Package suggested but not available for checking: 'epade'
'LazyData' is specified without a 'data' directory
Running examples in 'Keyboard-Ex.R' failed
The error most likely occurred in:

> base::assign(".ptime", proc.time(), pos = "CheckExEnv")
> ### Name: select.mtd.comb.kb
> ### Title: Maximum Tolerated Dose (MTD) Selection for Drug-combination
> ###   Trials
> ### Aliases: select.mtd.comb.kb
> 
> ### ** Examples
> 
> ### Drug-combination trial ###
> 
> ## Select the MTD based on the data from a 3 x 5 combination trial
> n <- matrix(c(3, 5, 0, 0, 0,
+               7, 6, 15, 0, 0,
+               0, 0, 4, 0, 0), ncol=5, byrow=TRUE)
> y <- matrix(c(0, 1, 0, 0, 0,
+               1, 1, 4, 0, 0,
+               0, 0, 2, 0, 0), ncol=5, byrow=TRUE)
> 
> sel.comb <- select.mtd.comb.kb(target=0.3, npts=n, ntox=y)
> 
> summary.kb(sel.comb)
The MTD is dose combination ( 2 ,  3 ) 

Isotonic estimates of toxicity probabilities for combinations are 
 0.02   0.19     NA     NA     NA  
 0.15   0.19   0.27     NA     NA  
   NA     NA   0.50     NA     NA  

NOTE: no estimate is provided for the doses at which no patient was treated.

> plot.kb(sel.comb)
Error: Package "epade" needed for this function to work.Please install it.
Execution halted
Package suggested but not available for checking: ‘epade’
'LazyData' is specified without a 'data' directory
Running examples in ‘Keyboard-Ex.R’ failed
The error most likely occurred in:

> base::assign(".ptime", proc.time(), pos = "CheckExEnv")
> ### Name: select.mtd.comb.kb
> ### Title: Maximum Tolerated Dose (MTD) Selection for Drug-combination
> ###   Trials
> ### Aliases: select.mtd.comb.kb
> 
> ### ** Examples
> 
> ### Drug-combination trial ###
> 
> ## Select the MTD based on the data from a 3 x 5 combination trial
> n <- matrix(c(3, 5, 0, 0, 0,
+               7, 6, 15, 0, 0,
+               0, 0, 4, 0, 0), ncol=5, byrow=TRUE)
> y <- matrix(c(0, 1, 0, 0, 0,
+               1, 1, 4, 0, 0,
+               0, 0, 2, 0, 0), ncol=5, byrow=TRUE)
> 
> sel.comb <- select.mtd.comb.kb(target=0.3, npts=n, ntox=y)
> 
> summary.kb(sel.comb)
The MTD is dose combination ( 2 ,  3 ) 

Isotonic estimates of toxicity probabilities for combinations are 
 0.02   0.19     NA     NA     NA  
 0.15   0.19   0.27     NA     NA  
   NA     NA   0.50     NA     NA  

NOTE: no estimate is provided for the doses at which no patient was treated.

> plot.kb(sel.comb)
Error: Package "epade" needed for this function to work.Please install it.
Execution halted
Package suggested but not available for checking: ‘epade’
'LazyData' is specified without a 'data' directory
Running examples in ‘Keyboard-Ex.R’ failed
The error most likely occurred in:

> ### Name: select.mtd.comb.kb
> ### Title: Maximum Tolerated Dose (MTD) Selection for Drug-combination
> ###   Trials
> ### Aliases: select.mtd.comb.kb
> 
> ### ** Examples
> 
> ### Drug-combination trial ###
> 
> ## Select the MTD based on the data from a 3 x 5 combination trial
> n <- matrix(c(3, 5, 0, 0, 0,
+               7, 6, 15, 0, 0,
+               0, 0, 4, 0, 0), ncol=5, byrow=TRUE)
> y <- matrix(c(0, 1, 0, 0, 0,
+               1, 1, 4, 0, 0,
+               0, 0, 2, 0, 0), ncol=5, byrow=TRUE)
> 
> sel.comb <- select.mtd.comb.kb(target=0.3, npts=n, ntox=y)
> 
> summary.kb(sel.comb)
The MTD is dose combination ( 2 ,  3 ) 

Isotonic estimates of toxicity probabilities for combinations are 
 0.02   0.19     NA     NA     NA  
 0.15   0.19   0.27     NA     NA  
   NA     NA   0.50     NA     NA  

NOTE: no estimate is provided for the doses at which no patient was treated.

