Error(s) in re-building vignettes:
--- re-building ‘Exposure_Response_Example.Rmd’ using rmarkdown
Warning in engine$weave(file, quiet = quiet, encoding = enc) :
  Pandoc (>= 1.12.3) not available. Falling back to R Markdown v1.
Building exprespmodel ... done.
Picking joint bandwidth of 0.015
Picking joint bandwidth of 0.015
Picking joint bandwidth of 0.0647
Picking joint bandwidth of 0.049
Picking joint bandwidth of 0.0482
Picking joint bandwidth of 0.065
`summarise()` has grouped output by 'paramname', 'ID', 'WT', 'DOSE', 'SEV', 'covname'. You can override using the `.groups` argument.
Scale for 'x' is already present. Adding another scale for 'x', which will
replace the existing scale.
Warning in grid.Call(C_stringMetric, as.graphicsAnnot(x$label)) :
  no font could be found for family "Arial"
Warning in grid.Call(C_stringMetric, as.graphicsAnnot(x$label)) :
  no font could be found for family "Arial"
Warning in grid.Call(C_stringMetric, as.graphicsAnnot(x$label)) :
  no font could be found for family "Arial"
Warning in grid.Call(C_stringMetric, as.graphicsAnnot(x$label)) :
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Warning in grid.Call(C_stringMetric, as.graphicsAnnot(x$label)) :
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Warning in grid.Call(C_stringMetric, as.graphicsAnnot(x$label)) :
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Warning in grid.Call(C_stringMetric, as.graphicsAnnot(x$label)) :
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Warning in grid.Call(C_stringMetric, as.graphicsAnnot(x$label)) :
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Warning in grid.Call(C_stringMetric, as.graphicsAnnot(x$label)) :
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Warning in grid.Call(C_stringMetric, as.graphicsAnnot(x$label)) :
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Warning in grid.Call(C_stringMetric, as.graphicsAnnot(x$label)) :
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Warning in grid.Call(C_stringMetric, as.graphicsAnnot(x$label)) :
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Warning in grid.Call(C_stringMetric, as.graphicsAnnot(x$label)) :
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Warning in grid.Call(C_stringMetric, as.graphicsAnnot(x$label)) :
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Warning in grid.Call(C_stringMetric, as.graphicsAnnot(x$label)) :
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Warning in grid.Call(C_stringMetric, as.graphicsAnnot(x$label)) :
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Warning in grid.Call(C_stringMetric, as.graphicsAnnot(x$label)) :
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Warning in grid.Call(C_stringMetric, as.graphicsAnnot(x$label)) :
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Warning in grid.Call(C_stringMetric, as.graphicsAnnot(x$label)) :
  no font could be found for family "Arial"
Warning in grid.Call(C_stringMetric, as.graphicsAnnot(x$label)) :
  no font could be found for family "Arial"
Warning in grid.Call(C_stringMetric, as.graphicsAnnot(x$label)) :
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Warning in grid.Call(C_stringMetric, as.graphicsAnnot(x$label)) :
  no font could be found for family "Arial"
Warning in grid.Call(C_stringMetric, as.graphicsAnnot(x$label)) :
  no font could be found for family "Arial"
Warning in grid.Call(C_stringMetric, as.graphicsAnnot(x$label)) :
  no font could be found for family "Arial"
Warning in grid.Call(C_stringMetric, as.graphicsAnnot(x$label)) :
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Warning in grid.Call(C_stringMetric, as.graphicsAnnot(x$label)) :
  no font could be found for family "Arial"
Warning in grid.Call(C_stringMetric, as.graphicsAnnot(x$label)) :
  no font could be found for family "Arial"
Warning in grid.Call(C_stringMetric, as.graphicsAnnot(x$label)) :
  no font could be found for family "Arial"
Warning in grid.Call(C_stringMetric, as.graphicsAnnot(x$label)) :
  no font could be found for family "Arial"
Warning in grid.Call(C_stringMetric, as.graphicsAnnot(x$label)) :
  no font could be found for family "Arial"
Warning in grid.Call(C_stringMetric, as.graphicsAnnot(x$label)) :
  no font could be found for family "Arial"
Warning in grid.Call(C_stringMetric, as.graphicsAnnot(x$label)) :
  no font could be found for family "Arial"
Warning in grid.Call(C_stringMetric, as.graphicsAnnot(x$label)) :
  no font could be found for family "Arial"
Warning in grid.Call(C_stringMetric, as.graphicsAnnot(x$label)) :
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Warning in grid.Call(C_textBounds, as.graphicsAnnot(x$label), x$x, x$y,  :
  no font could be found for family "Arial"
Warning in grid.Call(C_textBounds, as.graphicsAnnot(x$label), x$x, x$y,  :
  no font could be found for family "Arial"
Quitting from lines 352-417 (Exposure_Response_Example.Rmd) 
Error: processing vignette 'Exposure_Response_Example.Rmd' failed with diagnostics:
polygon edge not found
--- failed re-building ‘Exposure_Response_Example.Rmd’

--- re-building ‘Introduction_to_coveffectsplot.Rmd’ using rmarkdown
Warning in engine$weave(file, quiet = quiet, encoding = enc) :
  Pandoc (>= 1.12.3) not available. Falling back to R Markdown v1.
