* using log directory ‘/Volumes/Builds/packages/big-sur-x86_64/results/4.3/oncomsm.Rcheck’ * using R version 4.3.0 (2023-04-21) * using platform: x86_64-apple-darwin20 (64-bit) * R was compiled by Apple clang version 14.0.3 (clang-1403.0.22.14.1) GNU Fortran (GCC) 12.2.0 * running under: macOS Ventura 13.3.1 * using session charset: UTF-8 * checking for file ‘oncomsm/DESCRIPTION’ ... OK * checking extension type ... Package * this is package ‘oncomsm’ version ‘0.1.4’ * package encoding: UTF-8 * checking package namespace information ... OK * checking package dependencies ... OK * checking if this is a source package ... OK * checking if there is a namespace ... OK * checking for executable files ... OK * checking for hidden files and directories ... OK * checking for portable file names ... OK * checking for sufficient/correct file permissions ... OK * checking whether package ‘oncomsm’ can be installed ... [88s/113s] OK See 'https://www.r-project.org/nosvn/R.check/r-oldrel-macos-x86_64/oncomsm-00install.html' for details. * used C++ compiler: ‘Apple clang version 14.0.3 (clang-1403.0.22.14.1)’ * used SDK: ‘MacOSX11.3.sdk’ * checking C++ specification ... OK Not all R platforms support C++17 * checking installed package size ... NOTE installed size is 39.6Mb sub-directories of 1Mb or more: doc 1.1Mb libs 37.4Mb * checking package directory ... OK * checking ‘build’ directory ... OK * checking DESCRIPTION meta-information ... OK * checking top-level files ... OK * checking for left-over files ... OK * checking index information ... OK * checking package subdirectories ... OK * checking R files for non-ASCII characters ... OK * checking R files for syntax errors ... OK * checking whether the package can be loaded ... [2s/3s] OK * checking whether the package can be loaded with stated dependencies ... [1s/2s] OK * checking whether the package can be unloaded cleanly ... [1s/2s] OK * checking whether the namespace can be loaded with stated dependencies ... [2s/2s] OK * checking whether the namespace can be unloaded cleanly ... [2s/3s] OK * checking loading without being on the library search path ... [2s/3s] OK * checking dependencies in R code ... OK * checking S3 generic/method consistency ... OK * checking replacement functions ... OK * checking foreign function calls ... OK * checking R code for possible problems ... [5s/7s] OK * checking Rd files ... [0s/0s] OK * checking Rd metadata ... OK * checking Rd cross-references ... OK * checking for missing documentation entries ... OK * checking for code/documentation mismatches ... OK * checking Rd \usage sections ... OK * checking Rd contents ... OK * checking for unstated dependencies in examples ... OK * checking line endings in shell scripts ... OK * checking line endings in C/C++/Fortran sources/headers ... OK * checking line endings in Makefiles ... OK * checking compilation flags in Makevars ... OK * checking for GNU extensions in Makefiles ... NOTE GNU make is a SystemRequirements. * checking for portable use of $(BLAS_LIBS) and $(LAPACK_LIBS) ... OK * checking use of PKG_*FLAGS in Makefiles ... OK * checking compiled code ... OK * checking installed files from ‘inst/doc’ ... OK * checking files in ‘vignettes’ ... OK * checking examples ... [6s/9s] OK * checking for unstated dependencies in ‘tests’ ... OK * checking tests ... [49s/89s] OK Running ‘testthat.R’ [49s/89s] * checking for unstated dependencies in vignettes ... OK * checking package vignettes in ‘inst/doc’ ... OK * checking running R code from vignettes ... [1s/1s] NONE ‘avoiding-bias.Rmd’ using ‘UTF-8’... [0s/1s] OK ‘oncomsm.Rmd’ using ‘UTF-8’... [0s/0s] OK ‘prior-choice.Rmd’ using ‘UTF-8’... [0s/0s] OK * checking re-building of vignette outputs ... [24s/53s] ERROR Error(s) in re-building vignettes: --- re-building ‘avoiding-bias.Rmd’ using rmarkdown Pandoc is required to build R Markdown vignettes but not available. Please make sure it is installed. 2023-07-10 21:36:22.865 R[8426:2287719072] XType: Using static font registry. Warning in file.info(x, extra_cols = FALSE) : expanded path length 3828 would be too long for
library(dplyr)
#> 
#> Attaching package: 'dplyr'
#> The following objects are masked from 'package:stats':
#> 
#>     filter, lag
#> The following objects are masked from 'package:base':
#> 
#>     intersect, setdiff, setequal, union
library(tidyr)
library(oncomsm)

tl;dr: During interim looks, individuals might still be stable and thus ‘at risk’ of either progression or response. Especially when the respective follow-up times differ, or if there is a difference in median time to response and median time to progression, this might lead to bias in the analysis of the response probability.

mdl <- create_srpmodel(
  A = define_srp_prior(
    median_t_q05 = c(1, 4, 12), # shorter time to response than progression
    median_t_q95 = c(6, 8, 36),
    # essentially fixed shape:
    shape_q05 = c(0.99, 0.99, 0.9 [... truncated]
--- finished re-building ‘avoiding-bias.Rmd’

--- re-building ‘oncomsm.Rmd’ using rmarkdown
Pandoc is required to build R Markdown vignettes but not available. Please make sure it is installed.

Quitting from lines 52-58 [msm-1] (oncomsm.Rmd)
Error: processing vignette 'oncomsm.Rmd' failed with diagnostics:
Failed to start chrome. Error: 
--- failed re-building ‘oncomsm.Rmd’

--- re-building ‘prior-choice.Rmd’ using rmarkdown
Pandoc is required to build R Markdown vignettes but not available. Please make sure it is installed.
2023-07-10 21:36:41.319 R[17427:2287737071] XType: Using static font registry.
Warning in file.info(x, extra_cols = FALSE) :
  expanded path length 9231 would be too long for
library(dplyr)
#> 
#> Attaching package: 'dplyr'
#> The following objects are masked from 'package:stats':
#> 
#>     filter, lag
#> The following objects are masked from 'package:base':
#> 
#>     intersect, setdiff, setequal, union
library(tidyr)
library(ggplot2)
library(oncomsm)

tl;dr: Identification of the shape parameter is difficult settings with little data and it is thus recommended to restrict the shape parameter to \(1\) (exponential model) if no historical data for the construction of an informative prior is available. A beta-mixture prior is suggested for the response probability and log-normal priors on shape and median time-to-next-event for the time-to-event components.

Why Weibull transition times?

In oncomsm, the distributions of the between-state transition times [... truncated] --- finished re-building ‘prior-choice.Rmd’ SUMMARY: processing the following file failed: ‘oncomsm.Rmd’ Error: Vignette re-building failed. Execution halted * checking PDF version of manual ... [7s/12s] OK * DONE Status: 1 ERROR, 2 NOTEs * using check arguments '--no-clean-on-error ' * elapsed time (check, wall clock): 5:42