> plot.kb(sel.comb)
Error: Package "epade" needed for this function to work.Please install it.
Execution halted
Package suggested but not available for checking: ‘epade’
'LazyData' is specified without a 'data' directory
Running examples in ‘Keyboard-Ex.R’ failed
The error most likely occurred in:

> ### Name: select.mtd.comb.kb
> ### Title: Maximum Tolerated Dose (MTD) Selection for Drug-combination
> ###   Trials
> ### Aliases: select.mtd.comb.kb
> 
> ### ** Examples
> 
> ### Drug-combination trial ###
> 
> ## Select the MTD based on the data from a 3 x 5 combination trial
> n <- matrix(c(3, 5, 0, 0, 0,
+               7, 6, 15, 0, 0,
+               0, 0, 4, 0, 0), ncol=5, byrow=TRUE)
> y <- matrix(c(0, 1, 0, 0, 0,
+               1, 1, 4, 0, 0,
+               0, 0, 2, 0, 0), ncol=5, byrow=TRUE)
> 
> sel.comb <- select.mtd.comb.kb(target=0.3, npts=n, ntox=y)
> 
> summary.kb(sel.comb)
The MTD is dose combination ( 2 ,  3 ) 

Isotonic estimates of toxicity probabilities for combinations are 
 0.02   0.19     NA     NA     NA  
 0.15   0.19   0.27     NA     NA  
   NA     NA   0.50     NA     NA  

NOTE: no estimate is provided for the doses at which no patient was treated.

> plot.kb(sel.comb)
Error: Package "epade" needed for this function to work.Please install it.
Execution halted
'LazyData' is specified without a 'data' directory
Package suggested but not available for checking: ‘epade’
'LazyData' is specified without a 'data' directory
Running examples in ‘Keyboard-Ex.R’ failed
The error most likely occurred in:

> base::assign(".ptime", proc.time(), pos = "CheckExEnv")
> ### Name: select.mtd.comb.kb
> ### Title: Maximum Tolerated Dose (MTD) Selection for Drug-combination
> ###   Trials
> ### Aliases: select.mtd.comb.kb
> 
> ### ** Examples
> 
> ### Drug-combination trial ###
> 
> ## Select the MTD based on the data from a 3 x 5 combination trial
> n <- matrix(c(3, 5, 0, 0, 0,
+               7, 6, 15, 0, 0,
+               0, 0, 4, 0, 0), ncol=5, byrow=TRUE)
> y <- matrix(c(0, 1, 0, 0, 0,
+               1, 1, 4, 0, 0,
+               0, 0, 2, 0, 0), ncol=5, byrow=TRUE)
> 
> sel.comb <- select.mtd.comb.kb(target=0.3, npts=n, ntox=y)
> 
> summary.kb(sel.comb)
The MTD is dose combination ( 2 ,  3 ) 

Isotonic estimates of toxicity probabilities for combinations are 
 0.02   0.19     NA     NA     NA  
 0.15   0.19   0.27     NA     NA  
   NA     NA   0.50     NA     NA  

NOTE: no estimate is provided for the doses at which no patient was treated.

> plot.kb(sel.comb)
Error: Package "epade" needed for this function to work.Please install it.
Execution halted
Package suggested but not available for checking: ‘epade’
'LazyData' is specified without a 'data' directory
Running examples in ‘Keyboard-Ex.R’ failed
The error most likely occurred in:

> base::assign(".ptime", proc.time(), pos = "CheckExEnv")
> ### Name: select.mtd.comb.kb
> ### Title: Maximum Tolerated Dose (MTD) Selection for Drug-combination
> ###   Trials
> ### Aliases: select.mtd.comb.kb
> 
> ### ** Examples
> 
> ### Drug-combination trial ###
> 
> ## Select the MTD based on the data from a 3 x 5 combination trial
> n <- matrix(c(3, 5, 0, 0, 0,
+               7, 6, 15, 0, 0,
+               0, 0, 4, 0, 0), ncol=5, byrow=TRUE)
> y <- matrix(c(0, 1, 0, 0, 0,
+               1, 1, 4, 0, 0,
+               0, 0, 2, 0, 0), ncol=5, byrow=TRUE)
> 
> sel.comb <- select.mtd.comb.kb(target=0.3, npts=n, ntox=y)
> 
> summary.kb(sel.comb)
The MTD is dose combination ( 2 ,  3 ) 

Isotonic estimates of toxicity probabilities for combinations are 
 0.02   0.19     NA     NA     NA  
 0.15   0.19   0.27     NA     NA  
   NA     NA   0.50     NA     NA  

NOTE: no estimate is provided for the doses at which no patient was treated.

> plot.kb(sel.comb)
Error: Package "epade" needed for this function to work.Please install it.
Execution halted
'LazyData' is specified without a 'data' directory
'LazyData' is specified without a 'data' directory
'LazyData' is specified without a 'data' directory
'LazyData' is specified without a 'data' directory
'LazyData' is specified without a 'data' directory
'LazyData' is specified without a 'data' directory