Picking joint bandwidth of 0.0273
Picking joint bandwidth of 0.0326
Warning: Removed 57 rows containing non-finite values (stat_density).
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Warning in grid.Call(C_stringMetric, as.graphicsAnnot(x$label)) :
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Warning in grid.Call(C_stringMetric, as.graphicsAnnot(x$label)) :
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Warning in grid.Call(C_stringMetric, as.graphicsAnnot(x$label)) :
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Warning in grid.Call(C_stringMetric, as.graphicsAnnot(x$label)) :
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Warning in grid.Call(C_stringMetric, as.graphicsAnnot(x$label)) :
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Warning in grid.Call(C_textBounds, as.graphicsAnnot(x$label), x$x, x$y,  :
  no font could be found for family "Arial"
Warning in grid.Call(C_textBounds, as.graphicsAnnot(x$label), x$x, x$y,  :
  no font could be found for family "Arial"
Quitting from lines 304-325 (Introduction_to_coveffectsplot.Rmd) 
Error: processing vignette 'Introduction_to_coveffectsplot.Rmd' failed with diagnostics:
polygon edge not found
--- failed re-building ‘Introduction_to_coveffectsplot.Rmd’

--- re-building ‘PKPD_Example.Rmd’ using rmarkdown
Warning in engine$weave(file, quiet = quiet, encoding = enc) :
  Pandoc (>= 1.12.3) not available. Falling back to R Markdown v1.
Building codepkpdmodelcov ... done.
Scale for 'x' is already present. Adding another scale for 'x', which will
replace the existing scale.
Picking joint bandwidth of 0.0284
Picking joint bandwidth of 0.0401
Picking joint bandwidth of 0.0322
Picking joint bandwidth of 0.0274
Picking joint bandwidth of 0.0406
Picking joint bandwidth of 0.0292
Picking joint bandwidth of 0.0274
Picking joint bandwidth of 0.0402
Picking joint bandwidth of 0.0303
Picking joint bandwidth of 0.0282
Picking joint bandwidth of 0.0398
Picking joint bandwidth of 0.031
Picking joint bandwidth of 0.0374
Picking joint bandwidth of 0.0467
Picking joint bandwidth of 0.0414
Picking joint bandwidth of 0.0274
Picking joint bandwidth of 0.0401
Picking joint bandwidth of 0.0305
`summarise()` has grouped output by 'paramname', 'covname'. You can override using the `.groups` argument.
Scale for 'x' is already present. Adding another scale for 'x', which will
replace the existing scale.
Warning in grid.Call(C_stringMetric, as.graphicsAnnot(x$label)) :
  no font could be found for family "Arial"
Warning in grid.Call(C_stringMetric, as.graphicsAnnot(x$label)) :
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Warning in grid.Call(C_stringMetric, as.graphicsAnnot(x$label)) :
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Warning in grid.Call(C_stringMetric, as.graphicsAnnot(x$label)) :
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Warning in grid.Call(C_stringMetric, as.graphicsAnnot(x$label)) :
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Warning in grid.Call(C_stringMetric, as.graphicsAnnot(x$label)) :
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Warning in grid.Call(C_stringMetric, as.graphicsAnnot(x$label)) :
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Warning in grid.Call(C_textBounds, as.graphicsAnnot(x$label), x$x, x$y,  :
  no font could be found for family "Arial"
Warning in grid.Call(C_textBounds, as.graphicsAnnot(x$label), x$x, x$y,  :
  no font could be found for family "Arial"
Quitting from lines 489-558 (PKPD_Example.Rmd) 
Error: processing vignette 'PKPD_Example.Rmd' failed with diagnostics:
polygon edge not found
--- failed re-building ‘PKPD_Example.Rmd’

--- re-building ‘PK_Example.Rmd’ using rmarkdown
Warning in engine$weave(file, quiet = quiet, encoding = enc) :
  Pandoc (>= 1.12.3) not available. Falling back to R Markdown v1.
