Error(s) in re-building vignettes:
--- re-building 'Exposure_Response_Example.Rmd' using rmarkdown
Building exprespmodel ... done.
Picking joint bandwidth of 0.015
Picking joint bandwidth of 0.015
Picking joint bandwidth of 0.0648
Picking joint bandwidth of 0.0489
Picking joint bandwidth of 0.0491
Picking joint bandwidth of 0.0652
`summarise()` has grouped output by 'paramname', 'ID', 'WT', 'DOSE', 'SEV',
'covname'. You can override using the `.groups` argument.
Scale for 'x' is already present. Adding another scale for 'x', which will
replace the existing scale.
--- finished re-building 'Exposure_Response_Example.Rmd'

--- re-building 'PKPD_Example.Rmd' using rmarkdown
Building codepkpdmodelcov ... done.
Scale for 'x' is already present. Adding another scale for 'x', which will
replace the existing scale.
Picking joint bandwidth of 0.0276
Picking joint bandwidth of 0.0361
Picking joint bandwidth of 0.0328
Picking joint bandwidth of 0.0266
Picking joint bandwidth of 0.0372
Picking joint bandwidth of 0.0307
Picking joint bandwidth of 0.0266
Picking joint bandwidth of 0.0361
Picking joint bandwidth of 0.0299
Picking joint bandwidth of 0.027
Picking joint bandwidth of 0.0363
Picking joint bandwidth of 0.0299
Picking joint bandwidth of 0.0336
Picking joint bandwidth of 0.0404
Picking joint bandwidth of 0.0369
Picking joint bandwidth of 0.0266
Picking joint bandwidth of 0.036
Picking joint bandwidth of 0.0296
`summarise()` has grouped output by 'paramname', 'covname'. You can override
using the `.groups` argument.
Scale for 'x' is already present. Adding another scale for 'x', which will
replace the existing scale.
--- finished re-building 'PKPD_Example.Rmd'

--- re-building 'PK_Example.Rmd' using rmarkdown
Building codepkmodelcov ... done.
Warning: Transformation introduced infinite values in continuous y-axis
Picking joint bandwidth of 0.0169
Picking joint bandwidth of 0.0357
Picking joint bandwidth of 0.0117
Picking joint bandwidth of 0.0169
Picking joint bandwidth of 0.0357
Picking joint bandwidth of 0.0117
Coordinate system already present. Adding new coordinate system, which will replace the existing one.
Warning: Duplicated override.aes is ignored.
Scale for 'x' is already present. Adding another scale for 'x', which will
replace the existing scale.
Picking joint bandwidth of 0.00995
Picking joint bandwidth of 0.0206
Picking joint bandwidth of 0.00648
Picking joint bandwidth of 0.00311
Picking joint bandwidth of 0.0071
Picking joint bandwidth of 0.0013
Picking joint bandwidth of 0.00705
Picking joint bandwidth of 0.0168
Picking joint bandwidth of 0.00293
Scale for 'x' is already present. Adding another scale for 'x', which will
replace the existing scale.
Scale for 'x' is already present. Adding another scale for 'x', which will
replace the existing scale.
Scale for 'x' is already present. Adding another scale for 'x', which will
replace the existing scale.
Scale for 'x' is already present. Adding another scale for 'x', which will
replace the existing scale.
Scale for 'x' is already present. Adding another scale for 'x', which will
replace the existing scale.
Scale for 'x' is already present. Adding another scale for 'x', which will
replace the existing scale.
Scale for 'colour' is already present. Adding another scale for 'colour',
which will replace the existing scale.
--- finished re-building 'PK_Example.Rmd'

