C. Furlanello, M. Neteler, S. Merler,S. Menegon, S. Fontanari, A. Donini, A. Rizzoli, C. Chemini GIS and the Random Forest Predictor: Integration in R for Tick-Borne Disease Risk Assessment ************************************************************** We discuss how sophisticated machine learning methods may be rapidly integrated within a GIS for the development of new approaches in landscape epidemiology. A multitemporal predictive map is obtained by modeling in R, analyzing geodata and digital maps in GRASS, and managing biodata samples and weather data in PostgreSQL. In particular, we present a risk mapping system for tick-borne diseases, applied to model the risk of exposure to Lyme borreliosis and tick-borne encephalitis (TBE) in Trentino, Italian Alps.