REPRODUCIBLE STATISTICAL RESEARCH IN PRACTICE Friedrich Leisch Department of Statistics, University of Munich Scientific progress, for which statistical analyses often provide important supporting evidence, requires the reproduction of research results. This applies to statistical research done as part of a collaborative scientific team as well as the development of statistical theory and methods. Communication of results is also important, as required by the peer-review process and needed by the end consumers of the conducted research. Proper scientific review and evaluation should check the correctness of both theoretical evidence, through the checking of proofs and assumptions, and computational results as described by numerical studies and concrete implementations of the proposed methods. As motivating examples we will use two case studies: PhD students and postdocs attending a summer school of the German Biometric Society on "Reproducible Research and Software Validation" were asked to reproduce the results of several biostatistical papers in groups of 2-4 students in a hands-on session. All data necessary to reproduce the results and code provided as online supplement to the journal articles were given to the students. In an ongoing research project a random sample of one hundred articles of one of the leading journals of the field have been analyzed for availability of data, code and other instructions to reproduce results. This talk will discuss the general problem of making computational statistical research reproducible, and show which tools in R are available to assist the analysis. One possible solution is writing parts of manuscripts using Sweave and hence combine text and analysis into one entity. But in many cases providing validated code and data would be sufficient, with emphasis of code validation. In many cases mere availability of code gives others the feeling that results are reproducible, even if they are not. So the future challenge will be to create mechanisms for automatic checking of analysis code beyond the review process of a paper.