Error(s) in re-building vignettes:
--- re-building ‘Exposure_Response_Example.Rmd’ using rmarkdown
Building exprespmodel ... done.
`geom_smooth()` using formula 'y ~ x'
Fontconfig error: Cannot load default config file
Picking joint bandwidth of 0.714
Picking joint bandwidth of 0.0318
Picking joint bandwidth of 0.163
Picking joint bandwidth of 0.0356
Picking joint bandwidth of 0.105
Picking joint bandwidth of 0.0242
Picking joint bandwidth of 0.146
Picking joint bandwidth of 0.0357
dyld: lazy symbol binding failed: Symbol not found: ____chkstk_darwin
  Referenced from: /usr/local/bin/pandoc (which was built for Mac OS X 10.15)
  Expected in: /usr/lib/libSystem.B.dylib

dyld: Symbol not found: ____chkstk_darwin
  Referenced from: /usr/local/bin/pandoc (which was built for Mac OS X 10.15)
  Expected in: /usr/lib/libSystem.B.dylib

Error: processing vignette 'Exposure_Response_Example.Rmd' failed with diagnostics:
pandoc document conversion failed with error 6
--- failed re-building ‘Exposure_Response_Example.Rmd’

--- re-building ‘PKPD_Example.Rmd’ using rmarkdown
Fontconfig error: Cannot load default config file
Joining, by = "paramname"
Scale for 'x' is already present. Adding another scale for 'x', which will
replace the existing scale.
Picking joint bandwidth of 0.0303
Picking joint bandwidth of 0.0384
Picking joint bandwidth of 0.034
Picking joint bandwidth of 0.0303
Picking joint bandwidth of 0.0377
Picking joint bandwidth of 0.0334
Picking joint bandwidth of 0.0303
Picking joint bandwidth of 0.0376
Picking joint bandwidth of 0.0338
Picking joint bandwidth of 0.0303
Picking joint bandwidth of 0.0372
Picking joint bandwidth of 0.0339
Picking joint bandwidth of 0.0363
Picking joint bandwidth of 0.0458
Picking joint bandwidth of 0.0368
Picking joint bandwidth of 0.0303
Picking joint bandwidth of 0.0374
Picking joint bandwidth of 0.0338
Scale for 'x' is already present. Adding another scale for 'x', which will
replace the existing scale.
dyld: lazy symbol binding failed: Symbol not found: ____chkstk_darwin
  Referenced from: /usr/local/bin/pandoc (which was built for Mac OS X 10.15)
  Expected in: /usr/lib/libSystem.B.dylib

dyld: Symbol not found: ____chkstk_darwin
  Referenced from: /usr/local/bin/pandoc (which was built for Mac OS X 10.15)
  Expected in: /usr/lib/libSystem.B.dylib

Error: processing vignette 'PKPD_Example.Rmd' failed with diagnostics:
pandoc document conversion failed with error 6
--- failed re-building ‘PKPD_Example.Rmd’

--- re-building ‘PK_Example.Rmd’ using rmarkdown
Fontconfig error: Cannot load default config file
Picking joint bandwidth of 0.0317
Picking joint bandwidth of 0.0669
Picking joint bandwidth of 0.0115
Picking joint bandwidth of 0.0317
Picking joint bandwidth of 0.0669
Picking joint bandwidth of 0.0115
Dropping non-numeric columns: 
  covname
Scale for 'x' is already present. Adding another scale for 'x', which will
replace the existing scale.
Picking joint bandwidth of 0.0183
Picking joint bandwidth of 0.0301
Picking joint bandwidth of 0.0186
Picking joint bandwidth of 0.0192
Picking joint bandwidth of 0.0333
Picking joint bandwidth of 0.0184
Picking joint bandwidth of 0.0179
Picking joint bandwidth of 0.0292
Picking joint bandwidth of 0.0177
Picking joint bandwidth of 0.0179
Picking joint bandwidth of 0.029
Picking joint bandwidth of 0.0176
Scale for 'x' is already present. Adding another scale for 'x', which will
replace the existing scale.
Scale for 'x' is already present. Adding another scale for 'x', which will
replace the existing scale.
Scale for 'x' is already present. Adding another scale for 'x', which will
replace the existing scale.
Scale for 'x' is already present. Adding another scale for 'x', which will
replace the existing scale.
dyld: lazy symbol binding failed: Symbol not found: ____chkstk_darwin
  Referenced from: /usr/local/bin/pandoc (which was built for Mac OS X 10.15)
  Expected in: /usr/lib/libSystem.B.dylib

dyld: Symbol not found: ____chkstk_darwin
  Referenced from: /usr/local/bin/pandoc (which was built for Mac OS X 10.15)
  Expected in: /usr/lib/libSystem.B.dylib

Error: processing vignette 'PK_Example.Rmd' failed with diagnostics:
pandoc document conversion failed with error 6
--- failed re-building ‘PK_Example.Rmd’

--- re-building ‘introduction_to_coveffectsplot.Rmd’ using rmarkdown
Fontconfig error: Cannot load default config file
dyld: lazy symbol binding failed: Symbol not found: ____chkstk_darwin
  Referenced from: /usr/local/bin/pandoc (which was built for Mac OS X 10.15)
  Expected in: /usr/lib/libSystem.B.dylib

dyld: Symbol not found: ____chkstk_darwin
  Referenced from: /usr/local/bin/pandoc (which was built for Mac OS X 10.15)
  Expected in: /usr/lib/libSystem.B.dylib

Error: processing vignette 'introduction_to_coveffectsplot.Rmd' failed with diagnostics:
pandoc document conversion failed with error 6
--- failed re-building ‘introduction_to_coveffectsplot.Rmd’

SUMMARY: processing the following files failed:
  ‘Exposure_Response_Example.Rmd’ ‘PKPD_Example.Rmd’ ‘PK_Example.Rmd’
  ‘introduction_to_coveffectsplot.Rmd’

Error: Vignette re-building failed.
Execution halted