Building codepkmodelcov ... done.
Warning: Transformation introduced infinite values in continuous y-axis
Picking joint bandwidth of 0.0194
Picking joint bandwidth of 0.0402
Picking joint bandwidth of 0.0122
Picking joint bandwidth of 0.0194
Picking joint bandwidth of 0.0402
Picking joint bandwidth of 0.0122
Scale for 'x' is already present. Adding another scale for 'x', which will
replace the existing scale.
Picking joint bandwidth of 0.039
Picking joint bandwidth of 0.0676
Picking joint bandwidth of 0.0379
Picking joint bandwidth of 0.0385
Picking joint bandwidth of 0.0629
Picking joint bandwidth of 0.0366
Picking joint bandwidth of 0.0419
Picking joint bandwidth of 0.0765
Picking joint bandwidth of 0.0371
Picking joint bandwidth of 0.0382
Picking joint bandwidth of 0.0625
Picking joint bandwidth of 0.0363
Scale for 'x' is already present. Adding another scale for 'x', which will
replace the existing scale.
Warning in grid.Call(C_stringMetric, as.graphicsAnnot(x$label)) :
  no font could be found for family "Arial"
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Warning in grid.Call(C_stringMetric, as.graphicsAnnot(x$label)) :
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Warning in grid.Call(C_stringMetric, as.graphicsAnnot(x$label)) :
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Warning in grid.Call(C_stringMetric, as.graphicsAnnot(x$label)) :
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Warning in grid.Call(C_stringMetric, as.graphicsAnnot(x$label)) :
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Warning in grid.Call(C_textBounds, as.graphicsAnnot(x$label), x$x, x$y,  :
  no font could be found for family "Arial"
Warning in grid.Call(C_textBounds, as.graphicsAnnot(x$label), x$x, x$y,  :
  no font could be found for family "Arial"
Quitting from lines 548-617 (PK_Example.Rmd) 
Error: processing vignette 'PK_Example.Rmd' failed with diagnostics:
polygon edge not found
--- failed re-building ‘PK_Example.Rmd’

--- re-building ‘Pediatric_Cov_Sim.Rmd’ using rmarkdown
Warning in engine$weave(file, quiet = quiet, encoding = enc) :
  Pandoc (>= 1.12.3) not available. Falling back to R Markdown v1.
Building pedpkmodelcov ... done.
Warning: Transformation introduced infinite values in continuous y-axis
Picking joint bandwidth of 0.0339
Picking joint bandwidth of 0.0167
Warning in table1::eqcut(AGE, 2, f) :
  Because of duplicate values, it's not possible to form 2 equal-sized groups. Largest group size: 65000; smallest group size: 62400
Warning in table1::eqcut(AGE, 2, f) :
  Because of duplicate values, it's not possible to form 2 equal-sized groups. Largest group size: 65000; smallest group size: 62400
Warning in table1::eqcut(AGE, 2, f) :
  Because of duplicate values, it's not possible to form 2 equal-sized groups. Largest group size: 65000; smallest group size: 62400
`summarise()` has grouped output by 'ID', 'SEX', 'AGE'. You can override using the `.groups` argument.
Warning in table1::eqcut(nca.summaries$WT, 3, varlabel = "Weight") :
  Because of duplicate values, it's not possible to form 3 equal-sized groups. Largest group size: 3268; smallest group size: 3266
Warning in table1::eqcut(nca.summaries$AGE, 4, varlabel = "Age") :
  Because of duplicate values, it's not possible to form 4 equal-sized groups. Largest group size: 2600; smallest group size: 2400
Warning: attributes are not identical across measure variables;
they will be dropped
Picking joint bandwidth of 0.0241
Picking joint bandwidth of 0.0289
Picking joint bandwidth of 0.013
Picking joint bandwidth of 0.0155
Picking joint bandwidth of 0.0108
Picking joint bandwidth of 0.0129
Picking joint bandwidth of 0.0207
Picking joint bandwidth of 0.0249
Picking joint bandwidth of 0.0276
Picking joint bandwidth of 0.0332
`summarise()` has grouped output by 'paramname', 'covname'. You can override using the `.groups` argument.
Scale for 'x' is already present. Adding another scale for 'x', which will
replace the existing scale.
