Error(s) in re-building vignettes:
--- re-building 'case_study.Rmd' using rmarkdown
Loading required package: R.oo
Loading required package: R.methodsS3
R.methodsS3 v1.8.1 (2020-08-26 16:20:06 UTC) successfully loaded. See ?R.methodsS3 for help.
R.oo v1.24.0 (2020-08-26 16:11:58 UTC) successfully loaded. See ?R.oo for help.

Attaching package: 'R.oo'

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R.utils v2.10.1 (2020-08-26 22:50:31 UTC) successfully loaded. See ?R.utils for help.

Attaching package: 'R.utils'

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Attaching package: 'igraph'

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Loading required package: stats4
Loading required package: BiocGenerics
Loading required package: parallel

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Loading required package: Biobase
Welcome to Bioconductor

    Vignettes contain introductory material; view with
    'browseVignettes()'. To cite Bioconductor, see
    'citation("Biobase")', and for packages 'citation("pkgname")'.

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clusterProfiler v3.99.1  For help: https://guangchuangyu.github.io/software/clusterProfiler

If you use clusterProfiler in published research, please cite:
Guangchuang Yu, Li-Gen Wang, Yanyan Han, Qing-Yu He. clusterProfiler: an R package for comparing biological themes among gene clusters. OMICS: A Journal of Integrative Biology. 2012, 16(5):284-287.

Attaching package: 'clusterProfiler'

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trying URL 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4393113/bin/pone.0122882.s001.xlsx'
Warning in download.file("https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4393113/bin/pone.0122882.s001.xlsx",  :
  cannot open URL 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4393113/bin/pone.0122882.s001.xlsx': HTTP status was '503 Service Unavailable'
Quitting from lines 44-55 (case_study.Rmd) 
Error: processing vignette 'case_study.Rmd' failed with diagnostics:
cannot open URL 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4393113/bin/pone.0122882.s001.xlsx'
--- failed re-building 'case_study.Rmd'

--- re-building 'using_cRegulome.Rmd' using rmarkdown
Picking joint bandwidth of 0.0445
--- finished re-building 'using_cRegulome.Rmd'

SUMMARY: processing the following file failed:
  'case_study.Rmd'

Error: Vignette re-building failed.
Execution halted