to form 2 equal-sized groups. Largest group size: 98098; smallest group size: 97902
Warning in table1::eqcut(ALB, 2, f) :
  Because of duplicate values, it's not possible to form 2 equal-sized groups. Largest group size: 111622; smallest group size: 84378
Warning in table1::eqcut(WT, 2) :
  Because of duplicate values, it's not possible to form 2 equal-sized groups. Largest group size: 98098; smallest group size: 97902
Warning in table1::eqcut(ALB, 2, f) :
  Because of duplicate values, it's not possible to form 2 equal-sized groups. Largest group size: 111622; smallest group size: 84378
Warning: Computation failed in `stat_summary()`
Caused by error in `fun.data()`:
! The package `Hmisc` is required.
Warning: Computation failed in `stat_summary()`
Caused by error in `fun.data()`:
! The package `Hmisc` is required.
Warning: Computation failed in `stat_summary()`
Caused by error in `fun.data()`:
! The package `Hmisc` is required.
Warning: Computation failed in `stat_summary()`
Caused by error in `fun.data()`:
! The package `Hmisc` is required.
Warning: Computation failed in `stat_summary()`
Caused by error in `fun.data()`:
! The package `Hmisc` is required.
Warning: Computation failed in `stat_summary()`
Caused by error in `fun.data()`:
! The package `Hmisc` is required.
Warning: Computation failed in `stat_summary()`
Caused by error in `fun.data()`:
! The package `Hmisc` is required.
Warning: Computation failed in `stat_summary()`
Caused by error in `fun.data()`:
! The package `Hmisc` is required.
Warning: Problem while computing `WT = table1::eqcut(WT, 2, fwt)`.
ℹ Because of duplicate values, it's not possible to form 2 equal-sized groups.
  Largest group size: 980980; smallest group size: 979020
Warning: Problem while computing `ALB = table1::eqcut(ALB, 2, f)`.
ℹ Because of duplicate values, it's not possible to form 2 equal-sized groups.
  Largest group size: 1116220; smallest group size: 843780
`summarise()` has grouped output by 'time', 'WT', 'ALB'. You can override using
the `.groups` argument.
Coordinate system already present. Adding new coordinate system, which will
replace the existing one.
Warning in table1::eqcut(out.df.parameters$WT, 4, varlabel = "Weight") :
  Because of duplicate values, it's not possible to form 4 equal-sized groups. Largest group size: 15060; smallest group size: 14970
Warning in table1::eqcut(out.df.parameters$ALB, 3, varlabel = "Albumin") :
  Because of duplicate values, it's not possible to form 3 equal-sized groups. Largest group size: 25770; smallest group size: 15210
Picking joint bandwidth of 0.0388
Picking joint bandwidth of 0.0764
Picking joint bandwidth of 0.0258
Picking joint bandwidth of 0.0482
Picking joint bandwidth of 0.0749
Picking joint bandwidth of 0.0379
Picking joint bandwidth of 0.0521
Picking joint bandwidth of 0.0833
Picking joint bandwidth of 0.041
Picking joint bandwidth of 0.0419
Picking joint bandwidth of 0.067
Picking joint bandwidth of 0.0324
`summarise()` has grouped output by 'paramname', 'covname'. You can override
using the `.groups` argument.
Scale for x is already present.
Adding another scale for x, which will replace the existing scale.
--- finished re-building ‘PK_Example_full.Rmd’

--- re-building ‘Pediatric_Cov_Sim.Rmd’ using rmarkdown
Building pedpkmodelcov ... done.
Warning: Using `size` aesthetic for lines was deprecated in ggplot2 3.4.0.
ℹ Please use `linewidth` instead.
Warning: Transformation introduced infinite values in continuous y-axis
Warning: The dot-dot notation (`..quantile..`) was deprecated in ggplot2 3.4.0.
ℹ Please use `after_stat(quantile)` instead.
Picking joint bandwidth of 0.0339
Picking joint bandwidth of 0.0317
Picking joint bandwidth of 0.0167
Picking joint bandwidth of 0.0154
Warning: Using the `size` aesthietic with geom_segment was deprecated in ggplot2 3.4.0.
ℹ Please use the `linewidth` aesthetic instead.
Warning in table1::eqcut(AGE, 2, f) :
  Because of duplicate values, it's not possible to form 2 equal-sized groups. Largest group size: 65000; smallest group size: 62400
Warning in table1::eqcut(AGE, 2, f) :
  Because of duplicate values, it's not possible to form 2 equal-sized groups. Largest group size: 65000; smallest group size: 62400
Warning in table1::eqcut(AGE, 2, f) :
  Because of duplicate values, it's not possible to form 2 equal-sized groups. Largest group size: 65000; smallest group size: 62400
`summarise()` has grouped output by 'ID', 'SEX', 'AGE'. You can override using
the `.groups` argument.
Warning in table1::eqcut(nca.summaries$WT, 3, varlabel = "Weight") :
  Because of duplicate values, it's not possible to form 3 equal-sized groups. Largest group size: 3268; smallest group size: 3266
Warning in table1::eqcut(nca.summaries$AGE, 4, varlabel = "Age") :
  Because of duplicate values, it's not possible to form 4 equal-sized groups. Largest group size: 2600; smallest group size: 2400
Quitting from lines 268-328 (Pediatric_Cov_Sim.Rmd) 
Error: processing vignette 'Pediatric_Cov_Sim.Rmd' failed with diagnostics:
could not find function "rbind_dfs"
--- failed re-building ‘Pediatric_Cov_Sim.Rmd’

--- re-building ‘introduction_to_coveffectsplot.Rmd’ using rmarkdown
Warning: Using `size` aesthetic for lines was deprecated in ggplot2 3.4.0.
ℹ Please use `linewidth` instead.
Warning: The dot-dot notation (`..quantile..`) was deprecated in ggplot2 3.4.0.
ℹ Please use `after_stat(quantile)` instead.
Picking joint bandwidth of 0.0273
Warning: Using the `size` aesthietic with geom_segment was deprecated in ggplot2 3.4.0.
ℹ Please use the `linewidth` aesthetic instead.
Warning: Removed 57 rows containing non-finite values (`stat_density()`).
Picking joint bandwidth of 0.0248
Warning: `aes_string()` was deprecated in ggplot2 3.0.0.
ℹ Please use tidy evaluation ideoms with `aes()`
--- finished re-building ‘introduction_to_coveffectsplot.Rmd’

SUMMARY: processing the following file failed:
  ‘Pediatric_Cov_Sim.Rmd’

Error: Vignette re-building failed.
Execution halted