Error(s) in re-building vignettes:
--- re-building 'Exposure_Response_Example.Rmd' using rmarkdown
Building exprespmodel ... done.
Picking joint bandwidth of 0.015
Picking joint bandwidth of 0.015
Picking joint bandwidth of 0.0647
Picking joint bandwidth of 0.049
Picking joint bandwidth of 0.0482
Picking joint bandwidth of 0.065
`summarise()` has grouped output by 'paramname', 'ID', 'WT', 'DOSE', 'SEV',
'covname'. You can override using the `.groups` argument.
Scale for 'x' is already present. Adding another scale for 'x', which will
replace the existing scale.
--- finished re-building 'Exposure_Response_Example.Rmd'

--- re-building 'PKPD_Example.Rmd' using rmarkdown
Building codepkpdmodelcov ... done.
Scale for 'x' is already present. Adding another scale for 'x', which will
replace the existing scale.
Picking joint bandwidth of 0.0284
Picking joint bandwidth of 0.0401
Picking joint bandwidth of 0.0322
Picking joint bandwidth of 0.0274
Picking joint bandwidth of 0.0406
Picking joint bandwidth of 0.0292
Picking joint bandwidth of 0.0274
Picking joint bandwidth of 0.0401
Picking joint bandwidth of 0.0303
Picking joint bandwidth of 0.0282
Picking joint bandwidth of 0.0397
Picking joint bandwidth of 0.0311
Picking joint bandwidth of 0.0374
Picking joint bandwidth of 0.0467
Picking joint bandwidth of 0.0414
Picking joint bandwidth of 0.0274
Picking joint bandwidth of 0.0401
Picking joint bandwidth of 0.0305
`summarise()` has grouped output by 'paramname', 'covname'. You can override
using the `.groups` argument.
Scale for 'x' is already present. Adding another scale for 'x', which will
replace the existing scale.
--- finished re-building 'PKPD_Example.Rmd'

--- re-building 'PK_Example.Rmd' using rmarkdown
Building codepkmodelcov ... done.
Warning: Transformation introduced infinite values in continuous y-axis
Picking joint bandwidth of 0.0184
Picking joint bandwidth of 0.0381
Picking joint bandwidth of 0.0115
Picking joint bandwidth of 0.0184
Picking joint bandwidth of 0.0381
Picking joint bandwidth of 0.0115
Scale for 'x' is already present. Adding another scale for 'x', which will
replace the existing scale.
Picking joint bandwidth of 0.039
Picking joint bandwidth of 0.0676
Picking joint bandwidth of 0.0379
Picking joint bandwidth of 0.0385
Picking joint bandwidth of 0.0629
Picking joint bandwidth of 0.0366
Picking joint bandwidth of 0.0419
Picking joint bandwidth of 0.0765
Picking joint bandwidth of 0.0371
Picking joint bandwidth of 0.0382
Picking joint bandwidth of 0.0625
Picking joint bandwidth of 0.0363
Scale for 'x' is already present. Adding another scale for 'x', which will
replace the existing scale.
Scale for 'x' is already present. Adding another scale for 'x', which will
replace the existing scale.
Scale for 'x' is already present. Adding another scale for 'x', which will
replace the existing scale.
Scale for 'x' is already present. Adding another scale for 'x', which will
replace the existing scale.
Scale for 'x' is already present. Adding another scale for 'x', which will
replace the existing scale.
--- finished re-building 'PK_Example.Rmd'

--- re-building 'Pediatric_Cov_Sim.Rmd' using rmarkdown
Building pedpkmodelcov ... done.
Warning: Transformation introduced infinite values in continuous y-axis
Picking joint bandwidth of 0.0339
Picking joint bandwidth of 0.0167
Warning in open.connection(file, "rt") :
  InternetOpenUrl failed: 'Die Serververbindung konnte nicht hergestellt werden.'
Quitting from lines 193-225 (Pediatric_Cov_Sim.Rmd) 
Error: processing vignette 'Pediatric_Cov_Sim.Rmd' failed with diagnostics:
cannot open the connection
--- failed re-building 'Pediatric_Cov_Sim.Rmd'

--- re-building 'introduction_to_coveffectsplot.Rmd' using rmarkdown
Picking joint bandwidth of 0.0273
Picking joint bandwidth of 0.0326
Warning: Removed 57 rows containing non-finite values (stat_density).
--- finished re-building 'introduction_to_coveffectsplot.Rmd'

SUMMARY: processing the following file failed:
  'Pediatric_Cov_Sim.Rmd'

Error: Vignette re-building failed.
Execution halted