--- re-building 'PK_Example_full.Rmd' using rmarkdown
Building codepkmodelcov ... done.
Warning: Transformation introduced infinite values in continuous y-axis
Picking joint bandwidth of 0.0193
Picking joint bandwidth of 0.0404
Picking joint bandwidth of 0.0121
Picking joint bandwidth of 0.0193
Picking joint bandwidth of 0.0404
Picking joint bandwidth of 0.0121
`stat_bin()` using `bins = 30`. Pick better value with `binwidth`.
`stat_bin()` using `bins = 30`. Pick better value with `binwidth`.
Warning in table1::eqcut(ALB, 2, f) :
  Because of duplicate values, it's not possible to form 2 equal-sized groups. Largest group size: 111622; smallest group size: 84378
Warning in table1::eqcut(ALB, 2, f) :
  Because of duplicate values, it's not possible to form 2 equal-sized groups. Largest group size: 111622; smallest group size: 84378
Warning in table1::eqcut(ALB, 2, f) :
  Because of duplicate values, it's not possible to form 2 equal-sized groups. Largest group size: 111622; smallest group size: 84378
Warning in table1::eqcut(WT, 2) :
  Because of duplicate values, it's not possible to form 2 equal-sized groups. Largest group size: 98098; smallest group size: 97902
Warning in table1::eqcut(WT, 2) :
  Because of duplicate values, it's not possible to form 2 equal-sized groups. Largest group size: 98098; smallest group size: 97902
Warning in table1::eqcut(WT, 2) :
  Because of duplicate values, it's not possible to form 2 equal-sized groups. Largest group size: 98098; smallest group size: 97902
Warning in table1::eqcut(ALB, 2, f) :
  Because of duplicate values, it's not possible to form 2 equal-sized groups. Largest group size: 111622; smallest group size: 84378
Warning in table1::eqcut(WT, 2) :
  Because of duplicate values, it's not possible to form 2 equal-sized groups. Largest group size: 98098; smallest group size: 97902
Warning in table1::eqcut(ALB, 2, f) :
  Because of duplicate values, it's not possible to form 2 equal-sized groups. Largest group size: 111622; smallest group size: 84378
Warning in table1::eqcut(WT, 2) :
  Because of duplicate values, it's not possible to form 2 equal-sized groups. Largest group size: 98098; smallest group size: 97902
Warning in table1::eqcut(WT, 2) :
  Because of duplicate values, it's not possible to form 2 equal-sized groups. Largest group size: 98098; smallest group size: 97902
Warning in table1::eqcut(ALB, 2, f) :
  Because of duplicate values, it's not possible to form 2 equal-sized groups. Largest group size: 111622; smallest group size: 84378
Warning in table1::eqcut(WT, 2) :
  Because of duplicate values, it's not possible to form 2 equal-sized groups. Largest group size: 98098; smallest group size: 97902
Warning in table1::eqcut(ALB, 2, f) :
  Because of duplicate values, it's not possible to form 2 equal-sized groups. Largest group size: 111622; smallest group size: 84378
Warning in table1::eqcut(WT, 2) :
  Because of duplicate values, it's not possible to form 2 equal-sized groups. Largest group size: 98098; smallest group size: 97902
Warning in table1::eqcut(ALB, 2, f) :
  Because of duplicate values, it's not possible to form 2 equal-sized groups. Largest group size: 111622; smallest group size: 84378
Warning in table1::eqcut(WT, 2) :
  Because of duplicate values, it's not possible to form 2 equal-sized groups. Largest group size: 98098; smallest group size: 97902
Warning in table1::eqcut(ALB, 2, f) :
  Because of duplicate values, it's not possible to form 2 equal-sized groups. Largest group size: 111622; smallest group size: 84378
Quitting from lines 406-461 (PK_Example_full.Rmd) 
Error: processing vignette 'PK_Example_full.Rmd' failed with diagnostics:
number of characters is not computable in "bytes" encoding, element 1
--- failed re-building 'PK_Example_full.Rmd'

--- re-building 'Pediatric_Cov_Sim.Rmd' using rmarkdown
Building pedpkmodelcov ... done.
Warning: Transformation introduced infinite values in continuous y-axis
Picking joint bandwidth of 0.0339
Picking joint bandwidth of 0.0317
Picking joint bandwidth of 0.0167
Picking joint bandwidth of 0.0154
Warning in table1::eqcut(AGE, 2, f) :
  Because of duplicate values, it's not possible to form 2 equal-sized groups. Largest group size: 65000; smallest group size: 62400
Warning in table1::eqcut(AGE, 2, f) :
  Because of duplicate values, it's not possible to form 2 equal-sized groups. Largest group size: 65000; smallest group size: 62400
Warning in table1::eqcut(AGE, 2, f) :
  Because of duplicate values, it's not possible to form 2 equal-sized groups. Largest group size: 65000; smallest group size: 62400
`summarise()` has grouped output by 'ID', 'SEX', 'AGE'. You can override using
the `.groups` argument.
Warning in table1::eqcut(nca.summaries$WT, 3, varlabel = "Weight") :
  Because of duplicate values, it's not possible to form 3 equal-sized groups. Largest group size: 3268; smallest group size: 3266
Warning in table1::eqcut(nca.summaries$AGE, 4, varlabel = "Age") :
  Because of duplicate values, it's not possible to form 4 equal-sized groups. Largest group size: 2600; smallest group size: 2400
Warning in rq.fit.sfn(x, y, tau = tau, rhs = rhs, control = control, ...) :
  tiny diagonals replaced with Inf when calling blkfct

Warning in rq.fit.sfn(x, y, tau = tau, rhs = rhs, control = control, ...) :
  tiny diagonals replaced with Inf when calling blkfct

Warning in rq.fit.sfn(x, y, tau = tau, rhs = rhs, control = control, ...) :
  tiny diagonals replaced with Inf when calling blkfct

Warning in rq.fit.sfn(x, y, tau = tau, rhs = rhs, control = control, ...) :
  tiny diagonals replaced with Inf when calling blkfct

Warning in rq.fit.sfn(x, y, tau = tau, rhs = rhs, control = control, ...) :
  tiny diagonals replaced with Inf when calling blkfct

Warning in rq.fit.sfn(x, y, tau = tau, rhs = rhs, control = control, ...) :
  tiny diagonals replaced with Inf when calling blkfct

Warning: attributes are not identical across measure variables;
they will be dropped
Picking joint bandwidth of 0.0545
Picking joint bandwidth of 0.0376
Picking joint bandwidth of 0.0639
Picking joint bandwidth of 0.0334
Picking joint bandwidth of 0.0658
Picking joint bandwidth of 0.0348
Picking joint bandwidth of 0.0687
Picking joint bandwidth of 0.0402
Picking joint bandwidth of 0.0627
Picking joint bandwidth of 0.0432
`summarise()` has grouped output by 'paramname', 'covname'. You can override
using the `.groups` argument.
Scale for 'x' is already present. Adding another scale for 'x', which will
replace the existing scale.
--- finished re-building 'Pediatric_Cov_Sim.Rmd'

--- re-building 'introduction_to_coveffectsplot.Rmd' using rmarkdown
Picking joint bandwidth of 0.0273
Warning: Removed 57 rows containing non-finite values (stat_density).
Picking joint bandwidth of 0.0248
--- finished re-building 'introduction_to_coveffectsplot.Rmd'

SUMMARY: processing the following file failed:
  'PK_Example_full.Rmd'

Error: Vignette re-building failed.
Execution halted