Error(s) in re-building vignettes:
--- re-building ‘RxODE-cmt.Rmd’ using rmarkdown
Warning in engine$weave(file, quiet = quiet, encoding = enc) :
  Pandoc (>= 1.12.3) and/or pandoc-citeproc not available. Falling back to R Markdown v1.
--- finished re-building ‘RxODE-cmt.Rmd’

--- re-building ‘RxODE-covariates.Rmd’ using rmarkdown
Warning in engine$weave(file, quiet = quiet, encoding = enc) :
  Pandoc (>= 1.12.3) and/or pandoc-citeproc not available. Falling back to R Markdown v1.
udunits system database from /usr/local/share/udunits
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--- finished re-building ‘RxODE-covariates.Rmd’

--- re-building ‘RxODE-data-frame.Rmd’ using rmarkdown
Warning in engine$weave(file, quiet = quiet, encoding = enc) :
  Pandoc (>= 1.12.3) and/or pandoc-citeproc not available. Falling back to R Markdown v1.
udunits system database from /usr/local/share/udunits
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Attaching package: 'dplyr'

The following objects are masked from 'package:stats':

    filter, lag

The following objects are masked from 'package:base':

    intersect, setdiff, setequal, union

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--- finished re-building ‘RxODE-data-frame.Rmd’

--- re-building ‘RxODE-events.Rmd’ using rmarkdown
Warning in engine$weave(file, quiet = quiet, encoding = enc) :
  Pandoc (>= 1.12.3) and/or pandoc-citeproc not available. Falling back to R Markdown v1.
--- finished re-building ‘RxODE-events.Rmd’

--- re-building ‘RxODE-intro.Rmd’ using rmarkdown
Warning in engine$weave(file, quiet = quiet, encoding = enc) :
  Pandoc (>= 1.12.3) and/or pandoc-citeproc not available. Falling back to R Markdown v1.
--- finished re-building ‘RxODE-intro.Rmd’

--- re-building ‘RxODE-model-types.Rmd’ using rmarkdown
Warning in engine$weave(file, quiet = quiet, encoding = enc) :
  Pandoc (>= 1.12.3) and/or pandoc-citeproc not available. Falling back to R Markdown v1.
Quitting from lines 65-68 (RxODE-model-types.Rmd) 
Error: processing vignette 'RxODE-model-types.Rmd' failed with diagnostics:
cannot open the connection
--- failed re-building ‘RxODE-model-types.Rmd’

--- re-building ‘RxODE-rxUse.Rmd’ using rmarkdown
Warning in engine$weave(file, quiet = quiet, encoding = enc) :
  Pandoc (>= 1.12.3) and/or pandoc-citeproc not available. Falling back to R Markdown v1.
--- finished re-building ‘RxODE-rxUse.Rmd’

--- re-building ‘RxODE-shiny.Rmd’ using rmarkdown
Warning in engine$weave(file, quiet = quiet, encoding = enc) :
  Pandoc (>= 1.12.3) and/or pandoc-citeproc not available. Falling back to R Markdown v1.
--- finished re-building ‘RxODE-shiny.Rmd’

--- re-building ‘RxODE-stiff.Rmd’ using rmarkdown
Warning in engine$weave(file, quiet = quiet, encoding = enc) :
  Pandoc (>= 1.12.3) and/or pandoc-citeproc not available. Falling back to R Markdown v1.
--- finished re-building ‘RxODE-stiff.Rmd’

--- re-building ‘RxODE-syntax.Rmd’ using rmarkdown
Warning in engine$weave(file, quiet = quiet, encoding = enc) :
  Pandoc (>= 1.12.3) and/or pandoc-citeproc not available. Falling back to R Markdown v1.
--- finished re-building ‘RxODE-syntax.Rmd’

--- re-building ‘RxODE-transit-compartments.Rmd’ using rmarkdown
Warning in engine$weave(file, quiet = quiet, encoding = enc) :
  Pandoc (>= 1.12.3) and/or pandoc-citeproc not available. Falling back to R Markdown v1.
--- finished re-building ‘RxODE-transit-compartments.Rmd’

SUMMARY: processing the following file failed:
  ‘RxODE-model-types.Rmd’

Error: Vignette re-building failed.
Execution halted