Warning in grid.Call(C_stringMetric, as.graphicsAnnot(x$label)) :
  no font could be found for family "Arial"
Warning in grid.Call(C_stringMetric, as.graphicsAnnot(x$label)) :
  no font could be found for family "Arial"
Warning in grid.Call(C_stringMetric, as.graphicsAnnot(x$label)) :
  no font could be found for family "Arial"
Warning in grid.Call(C_stringMetric, as.graphicsAnnot(x$label)) :
  no font could be found for family "Arial"
Warning in grid.Call(C_stringMetric, as.graphicsAnnot(x$label)) :
  no font could be found for family "Arial"
Warning in grid.Call(C_stringMetric, as.graphicsAnnot(x$label)) :
  no font could be found for family "Arial"
Warning in grid.Call(C_stringMetric, as.graphicsAnnot(x$label)) :
  no font could be found for family "Arial"
Warning in grid.Call(C_stringMetric, as.graphicsAnnot(x$label)) :
  no font could be found for family "Arial"
Warning in grid.Call(C_stringMetric, as.graphicsAnnot(x$label)) :
  no font could be found for family "Arial"
Warning in grid.Call(C_stringMetric, as.graphicsAnnot(x$label)) :
  no font could be found for family "Arial"
Warning in grid.Call(C_stringMetric, as.graphicsAnnot(x$label)) :
  no font could be found for family "Arial"
Warning in grid.Call(C_stringMetric, as.graphicsAnnot(x$label)) :
  no font could be found for family "Arial"
Warning in grid.Call(C_stringMetric, as.graphicsAnnot(x$label)) :
  no font could be found for family "Arial"
Warning in grid.Call(C_stringMetric, as.graphicsAnnot(x$label)) :
  no font could be found for family "Arial"
Warning in grid.Call(C_stringMetric, as.graphicsAnnot(x$label)) :
  no font could be found for family "Arial"
Warning in grid.Call(C_stringMetric, as.graphicsAnnot(x$label)) :
  no font could be found for family "Arial"
Warning in grid.Call(C_stringMetric, as.graphicsAnnot(x$label)) :
  no font could be found for family "Arial"
Warning in grid.Call(C_stringMetric, as.graphicsAnnot(x$label)) :
  no font could be found for family "Arial"
Warning in grid.Call(C_stringMetric, as.graphicsAnnot(x$label)) :
  no font could be found for family "Arial"
Warning in grid.Call(C_stringMetric, as.graphicsAnnot(x$label)) :
  no font could be found for family "Arial"
Warning in grid.Call(C_stringMetric, as.graphicsAnnot(x$label)) :
  no font could be found for family "Arial"
Warning in grid.Call(C_stringMetric, as.graphicsAnnot(x$label)) :
  no font could be found for family "Arial"
Warning in grid.Call(C_stringMetric, as.graphicsAnnot(x$label)) :
  no font could be found for family "Arial"
Warning in grid.Call(C_stringMetric, as.graphicsAnnot(x$label)) :
  no font could be found for family "Arial"
Warning in grid.Call(C_stringMetric, as.graphicsAnnot(x$label)) :
  no font could be found for family "Arial"
Warning in grid.Call(C_stringMetric, as.graphicsAnnot(x$label)) :
  no font could be found for family "Arial"
Warning in grid.Call(C_stringMetric, as.graphicsAnnot(x$label)) :
  no font could be found for family "Arial"
Warning in grid.Call(C_stringMetric, as.graphicsAnnot(x$label)) :
  no font could be found for family "Arial"
Warning in grid.Call(C_textBounds, as.graphicsAnnot(x$label), x$x, x$y,  :
  no font could be found for family "Arial"
Warning in grid.Call(C_textBounds, as.graphicsAnnot(x$label), x$x, x$y,  :
  no font could be found for family "Arial"
Quitting from lines 365-454 (Pediatric_Cov_Sim.Rmd) 
Error: processing vignette 'Pediatric_Cov_Sim.Rmd' failed with diagnostics:
polygon edge not found
--- failed re-building ‘Pediatric_Cov_Sim.Rmd’

SUMMARY: processing the following files failed:
  ‘Exposure_Response_Example.Rmd’ ‘Introduction_to_coveffectsplot.Rmd’
  ‘PKPD_Example.Rmd’ ‘PK_Example.Rmd’ ‘Pediatric_Cov_Sim.Rmd’

Error: Vignette re-building failed.
Execution halted